@article{ZieglerRichterMahretal.2016, author = {Ziegler, C. and Richter, J. and Mahr, M. and Gajewska, A. and Schiele, M.A. and Gehrmann, A. and Schmidt, B. and Lesch, K.-P. and Lang, T. and Helbig-Lang, S. and Pauli, P. and Kircher, T. and Reif, A. and Rief, W. and Vossbeck-Elsebusch, A.N. and Arolt, V. and Wittchen, H.-U. and Hamm, A.O. and Deckert, J. and Domschke, K.}, title = {MAOA gene hypomethylation in panic disorder-reversibility of an epigenetic risk pattern by psychotherapy}, series = {Translational Psychiatry}, journal = {Translational Psychiatry}, number = {6}, doi = {10.1038/tp.2016.41}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-164422}, pages = {e773}, year = {2016}, abstract = {Epigenetic signatures such as methylation of the monoamine oxidase A (MAOA) gene have been found to be altered in panic disorder (PD). Hypothesizing temporal plasticity of epigenetic processes as a mechanism of successful fear extinction, the present psychotherapy-epigenetic study for we believe the first time investigated MAOA methylation changes during the course of exposure-based cognitive behavioral therapy (CBT) in PD. MAOA methylation was compared between N=28 female Caucasian PD patients (discovery sample) and N=28 age- and sex-matched healthy controls via direct sequencing of sodium bisulfite-treated DNA extracted from blood cells. MAOA methylation was furthermore analyzed at baseline (T0) and after a 6-week CBT (T1) in the discovery sample parallelized by a waiting time in healthy controls, as well as in an independent sample of female PD patients (N=20). Patients exhibited lower MAOA methylation than healthy controls (P<0.001), and baseline PD severity correlated negatively with MAOA methylation (P=0.01). In the discovery sample, MAOA methylation increased up to the level of healthy controls along with CBT response (number of panic attacks; T0-T1: +3.37±2.17\%), while non-responders further decreased in methylation (-2.00±1.28\%; P=0.001). In the replication sample, increases in MAOA methylation correlated with agoraphobic symptom reduction after CBT (P=0.02-0.03). The present results support previous evidence for MAOA hypomethylation as a PD risk marker and suggest reversibility of MAOA hypomethylation as a potential epigenetic correlate of response to CBT. The emerging notion of epigenetic signatures as a mechanism of action of psychotherapeutic interventions may promote epigenetic patterns as biomarkers of lasting extinction effects.}, language = {en} } @article{ZhouAllisonKuebleretal.2016, author = {Zhou, Sijie and Allison, Brendan Z. and K{\"u}bler, Andrea and Cichocki, Andrzej and Wang, Xingyu and Jin, Jing}, title = {Effects of Background Music on Objective and Subjective Performance Measures in an Auditory BCI}, series = {Frontiers in Computational Neuroscience}, volume = {10}, journal = {Frontiers in Computational Neuroscience}, number = {105}, doi = {10.3389/fncom.2016.00105}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-165101}, year = {2016}, abstract = {Several studies have explored brain computer interface (BCI) systems based on auditory stimuli, which could help patients with visual impairments. Usability and user satisfaction are important considerations in any BCI. Although background music can influence emotion and performance in other task environments, and many users may wish to listen to music while using a BCI, auditory, and other BCIs are typically studied without background music. Some work has explored the possibility of using polyphonic music in auditory BCI systems. However, this approach requires users with good musical skills, and has not been explored in online experiments. Our hypothesis was that an auditory BCI with background music would be preferred by subjects over a similar BCI without background music, without any difference in BCI performance. We introduce a simple paradigm (which does not require musical skill) using percussion instrument sound stimuli and background music, and evaluated it in both offline and online experiments. The result showed that subjects preferred the auditory BCI with background music. Different performance measures did not reveal any significant performance effect when comparing background music vs. no background. Since the addition of background music does not impair BCI performance but is preferred by users, auditory (and perhaps other) BCIs should consider including it. Our study also indicates that auditory BCIs can be effective even if the auditory channel is simultaneously otherwise engaged.}, language = {en} } @article{WunschPfisterHenningetal.2016, author = {Wunsch, Kathrin and Pfister, Roland and Henning, Anne and Aschersleben, Gisa and Weigelt, Matthias}, title = {No Interrelation of Motor Planning and Executive Functions across Young Ages}, series = {Frontiers in Psychology}, volume = {7}, journal = {Frontiers in Psychology}, number = {1031}, doi = {10.3389/fpsyg.2016.01031}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-165281}, year = {2016}, abstract = {The present study examined the developmental trajectories of motor planning and executive functioning in children. To this end, we tested 217 participants with three motor tasks, measuring anticipatory planning abilities (i.e., the bar-transport-task, the sword-rotation-task and the grasp-height-task), and three cognitive tasks, measuring executive functions (i.e., the Tower-of-Hanoi-task, the Mosaic-task, and the D2-attention-endurance-task). Children were aged between 3 and 10 years and were separated into age groups by 1-year bins, resulting in a total of eight groups of children and an additional group of adults. Results suggested (1) a positive developmental trajectory for each of the sub-tests, with better task performance as children get older; (2) that the performance in the separate tasks was not correlated across participants in the different age groups; and (3) that there was no relationship between performance in the motor tasks and in the cognitive tasks used in the present study when controlling for age. These results suggest that both, motor planning and executive functions are rather heterogeneous domains of cognitive functioning with fewer interdependencies than often suggested.