@book{Kleinhans1993, author = {Kleinhans, Martha}, title = {"Lucidere vault tant a dire comme donnant lumiere" : Untersuchung und Edition der Prosaversionen 2, 4 und 5 des Elucidarium}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-54488}, publisher = {Universit{\"a}t W{\"u}rzburg}, year = {1993}, abstract = {No abstract available}, subject = {Romanistik}, language = {de} } @article{BommakantiKlotzDratzetal.1993, author = {Bommakanti, R. K. and Klotz, Karl-Norbert and Dratz, E. A. and Jesaitis, A. J.}, title = {A carboxyl-terminal tail peptide of neutrophil chemotactic receptor disrupts its physical complex with G protein}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-60456}, year = {1993}, abstract = {No abstract available}, subject = {Toxikologie}, language = {en} } @article{Zillober1993, author = {Zillober, Christian}, title = {A globally convergent version of the method of moving asymptotes}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-31984}, year = {1993}, abstract = {No abstract available}, language = {en} } @article{HerrmannHappMoellmannetal.1993, author = {Herrmann, K. H. and Happ, M. and M{\"o}llmann, K.-P. and Tomm, J. W. and Becker, Charles R. and Kraus, M. M. and Yuan, S. and Landwehr, G.}, title = {A new model for the absorption coefficient of narrow gap (Hg,Cd)Te that simultaneously considers band tails and band filling}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-37894}, year = {1993}, abstract = {A semiempirical model is presented that correlates the broadening of the absorption edge with both transitions below the energy gap and with transitions by the Kane band model. This model correctly fits both the absorption and luminescence spectra of narrow-gap (Hg,Cd)Te samples that have been grown by the traveling heater method as well as by molecular-beam epitaxy. The accuracy of the band-gap determination is enhanced by this model.}, language = {en} } @article{StaikovaEngelsPericetal.1993, author = {Staikova, M. and Engels, Bernd and Peric, M. and Peyerimhoff, S. D.}, title = {Ab initio calculation of the vibronically averaged hyperfine coupling constants in the two lowest electronic states of H\(_2\)O\(^+\)}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-58998}, year = {1993}, abstract = {No abstract available}, subject = {Organische Chemie}, language = {en} } @article{KauppSchleyer1993, author = {Kaupp, Martin and Schleyer, Paul von Rague}, title = {Ab Initio Study of Structures and Stabilities of Substituted Lead Compounds. Why is Inorganic Lead Chemistry Dominated by Pb\(^{II}\) but Organolead Chemistry by Pb\(^{IV}\)?}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-60069}, year = {1993}, abstract = {No abstract available}, subject = {Anorganische Chemie}, language = {en} } @article{HockMoormannFischeretal.1993, author = {Hock, Robert and Moormann, Antoon and Fischer, Dagmar and Scheer, Ulrich}, title = {Absence of somatic histone H1 in oocytes and preblastula embryos of Xenopus laevis}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-41350}, year = {1993}, abstract = {Available data on the occurrence and expression of somatic histone HI during oogenesis and early embryogenesis of Xenopus laevis are contradictory. In particular the reported presence of a large storage pool of histone HIA in oocytes is difficult to reconcile with the high transcriptional activity of all gene classes in this specific cell type. In the present study we have used polyclonal antibodies raised against somatic Xenopus histone HI (HIA and HIA/B) for combined immunoblotting experiments to quantitate HI pools and immunolocalization studies to visualize chromosome- bound HI. Both approaches failed to detect soluble or chromosomal histone HI in vitellogenic oocytes, eggs, and cleavage-stage embryos up to early blastula. In addition, chromatin assembled in Xenopus egg extract was also negative for histone HI as revealed by immunofluorescence microscopy. Lampbrush chromosomes not only lacked histone HI but also the previously identified histone HI-like B4 protein (Smith et al., 1988, Genes Dev. 2,1284-1295). In contrast, chromosomes of eggs and early embryos fluoresced brightly with anti-B4 antibodies. Our results lend further support to the view that histone HI expression is developmentally regulated during Xenopus oogenesis and embryogenesis similar to what is known from other species.