@unpublished{ArrowsmithBoehnkeBraunschweigetal.2016, author = {Arrowsmith, Merle and B{\"o}hnke, Julian and Braunschweig, Holger and Celik, Mehmet and Claes, Christina and Ewing, William and Krummenacher, Ivo and Lubitz, Katharina and Schneider, Christoph}, title = {Neutral Diboron Analogues of Archetypal Aromatic Species by Spontaneous Cycloaddition}, doi = {10.1002/anie.201602384}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-142500}, pages = {4}, year = {2016}, abstract = {Among the numerous routes organic chemists have developed to synthesize benzene derivatives and heteroaro- matic compounds, transition-metal-catalyzed cycloaddition reactions are the most elegant. In contrast, cycloaddition reactions of heavier alkene and alkyne analogues, though limited in scope, proceed uncatalyzed. In this work we present the first spontaneous cycloaddition reactions of lighter alkene and alkyne analogues. Selective addition of unactivated alkynes to boron-boron multiple bonds under ambient con- ditions yielded diborocarbon equivalents of simple aromatic hydrocarbons, including the first neutral 6p-aromatic dibora- benzene compound, a 2 p-aromatic triplet biradical 1,3-dibor- ete, and a phosphine-stabilized 2 p-homoaromatic 1,3-dihydro- 1,3-diborete. DFT calculations suggest that all three com- pounds are aromatic and show frontier molecular orbitals matching those of the related aromatic hydrocarbons, C6H6 and C4H42+, and homoaromatic C4H5+.}, subject = {Diborane}, language = {en} } @unpublished{BraunschweigKrummenacherLichtenbergetal.2016, author = {Braunschweig, Holger and Krummenacher, Ivo and Lichtenberg, Crispin and Mattock, James and Sch{\"a}fer, Marius and Schmidt, Uwe and Schneider, Christoph and Steffenhagen, Thomas and Ullrich, Stefan and Vargas, Alfredo}, title = {Dibora[2]ferrocenophane: A Carbene-Stabilized Diborene in a Strained cis-Configuration}, series = {Angewandte Chemie, International Edition}, journal = {Angewandte Chemie, International Edition}, doi = {10.1002/anie.201609601}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-141981}, pages = {9}, year = {2016}, abstract = {Unsaturated bridges that link the two cyclopentadienyl ligands together in strained ansa metallocenes are rare and limited to carbon-carbon double bonds. The synthesis and isolation of a strained ferrocenophane containing an unsaturated two-boron bridge, isoelectronic with a C=C double bond, was achieved by reduction of a carbene-stabilized 1,1'-bis(dihaloboryl)ferrocene. A combination of spectroscopic and electrochemical measurements as well as density functional theory (DFT) calculations was used to assess the influence of the unprecedented strained cis configuration on the optical and electrochemical properties of the carbene-stabilized diborene unit. Initial reactivity studies show that the dibora[2]ferrocenophane is prone to boron-boron double bond cleavage reactions.}, subject = {Metallocene}, language = {en} } @article{ArrowsmithBoehnkeBraunschweigetal.2016, author = {Arrowsmith, Merle and B{\"o}hnke, Julian and Braunschweig, Holger and Celik, Mehmet and Claes, Christina and Ewing, William and Krummenacher, Ivo and Lubitz, Katharina and Schneider, Christoph}, title = {Neutral Diboron Analogues of Archetypal Aromatic Species by Spontaneous Cycloaddition}, series = {Angewandte Chemie, International Edition}, volume = {55}, journal = {Angewandte Chemie, International Edition}, doi = {10.1002/anie.201602384}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-138226}, pages = {11271-11275}, year = {2016}, abstract = {Among the numerous routes organic chemists have developed to synthesize benzene derivatives and heteroaro- matic compounds, transition-metal-catalyzed cycloaddition reactions are the most elegant. In contrast, cycloaddition reactions of heavier alkene and alkyne analogues, though limited in scope, proceed uncatalyzed. In this work we present the first spontaneous cycloaddition reactions of lighter alkene and alkyne analogues. Selective addition of unactivated alkynes to boron-boron multiple bonds under ambient con- ditions yielded diborocarbon equivalents of simple aromatic hydrocarbons, including the first neutral 6 π-aromatic dibora- benzene compound, a 2  π-aromatic triplet biradical 1,3-dibor- ete, and a phosphine-stabilized 2  π-homoaromatic 1,3-dihydro- 1,3-diborete. DFT calculations suggest that all three com- pounds are aromatic and show frontier molecular orbitals matching those of the related aromatic hydrocarbons, C\(_6\)H\(_6\) and C\(_4\)H\(_4\)\(^{2+}\), and homoaromatic C\(_4\)H\(_5\)\(^+\).