}, language = {en} } @article{WieserReichertsJuravleetal.2016, author = {Wieser, Matthias J. and Reicherts, Philipp and Juravle, Georgiana and von Leupoldt, Andreas}, title = {Attention mechanisms during predictable and unpredictable threat - a steady-state visual evoked potential approach}, series = {NeuroImage}, volume = {139}, journal = {NeuroImage}, doi = {10.1016/j.neuroimage.2016.06.026}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-187365}, pages = {167-175}, year = {2016}, abstract = {Fear is elicited by imminent threat and leads to phasic fear responses with selective attention, whereas anxiety is characterized by a sustained state of heightened vigilance due to uncertain danger. In the present study, we investigated attention mechanisms in fear and anxiety by adapting the NPU-threat test to measure steady-state visual evoked potentials (ssVEPs). We investigated ssVEPs across no aversive events (N), predictable aversive events (P), and unpredictable aversive events (U), signaled by four-object arrays (30 s). In addition, central cues were presented during all conditions but predictably signaled imminent threat only during the P condition. Importantly, cues and context events were flickered at different frequencies (15 Hz vs. 20 Hz) in order to disentangle respective electrocortical responses. The onset of the context elicited larger electrocortical responses for U compared to P context. Conversely, P cues elicited larger electrocortical responses compared to N cues. Interestingly, during the presence of the P cue, visuocortical processing of the concurrent context was also enhanced. The results support the notion of enhanced initial hypervigilance to unpredictable compared to predictable threat contexts, while predictable cues show electrocortical enhancement of the cues themselves but additionally a boost of context processing.}, language = {en} } @article{WalzMuehlbergerPauli2016, author = {Walz, Nora and M{\"u}hlberger, Andreas and Pauli, Paul}, title = {A human open field test reveals thigmotaxis related to agoraphobic fear}, series = {Biological Psychiatry}, volume = {80}, journal = {Biological Psychiatry}, number = {5}, doi = {10.1016/j.biopsych.2015.12.016}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-187607}, pages = {390-397}, year = {2016}, abstract = {BACKGROUND: Thigmotaxis refers to a specific behavior of animals (i.e., to stay close to walls when exploring an open space). Such behavior can be assessed with the open field test (OFT), which is a well-established indicator of animal fear. The detection of similar open field behavior in humans may verify the translational validity of this paradigm. Enhanced thigmotaxis related to anxiety may suggest the relevance of such behavior for anxiety disorders, especially agoraphobia. METHODS: A global positioning system was used to analyze the behavior of 16 patients with agoraphobia and 18 healthy individuals with a risk for agoraphobia (i.e., high anxiety sensitivity) during a human OFT and compare it with appropriate control groups (n = 16 and n = 19). We also tracked 17 patients with agoraphobia and 17 control participants during a city walk that involved walking through an open market square. RESULTS: Our human OFT triggered thigmotaxis in participants; patients with agoraphobia and participants with high anxiety sensitivity exhibited enhanced thigmotaxis. This behavior was evident in increased movement lengths along the wall of the natural open field and fewer entries into the center of the field despite normal movement speed and length. Furthermore, participants avoided passing through the market square during the city walk, indicating again that thigmotaxis is related to agoraphobia. CONCLUSIONS: This study is the first to our knowledge to verify the translational validity of the OFT and to reveal that thigmotaxis, an evolutionarily adaptive behavior shown by most species, is related to agoraphobia, a pathologic fear of open spaces, and anxiety sensitivity, a risk factor for agoraphobia.}, language = {en} } @phdthesis{Ulrich2016, author = {Ulrich, Natalie}, title = {Processing of Near Outcomes and Outcome Sequences in Gambling: Implications for the Biopsychological Basis of Problem Gambling}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-139612}, school = {Universit{\"a}t W{\"u}rzburg}, year = {2016}, abstract = {Gambling is a popular activity in Germany, with 40\% of a representative sample reporting having gambled at least once in the past year (Bundeszentrale f{\"u}r gesundheitliche Aufkl{\"a}rung, 2014). While the majority of gamblers show harmless gambling behavior, a subset develops serious problems due to their gambling, affecting their psychological well-being, social life and work. According to recent estimates, up to 0.8\% of the German population are affected by such pathological gambling. People in general and pathological gamblers in particular show several cognitive distortions, that is, misconceptions about the chances of winning and skill involvement, in gambling. The current work aimed at elucidating the biopsychological basis of two such kinds of cognitive distortions, the illusion of control and the gambler's and hot hand fallacies, and their modulation by gambling problems. Therefore, four studies were conducted assessing the processing of near outcomes (used as a proxy for the illusion of control) and outcome sequences (used as a proxy for the gambler's and hot hand fallacies) in samples of varying degrees of gambling problems, using a multimethod approach. The first study analyzed the processing and evaluation of near outcomes as well as choice behavior in a wheel of fortune paradigm using electroencephalography (EEG). To assess the influence of gambling problems, a group of problem gamblers was compared to a group of controls. The results showed that there were no differences in the processing of near outcomes between the two groups. Near compared to full outcomes elicited smaller P300 amplitudes. Furthermore, at a trend level, the choice behavior of participants showed signs of a pattern opposite to the gambler's fallacy, with longer runs of an outcome color leading to increased probabilities of choosing this color again on the subsequent trial. Finally, problem gamblers showed smaller feedback-related negativity (FRN) amplitudes relative to controls. The second study also targeted the processing of near outcomes in a wheel of fortune paradigm, this time using functional magnetic resonance imaging and a group of participants with varying degrees of gambling problems. The results showed increased activity in the bilateral superior parietal cortex following near compared to full outcomes. The third study examined the peripheral physiology reactions to near outcomes in the wheel of fortune. Heart period and skin conductance were measured while participants with varying degrees of gambling problems played on the wheel of fortune. Near compared to full outcomes led to increased heart period duration shortly after the outcome. Furthermore, heart period reactions and skin conductance responses (SCRs) were modulated by gambling problems. Participants with high relative to low levels of gambling problems showed increased SCRs to near outcomes and similar heart period reactions to near outcomes and full wins. The fourth study analyzed choice