@phdthesis{Schloer1994, author = {Schl{\"o}r, Joachim}, title = {Carl R. Rogers - Ein p{\"a}dagogischer Klassiker? Biographische Rekonstruktionen}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-231708}, school = {Universit{\"a}t W{\"u}rzburg}, year = {1994}, abstract = {not available}, language = {de} } @article{WaelbroeckCamusTastenoyetal.1994, author = {Waelbroeck, M. and Camus, J. and Tastenoy, M. and Feifel, R. and Mutschler, E. and Tacke, R. and Strohmann, C. and Rafeiner, K. and Rodrigues de Miranda, J. F. and Lambrecht, G.}, title = {Binding and functional properties of hexocyclium and sila-hexocyclium derivatives to muscarinic receptor suhtypes}, series = {British Journal of Pharmacology}, volume = {112}, journal = {British Journal of Pharmacology}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-128265}, pages = {505-514}, year = {1994}, abstract = {1 We have compared the binding properties of several hexocyclium and sila-hexocyclium derivatives to muscarinic Ml receptors (in rat brain, human neuroblastoma (NB-OK I) cells and calf superior cervical ganglia), rat heart M2 receptors, rat pancreas M3 receptors and M4 receptors in rat striatum, with their functional antimuscarinic properties in rabbit vas deferens (Ml/M4-like), guinea-pig atria (M2), and guinea-pig ileum (M3) muscarinic receptors. 2 Si la-substitution (C/Si exchange) of hexocyclium (~ sila-hexocyclium) and demethyl-hexocyclium (~demethyl-sila-hexocyclium) did not significantly affect their affinities for muscarinic receptors. By contrast, sila-substitution of demethoxy-hexocyclium increased its affinity 2 to 3 fold for all the muscarinic receptor subtypes studied. 3 The p-fluoro- and p-chloro-derivatives of sila-hexocyclium had lower affinities than the parent compound at the four receptor subtypes, in binding and pharmacological studies. 4 In binding studies, o-methoxy-sila-hexocyclium (Ml = M4 ~ M3 ~ M2) had a much lower affinity than sila-hexocyclium for the four receptor subtypes, and discriminated the receptor subtypes more poorly than sila-hexocyclium (Ml = M3> M4> M2)' This is in marked contrast with the very clear selectivity of demethoxy-sila-hexocyclium for the prejunctional MtlM4-like heteroreceptors in rabbit vas deferens. 5 The tertiary amines demethyl-hexocyclium, demethyl-sila-hexocyclium and demethyl-o-methoxy-silahexocyclium had 10 to 30 fold lower affinities than the corresponding quaternary ammonium derivatives.}, language = {en} } @article{HerbertHolzer1994, author = {Herbert, M. K. and Holzer, P.}, title = {Interleukin-1ß enhances capsaicin-induced neurogenic vasodilatation in the rat skin}, series = {British Journal of Pharmacology}, volume = {111}, journal = {British Journal of Pharmacology}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-128171}, pages = {681-686}, year = {1994}, abstract = {No abstract available.}, language = {en} } @incollection{Hoffmann1994, author = {Hoffmann, Joachim}, title = {Die visuelle Identifikation von Objekten}, series = {Wahrnehmung}, booktitle = {Wahrnehmung}, publisher = {Hogrefe}, address = {G{\"o}ttingen}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-127745}, publisher = {Universit{\"a}t W{\"u}rzburg}, pages = {391-456}, year = {1994}, abstract = {No abstract available.}, language = {de} } @article{Hoffmann1994, author = {Hoffmann, Joachim}, title = {Der implizite Erwerb von Handlungswissen}, series = {Psychologie und Sport : Zeitschrift f{\"u}r Sportpsychologie}, volume = {8}, journal = {Psychologie und Sport : Zeitschrift f{\"u}r Sportpsychologie}, number = {2}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-127709}, pages = {56-66}, year = {1994}, abstract = {Der Beitrag besch{\"a}ftigt sich mit {\"U}berlegungen zum Aufbau verhaltenssteuernder Strukturen. Er geht von dem Konzept de simpliziten Lernens aus, nach dem sich die Steuerung des Verhaltens, wenigstens unter bestimmten Bedingungen, unbewusst, aufmerksamkeitsunabhaengig und unwillk{\"u}rlich an strukturelle Eigenschaften der Umgebung anpasst. Eine kritische Analyse einschl{\"a}giger Untersuchungen f{\"u}hrt zu einer hypothetischen Lernstruktur, die es gestattet zu lernen, unter welchen Bedingungen welche Verhaltensakte zu welchen Konsequenzen f{\"u}hren. Der Lernprozess, so wird angenommen, wird in dieser Struktur von einem fundamentalen Beduerfnis nach sicherer Antizipierbarkeit von Verhaltenskonsequenzen getrieben. Eine Pilotstudie, die von diesen Annahmen ausgeht, wird ebenso diskutiert wie moegliche Anwendungen bei der Gestaltung von Trainingsprozessen im Sport.}, language = {de} } @unpublished{Kiesler1994, author = {Kiesler, Reinhard}, title = {Zum Stand der Forschung auf dem Gebiete der franz{\"o}sischen Umgangssprache (1994)}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-103365}, pages = {77 S.}, year = {1994}, abstract = {Der Artikel gibt einen {\"U}berblick {\"u}ber die Forschungen zur franz{\"o}sischen Umgangssprache von den Anf{\"a}ngen bis etwa 1992 in vier Abschnitten: 1. Die Anf{\"a}nge, 2. die Sprachschichtenforschung, 3. die Beitr{\"a}ge von Soziolinguistik und Variet{\"a}tenlinguistik und 4. die Arbeiten der "Gegenwart" um 1990. Eine Zusammenfassung und eine ausf{\"u}hrliche Bibliographie schließen den Forschungsbericht ab. Ber{\"u}cksichtigt werden alle sprachlichen Ebenen von der Aussprache {\"u}ber den Wortschatz bis zur Grammatik. Wo es angebracht erscheint, sind Hinweise auf Arbeiten zu anderen Umgangssprachen angef{\"u}hrt.