@book{OPUS4-5759, title = {W{\"u}rzburger Hochschulschriften : 1581 - 1803 ; Bestandsverzeichnis}, organization = {Universit{\"a}tsbibliothek W{\"u}rzburg}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-69739}, publisher = {Universit{\"a}t W{\"u}rzburg}, year = {1992}, abstract = {Die Universit{\"a}tsbibliothek W{\"u}rzburg hat f{\"u}r ihre umfangreiche Sammlung alter W{\"u}rzburger Hochschulschriften einen Katalog erarbeitet, der haupts{\"a}chlich Dissertationen und Thesen verzeichnet, aber auch andere Pr{\"u}fungsarbeiten, die f{\"u}r den Erwerb unterschiedlicher akademischer Grade und Titel ausgearbeitet und publiziert worden sind und die aus der f{\"u}rstbisch{\"o}flichen Zeit unserer Universit{\"a}t stammen (1582 - 1803).}, subject = {Universit{\"a}t}, language = {de} } @article{SchartlAdam1992, author = {Schartl, Manfred and Adam, Dieter}, title = {Molecular cloning, structural characterization, and analysis of transcription of the melanoma oncogene of xiphophorus}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-61989}, year = {1992}, abstract = {No abstract available}, subject = {Physiologische Chemie}, language = {en} } @article{GaultneyBjorklundSchneider1992, author = {Gaultney, Jane F. and Bjorklund, David F. and Schneider, Wolfgang}, title = {The role of children's expertise in a Strategie memory task}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-62190}, year = {1992}, abstract = {In a study intended to replicate and extend the findings from a recent experiment by Schneider and Bjorklund (1992), the expert/novice paradigm was used with second- and fourth-grade children in a sort/recall task. Children were classified as experts or novices for their knowledge of baseball, then given two sort/recall tasks, with a list consisting of either baseball or nonbaseball terms. Experts recalled more than novices on the baseball list only. While both groups used organizational strategies at sorting on the nonbaseball list, experts were marginally more strategic than novices on the baseball list, and no differences were found between the groups on either list for clustering. Baseball experts used more adultlike categories, suggesting that their enhanced levels of recall were attributed in part to strategy use, although there was also evidence that most of the substantial recall difference between the groups was attributed to item-specific effects associated with a more elaborated knowledge base. A second experiment using fifth-grade children on a multitrial sort/recall task using the baseball list also found increased recall by experts, and also found evidence of strategic behavior at the sort phase for trials 3 and 4.}, subject = {Psychologie}, language = {en} } @article{HerbertSchmidt1992, author = {Herbert, M. K. and Schmidt, R. F.}, title = {Activation of normal and inflamed fine articular afferent units by serotonin}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-59952}, year = {1992}, abstract = {In cats anesthetized with alpha-chloralose, extracellular recordings were made from fine afferent units belonging to the medial articular nerve (MAN) of the knee joint. The excitatory and sensitizing effects on articular afferents of serotonin (5-HT) applied intra-arterially close to the joint were examined. The joints were either normal or an experimental arthritis had been induced some hours before the recording session. Bolus injections of 1.35-135 p,g 5-HT excited about 43\% of group 111 (CV: 2.5-20 m/sec) and 73\% of group IV units (CV: < 2.5 mjsec) from normal joints. The latency was usually between 10 and 30 sec, and the duration and size of the responses were dose-dependent. Fast group 111 units (CV: > 16 mjsec) and group li units (CV: > 20 m/sec) were never excited by 5-HT. Repetitiveadministration led to pronounced tachyphylaxis of the 5-HT response. Inflammation induced an enhanced sensitivity of group III articular afferent units to close intra-arterial application of 5-HT. In particular the total duration of each response was considerably prolonged (4-10 min against 1-2 min under normal conditions). At the same time the tachyphylaxis seen under normal conditions was gteatly reduced. In contrast, group IV articular afferent units did not become sensitized to 5-HT in the course of inflammation. In normal joints 5-HT did not sensitize fineafferent units for movement-induced responses. However, after inflammation, a distinct sensitization to such movements by 5-HT application could be observed bothin group 111 and group IV fiber ranges. The sensitization had a short time course not exceeding 7 min. The tonic component of the movement-induced response was more enhanced than the phasic one. The bolus application of 5-HT led to temporary vasoconstriction of the knee joint vessels. This vasoconstriction was especially pronounced in inflamed joints and impeded the access of subsequently applied substances to the terminal regions of the afferent units under observation. lt is concluded that the present results support the notion that 5-HT may participate in the mediation of pain from inflamed tissue such as an arthritic joint by exciting and sensitizing fine afferent units. During inflammation group 111 units are particularly sensitive to 5-HT and, thus, may carry the bulk of the 5-HT-induced nociceptive messages.