@article{PenovRadakovicMadrahimovetal.2022,
  author    = {Penov, Kiril and Radakovic, Dejan and Madrahimov, Nodir and Aleksic, Ivan},
  title     = {Subacute Aortic Rupture Due to Mechanical Chest Compression with Indwelling Impella},
  series = {The Thoracic and Cardiovascular Surgeon Reports},
  volume    = {11},
  journal   = {The Thoracic and Cardiovascular Surgeon Reports},
  number    = {1},
  issn      = {2194-7635},
  doi       = {10.1055/s-0042-1757873},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-300174},
  pages     = {e64 -- e66},
  year      = {2022},
  abstract  = {Mechanical cardiopulmonary resuscitation (CPR) devices like Lund University Cardiopulmonary Assist System (LUCAS) cause more skeletal and visceral injuries than standard CPR. A 62-year-old woman with ST-elevation myocardial infarction was resuscitated with LUCAS and Impella CP for refractory cardiogenic shock during percutaneous coronary intervention. She suffered delayed ascending aortic rupture necessitating supracommissural ascending aortic replacement plus triple bypass grafting. Prolonged mechanical CPR with concomitant Impella may lead to aortic rupture. The combined use of LUCAS and Impella may have disastrous consequences.},
  language  = {en}
}
@article{GreiteStoermerGueleretal.2022,
  author    = {Greite, Robert and St{\"o}rmer, Johanna and Gueler, Faikah and Khalikov, Rasul and Haverich, Axel and K{\"u}hn, Christian and Madrahimov, Nodir and Natanov, Ruslan},
  title     = {Different acute kidney injury patterns after renal ischemia reperfusion injury and extracorporeal membrane oxygenation in mice},
  series = {International Journal of Molecular Sciences},
  volume    = {23},
  journal   = {International Journal of Molecular Sciences},
  number    = {19},
  issn      = {1422-0067},
  doi       = {10.3390/ijms231911000},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-288282},
  year      = {2022},
  abstract  = {The use of extracorporeal membrane oxygenation (ECMO) is associated with acute kidney injury (AKI) in thoracic organ transplantation. However, multiple other factors contribute to AKI development after these procedures such as renal ischemia-reperfusion injury (IRI) due to hypo-perfusion of the kidney during surgery. In this study, we aimed to explore the kidney injury patterns in mouse models of ECMO and renal IRI. Kidneys of C57BL/6 mice were examined after moderate (35 min) and severe (45 min) unilateral transient renal pedicle clamping and 2 h of veno-venous ECMO. Renal injury markers, neutrophil infiltration, tubular transport function, pro-inflammatory cytokines, and renal heme oxygenase-1 (HO-1) expression were determined by immunofluorescence and qPCR. Both procedures caused AKI, but with different injury patterns. Severe neutrophil infiltration of the kidney was evident after renal IRI, but not following ECMO. Tubular transport function was severely impaired after renal IRI, but preserved in the ECMO group. Both procedures caused upregulation of pro-inflammatory cytokines in the renal tissue, but with different time kinetics. After ECMO, but not IRI, HO-1 was strongly induced in tubular cells indicating contact with hemolysis-derived proteins. After IRI, HO-1 was expressed on infiltrating myeloid cells in the tubulo-interstitial space. In conclusion, renal IRI and ECMO both caused AKI, but kidney damage after renal IRI was more pronounced including severe neutrophil infiltration and tubular transport impairment. Enhanced HO-1 expression in tubular cells after ECMO encourages limitation of hemolysis as a therapeutic approach to reduce ECMO-associated AKI.},
  language  = {en}
}
@article{RadakovicPenovHamoudaetal.2022,
  author    = {Radakovic, Dejan and Penov, Kiril and Hamouda, Khaled and Madrahimov, Nodir and Radakovic, Darko and Bening, Constanze and Leyh, Rainer G. and Aleksic, Ivan},
  title     = {Benefits of intra-aortic balloon pump support in patients with postcardiotomy shock requiring venoarterial extracorporeal membrane oxygenation},
  series = {Life},
  volume    = {12},
  journal   = {Life},
  number    = {8},
  issn      = {2075-1729},
  doi       = {10.3390/life12081195},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-286241},
  year      = {2022},