}, subject = {Franz{\"o}sisch}, language = {de} } @incollection{Wilhelm1994, author = {Wilhelm, Gernot}, title = {Hymnen der Hethiter}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-87862}, publisher = {Universit{\"a}t W{\"u}rzburg}, year = {1994}, abstract = {no Abstract available}, subject = {Alter Orient}, language = {de} } @article{Wilhelm1994, author = {Wilhelm, Gernot}, title = {Bemerkungen zur urart{\"a}ischen Pal{\"a}ographie}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-87784}, year = {1994}, abstract = {no Abstract available}, subject = {Alter Orient}, language = {de} } @article{HeiserMuellerRuchholtzUlrichs1994, author = {Heiser, A. and M{\"u}ller-Ruchholtz, W. and Ulrichs, Karin}, title = {Isolation of Islets of Langerhans: Improvement of the Isolation Technique Using the Pig Model.}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-87765}, year = {1994}, abstract = {During the last view years, interest in pancreatic islet transplantation for the cure of type I diabetes has increased markedly. A serious barrier to clinical islet transplantation is the isolation of a sufficient mass of viable and functional islets. We used a porcine islet isolation model to examine various parameters of the isolation procedure and to improve isolation technique.}, subject = {Langerhans-Inseln}, language = {en} } @book{Wilhelm1994, author = {Wilhelm, Gernot}, title = {Medizinische Omina aus Hattuša in akkadischer Sprache}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-87733}, publisher = {Universit{\"a}t W{\"u}rzburg}, year = {1994}, abstract = {No abstract available.}, subject = {Akkadisch}, language = {de} } @article{SchneiderViseReimersetal.1994, author = {Schneider, Wolfgang and Vis{\´e}, Mechthild and Reimers, Petra and Blaesser, Barbara}, title = {Auswirkungen eines Trainings der sprachlichen Bewußtheit auf den Schriftspracherwerb in der Schule}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-87491}, year = {1994}, abstract = {Mit der vorliegenden Trainingsstudie wird der Versuch unternommen, Ergebni e eines F{\"o}rderprograrnms zur sprachlichen Bewußtheit (Lundberg, Frost \& Petersen 1988) im deutschsprachigen Raum zu validieren. An unserer Replikationsstudie nahmen insgesamt 371 Kinder teil, von denen 205 Kinder einer Trainingsgruppe und 166 Kinder einer Kontrollgruppe zugewiesen wurden. Das F{\"o}rderprograrnm bestand aus Sprachspielen, die {\"u}ber einen Zeitraum von zirka 6 Monaten t{\"a}glich 15 Minuten in den Kindergartengruppen durchgef{\"u}hrt wurden. Die Kontrollgruppe erhielt keine spezielle F{\"o}rderung, sondern nahm am regul{\"a}ren Kindergartenprogramm teil. Indikatoren der sprachlichen Bewußtheit und weitere metalinguistische und kognitive Variablen wurden unmittelbar vor und nach der F{\"o}rderung erhoben. Zu Beginn des ersten Schuljahres wurde ein metalinguistischer Transfertest, gegen Ende dann ein Rechtschreibtest durchgef{\"u}hrt. Die Befunde replizieren die Ergebnisse der d{\"a}nischen Ausgangsstudie insofern, als kurz- und langfristige Trainingseffekte gesichert werden konnten. Sie verdeutlichen jedoch zus{\"a}tzlich, daß die Qualit{\"a}t der F{\"o}rderung f{\"u}r die Langzeitwirkung entscheidend war.}, subject = {phonologische Bewusstheit}, language = {de} } @article{Schneider1994, author = {Schneider, Wolfgang}, title = {Lese-Rechtschreib-Forschung heute: Einf{\"u}hrung}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-87489}, year = {1994}, abstract = {Es wird eine Kurz{\"u}bersicht {\"u}ber relevante Str{\"o}mungen der Lese-Recht chreib-Forschung gegeben. Nachdem die sog. Legasthenieforschung aufgrund konzeptueller und methodologischer Probleme in die Kritik geraten war, treten gegenw{\"a}rtig eher theorieorientierte An {\"a}tze in den Vordergrund. euere Modelle zum Schriftspracherwerb haben zahlreiche L{\"a}ngsschnittstudien stimuliert, die die Relevanz metalinguistischer F{\"a}higkeiten f{\"u}r den p{\"a}teren Schriftspracherwerb dokumentieren.}, subject = {Leseforschung}, language = {de} } @article{GruberRenklSchneider1994, author = {Gruber, Hans and Renkl, Alexander and Schneider, Wolfgang}, title = {Expertise und Ged{\"a}chtnisentwicklung: L{\"a}ngsschnittliche Befunde aus der Dom{\"a}ne Schach}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-87473}, year = {1994}, abstract = {Die vorliegende Arbeit ging zwei Hauptfragestellungen nach: (I) Inwiefern unterscheiden sich Experten in der Dom{\"a}ne Schach von Aussteigern aus der Expertisekarriere? (2) Wie ver{\"a}ndern sich schachspezifische und generelle Ged{\"a}chtnisparameter {\"u}ber einen Zeitraum von mehreren Jahren? Es wurden 27 Experten und Novizen mit einem durchschnittlichen Alter von knapp 12 Jahren zum ersten Meßzeitpunkt und von 16 Jahren zum zweiten Meßzeitpunkt untersucht. Die Aussteiger aus der Expertisekarriere zeigten bereits bei der Erstmessung schlechtere schachspezifische Ged{\"a}chtnisleistungen als die {\"u}brigen Experten; die Annahme selektiver Aussteiger, die die Aussagekraft querschnittlicher Experten-Novizen-Vergleiche in Frage stellt, wird damit best{\"a}tigt. Sowohl f{\"u}r die Experten als auch f{\"u}r die Novizen zeigte sich ein Anstieg der schachspezifischen Ged{\"a}chtnisleistung von der Erst- zur Zweitmessung. W{\"a}hrend daf{\"u}r bei Experten dom{\"a}nenspezifische Faktoren verantwortlich sein d{\"u}rften, scheint dies bei Novizen auf die Entwicklung allgemeiner Ged{\"a}chtnisparameter zur{\"u}ckzugehen.}, subject = {Expertise}, language = {de} } @article{Schneider1994, author = {Schneider, Wolfgang}, title = {Der {\"U}bergang in weiterf{\"u}hrende Schulen nach dem 4. oder 6. Grundschuljahr? Theoretische Analysen und empirische Befunde zur Prognose des Schulerfolgs}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-87465}, year = {1994}, abstract = {No abstract available.