behavior and sequence effects in the processing of outcomes in a coin toss paradigm using EEG in a group of problem gamblers and controls. Again, problem gamblers showed generally smaller FRN amplitudes compared to controls. There were no differences between groups in the processing of outcome sequences. The break of an outcome streak led to increased power in the theta frequency band. Furthermore, the P300 amplitude was increased after a sequence of previous wins. Finally, problem gamblers compared to controls showed a trend of switching the outcome symbol relative to the previous outcome symbol more often. In sum, the results point towards differences in the processing of near compared to full outcomes in brain areas and measures implicated in attentional and salience processes. The processing of outcome sequences involves processes of salience attribution and violation of expectations. Furthermore, problem gamblers seem to process near outcomes as more win-like compared to controls. The results and their implications for problem gambling as well as further possible lines of research are discussed.}, subject = {Spielsucht}, language = {en} } @article{StoeckelEsserGameretal.2016, author = {Stoeckel, M. Cornelia and Esser, Roland W. and Gamer, Matthias and B{\"u}chel, Christian and von Leupoldt, Andreas}, title = {Brain Responses during the Anticipation of Dyspnea}, series = {Neural Plasticity}, volume = {2016}, journal = {Neural Plasticity}, number = {6434987}, doi = {10.1155/2016/6434987}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-166238}, year = {2016}, abstract = {Dyspnea is common in many cardiorespiratory diseases. Already the anticipation of this aversive symptom elicits fear in many patients resulting in unfavorable health behaviors such as activity avoidance and sedentary lifestyle. This study investigated brain mechanisms underlying these anticipatory processes. We induced dyspnea using resistive-load breathing in healthy subjects during functional magnetic resonance imaging. Blocks of severe and mild dyspnea alternated, each preceded by anticipation periods. Severe dyspnea activated a network of sensorimotor, cerebellar, and limbic areas. The left insular, parietal opercular, and cerebellar cortices showed increased activation already during dyspnea anticipation. Left insular and parietal opercular cortex showed increased connectivity with right insular and anterior cingulate cortex when severe dyspnea was anticipated, while the cerebellum showed increased connectivity with the amygdala. Notably, insular activation during dyspnea perception was positively correlated with midbrain activation during anticipation. Moreover, anticipatory fear was positively correlated with anticipatory activation in right insular and anterior cingulate cortex. The results demonstrate that dyspnea anticipation activates brain areas involved in dyspnea perception. The involvement of emotion-related areas such as insula, anterior cingulate cortex, and amygdala during dyspnea anticipation most likely reflects anticipatory fear and might underlie the development of unfavorable health behaviors in patients suffering from dyspnea.}, language = {en} } @article{SchieleReinhardReifetal.2016, author = {Schiele, Miriam A. and Reinhard, Julia and Reif, Andreas and Domschke, Katharina and Romanos, Marcel and Deckert, J{\"u}rgen and Pauli, Paul}, title = {Developmental aspects of fear: Comparing the acquisition and generalization of conditioned fear in children and adults}, series = {Developmental Psychobiology}, volume = {58}, journal = {Developmental Psychobiology}, number = {4}, doi = {10.1002/dev.21393}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-189488}, pages = {471-481}, year = {2016}, abstract = {Most research on human fear conditioning and its generalization has focused on adults whereas only little is known about these processes in children. Direct comparisons between child and adult populations are needed to determine developmental risk markers of fear and anxiety. We compared 267 children and 285 adults in a differential fear conditioning paradigm and generalization test. Skin conductance responses (SCR) and ratings of valence and arousal were obtained to indicate fear learning. Both groups displayed robust and similar differential conditioning on subjective and physiological levels. However, children showed heightened fear generalization compared to adults as indexed by higher arousal ratings and SCR to the generalization stimuli. Results indicate overgeneralization of conditioned fear as a developmental correlate of fear learning. The developmental change from a shallow to a steeper generalization gradient is likely related to the maturation of brain structures that modulate efficient discrimination between danger and (ambiguous) safety cues.}, language = {en} } @phdthesis{Rodrigues2016, author = {Rodrigues, Johannes}, title = {Let me change your mind… Frontal brain activity in a virtual T-maze}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-143280}, school = {Universit{\"a}t W{\"u}rzburg}, year = {2016}, abstract = {Frontal asymmetry, a construct invented by Richard Davidson, linking positive and negative valence as well as approach and withdrawal motivation to lateralized frontal brain activation has been investigated for over thirty years. The frontal activation patterns described as relevant were measured via alpha-band frequency activity (8-13 Hz) as a measurement of deactivation in electroencephalography (EEG) for homologous electrode pairs, especially for the electrode position F4/ F3 to account for the frontal relative lateralized brain activation. Three different theories about frontal activation patterns linked to motivational states were investigated in two studies. The valence theory of Davidson (1984; 1998a; 1998b) and its extension to the motivational direction theory by Harmon-Jones and Allen (1998) refers to the approach motivation with relative left frontal brain activity (indicated by relative right frontal alpha activity) and to withdrawal motivation with relative right frontal brain activation (indicated by relative left frontal alpha activity). The second theory proposed by Hewig and colleagues (2004; 2005; 2006) integrates the findings of Davidson and Harmon - Jones and Allen with the reinforcement sensitivity theory of Jeffrey A. Gray (1982, 1991). Hewig sees the lateralized frontal approach system and withdrawal system proposed by Davidson as subsystems of the behavioral activation system proposed by Gray and bilateral frontal activation as a biological marker for the behavioral activation system. The third theory investigated in the present studies is the theory from Wacker and colleagues (2003; 2008; 2010) where the frontal asymmetrical brain activation