@phdthesis{Traxler2021,
  author    = {Traxler, Claudia},
  title     = {Untersuchung serumpiegelabh{\"a}ngiger unerw{\"u}nschter Arzneimittelwirkungen von selektiven Serotonin-R{\"u}ckaufnahme-Inhibitoren sowie Serotonin-Noradrenalin-R{\"u}ckaufnahme-Inhibitoren},
  doi       = {10.25972/OPUS-23594},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-235946},
  school      = {Universit{\"a}t W{\"u}rzburg},
  year      = {2021},
  abstract  = {Hyponatri{\"a}mie, definiert als Serum-Natrium < 135 mmol/l, ist ein potentiell lebensbedrohender Zustand und wird h{\"a}ufig bei {\"a}lteren und psychiatrischen Patienten beobachtet. In den letzten Jahren wurden viele Case reports {\"u}ber SSRI- und SNRI- induzierte Hyponatri{\"a}mien publiziert. Kardiale Ver{\"a}nderungen, insbesondere eine verl{\"a}ngerte QT-Zeit oder erh{\"o}hte Herzfrequenz, werden auch als h{\"a}ufig beobachtete Nebenwirkungen unter Therapie mit Antidepressiva beschrieben. Dies konnte bislang insbesondere w{\"a}hrend der Einnahme von trizyklischen Antidepressiva beobachtet werden. Oft kann der beobachtete Effekt in Zusammenhang mit der verabreichten Dosis gebracht werden. Bei der SSRI- bzw. SNRI-induzierten Hyponatri{\"a}mie konnte dies bislang nicht gezeigt werden. In der Literatur lassen sich im Allgemeinen kaum Studien finden, die einen Zusammenhang der Serumkonzentration von SSRI und SNRI auf potentiell auftretende Nebenwirkungen untersucht haben. Ziel der vorliegenden Studie war zu zeigen, ob h{\"o}here Serumkonzentrationen von Citalopram, Escitalopram, Sertralin, Venlafaxin oder Duloxetin h{\"a}ufiger zu Hyponatri{\"a}mien bzw. Verl{\"a}ngerungen der QT-Zeit f{\"u}hren.},
  subject      = {Sertralin},
  language  = {de}
}
@article{ZapfFinze2021,
  author    = {Zapf, Ludwig and Finze, Maik},
  title     = {The crystal structure of poly[(μ \(_3\)-imidazolato-κ \(^3\) N:N:N′)(tetrahydrofuran- κ \(^1\) O)lithium(I)], C\(_7\)H\(_{11}\)LiN\(_2\)O},
  series = {Zeitschrift f{\"u}r Kristallographie - New Crystal Structures},
  volume    = {236},
  journal   = {Zeitschrift f{\"u}r Kristallographie - New Crystal Structures},
  number    = {5},
  doi       = {10.1515/ncrs-2021-0192},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-260745},
  pages     = {1007-1009},
  year      = {2021},
  abstract  = {C\(_7\)H\(_{11}\)LiN\(_2\)O, monoclinic, P2\(_1\)/c (no. 14), a = 8.9067(1) angstrom, b = 8.6975(1) angstrom, c = 10.2398(1) angstrom, beta = 101.900(3)degrees, V = 770.491(15) angstrom(3), Z = 4, R-gt (F) = 0.0338, wR(ref) (F\(^2\)) = 0.0925, T = 100 K.},
  language  = {en}
}
@article{LeutritzvanBraamPreisetal.2023,
  author    = {Leutritz, Anna Linda and van Braam, Lara and Preis, Katharina and Gehrmann, Andrea and Scherf-Clavel, Maike and Fiedler, Katrin and Unterecker, Stefan and Kittel-Schneider, Sarah},
  title     = {Psychotropic medication in pregnancy and lactation and early development of exposed children},
  series = {British Journal of Clinical Pharmacology},
  volume    = {89},
  journal   = {British Journal of Clinical Pharmacology},
  number    = {2},
  doi       = {10.1111/bcp.15533},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-318954},
  pages     = {737 -- 750},
  year      = {2023},
  abstract  = {There is still limited knowledge about alterations of blood concentrations of psychotropic drugs during pregnancy, the transfer of psychotropic drugs into breastmilk and the effects on exposed children. We investigated changes in concentrations of psychopharmacological medication during pregnancy and lactation in serum and breastmilk at different time points in a naturalistic sample of 60 mothers and observed the development of the exposed children in the first 12 months. We found a decrease in serum concentrations from the first to the second trimester of amitriptyline, duloxetine, escitalopram, quetiapine and sertraline. Citalopram stayed rather stable during pregnancy, sertraline levels interestingly increased again from the second to the third trimester. High concentration-by-dose ratios in breastmilk were found for venlafaxine as well as lamotrigine, low for quetiapine and clomipramine. Similarly, clomipramine and quetiapine showed low milk/serum-penetration ratios. Regarding the birth outcome measures in children, we found no significant differences between in utero exposed compared to nonexposed newborns. There were no significant differences in the development in the first 12 months. Psychotropic medication in the peripartum needs a balancing of risks and benefits and a continuous therapeutic drug monitoring can be a guidance for clinicians to monitor drug alteration patterns, which are likely to occur due to physiological pregnancy-associated changes in pharmacokinetics. Accordingly, therapeutic drug monitoring can optimize a medication in pregnancy and lactation with the lowest effective dose.},
  language  = {en}
}
@article{WieseDennstaedtHollmannetal.2021,
  author    = {Wiese, Teresa and Dennst{\"a}dt, Fabio and Hollmann, Claudia and Stonawski, Saskia and Wurst, Catherina and Fink, Julian and Gorte, Erika and Mandasari, Putri and Domschke, Katharina and Hommers, Leif and Vanhove, Bernard and Schumacher, Fabian and Kleuser, Burkard and Seibel, J{\"u}rgen and Rohr, Jan and Buttmann, Mathias and Menke, Andreas and Schneider-Schaulies, J{\"u}rgen and Beyersdorf, Niklas},