}, subject = {Grundschule}, language = {de} } @incollection{Schneider1994, author = {Schneider, Wolfgang}, title = {Methodische Ans{\"a}tze der empirischen Erziehungs- und Sozialisationsforschung}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-87454}, publisher = {Universit{\"a}t W{\"u}rzburg}, year = {1994}, abstract = {No abstract available.}, subject = {Methode}, language = {de} } @article{WinklerWittbrodtLammersetal.1994, author = {Winkler, Christoph and Wittbrodt, Joachim and Lammers, Reiner and Ullrich, Axel and Schartl, Manfred}, title = {Ligand-dependent tumor induction in medakafish embryos by a Xmrk receptor tyrosine kinase transgene}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-87107}, year = {1994}, abstract = {Xmrk encodes a subclass 1 receptor tyrosine kinase (RTK) which has been cloned from the melanomainducing locus Tu of the poeciliid fish Xiphophorus. To demonstrate a high oncogenic potential in vivo we transferred the gene into early embryos of the closely related medakafish. Ectopic expression of the Xmrk oncogene under the control of a strong, constitutive promoter (CMVTk) led to the induction of embryonic tumors with high incidence, after short latency periods, and with a specific pattern of affected tissues. We demonstrate ligand-dependent transformation in vivo using a chimeric receptor consisting of the extracellular and transmembrane domains of the human EGF receptor (HER) and the cytoplasmatic domain of Xmrk. Expression of the chimeric receptor alone does not lead to ldnase activation or induction of tumors. Coexpression of the chimera with its corresponding ligand, human transforming growth factor alpha (bTGF(X), however, results in the activation of the chimeric RTK. In injected fish embryos the induction of the neoplastic growth is observed with similar incidence and tissue distribution as in embryos carrying the native Xmrk oncogene suggesting that the ligand as well as factors downstream of tbe RTK are required for tumor formation. In this study we show single-step induction of tumors by ectopic expression of RTKs in vivo substantiating tbe significance of autocrine stimulation in RTK induced tumors in vertebrales.}, subject = {Japank{\"a}rpfling}, language = {en} } @article{UlrichsEcksteinKorsgrenetal.1994, author = {Ulrichs, Karin and Eckstein, V. and Korsgren, O. and Tibell, A. and Groth, C. G. and M{\"u}ller-Ruchholtz, W.}, title = {Characterization of natural and induced human xenophile antibodies before and after transplantation of the fetal porcine endocrine pancreas}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-86985}, year = {1994}, abstract = {No abstract available.}, subject = {Bauspeicheldr{\"u}se}, language = {de} } @article{TackeKropfgansTafeletal.1994, author = {Tacke, Reinhold and Kropfgans, Martin and Tafel, Andrea and Wiesenberger, Frank and Sheldrick, William S. and Mutschler, Ernst and Egerer, Hansj{\"o}rg and Rettenmayr, Nikola and Gross, Jan and Waelbroeck, Magali and Lambrecht, G{\"u}nter}, title = {(Hydroxymethyl)diphenyl(piperidinoalkyl)silane des Typs (HOCH2)(C6H5)2Si(CH2)nNC5H10 (n = 2,3) und deren Methoiodide: Synthese, Struktur und antimuscarinische Eigenschaften}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-86904}, year = {1994}, abstract = {No abstract available.}, language = {de} } @article{Sponholz1994, author = {Sponholz, Barbara}, title = {Ph{\´e}nom{\´e}nes karstiques dans les roches siliceuses au Niger oriental}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-86833}, year = {1994}, abstract = {Dans le Niger oriental, des ph{\´e}nomenes karstiques sont fr{\´e}quents dans les roches siliceuses: gres, silcretes, cro{\^u}tes ferrugineuses, roches cristallines. A partir des {\´e}tudes g{\´e}omorphologiques et micromorphologiques, on peut conclure a une kartsification, au sense de production de formes par dissolution. Les r{\´e}sultats permettent de dater du Tertiaire inf{\´e}rieur la principale p{\´e}riode de karstification. La r{\´e}partition r{\´e}gionale des formes induites par cette karstification indique une d{\´e}pendance probable des conditions pal{\´e}oclimatiques. Actuellement le karst influe encore sur le d{\´e}veloppement des autres formes de relief.}, language = {fr} } @article{McCarronWangSirenetal.1994, author = {McCarron, R. M. and Wang, L. and Sir{\´e}n, Anna-Leena and Spatz, M. and Hallenbeck, J. M.}, title = {Adhesion molecules on normotensive and hypertensive rat brain endothelial cells}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-86819}, year = {1994}, abstract = {The intercellular adhesion of circulating leukocytes to vascular endothellum ls a prerequisite for leukocyte emigration from the blood to extravascular tlssues. This process is facllltated by adhesion molecules on the surfaces of both the vascular endothelial cells and the leukocytes. The experiments presented here demonstrate for the first time that the leukocyte adhesion receptor, intercellular adhesion molecule-1, is constitutively expressed on cultured cerebromicrovascular endothelial cell lines derived from both spontaneously hypertensive (SHR) rats and normotensive WistarKyoto (WKY) rats. Both cultures contained simliar numbers of cells constitutively expressing this adhesion molecule (31.4\% and 29.6\%, respectlvely). Adhesion molecule expression was up-regulated by interleukin-1 ß, tumor necrosis factor-a, interferon-y and lipopolysaccharide in a dose- and time-dependent manner. Both cultures exhibited similar maximum levels of adhesion molecule up-regulation to optimal concentrations of all three cytokines. However, SHR endothelial cells were moresensitive to all three cytokines; significantly higher levels of intercellular adhesion molecule-1 expresslon were seen on SHR as opposed to WKY endothelial cells cultured with sub-optimal cytokine concentrations. It was also observed that lipopolysaccharide up-regulated intercellular adhesion molecule-1 expression on SHR endothelial cells to a greater extent than on WKY endothelial cells. The findings that intercellular adhesion molecule-1 can be up-regulated to a greater degree on SHR endothelial cells may have important implications for in vivo perivascular leukocyte accumulation under hypertensive conditions. These observations indicate a possible mechanism by which hypertension may predispose to the development of disorders such as atherosclerosis and stroke.