@article{MilanosElsharifJanzenetal.2017,
  author    = {Milanos, Sinem and Elsharif, Shaimaa A. and Janzen, Dieter and Buettner, Andrea and Villmann, Carmen},
  title     = {Metabolic Products of Linalool and Modulation of GABA\(_{A}\) Receptors},
  series = {Frontiers in Chemistry},
  volume    = {5},
  journal   = {Frontiers in Chemistry},
  number    = {46},
  doi       = {10.3389/fchem.2017.00046},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-170779},
  year      = {2017},
  abstract  = {Terpenoids are major subcomponents in aroma substances which harbor sedative physiological potential. We have demonstrated that various monoterpenoids such as the acyclic linalool enhance GABAergic currents in an allosteric manner in vitro upon overexpression of inhibitory α1β2 GABA\(_{A}\) receptors in various expression systems. However, in plants or humans, i.e., following intake via inhalation or ingestion, linalool undergoes metabolic modifications including oxygenation and acetylation, which may affect the modulatory efficacy of the generated linalool derivatives. Here, we analyzed the modulatory potential of linalool derivatives at α1β2γ2 GABA\(_{A}\) receptors upon transient overexpression. Following receptor expression control, electrophysiological recordings in a whole cell configuration were used to determine the chloride influx upon co-application of GABA EC\(_{10-30}\) together with the modulatory substance. Our results show that only oxygenated linalool metabolites at carbon 8 positively affect GABAergic currents whereas derivatives hydroxylated or carboxylated at carbon 8 were rather ineffective. Acetylated linalool derivatives resulted in non-significant changes of GABAergic currents. We can conclude that metabolism of linalool reduces its positive allosteric potential at GABAA receptors compared to the significant potentiation effects of the parent molecule linalool itself.},
  language  = {en}
}
@phdthesis{Hofmann2001,
  author    = {Hofmann, Marco},
  title     = {Ferriomethyl- und Wolframiomethyl-substituierte Silane, Silanole und Siloxane},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-1181579},
  school      = {Universit{\"a}t W{\"u}rzburg},
  year      = {2001},
  abstract  = {Das Interesse an {\"U}bergangsmetall-substituierten Siloxanen ist in den vergangenen Jahren stark angewachsen. Dies ist vor allem darauf zur{\"u}ckzuf{\"u}hren, dass diesen Systemen eine wichtige Modellfunktion f{\"u}r auf Silica-Oberfl{\"a}chen verankerte, katalytisch aktive {\"U}bergangsmetallkomplexe zukommt, die eine Vielzahl organischer Reaktionen katalysieren und dabei sowohl die Vorteile der Homogenkatalyse als auch der Heterogenkatalyse in einem einzigen System vereinen. Weiterhin kommt ihnen auch eine wichtige Bedeutung als Vorstufen zur Darstellung von Silicon-Polymeren und Keramiken zu, die definierte Metallzentren in ihrem Polymer-Grundger{\"u}st enthalten und somit als neue Werkstoffe mit hoher mechanischer und thermischer Stabilit{\"a}t sowie ausgezeichneten leitenden Eigenschaften dienen k{\"o}nnen. Metallosiloxane mit einer direkten Metall-Silicium-Bindung k{\"o}nnen {\"u}ber die entsprechenden Metallo-silanole generiert werden, die seit Beginn der 90er Jahre eine intensivere Bearbeitung erfahren. In dieser Arbeit wurden die ersten Vertreter von Metallo-silanolen dargestellt und bez{\"u}glich ihrer Reaktivit{\"a}t untersucht, in denen das Metall- und Siliciumatom durch einen Alkylidenspacer getrennt ist. Es wurde zun{\"a}chst eine Reihe von C5R5(OC)2FeCH2-substituierten Silanolen {\"u}ber die Et3N-assistierte Hydrolyse von Ferriomethyl-chlorsilanen bzw. Oxygenierung von Si-H-funktionellen Ferriomethyl-silanen mit Dimethyldioxiran dargestellt. Die Stabilisierung durch das Metallfragment in \&\#946;-Stellung zur Silanoleinheit erweist sich ebenfalls hinreichend f{\"u}r die Darstellung von Ferriomethyl-silandiolen und -silantriolen, wie anhand der Darstellung von Cp(OC)2Fe-CH2-Si(R)(OH)2 (R = Me, OH) nachgewiesen werden konnte. Allerdings zeigen diese Vertreter im Vergleich zu ihren Analoga mit direkter Fe-Si-Bindung eine z.T. deutlich erh{\"o}hte Eigenkondensationsneigung. Die R{\"o}ntgenstrukturanalysen der Ferriomethyl-diorganosilanole C5R5(OC)2Fe-CH2-Si(Me)(R')OH belegen deren Aggregation zu Tetrameren bzw. unendlichen Ketten im Festk{\"o}rper {\"u}ber starke intermolekulare OH...O-Wasserstoffbr{\"u}ckenbindungen. Durch Et3N-assistierte Kondensation mit Organochlorsilanen, wie z.B. Me2Si(H)Cl lassen sich kontrolliert Ferriomethyl-substiuierte Di-, Tri- und Tetrasiloxane generieren. Auch der Aufbau von mehrkernigen Heterosiloxanger{\"u}sten ist m{\"o}glich, wie exemplarisch anhand der Synthese von Cp(OC)2Fe-CH2-SiMe2O-M(Cl)Cp2 (M = Ti, Zr) {\"u}berpr{\"u}ft wurde. Weiterhin k{\"o}nnen auch Modifikationen am Metallfragment vorgenommen werden, wie der photochemisch induzierte CO/PR3-Austausch an Cp(OC)2-CH2-SiMe2OH beweist. Die synthetisierten Ferriomethyl-siloxane mit \&\#948;-st{\"a}ndiger Si-H-Funktion eignen sich f{\"u}r weitere Umsetzungen, wie z.B. der oxidativen Addition der Si-H-Funktion an unges{\"a}ttigte Metallfragmente. So lassen sich das Tri- bzw. Tetrasiloxan Cp(OC)2Fe-CH2-Si(R)(OSiMe2H)2 (R = Me, OSiMe2H) durch UV-Bestrahlung unter CO-Eliminierung glatt in die Cyclo(ferra)siloxane Cp(OC)(H)Fe-SiMe2-OSi(Me)(R)-OSiMe2 {\"u}berf{\"u}hren. Abschließend wurde {\"u}berpr{\"u}ft, ob sich die Chemie der Ferriomethyl-silanole auch auf andere {\"U}bergangsmetallfragmente {\"u}bertragen l{\"a}sst. Hierbei konnten Wolframiomethyl-silanole mit dem Cp(OC)2(Me3P)WCH2-Fragment dargestellt werden, wobei sich, im Gegensatz zu den Eisenvertretern, die Darstellungsmethode der Oxygenierung von Si-H-funktionellen Vorl{\"a}ufern als vorteilhafter erweist.},
