@phdthesis{KenntnerMabiala2006,
  author    = {Kenntner-Mabiala, Ramona},
  title     = {Affektive und aufmerksamkeitsbasierte Modulation somatosensorisch evozierter Potentiale : Die Wirkung von Emotionen und Aufmerksamkeit auf die Schmerzverarbeitung},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-22211},
  school      = {Universit{\"a}t W{\"u}rzburg},
  year      = {2006},
  abstract  = {Hintergrund: Ausgangspunkt f{\"u}r diese Arbeit sind korrelative Befunde, die das Bestehen eines Zusammenhangs zwischen einer negativen Emotionalit{\"a}t und der Verschlimmerung einer Schmerzproblematik nahe legen. Die motivationale Priming-Hypothese von Lang bietet einen theoretischen Rahmen zur Erkl{\"a}rung der Wirkung von Emotionen auf die Schmerzwahrnehmung. Allerdings wurden die Vorhersagen dieser Theorie bisher haupts{\"a}chlich f{\"u}r den Schreckreflex untersucht und m{\"u}ssen f{\"u}r die Schmerzreizverarbeitung noch validiert werden. Bis heute ist es außerdem eine offene Frage, welche Rolle Aufmerksamkeitsprozesse bei der affektiven Schmerzmodulation spielen. Experiment 1. Fragestellung war, ob die motivationale Priming-Hypothese auch f{\"u}r die Wahrnehmung und Verarbeitung von Schmerzreizen g{\"u}ltig ist. Methode: 30 Probanden erhielten schmerzhafte und nicht schmerzhafte elektrische Reize, w{\"a}hrend sie positive, neutrale und negative Bilder betrachteten. Zur Erfassung der Schmerzwahrnehmung wurden Schmerzintensit{\"a}tsratings erhoben und zur Messung der kortikalen Schmerzreizverarbeitung wurden somatosensorisch evozierte Potentiale (SEPs) aufgezeichnet. Ergebnisse: Die Valenz der Bilder beeinflusst die Intensit{\"a}tsratings und die N150 Amplituden mit h{\"o}heren Ratings und N150 Amplituden bei negativen als bei positiven Bildern. Dagegen wurde die Amplitude der P260 durch das Arousal der Bilder moduliert mit h{\"o}heren Amplituden bei neutralen als bei erregenden Hintergrundbildern. Interpretation: Die Vorhersagen der motivationalen Priming-Hypothese scheinen auch f{\"u}r die Verarbeitung und Wahrnehmung von Schmerzreizen valide zu sein. W{\"a}hrend die Modulation der N150 Amplitude eine affektive Schmerzmodulation zu reflektieren scheint, ist die Arousalmodulation der P260 vermutlich auf schmerzunspezifische Aufmerksamkeitsprozesse zur{\"u}ckzuf{\"u}hren. Experiment 2. Fragestellung war, ob die affektive Schmerzmodulation von Aufmerksamkeitsprozessen unabh{\"a}ngig ist und ob unterschiedliche neuronale Mechanismen der aufmerksamkeitsbasierten und der affektiven Schmerzmodulation zugrunde liegen. Methoden: 30 Probanden sahen positive, neutrale und negative Bilder, w{\"a}hrend sie schmerzhafte und nicht schmerzhafte elektrische Reize erhielten. Zur Aufmerksamkeitsmanipulation wurden die Probanden vor jeder Bildpr{\"a}sentation instruiert, sich auf die Bilder, auf die Intensit{\"a}t oder auf die Unangenehmheit des elektrischen Reizes zu konzentrieren. Zur Schmerzevaluation wurden affektive und sensorische Schmerzratings und SEPs erhoben. Die neuronalen Quellen der N150 und P260 Komponenten wurden mit Hilfe einer LORETA-Analyse bestimmt. Ergebnisse: Die Aufmerksamkeitsmanipulation beeinflusste die sensorischen Schmerzratings: Die Ratings waren am h{\"o}chsten, wenn die Aufmerksamkeit auf die Reizintensit{\"a}t gerichtet war. Die Affektinduktion wirkte sich haupts{\"a}chlich auf die affektiven Schmerzratings aus mit h{\"o}heren Ratings bei negativen als bei positiven Bildern. N150 Amplituden wurden durch die Valenz der affektiven Bilder moduliert mit h{\"o}heren Amplituden bei negativen als bei positiven Bildern. Die Aufmerksamkeitsmanipulation hatte keinen Effekt auf die N150 Amplituden. P260 Amplituden wurden durch das Arousal der Bilder moduliert mit h{\"o}heren Amplituden bei neutralen als bei erregenden Bildern. Außerdem waren die P260 Amplituden am h{\"o}chsten bei einem Aufmerksamkeitsfokus auf die Reizintensit{\"a}t. Die LORETA-Analyse erbrachte f{\"u}r die N150 bei schmerzhaften im Vergleich zu nicht schmerzhaften Reizen eine maximale Aktivierung im ACC und im Pr{\"a}cuneus und f{\"u}r die P260 im superioren und medialen frontalen Gyrus und im ACC. Diskussion: Beide Experimente unterst{\"u}tzen die motivationale Priming-Hypothese f{\"u}r die Wahrnehmung und Verarbeitung von Schmerzreizen. Dies zeigt sich in einer affektiven Modulation der sensorischen und affektiven Schmerzratings und der N150 Amplituden. Die Befunde des zweiten Experiments deuten außerdem darauf hin, dass die Wirkungen von Emotionen und Aufmerksamkeit auf die Schmerzwahrnehmung weitestgehend unabh{\"a}ngig voneinander sind: Aufmerksamkeitsmanipulationen wirken sich nur auf die sensorische Schmerzkomponente aus und Affektmanipulationen modulieren haupts{\"a}chlich die affektive Schmerzkomponente. Der affektiven und der aufmerksamkeitsbasierten Schmerzmodulation scheinen unterschiedliche neuronale Mechanismen zugrunde zu liegen: Die LORETA-Analyse erbrachte verschiedene neuronale Generatoren f{\"u}r die N150 und die P260 und die Wirkung von Aufmerksamkeit und Emotion dissoziiert f{\"u}r diese beiden Komponenten: die Modulation der N150 reflektiert eine affektive Schmerzmodulation und die Modulation der P260 reflektiert Aufmerksamkeitsprozesse.},
  subject      = {Gef{\"u}hl},
  language  = {de}
}
@phdthesis{Conzelmann2009,
  author    = {Conzelmann, Annette},
  title     = {Emotional-motivationale Defizite bei Erwachsenen und Kindern mit einer Aufmerksamkeitsdefizit-/Hyperaktivit{\"a}tsst{\"o}rung (ADHS)},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-46305},
  school      = {Universit{\"a}t W{\"u}rzburg},
  year      = {2009},
  abstract  = {Die Aufmerksamkeitsdefizit-/Hyperaktivit{\"a}tsst{\"o}rung (ADHS) zeichnet sich durch eine starke klinische Heterogenit{\"a}t aus, deren Ursachen bislang noch nicht v{\"o}llig gekl{\"a}rt sind. Als erfolgversprechendes Erkl{\"a}rungsmodell hat sich das Endoph{\"a}notypenkonzept herausgestellt, das davon ausgeht, dass unterschiedliche Dysfunktionen den vielf{\"a}ltigen klinischen Ph{\"a}notypen der ADHS zugrunde liegen. Emotional-motivationalen Defiziten wird hierbei eine große Bedeutung beigemessen, allerdings wurden diese bislang kaum untersucht. Die wenigen vorliegenden Studien bezogen sich auf subjektive Daten und differenzierten nicht nach klinischen Subgruppen, wodurch sich heterogene Ergebnisse ergaben. Die vorliegende Arbeit hatte somit zum Ziel, einen emotional-motivationalen Endoph{\"a}notyp der ADHS bei unterschiedlichen klinischen Subgruppen von ADHS-Patienten mit subjektiven und objektiven psychophysiologischen Daten zu untersuchen. Dies wurde mithilfe eines emotionalen Bilderparadigmas untersucht, bei dem neben subjektiven Bildbewertungen die affektmodulierte Startlereaktion als Valenzindikator und die elektrodermale Aktivit{\"a}t als Arousalindikator emotional-motivationaler Reaktivit{\"a}t gemessen wurden. Studie 1 (N = 325) konzentrierte sich auf die klinischen Subtypen der ADHS bei erwachsenen Patienten. Diese Studie konnte