  abstract  = {Background: The benefit of the combined use of an intra-aortic balloon pump (IABP) and venoarterial extracorporeal membrane oxygenation (VA-ECMO) for postcardiotomy shock remains unclear. We aimed to analyse the potential benefits and safety of combining these two devices. Methods: We enrolled 200 patients treated with either VA-ECMO only or in combination with IABP (ECMO-I group) between January 2012 and January 2021. To adjust the patients' backgrounds, we used propensity score matching for additional analyses, resulting in 57 pairs. The primary endpoint was 30-day survival. Secondary endpoints included successful weaning and complication rates. We also analysed hemodynamic parameters in both groups. Results: After propensity score matching, 30-day survival was better in the ECMO-I group (log-rank p = 0.004). The ECMO-I and ECMO-only groups differed regarding the secondary endpoints, including successful weaning (50.9\% and 26.3\%, respectively; p = 0.012) and the need for continuous renal replacement therapy (28.1\% and 50.9\%, p = 0.021). Complication rates were not statistically different between the two groups. Conclusion: Compared to VA-ECMO alone, the combined use of VA-ECMO and IABP is beneficial regarding 30-day survival in selected patients with postcardiotomy shock; successful ECMO weaning and freedom from renal replacement therapy is more common in patients supported with VA-ECMO plus IABP.},
  language  = {en}
}
@article{BeningSalesAlhussinietal.2021,
  author    = {Bening, Constanze and Sales, Virna L. and Alhussini, Khaled and Radakovic, Dejan and Cris Benitez, R. and Madrahimov, Nodir and Keller, Daria M. and Leyh, Rainer},
  title     = {Clinically inapparent right heart dysfunction is associated with reduced myofilament force development in coronary artery disease},
  series = {BMC Cardiovascular Disorders},
  volume    = {21},
  journal   = {BMC Cardiovascular Disorders},
  number    = {1},
  doi       = {10.1186/s12872-021-01926-6},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-259213},
  pages     = {125},
  year      = {2021},
  abstract  = {Background Right ventricular dysfunction after CABG is associated with poor peri- and postoperative outcomes. We aimed to identify clinical and experimental predictors for preoperative inapparent right ventricular dysfunction and therefore hypothesized that reduced myofilament force development as well as altered levels of biomarkers might predict inapparent right ventricular dysfunction. Methods From 08/2016 to 02/2018, 218 patients scheduled for CABG were divided into two groups (TAPSE ≥ 20 mm, n = 178; TAPSE < 20 mm, n = 40). Baseline serum samples for biomarkers (Galectin, TGFß1, N Acyl-SDMA, Arginine, ADMA and Pentraxin-3), clinical laboratory and transthoracic echocardiographic parameters were evaluated. To examine the myocardial apparatus of the right ventricle intraoperative right auricular tissue was harvested for stepwise skinned fiber force measurements. Results Patients with TAPSE < 20 mm had a higher incidence of DM (55 vs. 34\%, p = 0.018), preoperative AFib (43 vs. 16\%, p < 0.001), reduced GFR (67 ± 18 vs. 77 ± 24 ml/min/1.73 m\(^2\), p = 0.013), larger LA area (22 ± 6 vs. 20 ± 5 cm\(^2\), p = 0.005) and reduced LVEF (50 vs. 55\%, p = 0.008). Furthermore, higher serum ADMA (0.70 ± 0.13 vs. 0.65 ± 0.15 µmol/l, p = 0.046) and higher serum Pentraxin-3 levels (3371 ± 1068 vs. 2681 ± 1353 pg/dl, p = 0.004) were observed in these patients. Skinned fiber force measurements showed significant lower values at almost every step of calcium concentration (pCa 4.52 to pCa 5.5, p < 0.01 and pCa 5.75-6.0, p < 0.05). Multivariable analysis revealed DM (OR 2.53, CI 1.12-5.73, Euro Score II (OR 1.34, CI 1.02-1.78), preoperative AF (OR 4.86, CI 2.06-11.47), GFR (OR 7.72, CI 1.87-31.96), albumin (OR 1.56, CI 0.52-2.60), Pentraxin-3 (OR 19.68, CI 14.13-25.24), depressed LVEF (OR 8.61, CI 6.37-10.86), lower force values: (pCa 5.4; OR 2.34, CI 0.40-4.29 and pCa 5.2; OR 2.00, CI 0.39-3.60) as predictors for clinical inapparent right heart dysfunction. Conclusions These preliminary data showed that inapparent right heart dysfunction in CAD is already associated with reduced force development of the contractile apparatus.},
  language  = {en}
}