  title     = {Inhibition of acid sphingomyelinase increases regulatory T cells in humans},
  series = {Brain Communications},
  volume    = {3},
  journal   = {Brain Communications},
  number    = {2},
  doi       = {10.1093/braincomms/fcab020},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-259868},
  year      = {2021},
  abstract  = {Genetic deficiency for acid sphingomyelinase or its pharmacological inhibition has been shown to increase Foxp3\(^+\) regulatory T-cell frequencies among CD4\(^+\) T cells in mice. We now investigated whether pharmacological targeting of the acid sphingomyelinase, which catalyzes the cleavage of sphingomyelin to ceramide and phosphorylcholine, also allows to manipulate relative CD4\(^+\) Foxp3\(^+\) regulatory T-cell frequencies in humans. Pharmacological acid sphingomyelinase inhibition with antidepressants like sertraline, but not those without an inhibitory effect on acid sphingomyelinase activity like citalopram, increased the frequency of Foxp3\(^+\) regulatory T cell among human CD4\(^+\) T cells in vitro. In an observational prospective clinical study with patients suffering from major depression, we observed that acid sphingomyelinase-inhibiting antidepressants induced a stronger relative increase in the frequency of CD4\(^+\) Foxp3\(^+\) regulatory T cells in peripheral blood than acid sphingomyelinase-non- or weakly inhibiting antidepressants. This was particularly true for CD45RA\(^-\) CD25\(^{high}\) effector CD4\(^+\) Foxp3\(^+\) regulatory T cells. Mechanistically, our data indicate that the positive effect of acid sphingomyelinase inhibition on CD4\(^+\) Foxp3\(^+\) regulatory T cells required CD28 co-stimulation, suggesting that enhanced CD28 co-stimulation was the driver of the observed increase in the frequency of Foxp3+ regulatory T cells among human CD4\(^+\) T cells. In summary, the widely induced pharmacological inhibition of acid sphingomyelinase activity in patients leads to an increase in Foxp3+ regulatory T-cell frequencies among CD4\(^+\) T cells in humans both in vivo and in vitro.},
  language  = {en}
}
@article{PrelogHilligardtSchmidtetal.2016,
  author    = {Prelog, Martina and Hilligardt, Deborah and Schmidt, Christian A. and Przybylski, Grzegorz K. and Leierer, Johannes and Almanzar, Giovanni and El Hajj, Nady and Lesch, Klaus-Peter and Arolt, Volker and Zwanzger, Peter and Haaf, Thomas and Domschke, Katharina},
  title     = {Hypermethylation of FOXP3 Promoter and Premature Aging of the Immune System in Female Patients with Panic Disorder?},
  series = {PLoS ONE},
  volume    = {11},
  journal   = {PLoS ONE},
  number    = {6},
  doi       = {10.1371/journal.pone.0157930},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-179684},
  year      = {2016},
  abstract  = {Immunological abnormalities associated with pathological conditions, such as higher infection rates, inflammatory diseases, cancer or cardiovascular events are common in patients with panic disorder. In the present study, T cell receptor excision circles (TRECs), Forkhead-Box-Protein P3 gene (FOXP3) methylation of regulatory T cells (Tregs) and relative telomere lengths (RTLs) were investigated in a total and subsamples of 131 patients with panic disorder as compared to 131 age- and sex-matched healthy controls in order to test for a potential dysfunction and premature aging of the immune system in anxiety disorders. Significantly lower TRECs (p = 0.004) as well as significant hypermethylation of the FOXP3 promoter region (p = 0.005) were observed in female (but not in male) patients with panic disorder as compared to healthy controls. No difference in relative telomere length was discerned between patients and controls, but significantly shorter telomeres in females, smokers and older persons within the patient group. The presently observed reduced TRECs in panic disorder patients and FOXP3 hypermethylation in female patients with panic disorder potentially reflect impaired thymus and immunosuppressive Treg function, which might partly account for the known increased morbidity and mortality of anxiety disorders conferred by e.g. cancer and cardiovascular disorders.},
  language  = {en}
}
@inproceedings{WernerKobayashiWakabayashietal.2017,
  author    = {Werner, Rudolf and Kobayashi, Ryohei and Wakabayashi, Hiroshi and Lapa, Constantin and Menke, Andreas and Higuchi, Takahiro},
  title     = {Effect of Antidepressants on Radiolabeled Metaiodobenzylguanidine (MIBG) Uptake},
  series = {European Heart Journal - Cardiovascular Imaging},
  volume    = {18},
  booktitle = {European Heart Journal - Cardiovascular Imaging},
  number    = {Supplement},
  publisher = {Oxford University Press},
  issn      = {2047-2404},
  doi       = {10.1093/ehjci/jex080},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-161116},
  pages     = {i52-53},
  year      = {2017},
  abstract  = {No abstract available.},
  subject      = {MIBG},
  language  = {en}
}