}, language = {en} } @article{BraunschweigConstantinidisDellermannetal.2016, author = {Braunschweig, Holger and Constantinidis, Philipp and Dellermann, Theresa and Ewing, William and Fischer, Ingo and Hess, Merlin and Knight, Fergus and Rempel, Anna and Schneider, Christoph and Ullrich, Stefan and Vargas, Alfredo and Woolins, Derek}, title = {Highly Strained Heterocycles Constructed from Boron-Boron Multiple Bonds and Heavy Chalcogens}, series = {Angewandte Chemie, International Edition}, volume = {55}, journal = {Angewandte Chemie, International Edition}, number = {18}, doi = {10.1002/anie.201601691}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-138237}, pages = {5606 -- 5609}, year = {2016}, abstract = {The reactions of a diborene with elemental selenium or tellurium are shown to afford a diboraselenirane or diboratellurirane, respectively. These reactions are reminiscent of the sequestration of subvalent oxygen and nitrogen in the formation of oxiranes and aziridines; however, such reactivity is not known between alkenes and the heavy chalcogens. Although carbon is too electronegative to affect the reduction of elements with lower relative electronegativity, the highly reducing nature of the B B double bond enables reactions with Se0 and Te0. The capacity of multiple bonds between boron atoms to donate electron density is highlighted in reactions where diborynes behave as nucleophiles, attacking one of the two Te atoms of diaryltellurides, forming salts consisting of diboratellurenium cations and aryltelluride anions.}, subject = {Bor}, language = {en} } @unpublished{AuerhammerArrowsmithBissingeretal.2017, author = {Auerhammer, Dominic and Arrowsmith, Merle and Bissinger, Philipp and Braunschweig, Holger and Dellermann, Theresa and Kupfer, Thomas and Lenczyk, Carsten and Roy, Dipak and Sch{\"a}fer, Marius and Schneider, Christoph}, title = {Increasing the Reactivity of Diborenes: Derivatization of NHC- Supported Dithienyldiborenes with Electron-Donor Groups}, series = {Chemistry, A European Journal}, journal = {Chemistry, A European Journal}, doi = {10.1002/chem.201704669}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-155419}, year = {2017}, abstract = {A series of NHC-supported 1,2-dithienyldiborenes was synthesized from the corresponding (dihalo)thienylborane NHC precursors. NMR and UV-vis spectroscopic data, as well as X-ray crystallographic analyses, were used to assess the electronic and steric influences on the B=B double bond of various NHCs and electron-donating substituents on the thienyl ligands. Crystallographic data showed that the degree of coplanarity of the diborene core and thienyl groups is highly dependent on the sterics of the substituents. Furthermore, any increase in the electron- donating ability of the substituents resulted in the destabilization of the HOMO and greater instability of the resulting diborenes.}, language = {en} } @article{SchneiderWiewelhoveRaederetal.2019, author = {Schneider, Christoph and Wiewelhove, Thimo and Raeder, Christian and Flatt, Andrew A. and Hoos, Olaf and Hottenrott, Laura and Schumbera, Oliver and Kellmann, Michael and Meyer, Tim and Pfeiffer, Mark and Ferrauti, Alexander}, title = {Heart Rate Variability Monitoring During Strength and High-Intensity Interval Training Overload Microcycles}, series = {Frontiers in Physiology}, volume = {10}, journal = {Frontiers in Physiology}, doi = {10.3389/fphys.2019.00582}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-231515}, year = {2019}, abstract = {Objective: In two independent study arms, we determine the effects of strength training (ST) and high-intensity interval training (HIIT) overload on cardiac autonomic modulation by measuring heart rate (HR) and vagal heart rate variability (HRV). Methods: In the study, 37 well-trained athletes (ST: 7 female, 12 male; HIIT: 9 female, 9 male) were subjected to orthostatic tests (HR and HRV recordings) each day during a 4-day baseline period, a 6-day overload microcycle, and a 4-day recovery period. Discipline-specific performance was assessed before and 1 and 4 days after training. Results: Following ST overload, supine HR, and vagal HRV (Ln RMSSD) were clearly increased and decreased (small effects), respectively, and the standing recordings remained unchanged. In contrast, HIIT overload resulted in decreased HR and increased Ln RMSSD in the standing position (small effects), whereas supine recordings remained unaltered. During the recovery period, these responses were reversed (ST: small effects, HIIT: trivial to small effects). The correlations between changes in HR, vagal HRV measures, and performance were weak or inconsistent. At the group and individual levels, moderate to strong negative correlations were found between HR and Ln RMSSD when analyzing changes between testing days (ST: supine and standing position, HIIT: standing position) and individual time series, respectively. Use of rolling 2-4-day averages enabled more precise estimation of mean changes with smaller confidence intervals compared to single-day values of HR or Ln RMSSD. However, the use of averaged values displayed unclear effects for evaluating associations between HR, vagal HRV measures, and performance changes, and have the potential to be detrimental for classification of individual short-term responses. Conclusion: Measures of HR and Ln RMSSD during an orthostatic test could reveal different autonomic responses following ST or HIIT which may not be discovered by supine or standing measures alone. However, these autonomic changes were not consistently related to short-term changes in performance and the use of rolling averages may alter these relationships differently on group and individual level.}, language = {en} }