}, subject = {Medizin}, language = {en} } @article{StopperPechanSchiffmann1992, author = {Stopper, Helga and Pechan, R. and Schiffmann, D.}, title = {5-azacytidine induces micronuclei in and morphological transformation of Syrian hamster embryo fibroblasts in the absence of unscheduled DNA synthesis}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-63443}, year = {1992}, abstract = {lt is known that 5-azacytidine (5-AC) induces tumors in several organs of rats and mice. The mechanisms of these effects are still poorly understood although it is known that 5-AC can be incorporated into DNA. Furthermore, it can inhibit DNA methylation. The known data on its clastogenic andjor gene mutation-inducing potential are still controversial. Therefore, we have investigated the kinds of genotoxic effects caused by 5-AC in Syrian hamster embryo (SHE) fibroblasts. Three different endp6ints (micronucleus formation, unscheduled DNA synthesis (UDS) and cell transforrnation) were assayed under similar conditions of metabolism and dose at target in this cell system. 5-AC induces morphological transformation of SHE cells, but not UDS. Therefore, 5-AC does not seem to cause repairable DNA lesions. Furthermore, our studies revealed that 5-AC is a potent inducer of mkronuclei in the SHE system. Immunocytochemical analysis revealed that a certain percentage of these contain kinetochores indicating that 5-AC may induce both clastogenic events and numerical chromosome changes.}, subject = {Toxikologie}, language = {en} } @article{SchneiderBjorklund1992, author = {Schneider, Wolfgang and Bjorklund, David F.}, title = {Expertise, aptitude, and strategic remembering}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-62175}, year = {1992}, abstract = {Second- and fourth-grade children were classified according to their knowledge of soccer (experts vs. novices) and IQ (high vs. low), and given 2 sort-recall tasks. One task included items related to the game of soccer and the other included items from familiar natural language categories. Previous research has shown that expertise in a snbject can compensate for low levels of performance on text comprehension tasks. Our results, the flrst examing the effects of both expertise and intelligence on a strategic memory task, were that soccer expert children recalled more items on the soccer list bnt not on the nonsoccer list than soccer novice children. However, soccer expertise did not modify a significant effect of IQ level, with high-IQ children recalling more than low-IQ children for all contrasts. Interest in soccer was found to be related to expertise but did not contribute to differences in memory performance. The results demonstrate that the knowledge base plays an important role in children's memory, but that domain knowledge cannot fully eliminate the effects of IQ on sort-recall tasks using domain-related materials. That is, although rich domain knowledge seemed to compensate for low aptitude, in that low-aptitude experts performed at the level of high-aptitude novices, its effects were not strong enough to eliminate performance differences between highand low-aptitude soccer experts.}, subject = {Psychologie}, language = {en} } @article{WoloshynPressleySchneider1992, author = {Woloshyn, Vera E. and Pressley, Michael and Schneider, Wolfgang}, title = {Elaborative interrogation as a function of prior knowledge}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-62187}, year = {1992}, abstract = {No abstract available}, subject = {Psychologie}, language = {en} } @article{SchneiderSchauliesLiebertRagerZismanetal.1992, author = {Schneider-Schaulies, Sibylle and Liebert, U. G. and Rager-Zisman, B. and Wolfson, M. and ter Meulen, V.}, title = {Antibody-dependent transcriptional regulation of measles virus in persistently infected neural cells}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-62329}, year = {1992}, abstract = {No abstract available}, subject = {Virologie}, language = {en} } @article{JaffeyChanShaoetal.1992, author = {Jaffey, P. and Chan, L.-N. L. and Shao, J. and Schneider-Schaulies, J{\"u}rgen and Chan, T.-S.