aufzeigen, dass ADHS-Patienten in Abh{\"a}ngigkeit vom ADHS-Subtypus Defizite in der emotional-motivationalen Reaktivit{\"a}t aufwiesen. Der Mischtypus und der hyperaktiv-impulsive Typus zeichneten sich durch eine verminderte Reaktivit{\"a}t auf positive Stimuli aus, was sich in einer reduzierten Startleinhibition widerspiegelte. Der hyperaktiv-impulsive Typus reagierte zudem vermindert auf negative Stimuli, was sich in einer verringerten Startlepotenzierung zeigte. Im Gegensatz dazu reagierte der unaufmerksame Typus vergleichbar zu Kontrollpersonen mit einer leicht geringeren Startleinhibition bei positiven Stimuli. Die besonders beeintr{\"a}chtigte emotionale Reaktivit{\"a}t des hyperaktiv-impulsiven Typus spiegelte sich auch in einem Bias zu positiveren Bewertungen aller Bilder und einer verminderten Arousaleinsch{\"a}tzung negativer Stimuli bei M{\"a}nnern dieses Typus wider. Die ADHS-Patienten zeigten keine elektrodermalen Arousaldysfunktionen, wobei auch hier der hyperaktiv-impulsive Typus deskriptiv auffallend abgeflachte Werte in der Reaktivit{\"a}t auf emotionale Stimuli aufwies. Die gefundenen Dysfunktionen k{\"o}nnten zu hyperaktiv-impulsivem Verhalten und Sensation Seeking durch die Suche nach Verst{\"a}rkern f{\"u}hren. Gleichzeitig k{\"o}nnten die Ergebnisse die starken sozialen Dysfunktionen und antisoziales Verhalten von ADHS-Patienten mit hyperaktiv-impulsiven Symptomen erkl{\"a}ren. Zur Ber{\"u}cksichtigung von Entwicklungsaspekten im Endoph{\"a}notypenmodell und Untersuchung des emotional-motivationalen Endoph{\"a}notyps bei Kindern mit ADHS konzentrierte sich Studie 2 (N = 102) auf Jungen mit ADHS, die mit und ohne Methylphenidat untersucht wurden. Durch die zus{\"a}tzliche Methylphenidatgruppe sollten die klinische Relevanz emotional-motivationaler Dysfunktionen belegt und Erkenntnisse zur Wirkweise von Methylphenidat gewonnen werden. Diese Studie konnte aufzeigen, dass sich ADHS-Kinder ohne Methylphenidat durch Hypoarousal auszeichneten, was sich in verminderten Hautleitf{\"a}higkeitsreaktionen auf die Bilder und Startlet{\"o}ne sowie einem verminderten tonischen Hautleitf{\"a}higkeitsniveau widerspiegelte. Diese Dysfunktionen wurden durch Methylphenidat normalisiert. Die Startledaten konnten aus methodischen Gr{\"u}nden die affektive Modulation bei den Kindern nicht abbilden. Diese Daten lieferten jedoch Hinweise, dass Methylphenidat die emotional-motivationale Reaktivit{\"a}t steigerte, da die ADHS-Kinder mit Methylphenidat eine verst{\"a}rkte Startlereaktivit{\"a}t w{\"a}hrend der Bildbetrachtung aufwiesen. Das gefundene Hypoarousal auf Stimuli k{\"o}nnte dazu f{\"u}hren, dass vermindert auf Umweltreize und auch auf Belohnung und Bestrafung reagiert wird. Dies k{\"o}nnte soziale Dysfunktionen und externalisierendes Verhalten nach sich ziehen. Hyperaktiv-impulsives Verhalten und Sensation Seeking k{\"o}nnten kompensatorisch zur Anhebung des Arousals resultieren. Unaufmerksamkeit k{\"o}nnte durch einen suboptimalen Aktiviertheitsgrad bedingt sein. Methylphenidat k{\"o}nnte durch eine Steigerung des Arousals und die Verst{\"a}rkung der emotionalen Reaktivit{\"a}t diesen Symptomen entgegenwirken. Die vorliegende Arbeit konnte somit als erste einen emotional-motivationalen Endoph{\"a}notyp der ADHS unter Ber{\"u}cksichtigung valenz- und arousalbezogener Maße bei unterschiedlichen klinischen Subgruppen mit objektiven psychophysiologischen Parametern aufzeigen. Die Normalisierung des Hypoarousals von der Kindheit zum Erwachsenenalter k{\"o}nnte mit der Ver{\"a}nderung der ADHS-Symptome {\"u}ber die Entwicklung zusammenh{\"a}ngen. Die weitere Erforschung des Endoph{\"a}notypenmodells der ADHS ist eine wichtige Aufgabe f{\"u}r die Zukunft. Die vorliegende Arbeit versuchte, hierzu einen Beitrag zu leisten.},
  subject      = {Aufmerksamkeits-Defizit-Syndrom},
  language  = {de}
}
@phdthesis{Stemmler2011,
  author    = {Stemmler, Thomas},
  title     = {Just do it! Guilt as a moral intuition to cooperate - A parallel constraint satisfaction approach},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-74873},
  school      = {Universit{\"a}t W{\"u}rzburg},
  year      = {2011},
  abstract  = {Nach langer Dominanz rationaler Urteils- und Entscheidungsmodelle in der Moralpsychologie (z.B. Kohlberg, 1969) besteht seit einiger Zeit verst{\"a}rktes Interesse an intuitiven, emotionalen Einfl{\"u}ssen auf moralische Urteile und Entscheidungen (z.B. Greene, 2007; Haidt, 2001; Monin, Pizarro, \& Beer, 2007). Der Einfluss von Emotionen auf moralische Entscheidungen wird in der Literatur u.a. mittels heuristischer, non-kompensatorischer Informationsverarbeitung erkl{\"a}rt (z.B. Sinnott-Armstrong, Young, \& Cushman, 2010; Sunstein, 2005; Tobler, Kalis, \& Kalenscher, 2008). Hierbei wird jedoch der Prozess der Emotionsentstehung ignoriert. Appraisaltheorien postulieren, dass Emotionen durch die Inkoh{\"a}renz (oder Diskrepanz) von Verhaltensrepr{\"a}sentationen wie Zielen und Aktionen entstehen (Moors, 2009). Emotionsentstehung und (intuitives) Entscheiden kann in einem Modell vereint werden sobald man bei beiden Prozessen eine konnektionistische Struktur (z.B. Barnes \& Thagard, 1996) zugrunde legt. Die vorliegende Arbeit kontrastiert beide Perspektiven intuitiv-emotionalen Entscheidens im Hinblick auf Schuld und Kooperation.},
  subject      = {Kooperation},
  language  = {en}
}
@phdthesis{Likowski2011,
  author    = {Likowski, Katja U.},
  title     = {Facial mimicry, valence evaluation or emotional reaction? Mechanisms underlying the modulation of congruent and incongruent facial reactions to emotional facial expressions},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-65013},
  school      = {Universit{\"a}t W{\"u}rzburg},
  year      = {2011},
  abstract  = {Humans have the tendency to react with congruent facial expressions when looking at an emotional face. Interestingly, recent studies revealed that several situational moderators can modulate strength and direction of these reactions. In current literature, congruent facial reactions to emotional facial expressions are usually described in terms of "facial mimicry" and interpreted as imitative behavior. Thereby, facial mimicry is understood as a process of pure motor resonance resulting from overlapping representations for the perception and the execution of a certain behavior. Motor mimicry, however, is not the only mechanism by which congruent facial reactions can occur. Numerous studies have shown that facial muscles also indicate valence evaluations. Furthermore, facial reactions are also determined by our current emotional state. These thoughts suggest that the modulation of congruent facial reactions to emotional expressions can be based on both motor and affective processes. However, a separation of motor and affective processes in facial reactions is hard to make. None of the published studies that tried that could show a clear involvement of one or the other process so far. Therefore, the aim of