}, subject = {Endothelzelle}, language = {en} } @article{YongJacobowitzBaroneetal.1994, author = {Yong, Liu and Jacobowitz, David M. and Barone, Frank and McCarron, Richard and Spatz, Maria and Feuerstein, Giora and Hallenbeck, John M. and Sir{\´e}n, Anna-Leena}, title = {Quantitation of perivascular monocyte / macrophages around cerebral blood vessels of hypertensive and aged rats}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-86800}, year = {1994}, abstract = {The numbers of monocytes and macrophages in the walls of cerebral blood vessels were counted on perfusion-fixed frozen brain sections (16 JLffi) of spontaneously hypertensive rats (SHR), stroke-prone SHR (SHR-SP), normotensive Wistar-Kyoto (WKY) rats, and young (16-week-old) and old (2-year-old) normotensive Sprague-Dawley rats (SD-l6w and SD-2y, respectively) using monoclonal antiborlies against rat macrophages (ED2). The staining was visualized with fluoresceinlabeled second antiborlies. The ED2-specific staining in brain sections was restricted to macrophages in a perivascular location. The number of perivascular cells per square millimeter of high-power field was significantly greater in SHR-SP (8.6 ± 2.1; n = 4) and SHR (6. 7 ± 0.9; n = 6) than in normotensive WKY (4.0 ± 0.5; n = 6; p <0.01). The number of perivascular macrophages was also greater in SD-2y (7.5 ± 2.7; n = 9) than in SD-l6w (2.9 ± 1.8; n = 8; p < 0.01). No ED2 staining was found in the resident microglia or in the endothelial cells, which were identified by double staining with rhodamine-labeled anti-factor VIII-related antigen antiborlies. The results suggest that the stroke risk factors hypertension and advanced age are associated with increased subendothelial accumulation of monocytes and macrophages. This accumulation could increase the tendency for the endothelium to convert from an anticoagulant to a procoagulant surface in response to mediators released from these subendothelial cells.}, subject = {Willebrand-Faktor}, language = {en} } @incollection{Schneider1994, author = {Schneider, Wolfgang}, title = {Memory development}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-69331}, publisher = {Universit{\"a}t W{\"u}rzburg}, year = {1994}, abstract = {No abstract available.}, subject = {P{\"a}dagogik}, language = {en} } @article{Wilhelm1994, author = {Wilhelm, Gernot}, title = {Kumme und *Kumar: Zur hurritischen Ortsnamenbildung}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-86448}, year = {1994}, abstract = {no Abstract available}, subject = {Churritisch}, language = {de} } @inproceedings{SchreibmanSchartlKallmanetal.1994, author = {Schreibman, Martin P. and Schartl, Manfred and Kallman, Klaus D. and Magliulo-Cepriano, Lucia}, title = {Molecular approaches to study the genetic regulation of the fish reproductive system}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-86679}, year = {1994}, abstract = {No abstract available.}, subject = {Fische}, language = {en} } @article{XuShengGreineretal.1994, author = {Xu, Shanjia and Sheng, Xinqing and Greiner, P. and Becker, Charles R. and Geick, R.}, title = {High-order finite-element analysis of scattering properties of II-VI semiconductor materials}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-86283}, year = {1994}, abstract = {The sattering characteristics ot the n-VI semiconductors were analyzed by a method which combines the second-order finite-element method with the rigorous mode matching procedure. The method avolds the difficulty of solving the complex transcendental equation introduced in the multimode network method and calculates all the eigenvalues and eigenfunctions simultaneously which are needed for the mode matching treatment in the longitudinal direction. As a result, the whole solution procedure is significantly simplified. A comparison is given between the experimental data and the calculated results obtained with this analysis and tbe network method. Very good agreement has been achieved, the accuracy and efficiency of the present method are thus verified.}, subject = {Halbleiter}, language = {en} } @article{UlrichsEcksteinTibelletal.1994, author = {Ulrichs, Karin and Eckstein, V. and Tibell, A. and Groth, C. G. and Korsgren, O. and M{\"u}ller-Ruchholtz, W. and Thiede, A.}, title = {Nat{\"u}rliche und induzierte xenoreaktive Antik{\"o}rper vor und nach klinischer Transplantation f{\"o}taler porziner Pankreasinselzellen}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-72967}, year = {1994}, abstract = {No abstract available.