}, language = {en} } @article{KruegerSchoech1993, author = {Kr{\"u}ger, Hans-Peter and Sch{\"o}ch, Heinz}, title = {Absenkung der Promillegrenze. Ein zweifelhafter Beitrag zur Verkehrssicherheit}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-41911}, year = {1993}, abstract = {No abstract available}, language = {de} } @incollection{Schneider1993, author = {Schneider, Wolfgang}, title = {Acquiring expertise: determinants of exceptional performance}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-86652}, publisher = {Universit{\"a}t W{\"u}rzburg}, year = {1993}, abstract = {No abstract available.}, subject = {Hochbegabung}, language = {en} } @article{CavariHongFunkensteinetal.1993, author = {Cavari, Benzion and Hong, Yunhan and Funkenstein, Bruria and Moav, Boaz and Schartl, Manfred}, title = {All-fish gene constructs for growth hormone gene transfer in fish}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-61612}, year = {1993}, abstract = {In order to develop all-fish expression vectors for microinjection into fertilized fish eggs, we have prepared the following cunstructs: rainbow trout metallothionein a/b and the gilthead seabream growth hormone cDNA (ptMTa-gbsGHcDNA, ptMTb-gsbGHcDNA), carp ß-actin gilthead seabream GH cDNA (pcAßgsbGHcDNA). The inducible metallothionein promoters a and b were cloned from rainbow trout, and the constitutive promoter ß-actin was isolated from carp. The metallothionein promoters were cloned by using the PCR technique. The tMTa contains 430 bp, while the tMTb contains 260 bp (Hong et al. 1992). These two promoters were introduced to pGEM-3Z containing the GH cDNA of Sparus aurata to form ptMTa-gsbGH and ptMTb-gsbGH, respectively. The carp cytoplasmic ß-actin gene was chosen as a source for isolating strong constitutive regulatory sequences. One of these regulatory sequences in pUC118 was Iigated to GH cDNA of S. aurata to form the pcAß-gsbGHcDNA. Expression of the constructs containing the metallothionein promoters was tested in fish cell culture and was found tobe induced effectively by zinc. The ptMTa gsb-GH cDNA construct was microinjected into fertilized carp eggs, and integration in the genome of carp was detected in the DNA isolated from fins at the age of two months.}, subject = {Physiologische Chemie}, language = {en} } @article{MuellerKrennSchindleretal.1993, author = {M{\"u}ller, J. G. and Krenn, V. and Schindler, C. and Czub, S. and Stahl-Henning, C. and Coulibaly, C. and Hunsmann, G. and Kneitz, C. and Kerkau, T. and Rethwilm, A. and ter Meulen, V. and M{\"u}ller-Hermelink, H. K.}, title = {Alterations of Thymus Cortical Epithelium and Interdigitating Dendritic Cells but No Increase of Thymocyte Cell Death in the Early Course of Simian Immunodeficiency Virus Infection}, series = {American Journal of Pathology}, volume = {143}, journal = {American Journal of Pathology}, number = {3}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-128250}, pages = {699-713}, year = {1993}, abstract = {The role of the thymus in the pathogenesis of simian acquired immunodeficiency syndrome was investigated in 18 juvenile rhesus monkeys (Macaca mulatta). The thymus was infected from the first week post-SIVmac inoculation, but the amount of virus-positive cells was very low « 1 in 1 04 T cells) as demonstrated by polymerase chain reaction and in situ hybridization. First morphological alteration was a narrowing of the cortex at 12 and 24 wpi. Morphometry revealed no increase of pyknotic T cells but a decrease of the proliferation rate andflow cytometry showed a reduction of the immature \(CD4^+/CD8^+\) double-positive T cells. Ultrastructural analysis revealed vacuolization, shrinkage, andfinally cytolysis of the cortical epithelial cells and the interdigitating dendritic cells. Immunofluorescence staining exhibited a widespread loss of cortical epithelial cells. This damage to the thymic microenvironment could explain the breakdown of the intrathymic T cell proliferation. It preceded fully developed simian acquired immunodeficiency syndrome and is therefore considered to play a major role in its pathogenesis.