the present line of experiments is to shed light on the involvement of motor and affective processes in the modulation of congruent and incongruent facial reactions. Specifically, the experiments are designed to test the assumptions of a working model on mechanisms underlying the modulation of facial reactions and to examine the neuronal correlates involved in such modulations with a broad range of methods. Experiments 1 and 2 experimentally manipulate motor and affective mechanisms by using specific contexts. In the chose settings, motor process models and affective models of valence evaluations make competing predictions about resulting facial reactions. The results of Experiment 1 did not support the involvement of valence evaluations in the modulation of congruent and incongruent facial reactions to facial expressions. The results of Experiments 2a and 2b suggest that emotional reactions are the predominant determinant of facial reactions. Experiment 3 aimed at identifying the psychological mediators that indicate motor and affective mechanisms. Motor mechanisms are assessed via the psychological mediator empathy. Additionally, as a psychological mediator for clarifying the role of affective mechanisms subjective measures of the participants' current emotional state in response to the presented facial expressions were taken. Mediational analyses show that the modulation of congruent facial reactions can be explained by a decrease of state cognitive empathy. This suggests that motor processes mediate the effects of the context on congruent facial reactions. However, such a mechanism could not be observed for incongruent reactions. Instead, it was found that affective processes in terms of emotional reactions are involved in incongruent facial reactions. Additionally, the involvement of a third class of processes, namely strategic processes, was observed. Experiment 4 aimed at investigating whether a change in the strength of perception can explain the contextual modulation of facial reactions to facial expressions. According to motor process models the strength of perception is directly related to the strength of the spread of activation from perception to the execution of an action and thereby to the strength of the resulting mimicry behavior. The results suggest that motor mechanisms were involved in the modulation of congruent facial reactions by attitudes. Such an involvement of motor mechanisms could, however, not be observed for the modulation of incongruent reactions. In Experiment 5 the investigation of neuronal correlates shall be extended to the observation of involved brain areas via fMRI. The proposed brain areas depicting motor areas were prominent parts of the mirror neuron system. The regions of interest depicting areas involved in the affective processing were amygdala, insula, striatum. Furthermore, it could be shown that changes in the activity of parts of the MNS are related to the modulation of congruent facial reactions. Further on, results revealed the involvement of affective processes in the modulation of incongruent facial reactions. In sum, these results lead to a revised working model on the mechanisms underlying the modulation of facial reactions to emotional facial expressions. The results of the five experiments provide strong support for the involvement of motor mechanisms in congruent facial reactions. No evidence was found for the involvement of motor mechanisms in the occurrence or modulation of incongruent facial reactions. Furthermore, no evidence was found for the involvement of valence evaluations in the modulation of facial reactions. Instead, emotional reactions were found to be involved in the modulation of mainly incongruent facial reactions.},
  subject      = {Gef{\"u}hl},
  language  = {en}
}
@phdthesis{Dieler2011,
  author    = {Dieler, Alica Christina},
  title     = {Investigation of variables influencing cognitive inhibition: from the behavioral to the molecular level},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-65955},
  school      = {Universit{\"a}t W{\"u}rzburg},
  year      = {2011},
  abstract  = {The present work investigated the neural mechanisms underlying cognitive inhibition/thought suppression in Anderson's and Green's Think/No-Think paradigm (TNT), as well as different variables influencing these mechanisms at the cognitive, the neurophysiological, the electrophysiological and the molecular level. Neurophysiological data collected with fNIRS and fMRI have added up to the existing evidence of a fronto-hippocampal network interacting during the inhibition of unwanted thoughts. Some evidence has been presented suggesting that by means of external stimulation of the right dlPFC through iTBS thought suppression might be improved, providing further evidence for an implication of this region in the TNT. A combination of fNIRS with ERP has delivered evidence of a dissociation of early condition-independent attentional and later suppression-specific processes within the dlPFC, both contributing to suppression performance. Due to inconsistencies in the previous literature it was considered how stimulus valence would influence thought suppression by manipulating the emotional content of the to-be-suppressed stimuli. Findings of the current work regarding the ability to suppress negative word or picture stimuli have, however, been inconclusive as well. It has been hypothesized that performance in the TNT might depend on the combination of valence conditions included in the paradigm. Alternatively, it has been suggested that inconsistent findings regarding the suppression of negative stimuli or suppression at all might be due to certain personality traits and/or genetic variables, found in the present work to contribute to thought inhibition in the TNT. Rumination has been shown to be a valid predictor of thought suppression performance. Increased ruminative tendencies led to worse suppression performance which, in the present work, has been linked to less effective recruitment of the dlPFC and in turn less effective down-regulation of hippocampal activity during suppression trials. Trait anxiety has also been shown to interrupt thought suppression despite higher, however, inefficient recruitment of the dlPFC. Complementing the findings regarding ruminative tendencies and decreased thought inhibition a functional polymorphism in the KCNJ6 gene, encompassing a G-to-A transition, has been shown to disrupt thought suppression despite increased activation of the dlPFC. Through the investigation of thought suppression at different levels, the current work adds further evidence to the idea that the TNT reflects an executive control mechanism, which is sensitive to alterations in stimulus valence to some extent, neurophysiological functioning as indicated by its sensitivity to iTBS, functional modulations at the molecular level and personality traits, such as rumination and trait anxiety.},
  subject      = {Kognitiver Prozess},