}, subject = {Antik{\"o}rper}, language = {de} } @misc{KraemerNeubert1994, author = {Kr{\"a}mer-Neubert, Sabine}, title = {Hessen-Nassauisches Volksw{\"o}rterbuch}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-86011}, year = {1994}, abstract = {Unter F{\"o}rderung durch den Hessischen Kultusminister aus den f{\"u}r ein Hessen-Nassauisches W{\"o}rterbuch mit Hilfe aller Volkskreise und besonders der Lehrerschaft unseres Arbeitsbereiches von Ferdinand Wrede angelegten und verwalteten Sammlungen ausgew{\"a}hlt und bearbeitet von Luise Berhold und Hans Friebertsh{\"a}user; ab Lieferung 38: Mitarbeit Heinrich J. Dingeldein. Bd. IV, Bogen 1-32 (Lieferungen 31-38 des Gesamtwerks). "Taa-Wanst"}, language = {de} } @incollection{AltschmiedSchartl1994, author = {Altschmied, Joachim and Schartl, Manfred}, title = {Genetics and molecular biology of tumour formation in Xiphophorus}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-69752}, publisher = {Universit{\"a}t W{\"u}rzburg}, year = {1994}, abstract = {No abstract available.}, subject = {Schwertk{\"a}rpfling}, language = {en} } @article{StopperKirchnerSchiffmannetal.1994, author = {Stopper, Helga and Kirchner, S. and Schiffmann, D. and Poot, M.}, title = {Cell cycle disturbance in relation to micronucleus formation induced by the carcinogenic estrogen diethylstilbestrol}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-82250}, year = {1994}, abstract = {In addition to its tumor-promoting activity in honnone-receptive tissue, the carcinogenic estrogen diethylstilbestrol (DES) has been found to induce cell transformation, aneuploidy and micronucleus formation in mammalian cells. The majority of these micronuclei contained whole chromosomes and were fonned during mitosis. Here a possible relationship between a disturbance in cell cycle progression and micronucleus fonnation is investigated by exposing Syrian hamster embryo (SHE) cells to DES. Continuous bromodeoxyuridine labeling followed by bivariate Hoechst 33258/ethidium bromide flow cytometry was employed for analysis of cell cycle transit and related to the time course of micronucleus formation. Treatment of SHE cells with DES resulted in delayed and impaired cell activation (exit from the GO/G 1 phase), impaired S-phase transit and, mainly, G2-phase traverse. Cells forming micronuclei, on the other hand, were predominantly in G2 phase during DES treatment. These results suggest that impairment of Sand G2 transit may involve a process ultimately leading to micronucleus formation.}, subject = {Toxikologie}, language = {en} } @article{FranzekStoeberBeckmann1994, author = {Franzek, E. and St{\"o}ber, Gerald and Beckmann, H.}, title = {Malignes neuroleptisches und lebensbedrohliches katatones Syndrom: Eine identische Komplikation im Verlauf von funktionellen Psychosen}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-82243}, year = {1994}, abstract = {no abstract available}, subject = {Neuropsychiatrie}, language = {de} } @article{BeckerFranzekJostetal.1994, author = {Becker, T. and Franzek, E. and Jost, C. and Hofmann, E. and Schneider, M. and St{\"o}ber, Gerald}, title = {Hirnl{\"a}sionen bei affektiven Erkrankungen: eine retrospektive CT-Studie}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-82237}, year = {1994}, abstract = {46 Patienten mit affektiven Erkrankungen und pathologischem CT wurden untersucht (Infarkt: 22, Kontusion: 6, Leukoaraiose: 11, fr{\"u}hkindlicher Hirnschaden: 7). Monopolar Depressive (DSMIII- R; MD) zeigten oft Leukoaraiose, Infarkte waren mit MD, Kontusionen und fr{\"u}hkindliche Sch{\"a}den mit bipolarer Erkrankung assoziiert (BP; ANCOV A, p< .1). Kortikale L{\"a}sionen waren bei BP h{\"a}ufiger, jedoch fehlten signifikante Effekte von L{\"a}sionsort oder -zeitpunkt auf die Polarit{\"a}t der Erkrankung (ANOV A). Bei einigen Infarktpatienten kam es zur Verlaufs{\"a}nderung (Chronifizierung, Bipolarit{\"a}t) nach Infarkt, alle Post-Infarkt-Ersterkrankungen waren bipolar.}, subject = {Psychiatrie}, language = {de} } @article{RoeschHockSchuessleretal.1994, author = {R{\"o}sch, C. and Hock, R. and Sch{\"u}ssler, Ulrich and Yule, P.}, title = {Pr{\"a}islamische Schmuckperlen aus dem Oman - Erste Ergebnisse mineralogisch-materialkundlicher Untersuchungen}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-81822}, year = {1994}, abstract = {no abstracts available}, subject = {Schmuckperle}, language = {de} } @article{Scheer1994, author = {Scheer, Ulrich}, title = {Harold Garnet Callan 1917-1993}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-80789}, year = {1994}, abstract = {Professor Harold Gamet Callan, honorary member of the German Society for Cell Biology, died on the 3rd November 1993, at the age of 76. His name is inseparably connected with lampbrush chromosomes, the most spectacular and aesthetically ailuring form of chromosomes, which occupied the major part of his scientific career. " Mick" Callan's pioneering studies led to fruitful new concepts, served as a building block for many subsequent studies by others, and contributed enormously to our current understanding of chromosome organization and activity ...}, subject = {Harold Garnet Callan}, language = {en} } @inproceedings{Macht1994, author = {Macht, Michael}, title = {Kovariation und Dissoziation psychophysiologischer Variablen unter kurzzeitig verminderter Energiezufuhr}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-80187}, year = {1994}, abstract = {no abstract available}, subject = {Psychologie}, language = {de} } @inproceedings{KrebsJankeMachtetal.1994, author = {Krebs, H. and Janke, W. and Macht, Michael and Weijers, H.-G. and Weyers, P.