}, language = {en} } @article{MuellerKrennSchindleretal.1993, author = {M{\"u}ller, J. G. and Krenn, V. and Schindler, C. and Czub, S. and Stahl-Henning, C. and Coulibaly, C. and Hunsmann, G. and Kneitz, C. and Kerkau, Thomas and Rethwilm, Axel and terMeulen, Volker}, title = {Alterations of thymus cortical epithelium and interdigitating dendritic cells but no increase of thymocyte cell death in the early course of simian immunodeficiency virus infection}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-32583}, year = {1993}, abstract = {No abstract available}, language = {en} } @article{KredlerZilloberJohannesetal.1993, author = {Kredler, Christian and Zillober, Christian and Johannes, Frank and Sigl, Georg}, title = {An application of preconditioned conjugate gradients to relative placement in chip design}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-31996}, year = {1993}, abstract = {In distance geometry problems and many other applications, we are faced with the optimization of high-dimensional quadratic functions subject to linear equality constraints. A new approach is presented that projects the constraints, preserving sparsity properties of the original quadratic form such that well-known preconditioning techniques for the conjugate gradient method remain applicable. Very-largescale cell placement problems in chip design have been solved successfully with diagonal and incomplete Cholesky preconditioning. Numerical results produced by a FORTRAN 77 program illustrate the good behaviour of the algorithm.}, language = {en} } @incollection{CantoreggiGuptaLutz1993, author = {Cantoreggi, S. and Gupta, R. C. and Lutz, Werner K.}, title = {An improved 32P-postlabelling assay for detection and quantitation of styrene 7,8-oxide-DNA adducts}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-86305}, publisher = {Universit{\"a}t W{\"u}rzburg}, year = {1993}, abstract = {Using DNA modified with [7-3H]styrene 7,8-oxide (SO) in vitro we have standardized the 32P-postlabelling assay for detecting SO-DNA adducts. Nuclease P 1-enriched adducts were 32P-labelled and purified by high-salt ( 4.0 M ammonium formate, pH 6.1} C1s reverse-phase TLC. After elution from the layer with 2-butoxyethanol:H20 (4:6), adducts were separated by two-dimensional PEI cellulose TLC in non-urea solvents (2.0 M ammonium formate, pH 3.5, and 2.7 M sodium phosphate, pH 5.6). One major, three minor and several trace adducts were detected. The efficiency of the kinase reaction depended on the ATP concentration. Use of standard labelling conditions (['Y· 32P]ATP, <3000 Ci/mmol; <2 Mikromol) resulted in poor ( 4-7\%) adduct recovery. An ATP concentration of 40 Mikromol, however, increased the labeJling efficiency by a factor of 5-8 (35-55\% based on 3H-SO labelied DNA). The results indicate that the new separation technique is suitable for the relatively polar SO-DNA adducts and that high labelling efficiency can be achieved.}, subject = {Medizin}, language = {en} } @article{StopperKoerberSpenceretal.1993, author = {Stopper, Helga and K{\"o}rber, C. and Spencer, D. L. and Kirchner, S. and Caspary, W.J. and Schiffmann, D.}, title = {An investigation of micronucleus and mutation induction by oxazepam in mammalian cells}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-63404}, year = {1993}, abstract = {Tbe benzodiazepines are a class of d.rugs that are widely used in the treatment of various psychiatric disorders. One member of um ~' oxazepam, is also a common metabolite of sevmd other benzod.iazepines. Since the evidence for the genetic toxicity and carcinogenic properties of these compounds is incol:lsb1ent, we investigated the oxazepam-induced fonnation of micronuclei in Syrian Hamster embryo fibroblast (SHE) cells, human amniotic