  language  = {en}
}
@article{ConzelmannReifJacobetal.2012,
  author    = {Conzelmann, Annette and Reif, Andreas and Jacob, Christian and Weyers, Peter and Lesch, Klaus-Peter and Lutz, Beat and Pauli, Paul},
  title     = {A polymorphism in the gene of the endocannabinoid-degrading enzyme FAAH (FAAH C385A) is associated with emotional-motivational reactivity},
  series = {Psychopharmacology},
  volume    = {224},
  journal   = {Psychopharmacology},
  number    = {4},
  doi       = {10.1007/s00213-012-2785-y},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-126845},
  pages     = {573-579},
  year      = {2012},
  abstract  = {RATIONALE: The endocannabinoid (eCB) system is implicated in several psychiatric disorders. Investigating emotional-motivational dysfunctions as underlying mechanisms, a study in humans revealed that in the C385A polymorphism of the fatty acid amide hydrolase (FAAH), the degrading enzyme of the eCB anandamide (AEA), A carriers, who are characterized by increased signaling of AEA as compared to C/C carriers, exhibited reduced brain reactivity towards unpleasant faces and enhanced reactivity towards reward. However, the association of eCB system with emotional-motivational reactivity is complex and bidirectional due to upcoming compensatory processes. OBJECTIVES: Therefore, we further investigated the relationship of the FAAH polymorphism and emotional-motivational reactivity in humans. METHODS: We assessed the affect-modulated startle, and ratings of valence and arousal in response to higher arousing pleasant, neutral, and unpleasant pictures in 67 FAAH C385A C/C carriers and 45 A carriers. RESULTS: Contrarily to the previous functional MRI study, A carriers compared to C/C carriers exhibited an increased startle potentiation and therefore emotional responsiveness towards unpleasant picture stimuli and reduced startle inhibition indicating reduced emotional reactivity in response to pleasant pictures, while both groups did not differ in ratings of arousal and valence. CONCLUSIONS: Our findings emphasize the bidirectionality and thorough examination of the eCB system's impact on emotional reactivity as a central endophenotype underlying various psychiatric disorders.},
  language  = {en}
}
@article{ConzelmannReifJacobetal.2012,
  author    = {Conzelmann, Annette and Reif, Andreas and Jacob, Christian and Weyers, Peter and Lesch, Klaus-Peter and Lutz, Beat and Pauli, Paul},
  title     = {A polymorphism in the gene of the endocannabinoid-degrading enzyme FAAH (FAAH C385A) is associated with emotional-motivational reactivity},
  series = {Psychopharmacology},
  volume    = {224},
  journal   = {Psychopharmacology},
  number    = {4},
  doi       = {10.1007/s00213-012-2785-y},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-129936},
  pages     = {573-579},
  year      = {2012},
  abstract  = {Rationale The endocannabinoid (eCB) system is implicated in several psychiatric disorders. Investigating emotional-motivational dysfunctions as underlying mechanisms, a study in humans revealed that in the C385A polymorphism of the fatty acid amide hydrolase (FAAH), the degrading enzyme of the eCB anandamide (AEA), A carriers, who are characterized by increased signaling of AEA as compared to C/C carriers, exhibited reduced brain reactivity towards unpleasant faces and enhanced reactivity towards reward. However, the association of eCB system with emotional-motivational reactivity is complex and bidirectional due to upcoming compensatory processes. Objectives Therefore, we further investigated the relationship of the FAAH polymorphism and emotional-motivational reactivity in humans. Methods We assessed the affect-modulated startle, and ratings of valence and arousal in response to higher arousing pleasant, neutral, and unpleasant pictures in 67 FAAH C385A C/C carriers and 45 A carriers. Results Contrarily to the previous functional MRI study, A carriers compared to C/C carriers exhibited an increased startle potentiation and therefore emotional responsiveness towards unpleasant picture stimuli and reduced startle inhibition indicating reduced emotional reactivity in response to pleasant pictures, while both groups did not differ in ratings of arousal and valence. Conclusions Our findings emphasize the bidirectionality and thorough examination of the eCB system's impact on emotional reactivity as a central endophenotype underlying various psychiatric disorders.},
  language  = {en}
}
@incollection{Schmitz2012,
  author    = {Schmitz, Barbara},
  title     = {Antiochus Epiphanes und der epiphane Gott. Gef{\"u}hle, Emotionen und Affekte im Zweiten Makkab{\"a}erbuch},
  doi       = {10.1515/dcly.2012.2011.1.253},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-108916},
  publisher      = {Universit{\"a}t W{\"u}rzburg},
  year      = {2012},
  abstract  = {Das Zweite Makkab{\"a}erbuch ist eine absichtsvoll komponierte Erz{\"a}hlung, die ihr Erz{\"a}hlinteresse in der Vorrede (2Makk 2,19-32) und im Epilog (2Makk 15,37-39) benennt. Die Erz{\"a}hlung soll - so die Selbstauskunft der Erz{\"a}hlung im Vorwort - den Leserinnen und Lesern zur Psnchagogia, „Seelenf{\"u}hrung, Vergn{\"u}gung, Lockung", zur eukopia, „Leichtigkeit" sowie zur opheleia, „Vorteil, Nutzen, n{\"u}tzlichen Kenntnis" dienen (2Makk 2,25). Damit pr{\"a}sentiert sich das Zweite Makkab{\"a}erbuch als eine absichtsvolle literarische Erz{\"a}hlung, die ganz bewusst bei den Leserinnen und Lesern emotionale Wirkung, Gef{\"u}hle und Affekte hervorrufen will. Dieses Ziel wird gleich zu Beginn der Erz{\"a}hlung auf der Kommunikationsebene zwischen Erz{\"a}hlstimme und Lesenden benannt. Das auf diese Weise offengelegte Vorhaben der Erz{\"a}hlung l{\"a}sst zun{\"a}chst fragen, wie die emotionale Wirkung bei den Leserinnen und Lesern erzielt werden soll. Dar{\"u}ber hinaus ist die viel grundlegendere Frage zu stellen, warum es f{\"u}r das Zweite Makkab{\"a}erbuch von so zentralem Interesse ist, Emotionen bei den Rezipienten hervorzurufen.},
  subject      = {Makkab{\"a}er <Buch, II.>},
  language  = {de}
}
@article{HerbertSuetterlin2012,
  author    = {Herbert, Cornelia and S{\"u}tterlin, Stefan},
  title     = {Do not respond! Doing the think/no-think and go/no-go tasks concurrently leads to memory impairment of unpleasant items during later recall},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-76028},
  year      = {2012},
  abstract  = {Previous research using neuroimaging methods proposed a link between mechanisms controlling motor response inhibition and suppression of unwanted memories.The present study investigated this hypothesis behaviorally by combining the think/no-think paradigm (TNT) with a go/no-go motor inhibition task. Participants first learned unpleasant cue-target pairs. Cue words were then presented as go or no-go items in the TNT. Participants' task was to respond to the cues and think of the target word aloud or to inhibit their response to the cue and the target word from coming to mind. Cued recall assessed immediately after the TNT revealed reduced recall performance for no-go targets compared to go targets or baseline cues not presented in the TNT. The results demonstrate that doing the no-think and no-go task concurrently leads to memory suppression of unpleasant items during later recall. Results are discussed in line with recent empirical research and theoretical positions.},