}, title = {Differentielle Tierpsychologie: Hypo- und hyperphage Reaktionen unter Streß}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-80175}, year = {1994}, abstract = {no abstract available}, subject = {Psychologie}, language = {de} } @article{Stoeber1994, author = {St{\"o}ber, Gerald}, title = {Schwangerschaftsinfektionen bei M{\"u}ttern von chronisch Schizophrenen: die Bedeutung einer differenzierten Nosologie}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-78438}, year = {1994}, abstract = {In einer retrospektiven Untersuchung erinnerten 16 von 80 M{\"u}ttern von chronisch Schizophrenen eine schwere Infektionserkrankung in der Schwangerschaft. Im zweiten Trimenon waren geh{\"a}uft Infektionen aufgetreten. Zehn von 80 M{\"u}ttern von Kontrollpersonen erinnerten ebenfalls eine Infektion. Im Vergleich zu den Kontrollen halfen M{\"u}tter Schizophrener im 5. Schwangerschaftsmonat h{\"a}ufiger Infektionen als in den anderen Gestationsmonaten (p < 0,05). Bei "famili{\"a}ren" und "sporadischen" Schizophrenen gem{\"a}ß DSM III-R kamen im Vergleich zu Kontrollen Infektionen in gleicher H{\"a}ufigkeit vor. Wurden hingegen in der Diagnostik schizophrener Psychosen die Definitionen von Leonhard zugrunde gelegt, ergaben sich signifikante Unterschiede! Bei den systematischen Schizophrenen (denen nach Leonhard keine erbliche Disposition zugrunde liegt) waren Infektionen geh{\"a}uft im 2. Schwangerschaftsdrittel aufgetreten, sowohl im Vergleich zu Kontrollen (p < 0,01) als auch im Vergleich zu den unsystematischen Schizophrenen, die haupts{\"a}chlich genetisch bedingt zu sein scheinen (p < 0,001). Infektionserkrankungen im 5. Schwangerschaftsmonat waren ausschließlich bei den M{\"u}ttern von systematischen Schizophrenen vorgekommen. Bei diesen Krankheitsformen scheinen Infektionen im 2. Schwangerschaftstrimenon und insbesondere im 5. Schwangerschaftsmonat wichtige {\"a}tiologische Faktoren zu sein und k{\"o}nnten miturs{\"a}chlich sein f{\"u}r die beschriebenen zytoarchitektonischen Aberrationen im Zentralnervensystem von chronisch Schizophrenen.}, subject = {Medizin}, language = {de} } @article{BeckerSchmidtkeStoeberetal.1994, author = {Becker, T. and Schmidtke, A. and St{\"o}ber, Gerald and Franzek, E. and Teichmann, E. and Hofmann, E.}, title = {Hyperintense Marklagerl{\"a}sionen bei psychiatrischen Patienten: r{\"a}umliche Verteilung und psychopathologische Symptome}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-78288}, year = {1994}, abstract = {In einem Kollektiv von 130 MR-tomographisch untersuchten psychiatrischen Patienten (axiale T2-SE-Sequenz) wurden Zahl und r{\"a}umliche Verteilung von hyperintensen Marklagerl{\"a}sionen ("white matter lesions"; WM L) erfaßt und die Ventricle-to-brain-Ratio (VBR) bestimmt. Eine Konfigurationsfrequenzanalyse auf der Grundlage der r{\"a}umlichen WMLVerteilung erlaubte die Abgrenzung von vier Patientengruppen: 1. keine WML (n = 35), 2. WML rechts frontotemporal (n = 23), 3. WML bifrontal (n = 12), 4. WML ubiquit{\"a}r (n = 16). Die w{\"a}hrend 3 Jahren beobachteten psychopathologischen Symptome dieser Patienten wurden retrospektiv nach dem AMDP-Systemdokumentiert. In der Gruppe mit ubiquit{\"a}ren WML {\"u}berwogen organisch-psychopathologische Ttems, die VER war gr{\"o}ßer als in den anderen Gruppen (ANOVA;p < 0,001). Die r{\"a}umliche W M L- Verteilung erkl{\"a}rte 10,24 \% der Gesamtvarianz psychopathologischer M erkmalsverteilung in den Gruppen. Das Patientenalter (MANCOVA; p < 0,021), nicht aber die VER hattesignifikanten Einfluß auf das psychopathologische Symptomprofil. Nach Ausblendung der Patientengruppe mit ubiquit{\"a}ren WMLblieb der Einfluß der WML-Verteilung auf die psychopathologische Symptomatiksignifikantc (p <0,05). Bifrontale WML waren mit Denkst{\"o}rung, rechts frontotemporale WML mit affektiven Symptomen assoziiert. Die Befunde sprechen f{\"u}r einen Einfluß der r{\"a}umlichen Verteilung unspezifischer Marklagerl{\"a}sionen auf die psychopathologische Symptomatik.}, subject = {Medizin}, language = {de} } @incollection{Herbert1994, author = {Herbert, M. K.}, title = {Analgetikaeinsatz beim geriatrischen Patienten}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-78001}, publisher = {Universit{\"a}t W{\"u}rzburg}, year = {1994}, abstract = {Nicht nur bei traumatologischen, sondern auch bei vielen internistischen und neurologischen Notf{\"a}llen ist der Schmerz das oder eines der Leitsymptome. Neben der Wiederherstellung und Sicherung der Vitalfunktionen ist die rasche und effiziente Schmerzlinderung eine der wichtigsten Aufgaben des Notarztes. Eine erfolgreiche analgetische Therapie verbessert zum einen die subjektive Befindlichkeit des Patienten und unterbricht zum anderen die durch starke Schmerzen initiierten und unterhaltenen sympathiko-adrenergen und metabolisch-endokrinen Streßreaktionen, mit all ihren nachteiligen Auswirkungen auf die H{\"a}modynamik und Respiration. Letzteres ist eine wichtige, positive Wirkung einer guten analgetischen Therapie, insbesondere beim kranken geriatrischen Patienten, der in den Kompensationsm{\"o}glichkeiten einzelner Organsysteme oft deutlich eingeschr{\"a}nkt ist. L{\"a}nger fortbestehende starke Schmerzen w{\"u}rden gerade bei diesen Patienten eine Einschr{\"a}nkung der H{\"a}modynamik und Respiration perpetuieren.}, subject = {Medizin}, language = {de} } @incollection{Kuenzler1994, author = {K{\"u}nzler, Jan}, title = {Partnerschaft und Elternschaft im Familiensystem}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-50795}, publisher = {Universit{\"a}t W{\"u}rzburg}, year = {1994}, abstract = {Partnerschaft und Elternschaft waren im Begriff der Familie bislang essentiell zusammengedacht: Partnerschaft und Elternschaft, Ehe und Filiation, beschreiben exklusiv und vollst{\"a}ndig die Prinzipien, anhand derer sich das Familienpersonal rekrutiert (vgl. Tyrell 1983, S. 363). Beides muß nicht in Familien zusammenfallen. Immer mehr Ehen bleiben dauerhaft kinderlos -immer mehr Familien kommen als Ein-Elternfamilien ohne Partnerschaft aus. Das ist die sozialstrukturelle Version einer Entkoppelung von Partnerschaft und Elternschaft. Auf der anderen Seite sind Partnerschaft und Elternschaft in der {\"u}berwiegenden Zahl der F{\"a}lle immer noch in Familien "fusioniert".