fluid fibroblast-like (AFFL) cells and LS178Y mouse cells. A dose-dependent increase in micronucleus fractions was found in all tbree ceU llnes. The time course of micronucleus induction in L5178Y cells showed a maximum at 5 h after treatment, suggesting that the micronuclei were fonned in the first mitosis after treatment. Kinetochore staining (CREST -antiserum) revealed the presence of kinetochores in -SO\% of the micronuclei in aU tbree ceU types. ThJs resu1t was further confinned by in situ bybridization in LS178Y cells and indicates tbe presence of wbole Chromosomes or centric fragments as weU as acentric fragments in the oxazepam-induced micronuclei. The LS178Y cells did not show a mutagenic response to oxazepam at any of the doses or expression times used.}, subject = {Toxikologie}, language = {en} } @article{GittinsHarrisFieldetal.1993, author = {Gittins, C. M. and Harris, N. A. and Field, R. W. and Verges, J. and Ernst, W. E. and B{\"u}ndgen, P. and Engels, Bernd}, title = {Analysis and Depertubation of the C\(^2\)Π and D\(^2\)Σ\(^+\) states of CaF}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-58980}, year = {1993}, abstract = {No abstract available}, subject = {Organische Chemie}, language = {en} } @article{HackerOttWintermeyeretal.1993, author = {Hacker, J{\"o}rg and Ott, Manfred and Wintermeyer, Eva and Ludwig, Birgit and Fischer, Gunter}, title = {Analysis of virulence factors of Legionella pneumophila.}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-70620}, year = {1993}, abstract = {Legionella pneumophila, the causative agent of Legionnaires' disease is a facultative intracellular bacterium, which in the course of human infection multiplies in lung macrophages predominantly manifesting as pneumonia. The natural habitat of Legionella is found in sweet water reservoirs and man-made water systems. Virulent L. pneumophila spontaneously convert to an avirulent status at a high frequency. Genetic approaches have led to the identification of various L. pneumophila genes. The mip (macrophage infectivity potentiator) determinant remains at present the sole established virulence factor. The Mip protein exhibits activity of a peptidyl prolyl cis trans isomerase (PPiase), an enzyme which is able to bind the immunosuppressant FK506 and is involved in protein folding. The recently cloned major outer membrane protein (MOMP) could play a role in the uptake of legionellae by macrophages. Cellular models are useful in studying the intracellular replication of legionellae in eukaryotic cells. Human celllines and protozoan models are appropriate for this purpose. By using U 937 macrophage-like cells and Acanthamoeba castellanii as hosts, we could discriminate virulent and avirulent L. pneumophila variants since only the virulent strain was capable of intracellular growth at 37 oc. By using these systems we further demonstrated that a hemolytic factor cloned and characterized in our laboratory, legiolysin (lly), had no influence on the intracellular growth of L. pneumophila.}, subject = {Legionella pneumophila}, language = {en} } @inproceedings{KreuzerHenjesKunstSeideletal.1993, author = {Kreuzer, H. and Henjes-Kunst, F. and Seidel, E. and Sch{\"u}ssler, Ulrich and B{\"u}hn, B.}, title = {Ar-Ar spectra on minerals from KTB and related medium-pressure units}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-86731}, year = {1993}, abstract = {No abstract available.}, subject = {Kontinentales Tiefbohrprogramm}, language = {en} } @article{FalkMarohn1993, author = {Falk, Michael and Marohn, Frank}, title = {Asymptotically optimal tests for conditional distributions}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-45823}, year = {1993}, abstract = {No abstract available}, language = {en} } @incollection{Hoffmann1993, author = {Hoffmann, Joachim}, title = {Aufmerksamkeit, Automatisierung und antizipative Verhaltensteuerung}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-78315}, publisher = {Universit{\"a}t W{\"u}rzburg}, year = {1993}, abstract = {no abstract available}, subject = {Automation}, language = {de} }