  subject      = {Psychologie},
  language  = {en}
}
@misc{WieserBrosch2012,
  author    = {Wieser, Mattias J. and Brosch, Tobias},
  title     = {Faces in context: A review and systematization of contextual influences on affective face processing},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-76351},
  year      = {2012},
  abstract  = {Facial expressions are of eminent importance for social interaction as they convey information about other individuals' emotions and social intentions. According to the predominant "basic emotion" approach, the perception of emotion in faces is based on the rapid, auto- matic categorization of prototypical, universal expressions. Consequently, the perception of facial expressions has typically been investigated using isolated, de-contextualized, static pictures of facial expressions that maximize the distinction between categories. However, in everyday life, an individual's face is not perceived in isolation, but almost always appears within a situational context, which may arise from other people, the physical environment surrounding the face, as well as multichannel information from the sender. Furthermore, situational context may be provided by the perceiver, including already present social infor- mation gained from affective learning and implicit processing biases such as race bias.Thus, the perception of facial expressions is presumably always influenced by contextual vari- ables. In this comprehensive review, we aim at (1) systematizing the contextual variables that may influence the perception of facial expressions and (2) summarizing experimental paradigms and findings that have been used to investigate these influences. The studies reviewed here demonstrate that perception and neural processing of facial expressions are substantially modified by contextual information, including verbal, visual, and auditory information presented together with the face as well as knowledge or processing biases already present in the observer. These findings further challenge the assumption of auto- matic, hardwired categorical emotion extraction mechanisms predicted by basic emotion theories. Taking into account a recent model on face processing, we discuss where and when these different contextual influences may take place, thus outlining potential avenues in future research.},
  subject      = {Psychologie},
  language  = {en}
}
@article{HohoffGorjiKaiseretal.2013,
  author    = {Hohoff, Christa and Gorji, Ali and Kaiser, Sylvia and Willscher, Edith and Korsching, Eberhard and Ambr{\´e}e, Oliver and Arolt, Volker and Lesch, Klaus-Peter and Sachser, Norbert and Deckert, J{\"u}rgen and Lewejohann, Lars},
  title     = {Effect of Acute Stressor and Serotonin Transporter Genotype on Amygdala First Wave Transcriptome in Mice},
  series = {PLoS ONE},
  volume    = {8},
  journal   = {PLoS ONE},
  number    = {3},
  doi       = {10.1371/journal.pone.0058880},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-131040},
  pages     = {e58880},
  year      = {2013},
  abstract  = {The most prominent brain region evaluating the significance of external stimuli immediately after their onset is the amygdala. Stimuli evaluated as being stressful actuate a number of physiological processes as an immediate stress response. Variation in the serotonin transporter gene has been associated with increased anxiety- and depression-like behavior, altered stress reactivity and adaptation, and pathophysiology of stress-related disorders. In this study the instant reactions to an acute stressor were measured in a serotonin transporter knockout mouse model. Mice lacking the serotonin transporter were verified to be more anxious than their wild-type conspecifics. Genome-wide gene expression changes in the amygdala were measured after the mice were subjected to control condition or to an acute stressor of one minute exposure to water. The dissection of amygdalae and stabilization of RNA was conducted within nine minutes after the onset of the stressor. This extremely short protocol allowed for analysis of first wave primary response genes, typically induced within five to ten minutes of stimulation, and was performed using Affymetrix GeneChip Mouse Gene 1.0 ST Arrays. RNA profiling revealed a largely new set of differentially expressed primary response genes between the conditions acute stress and control that differed distinctly between wild-type and knockout mice. Consequently, functional categorization and pathway analysis indicated genes related to neuroplasticity and adaptation in wild-types whereas knockouts were characterized by impaired plasticity and genes more related to chronic stress and pathophysiology. Our study therefore disclosed different coping styles dependent on serotonin transporter genotype even directly after the onset of stress and accentuates the role of the serotonergic system in processing stressors and threat in the amygdala. Moreover, several of the first wave primary response genes that we found might provide promising targets for future therapeutic interventions of stress-related disorders also in humans.},
  language  = {en}
}
@article{WieserGerdesReichertsetal.2014,
  author    = {Wieser, Matthias J. and Gerdes, Antje B. M. and Reicherts, Philipp and Pauli, Paul},
  title     = {Mutual influences of pain and emotional face processing},
  series = {Frontiers in Psychology},
  volume    = {5},
  journal   = {Frontiers in Psychology},
  issn      = {1664-1078},
  doi       = {10.3389/fpsyg.2014.01160},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-118446},
  pages     = {1160},
  year      = {2014},
  abstract  = {The perception of unpleasant stimuli enhances whereas the perception of pleasant stimuli decreases pain perception. In contrast, the effects of pain on the processing of emotional stimuli are much less known. Especially given the recent interest in facial expressions of pain as a special category of emotional stimuli, a main topic in this research line is the mutual influence of pain and facial expression processing. Therefore, in this mini-review we selectively summarize research on the effects of emotional stimuli on pain, but more extensively turn to the opposite direction namely how pain influences concurrent processing of affective stimuli such as facial expressions. Based on the motivational priming theory one may hypothesize that the perception of pain enhances the processing of unpleasant stimuli and decreases the processing of pleasant stimuli. This review reveals that the literature is only partly consistent with this assumption: pain reduces the processing of pleasant pictures and happy facial expressions, but does not - or only partly - affect processing of unpleasant pictures. However, it was demonstrated that pain selectively enhances the processing of facial expressions if these are pain-related (i.e., facial expressions of pain). Extending a mere affective modulation theory, the latter results suggest pain-specific effects which may be explained by the perception-action model of empathy. Together, these results underscore the important mutual influence of pain and emotional face processing.},