}, title = {Retinoic acid inhibition of serum-induced c-fos transcription in a fibrosarcoma cell line}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-54863}, year = {1992}, abstract = {No abstract available}, subject = {Immunologie}, language = {en} } @article{SchneiderSchauliesSchneiderSchauliesBrinkmannetal.1992, author = {Schneider-Schaulies, J{\"u}rgen and Schneider-Schaulies, Sibylle and Brinkmann, R. and Tas, P. and Halbr{\"u}gge, M. and Walter, U. and Holmes, H.C. and ter Meulen, Volker}, title = {HIV-1 gp120 receptor on CD4-negative brain cells activates a tyrosine kinase}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-54872}, year = {1992}, abstract = {Human immunodeficiency virus (HIV-1) infection in the human brain Ieads to characteristic neuropathological changes, which may result indirectly from interactions of the envelope glycoprotein gp 120 with neurons and/or glial cells. We therefore investigated the binding of recombinant gp120 (rgp120) to human neural cells and its effect on int~acellular.s.ignallin~. Herewe pre~ent evidence that rgp120, besides binding to galactocerebroside or galactosyl-sulfatlde, spec1f1cally bmds to a protem receptor of a relative molecular mass of approximately 180,000 Da (180 kDa) pre~ent. on the CD4-negative glioma cells D-54, but not on Molt4 T lymphocytes. Binding of rgp120 to this receptor rap1dly 1nduced a tyrosine-specific protein kinase activity leading to tyrosine phosphorylation of 130- and 115-kDa p~oteins. The c~ncentration of intracellular calciumwas not affected by rgp120 in these cells. Our data suggest a novel Signal transduc1ng HIV-1 gp120 receptor on CD4-negative glial cells, which may contribute to the neuropathological changes observed in HIV-1-infected brains.}, subject = {Immunologie}, language = {en} } @article{PaakkariPaakkariFeuersteinetal.1992, author = {Paakkari, P. and Paakkari, I. and Feuerstein, G. and Sir{\´e}n, Anna-Leena}, title = {Evidence for differential opioid µ\(_1\)- and µ\(_2\)-receptor regulation of heart rate in the conscious rat}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-63017}, year = {1992}, abstract = {The possibility that \(\mu\)Opioid-induced tachycardia and bradycardia could be mediated by different subtypes of the \(\mu\)·receptor was studied in conscious Sprague-Dawley rats. The selective \(\mu\)·receptor agonist dermorphin and its analog, TAPS (Tyr-o-Arg-Phe-sarcosine), a putative \(\mu _1\)-receptor agonist, were given centrally. Tyr-o-Arg-Phe-sarcosine increased the heart rate, the response being inversely correlated to the dose (an increase of 71 ± 22, 49 ± 14 and 30 ± 17 beats/min at doses of 0.3, 3 and 30 pmol, respectively). Dermorphin induced less clear changes in heart rate (maximum increase of 39 ± 14 beats/min at the dose of 1 pmol). Aftertreatment with the Jl 1-selective antagonist naloxonazine (NAZ), TAPS 30 pmol and dennorphin I pmol decreased heart rate by -22 ± 10 and -24 ± 7 bpm, respectively. The bradycardic effect oflarger doses of dennorphin was potentiated by NAZ (from -25 ± 8 to -97 ± 22 bpm) but abolished by the non-selective antagonist naloxone. These data suggest that the high affinity \(\mu _1\)-opioid receptors mediate tachycardic responses and \(\mu _2\)-receptors mediate bradycardic responses.}, subject = {Neurobiologie}, language = {en} } @article{AdeyemoSiren1992, author = {Adeyemo, M. and Sir{\´e}n, Anna-Leena}, title = {Cardio-respiratory changes and mortality in the conscious rat induced by (+)- and (±)- anatoxin-a}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-63027}, year = {1992}, abstract = {0. M. ADEYEMO and A.-L. SIREN. Cardio-respiratory changes and mortality in the conscious rat induced by ( + )- and ( ± )-anatoxin-a. Toxicon 30, 899-905, 1992.-Anatoxin-a (AnTx-a) isapotent nicotinic cholinergic receptor agonist. The relative potencies of the ( + )-AnTx-a and the racemic mixture ( ± )-AnTxa were investigated in the conscious rat by comparing their effects on mean arterial blood pressure (BP), heart rate (HR), blood oxygen and carbon dioxide pressures (p02 and pC02, respective1y), acid-base balance (pH) and mortality. The present experiments show that while both forms of AnTx-a produce dose-dependent increases in BP and decreases in HR, ( + )-AnTx-a is about IO-fo1d morepotent than the optically inactive isomer. ( + )-AnTx-a was also 6-fo1d more potent than ( ± )-AnTx-a in produclog severe hypoxemia, and more than 4-fold as potent as the (±}-AnTx-a in producing significant hypercapnia accompanied with severe acidosis. The approximate median Iethai dose (Ln so) of ( + )-AnTx-a was about 5-fold less than that of ( ± )-AnTx-a. We conclude that ( + )-AnTx-a is more potent than the ( ± )-AnTx-a racemic mixture in causing detrimental cardio-respiratory changes and therefore increased mortality in the rat.}, subject = {Neurobiologie}, language = {en} } @article{SirenFeuerstein1992, author = {Sir{\´e}n, Anna-Leena and Feuerstein, G.}, title = {The Opioid System in circulatory control}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-63045}, year = {1992}, abstract = {Opioid peptidesandmultiple opioid receptors are found in brain cardiovascular nuclei, autonomic ganglia, the heart, and blood vessels, and opioids induce potent cardiovascular changes. The role of endogenaus opioids in normal cardiovascular homeostasis is unclear; however, current data suggest opioid involvement in stress.