  subject      = {{\"U}bergangsmetallkomplexe},
  language  = {de}
}
@article{BornHolmbergGoernetetal.2014,
  author    = {Born, Dennis-Peter and Holmberg, Hans-Christer and Goernet, Florian and Sperlich, Billy},
  title     = {A novel compression garment with adhesive silicone stripes improves repeated sprint performance - a multi-experimental approach on the underlying mechanisms},
  series = {BMC Sports Science, Medicine and Rehabilitation},
  volume    = {6},
  journal   = {BMC Sports Science, Medicine and Rehabilitation},
  number    = {21},
  issn      = {2052-1847},
  doi       = {10.1186/2052-1847-6-21},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-120591},
  year      = {2014},
  abstract  = {Background Repeated sprint performance is determined by explosive production of power, as well as rapid recovery between successive sprints, and there is evidence that compression garments and sports taping can improve both of these factors. Methods In each of two sub-studies, female athletes performed two sets of 30 30-m sprints (one sprint per minute), one set wearing compression garment with adhesive silicone stripes (CGSS) intended to mimic taping and the other with normal clothing, in randomized order. Sub-study 1 (n = 12) focused on cardio-respiratory, metabolic, hemodynamic and perceptual responses, while neuronal and biomechanical parameters were examined in sub-study 2 (n = 12). Results In both sub-studies the CGSS improved repeated sprint performance during the final 10 sprints (best P < 0.01, d = 0.61). None of the cardio-respiratory or metabolic variables monitored were altered by wearing this garment (best P = 0.06, d = 0.71). Also during the final 10 sprints, rating of perceived exertion by the upper leg muscles was reduced (P = 0.01, d = 1.1), step length increased (P = 0.01, d = 0.91) and activation of the m. rectus femoris elevated (P = 0.01, d = 1.24), while the hip flexion angle was lowered throughout the protocol (best P < 0.01, d = 2.28) and step frequency (best P = 0.34, d = 0.2) remained unaltered. Conclusion Although the physiological parameters monitored were unchanged, the CGSS appears to improve performance during 30 30-m repeated sprints by reducing perceived exertion and altering running technique.},
  language  = {en}
}
@article{BornHolmbergGoernertetal.2014,
  author    = {Born, Dennis-Peter and Holmberg, Hans-Christer and Goernert, Florian and Sperlich, Billy},
  title     = {A novel compression garment with adhesive silicone stripes improves repeated sprint performance - a multi-experimental approach on the underlying mechanisms},
  series = {BMC Sports Science, Medicine and Rehabilitation},
  volume    = {6},
  journal   = {BMC Sports Science, Medicine and Rehabilitation},
  number    = {21},
  doi       = {doi:10.1186/2052-1847-6-21},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-116995},
  year      = {2014},
  abstract  = {Background Repeated sprint performance is determined by explosive production of power, as well as rapid recovery between successive sprints, and there is evidence that compression garments and sports taping can improve both of these factors. Methods In each of two sub-studies, female athletes performed two sets of 30 30-m sprints (one sprint per minute), one set wearing compression garment with adhesive silicone stripes (CGSS) intended to mimic taping and the other with normal clothing, in randomized order. Sub-study 1 (n = 12) focused on cardio-respiratory, metabolic, hemodynamic and perceptual responses, while neuronal and biomechanical parameters were examined in sub-study 2 (n = 12). Results In both sub-studies the CGSS improved repeated sprint performance during the final 10 sprints (best P < 0.01, d = 0.61). None of the cardio-respiratory or metabolic variables monitored were altered by wearing this garment (best P = 0.06, d = 0.71). Also during the final 10 sprints, rating of perceived exertion by the upper leg muscles was reduced (P = 0.01, d = 1.1), step length increased (P = 0.01, d = 0.91) and activation of the m. rectus femoris elevated (P = 0.01, d = 1.24), while the hip flexion angle was lowered throughout the protocol (best P < 0.01, d = 2.28) and step frequency (best P = 0.34, d = 0.2) remained unaltered. Conclusion Although the physiological parameters monitored were unchanged, the CGSS appears to improve performance during 30 30-m repeated sprints by reducing perceived exertion and altering running technique.},
  language  = {en}
}