@inproceedings{AndersSchartlScholl1981,
  author    = {Anders, F. and Schartl, Manfred and Scholl, E.},
  title     = {Evaluation of environmental and hereditary factors in carcinogenesis, based on studies in Xiphophorus},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-72741},
  year      = {1981},
  abstract  = {Neoplasia in Xiphophorus can be classified into a) a large group that is triggered by carcinogens; b) a large group triggered by promoters; c) a small group that develops "spontaneously" following interpopulational and interracial hybridizations; and d) a small group that develops "spontaneously" following germ line mutation. The process leading to susceptibility for neoplasia is represented by the disintegration of gene systems that normally protect the fish from neoplasia. Hybridization is the most effective process that leads to disintegration of the protection gene systems. Environmental factors may complete disintegration and thus may trigger neoplasia. It is discussed whether the findings on Xiphophorus may also apply to humans.},
  subject      = {Schwertk{\"a}rpfling},
  language  = {en}
}
@inproceedings{Scheer1982,
  author    = {Scheer, Ulrich},
  title     = {Electron microscopic analysis of chromatin and gene expression},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-39456},
  year      = {1982},
  abstract  = {No abstract available},
  language  = {en}
}
@inproceedings{ScheerRose1984,
  author    = {Scheer, Ulrich and Rose, Kathleen M.},
  title     = {Localization of RNA polymerase I in interphase cells and mitotic chromosomes by light and electron microscopic immunocytochemistry},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-33223},
  year      = {1984},
  abstract  = {Rabbit antibodies to RNA polymerase I from a rat hepatoma have been used to localize the enzyme in a variety of cells at the light and electron microscopic level. In interphase cells the immunofluorescence pattern indicated that polymerase I is contained exclusively within the nucleolus. That this fluorescence, which appeared punctated rather than uniform, represented transcriptional complexes of RNA polymerase I and rRNA genes was suggested by the observation that it was enhanced in regenerating liver and in a hepatoma and was markedly diminished in cells treated with actinomycin D. Electron microscopic immunolocalization using gold-coupled second antibodies showed that transcribed rRNA genes are located in, and probably confined to, the fibrillar centers of the nucleolus. In contrast, the surrounding dense fibrillar component, previously thought to be the site of nascent prerRNA, did not contain detectable amounts of polymerase I. During mitosis, polymerase I molecules were detected by immunofluorescence microscopy at the chromosomal nucleolus organizer region, indicating that a considerable quantity of the enzyme remains bound to the rRNA genes. From this we conclude that rRNA genes loaded with polymerase I molecules are transmitted from one cell generation to the next one and that factors other than the polymerase itself are involved in the modulation of transcription of DNA containing rRNA genes during the cell cycle.},
  language  = {en}
}
@inproceedings{AndersSchartlBarnekow1984,
  author    = {Anders, Fritz and Schartl, Manfred and Barnekow, Angelika},
  title     = {Xiphophorus as an in vivo model for studies on oncogenes},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-86398},
  year      = {1984},
  abstract  = {The capacity of Xiphophorus to develop neoplasia can be formally assigned to a "tumor gene" (Tu), which appears to be a normal part of the genome of all individuals. The wild fish have evolved population-specific and cell type-specific systems of regulatory genes (R) for Tu that protect the fish from neoplasia. Hybridization of members of different wild populations in the laborstory followed by treatment of the hybrids with carcinogens led to disintegration of the R systems permitting excessive expression of Tu and thus resulting in neoplasia. Certain hybrids developed neoplasia even spontaneously. Observations on the genuine phenotypic effect of the derepressed Tu in the early embryo indicated an essential normal function of this oncogene in cell differentiation, proliferation and cell-cell communication. Tu appeared to be indispensable in the genome but may also be present in accessory copics. Recently, c-src, the cellular homolog of the Rous sarcoma virus oncogene v-src, was detected in Xiphophorus. The protein product of c-src, pp60c-src, was identified and then examined by its associated kinase activity. This pp60c-src was found in all individuals tested, but, depending on the genotype, its kinase activity was different. The genetic characters of c-src, such as linkage relations, dosage relations, expression, etc., correspond to those of Tu. From a systematic study which showed that pp60c-src was present in all metazoa tested ranging from mammals down to sponges, we concluded that c-src has evolved with the multicellular organization of animals. Neoplasia of animals and humans is a characteristic closely related to this evolution. Our data showed that small aquariurn fish, besides being used successfully because they are time-, space-, and money-saving systems for carcinogenicity testing, are also highly suitable for basic studies on neoplasia at the populational, morphological, developmental, cell biological, and molecular levels.},
  subject      = {Schwertk{\"a}rpfling},
  language  = {en}
}
@inproceedings{RiehlSchartlAnders1985,
  author    = {Riehl, R{\"u}diger and Schartl, Manfred and Anders, Fritz},
  title     = {An ultrastructural study of melanoma in Xiphophorus},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-70978},
  year      = {1985},