  language  = {en}
}
@article{DiemerAlpersPeperkornetal.2015,
  author    = {Diemer, Julia and Alpers, Georg W. and Peperkorn, Henrik M. and Shiban, Youssef and M{\"u}hlberger, Andreas},
  title     = {The impact of perception and presence on emotional reactions: a review of research in virtual reality},
  series = {Frontiers in Psychology},
  volume    = {6},
  journal   = {Frontiers in Psychology},
  number    = {26},
  doi       = {10.3389/fpsyg.2015.00026},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-144200},
  year      = {2015},
  abstract  = {Virtual reality (VR) has made its way into mainstream psychological research in the last two decades. This technology, with its unique ability to simulate complex, real situations and contexts, offers researchers unprecedented opportunities to investigate human behavior in well controlled designs in the laboratory. One important application of VR is the investigation of pathological processes in mental disorders, especially anxiety disorders. Research on the processes underlying threat perception, fear, and exposure therapy has shed light on more general aspects of the relation between perception and emotion. Being by its nature virtual, i.e., simulation of reality, VR strongly relies on the adequate selection of specific perceptual cues to activate emotions. Emotional experiences in turn are related to presence, another important concept in VR, which describes the user's sense of being in a VR environment. This paper summarizes current research into perception of fear cues, emotion, and presence, aiming at the identification of the most relevant aspects of emotional experience in VR and their mutual relations. A special focus lies on a series of recent experiments designed to test the relative contribution of perception and conceptual information on fear in VR. This strand of research capitalizes on the dissociation between perception (bottom up input) and conceptual information (top-down input) that is possible in VR. Further, we review the factors that have so far been recognized to influence presence, with emotions (e.g., fear) being the most relevant in the context of clinical psychology. Recent research has highlighted the mutual influence of presence and fear in VR, but has also traced the limits of our current understanding of this relationship. In this paper, the crucial role of perception on eliciting emotional reactions is highlighted, and the role of arousal as a basic dimension of emotional experience is discussed. An interoceptive attribution model of presence is suggested as a first step toward an integrative framework for emotion research in VR. Gaps in the current literature and future directions are outlined.},
  language  = {en}
}
@article{TopolinskiStrack2015,
  author    = {Topolinski, Sascha and Strack, Fritz},
  title     = {Corrugator activity confirms immediate negative affect in surprise},
  series = {Frontiers in Psychology},
  volume    = {6},
  journal   = {Frontiers in Psychology},
  number    = {134},
  doi       = {10.3389/fpsyg.2015.00134},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-144068},
  year      = {2015},
  abstract  = {The emotion of surprise entails a complex of immediate responses, such as cognitive interruption, attention allocation to, and more systematic processing of the surprising stimulus. All these processes serve the ultimate function to increase processing depth and thus cognitively master the surprising stimulus. The present account introduces phasic negative affect as the underlying mechanism responsible for this switch in operating mode. Surprising stimuli are schema discrepant and thus entail cognitive disfluency, which elicits immediate negative affect. This affect in turn works like a phasic cognitive tuning switching the current processing mode from more automatic and heuristic to more systematic and reflective processing. Directly testing the initial elicitation of negative affect by surprising events, the present experiment presented high and low surprising neutral trivia statements to N = 28 participants while assessing their spontaneous facial expressions via facial electromyography. High compared to low surprising trivia elicited higher corrugator activity, indicative of negative affect and mental effort, while leaving zygomaticus (positive affect) and frontalis (cultural surprise expression) activity unaffected. Future research shall investigate the mediating role of negative affect in eliciting surprise-related outcomes.},
  language  = {en}
}
@article{CitronAbugaberHerbert2016,
  author    = {Citron, Francesca M. M. and Abugaber, David and Herbert, Cornelia},
  title     = {Approach and Withdrawal Tendencies during Written Word Processing: Effects of Task, Emotional Valence, and Emotional Arousal},
  series = {frontiers in Psychology},
  volume    = {6},
  journal   = {frontiers in Psychology},
  number    = {1935},
  doi       = {10.3389/fpsyg.2015.01935},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-165318},
  year      = {2016},
  abstract  = {The affective dimensions of emotional valence and emotional arousal affect processing of verbal and pictorial stimuli. Traditional emotional theories assume a linear relationship between these dimensions, with valence determining the direction of a behavior (approach vs. withdrawal) and arousal its intensity or strength. In contrast, according to the valence-arousal conflict theory, both dimensions are interactively related: positive valence and low arousal (PL) are associated with an implicit tendency to approach a stimulus, whereas negative valence and high arousal (NH) are associated with withdrawal. Hence, positive, high-arousal (PH) and negative, low-arousal (NL) stimuli elicit conflicting action tendencies. By extending previous research that used several tasks and methods, the present study investigated whether and how emotional valence and arousal affect subjective approach vs. withdrawal tendencies toward emotional words during two novel tasks. In Study 1, participants had to decide whether they would approach or withdraw from concepts expressed by written words. In Studies 2 and 3 participants had to respond to each word by pressing one of two keys labeled with an arrow pointing upward or downward. Across experiments, positive and negative words, high or low in arousal, were presented. In Study 1 (explicit task), in line with the valence-arousal conflict theory, PH and NL words were responded to more slowly than PL and NH words. In addition, participants decided to approach positive words more often than negative words. In Studies 2 and 3, participants responded faster to positive than negative words, irrespective of their level of arousal. Furthermore, positive words were significantly more often associated with "up" responses than negative words, thus supporting the existence of implicit associations between stimulus valence and response coding (positive is up and negative is down). Hence, in contexts in which participants' spontaneous responses are based on implicit associations between stimulus valence and response, there is no influence of arousal. In line with the valence-arousal conflict theory, arousal seems to affect participants' approach-withdrawal tendencies only when such tendencies are made explicit by the task, and a minimal degree of processing depth is required.},