}, subject = {Partnerschaft}, language = {de} } @article{KurtzCostesSchneider1994, author = {Kurtz-Costes, Beth E. and Schneider, Wolfgang}, title = {Self-concept, attributional beliefs, and school achievement: A longitudinal analysis}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-62245}, year = {1994}, abstract = {No abstract available}, subject = {Psychologie}, language = {en} } @article{BjorklundSchneiderCasseletal.1994, author = {Bjorklund, David F. and Schneider, Wolfgang and Cassel, William S. and Ashley, Elizabeth}, title = {Training and Extension of a Memory Strategy: Evidence for Utilization Deficiencies in the Acquisition of an Organizational Strategy in High- and Low-IQ Children}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-62234}, year = {1994}, abstract = {143 9- and 10-year-oId children were classified into high- and Jow-IQ groups and given 4 different sort/recall lists (baseline, training, near [immediate] extension, far [l-week] extension) to assess training and extension of an organizational memory strategy. All children received categorized items of moderate typicality for Phases 1, 3, and 4. For Phase 2, children were assigned to either a training or control group, with half of the children in each group receiving category typical items and the others category atypical items. Levels of recall, sorting, and clustering were greater in Phase 2 for high-IQ children, for the typical lists, and for trained children. Both the high- and low-IQ children trained with typical items continued to show high levels of recall on the near extension phase. No group of subjects maintained high levels of recall after 1 week, although levels of sorting and/or clustering on the extension trials remained high for all groups of subjects except the low-IQ control children. This latter pattern (elevated sorting/clustering with low levels of recall) is an indication of a utilization deficiency, a phase in strategy development when children use a strategy but gain little or no benefit n performance. The results provide evidence for IQ, training, and material effects in the demonstration of a utilization deficiency.}, subject = {Psychologie}, language = {en} } @article{RabinowitzOrnsteinFoldsBennettetal.1994, author = {Rabinowitz, Mitchell and Ornstein, Peter A. and Folds-Bennett, Trisha H. and Schneider, Wolfgang}, title = {Age-related differences in speed of processing: Unconfounding age and experience}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-62223}, year = {1994}, abstract = {No abstract available}, subject = {Psychologie}, language = {en} } @article{McCarronWangSirenetal.1994, author = {McCarron, R. M. and Wang, L. and Sir{\´e}n, Anna-Leena and Spatz, M. and Hallenbeck, J. M.}, title = {Monocyte adhesion to cerebromicrovascular endothelial cells derived from hypertensive and normotensive rats}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-62960}, year = {1994}, abstract = {No abstract available}, subject = {Neurobiologie}, language = {en} } @techreport{WangSirenLiuetal.1994, author = {Wang, X. and Sir{\´e}n, Anna-Leena and Liu, Y. and Yue, T-L. and Barone, F. C. and Feuerstein, G. Z.}, title = {Upregulation of intercellular adhesion molecule-1 (ICAM-1) on brain microvascular endothelial cells in rat ischemic cortex [Research Report]}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-62952}, year = {1994}, abstract = {The expression of intercellular adhesion molecule 1 (ICAM-1) was studied in rat focal ischemic cortex. A significant increase in ICAM-1 mRNA expression in the ischemic cortex over Ievels in contralateral (nonischemic) site was observed by means of Northern blot analysis following either permanent or temporary occlusion with reperfusion of the middle cerebral artery (PMCAO or MCAO with reperfusion) in spontaneously hypertensive rats. In the ischemic cortex, Ievels of ICAM-1 mRNA increased significantly at 3 h (2.6-fold, n = 3, P < 0.05), peaked at 6 to 12 h (6.0-fold, P < 0.01) and remained elevated up to 5 days (2.5-fold, P < 0.05) after PMCAO. The profile of ICAM-1 mRNA expression in the ischemic cortex following MCAO with reperfusion was similar to that following PMCAO, except that ICAM-1 mRNA was significantly increased as early as 1 h (6.3-fold, n = 3, P < 0.05) and then gradually reached a peak at 12 h (12-fold, P < 0.01) after reperfusion. ICAM-1 mRNA expression in ischemic cortex following PMCAO was significantly greater in hypertensive rats than in two normotensive rat strains. Immunostaining using anti-ICAM-1 antiborlies indicated that upregulated ICAM-1 expressionwas localized to endotheIial cells of intraparenchymal blood vessels in the ischemic but not contralateral cortex. The data suggest that an upregulation of ICAM-1 mRNA and protein on brain capillary endothelium may play an important rote in leukocyte migration into ischemic brain tissue.}, subject = {Neurobiologie}, language = {en} } @techreport{McCarronDoronSirenetal.1994, author = {McCarron, R. M. and Doron, D. A. and Sir{\´e}n, Anna-Leena and Feuerstein, G. Z. and Heldman, E. and Pollard, H. B. and Spatz, M. and Hallenbeck, J. M.