  abstract  = {Melanotic melanoma (MM) of Xiphophorus (Teleostei: Poeciliidae) was studied by conventional preparations and freeze-etch preparations for electron microscopy. MM of Xiphophorus exhibits tightly packed pigment cells with prominent dendritic processes and interdigitations of their plasma membranes. The most impressive feature of MM cells is the occurrence of Iarge lobulated nuclei with numerous nuclear pores and some nuclear pockets. Abundant spheroidal or ellipsoidal melanosomes (diameter 200-650 nm) and vesicular structures are distributed throughout the cellular dendrites, whereas the perinucJear cytoplasm is free of melanosomes. A further characteristic feature of melanoma cells in fish is the occurrence of melanosome complexes (i.e., "compound melanosomes"). These melanosome complexes consist of a few to numerous melanosomes, which are enveloped by a separate rnembrane. Pinocytotic vesicles couJd be demonstrated with distinct differences in frequency and distribution patterns, indicating differences in the metabolic activities of the cells in the same melanoma. Intercellular junctions are lacking in the MM cells. The conventional TEM technique showed clear advantages in the demonstration of intemal architecture of organelles, whereas FE bad considerable potential in respect to the visualization of membrane surface specializations.},
  subject      = {Schwertk{\"a}rpfling},
  language  = {en}
}
@inproceedings{PeterSchartlAndersetal.1985,
  author    = {Peter, R. U. and Schartl, Manfred and Anders, F. and Duncker, H.-R.},
  title     = {Pigment pattern formation during embryogenesis in Xiphophorus},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-69370},
  year      = {1985},
  abstract  = {No abstract available.},
  subject      = {Schwertk{\"a}rpfling},
  language  = {en}
}
@inproceedings{SchartlMaeuelerRaulfetal.1988,
  author    = {Schartl, Manfred and M{\"a}ueler, Winfried and Raulf, Friedrich and Robertson, Scott M.},
  title     = {Molecular aspects of melanoma formation in Xiphophorus},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-72689},
  year      = {1988},
  abstract  = {No abstract available.},
  subject      = {Schwertk{\"a}rpfling},
  language  = {en}
}
@inproceedings{Mahsberg1990,
  author    = {Mahsberg, Dieter},
  title     = {Brood care and family cohesion in the tropical scorpion Pandinus imperator (Koch) (Scorpiones: Scorpionidae)},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-45776},
  year      = {1990},
  abstract  = {Pandinus imperator is a forest dweller of tropical West Africa. In the field, lobserved aggregations of up to 15 individuals. In the laboratory, mixed age groups of related and also unrelated animals lived jointly in terraria rarely showing within-group aggression or cannibalism. Brood-caring behavior of the mother influenced growth rate and survival probability of the young. With birth, mothers became very aggressive. To study family cohesion in Pandinus, experiments with family groups were conducted. Siblings aggregated around their mother. In choice experiments with two family groups, mothers were placed in enclosures that only the young were able to enter or to leave. Second instars significantly preferred the enclosure containing their own mother. Aggression among unrelated young of the same age was not observed. Feeding experiments studied the possible advantages of long-Iasting group living with regard to enhanced success in prey capture and its effect on growth of the young. Even groups of second instars were unable to subdue large prey on their own. Sibling groups with their mother removed suffered high mortality due to starvation and cannibalism compared to groups with mothers present. Here, young grew significantly faster: they shared the prey that only the mother was able to kill and dismember. Pandinus imperator has to be considered an intermediate subsocial scorpion.},
  subject      = {Skorpion},
  language  = {en}
}
@inproceedings{DandekarArgos1993,
  author    = {Dandekar, Thomas and Argos, P.},
  title     = {Genetic algorithms as a new tool to study protein stability},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-29990},
  year      = {1993},
  abstract  = {No abstract available},
  language  = {en}
}
@inproceedings{GotzSchartl1994,
  author    = {Gotz, R. and Schartl, Manfred},
  title     = {The conservation of neurotrophic factors during vertebrate evolution},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-61964},
  year      = {1994},
  abstract  = {No abstract available},
  subject      = {Physiologische Chemie},
  language  = {en}
}
@inproceedings{FialaFederleMaschwitzetal.1994,
  author    = {Fiala, Brigitte and Federle, W. and Maschwitz, U. and Azarae, Idris},
  title     = {The first myrmecophytic 2-partner-system in the genus Macaranga: The association between Macaranga puncticulata and a Componotus (Colobopsis) in Malaysia},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-55144},
  year      = {1994},
  abstract  = {No abstract available},
  subject      = {Biologie},
  language  = {en}
}
@inproceedings{DabauvalleWilkenEwaldetal.1994,
  author    = {Dabauvalle, M.-C. and Wilken, N. and Ewald, A. and Kuhbier, A. and Sen{\´e}cal, J.-L. and Scheer, Ulrich},
  title     = {Nuclear pore complex structure analyzed by immunogold EM with human autoantibodies},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-39439},
  year      = {1994},
  abstract  = {No abstract available},
  language  = {en}
}
@inproceedings{SchreibmanSchartlKallmanetal.1994,
  author    = {Schreibman, Martin P. and Schartl, Manfred and Kallman, Klaus D. and Magliulo-Cepriano, Lucia},
  title     = {Molecular approaches to study the genetic regulation of the fish reproductive system},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-86679},
  year      = {1994},
  abstract  = {No abstract available.},
  subject      = {Fische},
  language  = {en}
}
@inproceedings{FialaRabensteinMaschwitz1994,
  author    = {Fiala, Brigitte and Rabenstein, R. and Maschwitz, Ulrich},
  title     = {Ant-attracting plant-structures: Food bodies of SE Asian Vitaceae},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-55177},
  year      = {1994},
  abstract  = {No abstract available},
  subject      = {Pflanzen},
  language  = {en}
}