  language  = {en}
}
@techreport{Fuchs2018,
  type      = {Working Paper},
  author    = {Fuchs, Florian},
  title     = {„Disney Dreams!" - Eine Abendshow im Spannungsfeld von Masse, Gemeinschaft, Emotionen und Religion},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-159931},
  pages     = {20},
  year      = {2018},
  abstract  = {Der Text besch{\"a}ftigt sich mit der Abendshow des Disneyland Paris "Disney Dreams!" aus den Perspektiven Masse, Gemeinschaft, Religion und Emotionen. Es wird versucht, diese popkulturelle Show soziologisch und theologisch zu erschließen.},
  subject      = {Theologie},
  language  = {de}
}
@techreport{Fuchs2018,
  type      = {Working Paper},
  author    = {Fuchs, Florian},
  title     = {"Disney Dreams!" - A Nighttime Spectacular in the Tension Field of Crowds, Communion, Emotion, and Religion},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-159949},
  pages     = {19},
  year      = {2018},
  abstract  = {The text deals with the nighttime spectacular of Disneyland Paris´ "Disney Dreams!" from the perspectives of mass, community, religion and emotions. It tries to open up this pop cultural show sociologically and theologically.},
  subject      = {Soziologie},
  language  = {en}
}
@article{MadanBayerGameretal.2018,
  author    = {Madan, Christopher R. and Bayer, Janine and Gamer, Matthias and Lonsdorf, Tina B. and Sommer, Tobias},
  title     = {Visual Complexity and Affect: Ratings Reflect More Than Meets the Eye},
  series = {Frontiers in Psychology},
  volume    = {8},
  journal   = {Frontiers in Psychology},
  number    = {2368},
  issn      = {1664-1078},
  doi       = {10.3389/fpsyg.2017.02368},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-190015},
  year      = {2018},
  abstract  = {Pictorial stimuli can vary on many dimensions, several aspects of which are captured by the term 'visual complexity.' Visual complexity can be described as, "a picture of a few objects, colors, or structures would be less complex than a very colorful picture of many objects that is composed of several components." Prior studies have reported a relationship between affect and visual complexity, where complex pictures are rated as more pleasant and arousing. However, a relationship in the opposite direction, an effect of affect on visual complexity, is also possible; emotional arousal and valence are known to influence selective attention and visual processing. In a series of experiments, we found that ratings of visual complexity correlated with affective ratings, and independently also with computational measures of visual complexity. These computational measures did not correlate with affect, suggesting that complexity ratings are separately related to distinct factors. We investigated the relationship between affect and ratings of visual complexity, finding an 'arousal-complexity bias' to be a robust phenomenon. Moreover, we found this bias could be attenuated when explicitly indicated but did not correlate with inter-individual difference measures of affective processing, and was largely unrelated to cognitive and eyetracking measures. Taken together, the arousal-complexity bias seems to be caused by a relationship between arousal and visual processing as it has been described for the greater vividness of arousing pictures. The described arousal-complexity bias is also of relevance from an experimental perspective because visual complexity is often considered a variable to control for when using pictorial stimuli.},
  language  = {en}
}
@phdthesis{RamirezPasos2019,
  author    = {Ramirez Pasos, Uri Eduardo},
  title     = {Subthalamic Nucleus Neural Synchronization and Connectivity during Limbic Processing of Emotional Pictures: Evidence from Invasive Recordings in Patients with Parkinson's Disease},
  doi       = {10.25972/OPUS-16985},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-169850},
  school      = {Universit{\"a}t W{\"u}rzburg},
  year      = {2019},
  abstract  = {In addition to bradykinesia and tremor, patients with Parkinson's disease (PD) are known to exhibit non-motor symptoms such as apathy and hypomimia but also impulsivity in response to dopaminergic replacement therapy. Moreover, a plethora of studies observe differences in electrocortical and autonomic responses to both visual and acoustic affective stimuli in PD subjects compared to healthy controls. This suggests that the basal ganglia (BG), as well as the hyperdirect pathway and BG thalamocortical circuits, are involved in affective processing. Recent studies have shown valence and dopamine-dependent changes in synchronization in the subthalamic nucleus (STN) in PD patients during affective tasks. This thesis investigates the role of dopamine, valence, and laterality in STN electrophysiology by analyzing event-related potentials (ERP), synchronization, and inter-hemispheric STN connectivity. STN recordings were obtained from PD patients with chronically implanted electrodes for deep brain stimulation during a passive affective picture presentation task. The STN exhibited valence-dependent ERP latencies and lateralized 'high beta' (28-40 Hz) event-related desynchronization. This thesis also examines the role of dopamine, valence, and laterality on STN functional connectivity with the anterior cingulate cortex (ACC) and the amygdala. The activity of these limbic structures was reconstructed using simultaneously recorded electroencephalographic signals. While the STN was found to establish early coupling with both structures, STN-ACC coupling in the 'alpha' range (7-11 Hz) and uncoupling in the 'low beta' range (14-21 Hz) were lateralized. Lateralization was also observed at the level of synchrony in both reconstructed sources and for ACC ERP amplitude, whereas dopamine modulated ERP latency in the amygdala. These results may deepen our current understanding of the STN as a limbic node within larger emotional-motor networks in the brain.