patterns are linked to the revised reinforcement sensitivity theory of Gray and McNaughton (2000). Here, right frontal brain activity (indicated by lower relative right frontal alpha activity) accounts for conflict, behavioral inhibition and activity of the revised behavioral inhibition system, while left frontal brain activation (indicated by lower relative left frontal alpha activity) stands for active behavior and the activity of the revised behavioral activation system as well as the activation of the revised flight fight freezing system. In order to investigate these three theories, a virtual reality T-maze paradigm was introduced to evoke motivational states in the participants, offering the opportunity to measure frontal brain activation patterns via EEG and behavior simultaneously in the first study. In the second study the virtual reality paradigm was additionally compared to mental imagery and a movie paradigm, two well-known state inducing paradigms in the research field of frontal asymmetry. In the two studies, there was confirming evidence for the theory of Hewig and colleages (2004; 2005; 2006), showing higher bilateral frontal activation for active behavior and lateralized frontal activation patterns for approach (left frontal brain activation) and avoidance (right frontal brain activation) behavior. Additionally a limitation for the capability model of anterior brain asymmetry proposed by Coan and colleagues (2006), where the frontal asymmetry should be dependent on the relevant traits driving the frontal asymmetry pattern if a relevant situation occurs, could be found. As the very intense virtual reality paradigm did not lead to a difference of frontal brain activation patterns compared to the mental imagery paradigm or the movie paradigm for the traits of the participants, the trait dependency of the frontal asymmetry in a relevant situation might not be given, if the intensity of the situation exceeds a certain level. Nevertheless there was an influence of the traits in the virtual reality T-maze paradigm, because the shown behavior in the maze was trait-dependent. The implications of the findings are multifarious, leading from possible objective personality testing via diversification of the virtual reality paradigm to even clinical implications for depression treatments based on changes in the lateralized frontal brain activation patterns for changes in the motivational aspects, but also for changes in bilateral frontal brain activation when it comes to the drive and preparedness for action in patients. Finally, with the limitation of the capability model, additional variance in the different findings about frontal asymmetry can be explained by taking the intensity of a state manipulation into account.}, subject = {Electroencephalographie}, language = {en} } @article{RieplMusselOsinskyetal.2016, author = {Riepl, Korbinian and Mussel, Patrick and Osinsky, Roman and Hewig, Johannes}, title = {Influences of State and Trait Affect on Behavior, Feedback-Related Negativity, and P3b in the Ultimatum Game}, series = {PLoS One}, volume = {7}, journal = {PLoS One}, number = {11}, doi = {10.1371/journal.pone.0146358}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-147386}, pages = {e0146358}, year = {2016}, abstract = {The present study investigates how different emotions can alter social bargaining behavior. An important paradigm to study social bargaining is the Ultimatum Game. There, a proposer gets a pot of money and has to offer part of it to a responder. If the responder accepts, both players get the money as proposed by the proposer. If he rejects, none of the players gets anything. Rational choice models would predict that responders accept all offers above 0. However, evidence shows that responders typically reject a large proportion of all unfair offers. We analyzed participants' behavior when they played the Ultimatum Game as responders and simultaneously collected electroencephalogram data in order to quantify the feedback-related negativity and P3b components. We induced state affect (momentarily emotions unrelated to the task) via short movie clips and measured trait affect (longer-lasting emotional dispositions) via questionnaires. State happiness led to increased acceptance rates of very unfair offers. Regarding neurophysiology, we found that unfair offers elicited larger feedback-related negativity amplitudes than fair offers. Additionally, an interaction of state and trait affect occurred: high trait negative affect (subsuming a variety of aversive mood states) led to increased feedback-related negativity amplitudes when participants were in an angry mood, but not if they currently experienced fear or happiness. We discuss that increased rumination might be responsible for this result, which might not occur, however, when people experience happiness or fear. Apart from that, we found that fair offers elicited larger P3b components than unfair offers, which might reflect increased pleasure in response to fair offers. Moreover, high trait negative affect was associated with decreased P3b amplitudes, potentially reflecting decreased motivation to engage in activities. We discuss implications of our results in the light of theories and research on depression and anxiety.}, language = {en} } @article{ReichertsGerdesPaulietal.2016, author = {Reicherts, Philipp and Gerdes, Antje B. M. and Pauli, Paul and Wieser, Matthias J.}, title = {Psychological placebo and nocebo effects on pain rely on expectation and previous experience}, series = {Journal of Pain}, volume = {17}, journal = {Journal of Pain}, number = {2}, doi = {10.1016/j.jpain.2015.10.010}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-190962}, pages = {203-214}, year = {2016}, abstract = {Expectation and previous experience are both well established key mediators of placebo and nocebo effects. However, the investigation of their respective contribution to placebo and nocebo responses is rather difficult because most placebo and nocebo manipulations are contaminated by pre-existing treatment expectancies resulting from a learning history of previous medical interventions. To circumvent any resemblance to classical treatments, a purely psychological placebonocebo manipulation was established, namely, the "visual stripe pattern induced modulation of pain." To this end, experience and expectation regarding the effects of different visual cues (stripe patterns) on pain were varied across 3 different groups, with either only placebo instruction (expectation), placebo conditioning (experience), or both (expectation + experience) applied. Only the combined manipulation (expectation + experience) revealed significant behavioral and physiological placebo nocebo effects on pain. Two subsequent experiments, which, in addition to placebo and nocebo cues, included a neutral control condition further showed that especially nocebo responses were more easily induced by this psychological placebo and nocebo manipulation. The results emphasize the great effect of psychological processes on placebo and nocebo effects. Particularly, nocebo effects should be addressed more thoroughly and carefully considered in clinical practice to prevent the accidental induction of side effects.