}, subject = {Neurobiologie}, language = {en} } @article{DoronMcCarronHeldmanetal.1992, author = {Doron, D. A. and McCarron, D. M. and Heldman, E. and Sir{\´e}n, Anna-Leena and Spatz, M. and Feuerstein, G. and Pollard, H. B. and Hallenbeck, J. M.}, title = {Comparison of stimulated tissue factor expression by brain microvascular endothelial cells from normotensive (WKY) and hypertensive (SHR) rats}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-63032}, year = {1992}, abstract = {The amounts of tissue factor (TF) expressed by brain microvascular endothelial cells (BMECs) from normotensive Wistar-Kyoto rats (WKY) and spontaneously hypertensive rats (SHR) were compared after stimulating the cells with different doses of lipopolysaccharide (LPS), thrombin, phorbol myristic acid (PMA), Ca\(^{2+}\)·ionophore (A23187), or tumor necrosis factor (TNF) and interleukin·l (IL.l). Treatment ofcultured BMECs fron. WKY and SHR with all of these factors dose·dependently increased their total amount of TF; no substantive differences in the Ieveis of enhanced TF expression were observed between WKY and SHR BMECs. We conclude that stimulated endothelium from rats with hypertension, a major stroke risk factor, is not hyperresponsive with respect to TF expression when compared to normotensive controls.}, subject = {Neurobiologie}, language = {en} } @article{BjorklundSchneiderHarnishfegeretal.1992, author = {Bjorklund, David F. and Schneider, Wolfgang and Harnishfeger, Katherine Kipp and Cassel, William S. and Bjorklund, Barbara R. and Bernholtz, Jean E.}, title = {The role of IQ, expertise, and motivation in the recall of familiar Information}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-62204}, year = {1992}, abstract = {High- and low-IQ children in the first, third, and fifth grades performed two free-recall tasks: a sort-recall task with sets of categorically related pictures, and a class-recall task, with children recalling the current members of their school class. All children were deemed to be experts concerning the composition of their school class, but, unlike experts in other domains, had no special motivation associated with their expertise. Recall and clustering on both tasks were high. The high-IQ children performed better than low-IQ children only on the sort-recall task. IQ was significantly correlated with measures of performance on the sort-recall task but not on the class-recall task. The results reflect the fact that the memory benefits associated with being an expert (here, elimination of IQ effects) are related to the greater knowledge the expert possesses and not to factors of motivation.}, subject = {Psychologie}, language = {en} } @incollection{Stickler1992, author = {Stickler, Matthias}, title = {"Rache" in Mozarts "Don Giovanni" : Zur Sozialgeschichte und Soziologie des Motivs}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-50654}, publisher = {Universit{\"a}t W{\"u}rzburg}, year = {1992}, abstract = {No abstract available}, subject = {Mozart}, language = {de} } @inproceedings{HeiserUlrichsEcksteinetal.1992, author = {Heiser, A. and Ulrichs, Karin and Eckstein, V. and M{\"u}ller-Ruchholtz, W.}, title = {Xenogeneic Cellular Response of Human Lymphocytes Against Porcine Lymphocytes and Isolated Pancreatic Islets}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-45479}, year = {1992}, abstract = {no abstract available}, language = {en} } @article{KerkauGernertKneitzetal.1992, author = {Kerkau, T. and Gernert, S. and Kneitz, C. and Schimpl, A.}, title = {Mechanism of MHC class I downregulation in HIV infected cells}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-56849}, year = {1992}, abstract = {HIV infection of CD4+ peripheral blood lymphocytes leads to a loss of MHC dass I molecules on the surface of the infected cells as detectable by monodonal antibody staining and flow cytometry. Incubation of the infected cells at 26 oe or treatment at 37 oe with peptides leads to upregulation of MHC dass I to levels equal to those found on uninfected cells cultured und er the same conditions. The data suggest that, after HIV infection, the mechanisms responsible for peptide generation, peptide transport and thus stable association between peptides and MHC dass I molecules are severely affected.}, subject = {HIV}, language = {en} } @article{KuenzlerPfrang1992, author = {K{\"u}nzler, Jan and Pfrang, Horst}, title = {Geschlecht als soziologische Kategorie: Brauchen wir einen neuen Grundbegriff?}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-50739}, year = {1992}, abstract = {No abstract available}, subject = {Ethik}, language = {de} } @incollection{DonhauserIrrgangKlawitter1992, author = {Donhauser, Karin and Irrgang, Bernhard and Klawitter, J{\"o}rg}, title = {Editorial [zu: Vernunft als mentaler Prozeß]}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-44425}, publisher = {Universit{\"a}t W{\"u}rzburg}, year = {1992}, abstract = {No abstract available}, subject = {Vernunft}, language = {de} }