}, title = {Agonist-stimulated release of von Willebrand factor and procoagulant factor VIII in rats with and without risk factors for stroke [Research Report]}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-62945}, year = {1994}, abstract = {Lipopolysaccharidc (LPS)-induced (i.v. or i.c.v., 1.8 mg/kg) release of von Willebrand factor (vWF) ·was examined in spontaneously hypertensive (SHR) and normotensive Wistar-Kyoto (WKY) rats. SHR rats releascd significantly (P < 0.05) more vWF than WKY rats in response to LPS. LPS also inhibited factor VIII procoagulant activity (FVIII: c) which may indicate an increase in thrombin activity. Cultured cerebrovascular endothelial cells (EC) derived from both SHR and WKY rats, as weil as human umbilical vein EC (HUVEC) cultures constitutively released vWF. Treatment with agonists including LPS, thrombin and tumor necrosis factor-a (TNFa) did not affect the in vitro secretion of vWF by cerebrovascular EC cultures but significantly upregulated vWF release by HUVEC cultur~s. Preincubation of cerebrovascular EC cultures with interleukin-1 OL-l) ± TNFa or co-culturing in the presence of LPS-activated syngeneic monocytes had no effect on vWF secretion. The findings demoostrate that conditions of hypertension may affect endothelial cells and make them more responsive to agonist Stimulation and thereby increase secretion of vWF, an important factqr in hemostasis as weil as thrombosis. The capacity of LPS to significantly affect the in vivo secretion of vWF in SHR and WKY rats but not cultured cerebrovascular EC indicates that observed elevations in plasma vWF were not derived from cerebrovascular EC. lt is suggested that hypertension may function as a risk factor for thrombotic stroke by influencing factors involved in coagulation processes, such as vWF and factor VIII : c.}, subject = {Neurobiologie}, language = {en} } @article{StopperEckertSchiffmannetal.1994, author = {Stopper, Helga and Eckert, I. and Schiffmann, D. and Spencer, D. L. and Caspary, W. J.}, title = {Is micronucleus induction by aneugens an early event leading to mutagenesis?}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-63390}, year = {1994}, abstract = {This study was designed to investigate a previously unidentified potential mechanism for mutation induction as well as to clarify a biological comequence of micronucleus formation. We compared the induction of micronuclei with mutation inductioo as measured by trißuorothymidine (TFI') resistance in mouse L5178Y cells using four aneugens: colcemid, diethylstilbestrol, griseofulvin and vioblastine. AU four compounds induced micronuclei which appeared in the first cell cycle after treatment. More than 85\% of the micronuclei induced by each compound stained positive for the presence of kinetochores implying that the micronuclei contained wbole cbromosomes. However, these same compounds were unable to induce TFf resistance under tbree different treatment regimes. We concluded that tbese compounds, under conditions where tbey induce primarily kinetochore positive micronuclel, were not able to induce mutations. Thus, the induction of micronuclei containing wbole chromosomes barborlog a select.able gene is not an early event leadlog to mutations in these cells.}, subject = {Toxikologie}, language = {en} } @article{StopperKuehnelPodschun1994, author = {Stopper, Helga and K{\"u}hnel, A. and Podschun, B.}, title = {Combination of the chemotherapeutic agent 5-fluorouracil with an inhibitor of its catabolism results in increased micronucleus induction}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-63383}, year = {1994}, abstract = {The rate limiting step in 5-fluorouracil catabolism is catalyzed by the enzyme dihydropyrimidine dehydrogenase. Since degradation of 5-fluorouracil decreases its efficacy in chemotherapy, the inhibition of its catabolism is a promising tool. We investigated the formation of micronuclei in vitro in mouse L5178Y cells. 5-fluorouracil induced an increase in micronucleus frequency, which could significantly be enhanced by the concurrent application of 2,6-dihydroxypyridine, an inhibitor of dihydropyrimidine dehydrogenase. The 5-fluorouracil concentration necessary to reach maximal genotoxic effects could be reduced to half in the presence of inhibitor. 2,6-Dihydroxypyridine alone and the naturally occuring enzyme substrate uracil did not induce micronucleus formation. Combined application of the chemotherapeutic agent 5-fluorouracil and an inhibitor of its could reduce side-effects by lowering the effective dose of the active drug. With this study we provide further support for the usefulness of this concept.}, subject = {Toxikologie}, language = {en} } @article{LubjuhnSchartlEpplen1994, author = {Lubjuhn, T. and Schartl, Manfred and Epplen, J. T.}, title = {Methodik und Anwendungsgebiete des genetischen Fingerabdruckverfahrens}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-61978}, year = {1994}, abstract = {No abstract available}, subject = {Physiologische Chemie}, language = {en} } @inproceedings{GotzSchartl1994, author = {Gotz, R. and Schartl, Manfred}, title = {The conservation of neurotrophic factors during vertebrate evolution}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-61964}, year = {1994}, abstract = {No abstract available}, subject = {Physiologische Chemie}, language = {en} } @article{SchartlDimitrijevicSchartl1994, author = {Schartl, A. and Dimitrijevic, N. and Schartl, Manfred}, title = {Evolutionary origin and molecular biology of the melanoma-inducing oncogene of Xiphophorus}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-61954}, year = {1994}, abstract = {No abstract available}, subject = {Physiologische Chemie}, language = {en} }