}, language = {en} } @phdthesis{Pieczykolan2016, author = {Pieczykolan, Aleksandra}, title = {Cross-Modal Action Control}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-142356}, school = {Universit{\"a}t W{\"u}rzburg}, year = {2016}, abstract = {Multitasking als allgegenw{\"a}rtiges Ph{\"a}nomen wird heutzutage in verschiedenen wissenschaftlichen Disziplinen diskutiert. In der vorliegenden Arbeit wird Multitasking aus der Perspektive der kognitiven Verhaltenswissenschaften beleuchtet mit dem Fokus auf der Rolle von Konfliktl{\"o}sungs- prozessen bei der Verarbeitung von Mehrfacht{\"a}tigkeiten. Insbesondere liegt der Fokus auf kognitiven Mechanismen der crossmodalen Handlungskontrolle, d.h. der Kontrolle von zwei Handlungen in verschiedenen Effektorsystemen. Mit dem Ziel, den bisherigen Umfang derjenigen Handlungsmodalit{\"a}ten zu erweitern, die {\"u}blicherweise in Studien eingesetzt wurden, wurden okulomotorische Reaktionen (d.h. Sakkaden), die bisher als Handlungsmodalit{\"a}t in der Forschung vernachl{\"a}ssigt wurden, in Kombination mit Reaktionen in anderen Efffektorsystemen untersucht (d.h. mit manuellen und vokalen Reaktionen). Weiterhin wurde beabsichtigt, Mechanismen von Crosstalk zu spezifizieren, welches ein Erkl{\"a}rungskonzept darstellt, das sich auf den Aufgabeninhalt bezieht. Crosstalk erscheint besonders relevant f{\"u}r crossmodale Handlungen, da sich Handlungsmodalit{\"a}ten vor allem bez{\"u}glich ihrer Reaktionsmerkmale unterscheiden. In der vorliegenden Arbeit werden vier Studien berichtet, die auf jeweils zwei oder drei Experimenten beruhen. In Studie A wurden crossmodale Doppelreaktionen auf einen einzelnen Stimulus untersucht mit der Fragestellung, wie sich das Zusammenspiel des Vorhandenseins von Reaktionsalternativen und der Kompatibilit{\"a}t zwischen Reaktionen (also dem Crosstalkpotential) auswirkt. In drei Experimenten zeigte sich, dass Crosstalk in mehrere Komponenten dissoziiert werden kann, n{\"a}mlich eine Komponente, die auf der aktuellen Konfliktst{\"a}rke (Online-Crosstalk) basiert, und eine ged{\"a}chtnisbasierte Komponente, die entweder durch Restaktivit{\"a}t vergangener Handlungsanforderungen bestimmt wird (retrospektiver Crosstalk), oder durch Vorbereitung auf zuk{\"u}nftige Handlungsanforderungen (prospektiver Crosstalk). Studie B lieferte Evidenz daf{\"u}r, dass okulomotorische Reaktionen sowohl struktureller als auch inhaltsbasierte Interferenz unterliegen. In drei Experimenten wurde das Paradigma zeitlich {\"u}berlappender Aufgaben verwendet, bei dem zwei Stimuli mit zeitlichem Versatz pr{\"a}sentiert wurden, auf die jeweils mit einer okulomotorischen und einer manuellen Handlung reagiert werden musste. Dabei wurden sowohl Hinweise auf einen seriellen als auch auf einen parallelen Verarbeitungsmodus gefunden. Weiterhin deuteten die Ergebnisse darauf hin, dass abh{\"a}ngig von der Aufgabenkompatibilit{\"a}t zwischen diesen Verarbeitungsmodi gewechselt wurde, d.h. zu eher paralleler Verarbeitung bei kompatiblen Aufgabenanforderungen und zu eher serieller Verarbeitung bei inkompatiblen Aufgabenanforderungen. In Studie C wurden Verarbeitungspriorit{\"a}ten zwischen Effektorsystemen untersucht. In zwei Experimenten zeigte sich, dass das zuvor berichtete Verarbeitungsdominanzmuster repliziert werden konnte, bei der okulomotorische Reaktionen vokale Reaktionen dominieren und diese wiederum manuelle Reaktionen dominieren. Die relative St{\"a}rke der Dominanz konnte allerdings bei vorhandenem Reaktionskonflikt angepasst werden. Die Verarbeitungspriorit{\"a}ten wurden hierbei zum Teil in Richtung derjenigen Reaktion verschoben, in der bereits ein Konflikt im Bezug auf die Kompatibilit{\"a}t zwischen Stimulus und Reaktion gel{\"o}st werden musste. Dieses Ergebnis zeigt, dass Verarbeitungspriorit{\"a}ten flexibel an die spezifischen Handlungsanforderungen angepasst werden k{\"o}nnen. Studie D besch{\"a}ftigte sich mit einem bisher weitgehend vernachl{\"a}ssigten Bereich innerhalb der Doppelaufgabenforschung, n{\"a}mlich der Kontrolle der zeitlichen Reaktionsreihenfolge. In einer drei Experimente umfassenden Untersuchung wurden mehrere Faktoren variiert, die sich in fr{\"u}heren Studien bereits als relevant f{\"u}r Mechanismen der Doppelaufgabeninterferenz gezeigt haben. In der vorliegenden Studie wurde gezeigt, dass die finale Reaktionsreihenfolge in einem Handlungsdurchgang das Ergebnis eines kontinuierlichen Anpassungsprozesses ist, welcher auf dem Zusammenspiel mehrerer top-down-Faktoren, z.B. der Antizipation von Reaktionsmerkmalen, und mehrerer bottom-up-Faktoren, wie z.B. der Stimulusreihenfolge oder der Aufgabenkompatibilit{\"a}t, basiert. Die vorliegende Arbeit liefert somit einen wichtigen Beitrag zum Fortschritt des Verst{\"a}ndnisses der Verarbeitung komplexer Handlungsanforderungen aus der Perspektive crossmodaler Handlungen. Insbesondere wurden Spezifikationen f{\"u}r Mechanismen der Effektorpriorisierung und der Kontrolle der Reaktionsreihenfolge als auch eine neuartige Taxonomie von Crosstalk vorgestellt, welche als umfassende Rahmenvorstellung zur Erkl{\"a}rung von Interferenzmechanismen bei Kontrollprozessen von Mehrfachanforderungen dienlich sein kann.}, subject = {Kognition}, language = {en} } @article{PeperkornDiemerAlpersetal.2016, author = {Peperkorn, Henrik M. and Diemer, Julia E. and Alpers, Georg W. and M{\"u}hlberger, Andreas}, title = {Representation of Patients' Hand Modulates Fear Reactions of Patients with Spider Phobia in Virtual Reality}, series = {frontiers in Psychology}, volume = {7}, journal = {frontiers in Psychology}, number = {268}, doi = {10.3389/fpsyg.2016.00268}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-165307}, year = {2016}, abstract = {Embodiment (i.e., the involvement of a bodily representation) is thought to be relevant in emotional experiences. Virtual reality (VR) is a capable means of activating phobic fear in patients. The representation of the patient's body (e.g., the right hand) in VR enhances immersion and increases presence, but its effect on phobic fear is still unknown. We analyzed the influence of the presentation of the participant's hand in VR on presence and fear responses in 32 women with spider phobia and 32 matched controls. Participants sat in front of a table with an acrylic glass container within reaching distance. During the experiment this setup was concealed by a head-mounted display (HMD). The VR scenario presented via HMD showed the same setup, i.e., a table with an acrylic glass container. Participants were randomly assigned to one of two experimental groups. In one group, fear responses were triggered by fear-relevant visual input in VR (virtual spider in the virtual acrylic glass container), while information about a real but unseen neutral control animal (living snake in the acrylic glass container) was given. The second group received fear-relevant information of the real but unseen situation (living spider in the acrylic glass container), but visual input was kept neutral VR (virtual snake in the virtual acrylic glass container). Participants were instructed to touch the acrylic glass container with their right hand in 20 consecutive trials. Visibility of the hand was varied randomly in a within-subjects design. We found for all participants that visibility of the participant's hand increased presence independently of the fear trigger. However, in patients, the influence of the virtual hand on fear depended on the fear trigger. When fear was triggered perceptually, i.e., by a virtual spider, the virtual hand increased fear. When fear was triggered by information about a real spider, the virtual hand had no effect on fear. Our results shed light on the significance of different fear triggers (visual, conceptual) in interaction with body representations.}, language = {en} } @phdthesis{Muenchow2016, author = {M{\"u}nchow, Hannes}, title = {I feel, therefore I learn - Effectiveness of affect induction interventions and possible covariates on learning outcomes}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-148432}, school = {Universit{\"a}t W{\"u}rzburg}, year = {2016}, abstract = {Affective states in the context of learning and achievement can influence the learning process essentially. The impact of affective states can be both directly on the learning performance and indirectly mediated via, for example, motivational processes. Positive activating affect is often associated with increased memory skills as well as advantages in creative problem solving. Negative activating affect on the other hand is regarded to impair learning outcomes because of promoting task-irrelevant thinking. While these relationships were found to be relatively stable in correlation studies, causal relationships have been examined rarely so far. This dissertation aims to investigate the effects of positive and negative affective states in multimedia learning settings and to identify potential moderating factors. Therefore, three experimental empirical studies on university students were conducted. In Experiment 1, N = 57 university students were randomly allocated to either a positive or negative affect induction group. Affects were elicited using short film clips. After a 20-minute learning phase in a hypertext-based multimedia learning environment on "functional neuroanatomy" the learners' knowledge as well as transfer performance were measured. It was assumed that inducing positive activating affect should enhance learning performance. Eliciting negative activating affect on the other hand should impair learning performance. However, it was found that the induction of negative activating affect prior to the learning phase resulted in slight deteriorations in knowledge. Contrary to the assumptions, inducing positive activating affect before the learning phase did not improve learning performance. Experiment 2 induced positive activating affect directly during learning. To induce affective states during the entire duration of the learning phase, Experiment 2 used an emotional design paradigm. Therefore, N = 111 university students were randomly assigned to learn either in an affect inducing multimedia learning environment (use of warm colours and round shapes) or an affectively neutral counterpart (using shades of grey and angular shapes) on the same topic as in Experiment 1. Again, knowledge as well as transfer performance were measured after learning for 20 minutes. In addition, positive and negative affective states were measured before and after learning. Complex interaction patterns between the treatment and initial affective states were found. Specifically, learners with high levels of positive affect before learning showed better transfer performance when they learned in the affect inducing learning environment. Regarding knowledge, those participants who reported high levels of negative activating affect prior to the learning period performed worse. However, the effect on knowledge did not occur for those students learning in the affect inducing learning environment. For knowledge, the treatment therefore protected against poorer performance due to high levels of negative affective states. Results of Experiment 2 showed that the induction of positive activating affect influenced learning performance positively when taking into account affective states prior to the learning phase. In order to confirm these interaction effects, a conceptual replication of the previous experiment was conducted in Experiment 3. Experiment 3 largely retained the former study design, but changed the learning materials and tests used. Analogous to Experiment 2, N = 145 university students learning for 20 minutes in either an affect inducing or an affectively neutral multimedia learning environment on "eukaryotic cell". To strengthen the treatment, Experiment 3 also used anthropomorphic design elements to induce affective states next to warm colours and round shapes. Moreover, in order to assess the change in affective states more exactly, an additional measurement of positive and negative affective states after half of the learning time was inserted. Knowledge and transfer were assessed again to measure learning performance. The learners' memory skills were used as an additional learning outcome. To control the influence of potential confounding variables, the participants' general and current achievement motivation as well as interest, and emotion regulation skills were measured. Contrary to the assumptions, Experiment 3 could not confirm the interaction effects of Experiment 2. Instead, there was a significant impact of positive activating affect prior to the learning phase on transfer, irrespective of the learners' group affiliation. This effect was further independent of the control variables that were measured. Nevertheless, the results of Experiment 3 fit into the picture of findings regarding "emotional design" in hypermedia learning settings. To date, the few publications that have used this approach propose heterogeneous results, even when using identical materials and procedures.}, subject = {Affekt}, language = {en} } @article{MusselUlrichAllenetal.2016, author = {Mussel, Patrick and Ulrich, Nathalie and Allen, John J. B. and Osinsky, Roman and Hewig, Johannes}, title = {Patterns of theta oscillation reflect the neural basis of individual differences in epistemic motivation}, series = {Scientific Reports}, volume = {6}, journal = {Scientific Reports}, doi = {10.1038/srep29245}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-146957}, pages = {29245}, year = {2016}, abstract = {Theta oscillations in the EEG have been shown to reflect ongoing cognitive processes related to mental effort. Here, we show that the pattern of theta oscillation in response to varying cognitive demands reflects stable individual differences in the personality trait epistemic motivation: Individuals with high levels of epistemic motivation recruit relatively more cognitive resources in response to situations possessing high, compared to low, cognitive demand; individuals with low levels do not show such a specific response. Our results provide direct evidence for the theory of the construct need for cognition and add to our understanding of the neural processes underlying theta oscillations. More generally, we provide an explanation how individual differences in personality traits might be represented on a neural level.}, language = {en} } @article{MeulePlatte2016, author = {Meule, Adrian and Platte, Petra}, title = {Attentional bias toward high-calorie food-cues and trait motor impulsivity interactively predict weight gain}, series = {Health Psychology Open}, journal = {Health Psychology Open}, doi = {10.1177/2055102916649585}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-168504}, year = {2016}, abstract = {Strong bottom-up impulses and weak top-down control may interactively lead to overeating and, consequently, weight gain. In the present study, female university freshmen were tested at the start of the first semester and again at the start of the second semester. Attentional bias toward high- or low-calorie food-cues was assessed using a dot-probe paradigm and participants completed the Barratt Impulsiveness Scale. Attentional bias and motor impulsivity interactively predicted change in body mass index: motor impulsivity positively predicted weight gain only when participants showed an attentional bias toward high-calorie food-cues. Attentional and non-planning impulsivity were unrelated to weight change. Results support findings showing that weight gain is prospectively predicted by a combination of weak top-down control (i.e. high impulsivity) and strong bottom-up impulses (i.e. high automatic motivational drive toward high-calorie food stimuli). They also highlight the fact that only specific aspects of impulsivity are relevant in eating and weight regulation.}, language = {en} } @article{MavratzakisHerbertWalla2016, author = {Mavratzakis, Aimee and Herbert, Cornelia and Walla, Peter}, title = {Emotional facial expressions evoke faster orienting responses, but weaker emotional responses at neural and behavioural levels compared to scenes: a simultaneous EEG and facial EMG study}, series = {NeuroImage}, volume = {124}, journal = {NeuroImage}, number = {Part A}, doi = {10.1016/j.neuroimage.2015.09.065}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-191535}, pages = {931-946}, year = {2016}, abstract = {In the current study, electroencephalography (EEG) was recorded simultaneously with facial electromyography (fEMG) to determine whether emotional faces and emotional scenes are processed differently at the neural level. In addition, it was investigated whether these differences can be observed at the behavioural level via spontaneous facial muscle activity. Emotional content of the stimuli did not affect early P1 activity. Emotional faces elicited enhanced amplitudes of the face-sensitive N170 component, while its counterpart, the scene-related N100, was not sensitive to emotional content of scenes. At 220-280 ms, the early posterior negativity (EPN) was enhanced only slightly for fearful as compared to neutral or happy faces. However, its amplitudes were significantly enhanced during processing of scenes with positive content, particularly over the right hemisphere. Scenes of positive content also elicited enhanced spontaneous zygomatic activity from 500-750 ms onwards, while happy faces elicited no such changes. Contrastingly, both fearful faces and negative scenes elicited enhanced spontaneous corrugator activity at 500-750 ms after stimulus onset. However, relative to baseline EMG changes occurred earlier for faces (250 ms) than for scenes (500 ms) whereas for scenes activity changes were more pronounced over the whole viewing period. Taking into account all effects, the data suggests that emotional facial expressions evoke faster attentional orienting, but weaker affective neural activity and emotional behavioural responses compared to emotional scenes.}, language = {en} } @phdthesis{Loeffler2016, author = {L{\"o}ffler, Elisabeth Therese}, title = {Die Entwicklung des prozeduralen Metaged{\"a}chtnisses {\"u}ber die Lebensspanne}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-150424}, school = {Universit{\"a}t W{\"u}rzburg}, year = {2016}, abstract = {Der Entwicklungsverlauf metakognitiver {\"U}berwachungsprozesse und das Zusammenspiel von {\"U}berwachungs- und Kontrollprozessen ist {\"u}ber die gesamte Lebensspanne hinweg nur f{\"u}r isolierte Altersgruppen, nicht aber in Studien, die Teilnehmer vom Kindes- bis zum h{\"o}heren Erwachsenenalter einschließen, untersucht worden. Diese L{\"u}cke sollte mit der vorliegenden Arbeit geschlossen werden, denn gerade solche Designs k{\"o}nnen dazu beitragen, Aufbau- und Abbauprozesse zu kontrastieren, und Hinweise auf fr{\"u}hzeitig vorhandene sowie im Altersverlauf bestehende F{\"a}higkeiten geben, die dann kompensatorisch genutzt werden k{\"o}nnen. Die eigene Arbeit befasste sich dabei mit dem Verlauf einer Vielzahl von pro- und retrospektiven {\"U}berwachungsvorg{\"a}ngen {\"u}ber die Lebensspanne. Der Schwerpunkt lag auf dem Einfluss verschiedener Kontextfaktoren (z.B. Komplexit{\"a}t des Lernmaterials, Vorwissen, Strategienutzung) auf die {\"U}berwachungsleistung in den jeweiligen Altersstufen. Außerdem wurde {\"u}berpr{\"u}ft, inwieweit wechselseitige Zusammenh{\"a}nge zwischen {\"U}berwachungs- und Steuerungsprozessen in den untersuchten Altersgruppen unterschiedlich stark ausgepr{\"a}gt sind. Diese Fragestellungen wurden in sechs Experimenten mit insgesamt 816 Teilnehmern untersucht. Es handelte sich dabei um Drittkl{\"a}ssler im Alter zwischen 7 und 9 Jahren, Jugendliche zwischen 12 und 14 Jahren, j{\"u}ngere Erwachsene zwischen ca. 18 und 25 Jahren sowie {\"a}ltere Erwachsene zwischen ca. 60 und 80 Jahren. Erhoben wurden Ease-of-Learning-Urteile (EOLs) bzw. ein globales Verst{\"a}ndnisurteil als Maß der {\"U}berwachung vor dem eigentlichen Lernprozess, Judgments of Learning (JOLs) als Maß der {\"U}berwachung nach dem Lernvorgang und Sicherheitsurteile (SUs) als Maß der {\"U}berwachung nach dem Erinnerungsabruf. Es zeigte sich, dass die {\"U}berwachungsleistung sowohl, was die Differenzierungsf{\"a}higkeit zwischen richtigen und falschen Antworten, als auch, was die Genauigkeit betrifft, bez{\"u}glich der JOLs und der SUs {\"u}ber die gesamte untersuchte Altersspanne hinweg im Wesentlichen konstant und auf recht hohem Niveau blieb. Lediglich bei den EOLs ergaben sich Alterseffekte: Die j{\"u}ngeren Erwachsenen schnitten besser ab als die anderen Altersgruppen, was mit besseren F{\"a}higkeiten, sp{\"a}tere Lern- und Erinnerungsvorg{\"a}nge zu antizipieren, erkl{\"a}rt werden kann. In Bezug auf den Einfluss von Kontextfaktoren konnte nachgewiesen werden, dass sich die {\"U}berwachungsleistungen bei verschieden komplexen Materialien (Paar-Assoziationen versus Film- oder Textmaterial) unter g{\"u}nstigen Bedingungen, z.B. wenn die Leistungsvorhersagen stark mit der Erinnerungsabfrage korrespondieren, kaum unterscheiden. Bei Rekognitionsaufgaben fielen die {\"U}berwachungsleistungen im Vergleich zu Aufgaben zur freien Erinnerung insgesamt schlechter aus. Ein großes bereichsspezifisches Vorwissen resultierte {\"u}ber alle Maße hinweg eher in einer {\"U}bersch{\"a}tzung der eigenen Leistung, bei den SUs jedoch auch in einer verbesserten Leistung im Vergleich zu Personen mit weniger Vorwissen. Ein Strategietraining wirkte sich besonders bei den Grundsch{\"u}lern und den {\"a}lteren Erwachsenen positiv auf die {\"U}berwachungsleistung aus. Die eher gering ausgepr{\"a}gten Alterseffekte weisen darauf hin, dass die einzelnen Kontextfaktoren {\"u}ber die Lebensspanne hinweg einen vergleichbaren Einfluss zu haben scheinen. Hinsichtlich sequenzieller Zusammenh{\"a}nge zwischen {\"U}berwachungs- und Steuerungsprozessen (hier operationalisiert durch JOLs und die selbst gesteuerte Lernzeiteinteilung) zeigte sich, dass die Teilnehmer aller Altersgruppen in der Lage waren, sowohl Informationen aus den JOLs f{\"u}r die Anpassung der Lernzeit (Monitoring-affects-control-Modell) als auch - in etwas geringerem Ausmaß - Informationen aus der Lernzeit f{\"u}r die Anpassung der JOLs zu nutzen (Control-affects-monitoring-Modell). Der simultane Wechsel zwischen beiden Modellen stellt einen deutlich komplexeren Vorgang dar und konnte deshalb vor allem bei den Jugendlichen und den {\"a}lteren Erwachsenen nachgewiesen werden. Insgesamt gesehen belegen die Ergebnisse der sechs Experimente, dass metakognitive {\"U}berwachungsf{\"a}higkeiten bereits recht fr{\"u}h, d.h. im mittleren Grundschulalter, gut ausgepr{\"a}gt sind und auch bei {\"a}lteren Erwachsenen noch lange auf gutem Niveau erhalten bleiben. Lediglich der flexible Wechsel zwischen {\"U}berwachungs- und Kontrollprozessen scheint in diesen beiden Altersgruppen noch Schwierigkeiten zu bereiten. Die {\"a}hnliche Wirkweise der Kontextfaktoren in den einzelnen Altersgruppen weist auf vergleichbare zugrunde liegende Prozesse hin. Die grunds{\"a}tzlich guten metakognitiven Leistungen bei Kindern und {\"a}lteren Erwachsenen sollten demnach genutzt werden, um Ged{\"a}chtnisprozesse insbesondere in diesen Altersgruppen zu f{\"o}rdern.}, subject = {Metakognition}, language = {de} } @article{LugoQuitadamoBianchietal.2016, author = {Lugo, Zulay R. and Quitadamo, Lucia R. and Bianchi, Luigi and Pellas, Fr{\´e}deric and Veser, Sandra and Lesenfants, Damien and Real, Ruben G. L. and Herbert, Cornelia and Guger, Christoph and Kotchoubey, Boris and Mattia, Donatella and K{\"u}bler, Andrea and Laureys, Steven and Noirhomme, Quentin}, title = {Cognitive Processing in Non-Communicative Patients: What Can Event-Related Potentials Tell Us?}, series = {Frontiers in Human Neuroscience}, volume = {10}, journal = {Frontiers in Human Neuroscience}, number = {569}, doi = {10.3389/fnhum.2016.00569}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-165165}, year = {2016}, abstract = {Event-related potentials (ERP) have been proposed to improve the differential diagnosis of non-responsive patients. We investigated the potential of the P300 as a reliable marker of conscious processing in patients with locked-in syndrome (LIS). Eleven chronic LIS patients and 10 healthy subjects (HS) listened to a complex-tone auditory oddball paradigm, first in a passive condition (listen to the sounds) and then in an active condition (counting the deviant tones). Seven out of nine HS displayed a P300 waveform in the passive condition and all in the active condition. HS showed statistically significant changes in peak and area amplitude between conditions. Three out of seven LIS patients showed the P3 waveform in the passive condition and five of seven in the active condition. No changes in peak amplitude and only a significant difference at one electrode in area amplitude were observed in this group between conditions. We conclude that, in spite of keeping full consciousness and intact or nearly intact cortical functions, compared to HS, LIS patients present less reliable results when testing with ERP, specifically in the passive condition. We thus strongly recommend applying ERP paradigms in an active condition when evaluating consciousness in non-responsive patients.}, language = {en} } @book{Lingel2016, author = {Lingel, Klaus}, title = {Metakognitives Wissen Mathematik - Entwicklung und Zusammenhang mit der Mathematikleistung in der Sekundarstufe I}, publisher = {W{\"u}rzburg University Press}, address = {W{\"u}rzburg}, isbn = {978-3-95826-004-7 (print)}, doi = {10.25972/WUP-978-3-95826-005-4}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-103269}, publisher = {W{\"u}rzburg University Press}, pages = {312}, year = {2016}, abstract = {Das Wissen {\"u}ber kognitive Prozesse oder metakognitives Wissen ist seit den 1970er-Jahren Gegenstand der entwicklungspsychologischen Forschung. Im Inhaltsbereich der mathematischen Informationsverarbeitung ist das Konstrukt jedoch - trotz elaborierter theoretischer Modelle {\"u}ber Struktur und Inhalt - empirisch nach wie vor weitgehend unerschlossen. Die vorliegende Studie schließt diese L{\"u}cke, indem sie die Entwicklung des mathematischen metakognitiven Wissens im L{\"a}ngsschnitt untersucht. Dazu wurde nicht nur der Entwicklungsverlauf beschrieben, sondern auch nach den Quellen f{\"u}r die beobachteten individuellen Unterschiede in der Entwicklung gesucht. Auch die aus p{\"a}dagogischen Gesichtspunkten interessanten Zusammenh{\"a}nge zwischen der metakognitiven Wissensentwicklung und der parallel dazu verlaufenden Entwicklung der mathematischen Kompetenzen wurden analysiert.}, subject = {Kognitiver Prozess}, language = {de} }