},
  subject      = {Nucleus subthalamicus},
  language  = {en}
}
@phdthesis{Menne2020,
  author    = {Menne, Isabelle M.},
  title     = {Facing Social Robots - Emotional Reactions towards Social Robots},
  edition   = {1. Auflage},
  publisher = {W{\"u}rzburg University Press},
  address   = {W{\"u}rzburg},
  isbn      = {978-3-95826-120-4},
  doi       = {10.25972/WUP-978-3-95826-121-1},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-187131},
  school      = {W{\"u}rzburg University Press},
  pages     = {XXIV, 201},
  year      = {2020},
  abstract  = {Ein Army Colonel empfindet Mitleid mit einem Roboter, der versuchsweise Landminen entsch{\"a}rft und deklariert den Test als inhuman (Garreau, 2007). Roboter bekommen milit{\"a}rische Bef{\"o}rderungen, Beerdigungen und Ehrenmedaillen (Garreau, 2007; Carpenter, 2013). Ein Schildkr{\"o}tenroboter wird entwickelt, um Kindern beizubringen, Roboter gut zu behandeln (Ackermann, 2018). Der humanoide Roboter Sophia wurde erst k{\"u}rzlich Saudi-Arabischer Staatsb{\"u}rger und es gibt bereits Debatten, ob Roboter Rechte bekommen sollen (Delcker, 2018). Diese und {\"a}hnliche Entwicklungen zeigen schon jetzt die Bedeutsamkeit von Robotern und die emotionale Wirkung die diese ausl{\"o}sen. Dennoch scheinen sich diese emotionalen Reaktionen auf einer anderen Ebene abzuspielen, gemessen an Kommentaren in Internetforen. Dort ist oftmals die Rede davon, wieso jemand {\"u}berhaupt emotional auf einen Roboter reagieren kann. Tats{\"a}chlich ist es, rein rational gesehen, schwierig zu erkl{\"a}ren, warum Menschen mit einer leblosen (‚mindless') Maschine mitf{\"u}hlen sollten. Und dennoch zeugen nicht nur oben genannte Berichte, sondern auch erste wissenschaftliche Studien (z.B. Rosenthal- von der P{\"u}tten et al., 2013) von dem emotionalen Einfluss den Roboter auf Menschen haben k{\"o}nnen. Trotz der Bedeutsamkeit der Erforschung emotionaler Reaktionen auf Roboter existieren bislang wenige wissenschaftliche Studien hierzu. Tats{\"a}chlich identifizierten Kappas, Krumhuber und K{\"u}ster (2013) die systematische Analyse und Evaluation sozialer Reaktionen auf Roboter als eine der gr{\"o}ßten Herausforderungen der affektiven Mensch-Roboter Interaktion. Nach Scherer (2001; 2005) bestehen Emotionen aus der Koordination und Synchronisation verschiedener Komponenten, die miteinander verkn{\"u}pft sind. Motorischer Ausdruck (Mimik), subjektives Erleben, Handlungstendenzen, physiologische und kognitive Komponenten geh{\"o}ren hierzu. Um eine Emotion vollst{\"a}ndig zu erfassen, m{\"u}ssten all diese Komponenten gemessen werden, jedoch wurde eine solch umfassende Analyse bisher noch nie durchgef{\"u}hrt (Scherer, 2005). Haupts{\"a}chlich werden Frageb{\"o}gen eingesetzt (vgl. Bethel \& Murphy, 2010), die allerdings meist nur das subjektive Erleben abfragen. Bakeman und Gottman (1997) geben sogar an, dass nur etwa 8\% der psychologischen Forschung auf Verhaltensdaten basiert, obwohl die Psychologie traditionell als das ‚Studium von Psyche und Verhalten' (American Psychological Association, 2018) definiert wird. Die Messung anderer Emotionskomponenten ist selten. Zudem sind Frageb{\"o}gen mit einer Reihe von Nachteilen behaftet (Austin, Deary, Gibson, McGregor, Dent, 1998; Fan et al., 2006; Wilcox, 2011). Bethel und Murphy (2010) als auch Arkin und Moshkina (2015) pl{\"a}dieren f{\"u}r einen Multi-Methodenansatz um ein umfassenderes Verst{\"a}ndnis von affektiven Prozessen in der Mensch-Roboter Interaktion zu erlangen. Das Hauptziel der vorliegenden Dissertation ist es daher, mithilfe eines Multi-Methodenansatzes verschiedene Komponenten von Emotionen (motorischer Ausdruck, subjektive Gef{\"u}hlskomponente, Handlungstendenzen) zu erfassen und so zu einem vollst{\"a}ndigeren und tiefgreifenderem Bild emotionaler Prozesse auf Roboter beizutragen. Um dieses Ziel zu erreichen, wurden drei experimentelle Studien mit insgesamt 491 Teilnehmern durchgef{\"u}hrt. Mit unterschiedlichen Ebenen der „apparent reality" (Frijda, 2007) sowie Macht / Kontrolle {\"u}ber die Situation (vgl. Scherer \& Ellgring, 2007) wurde untersucht, inwiefern sich Intensit{\"a}t und Qualit{\"a}t emotionaler Reaktionen auf Roboter {\"a}ndern und welche weiteren Faktoren (Aussehen des Roboters, emotionale Expressivit{\"a}t des Roboters, Behandlung des Roboters, Autorit{\"a}tsstatus des Roboters) Einfluss aus{\"u}ben. Experiment 1 basierte auf Videos, die verschiedene Arten von Robotern (tier{\"a}hnlich, anthropomorph, maschinenartig), die entweder emotional expressiv waren oder nicht (an / aus) in verschiedenen Situationen (freundliche Behandlung des Roboters vs. Misshandlung) zeigten. Frageb{\"o}gen {\"u}ber selbstberichtete Gef{\"u}hle und die motorisch-expressive Komponente von Emotionen: Mimik (vgl. Scherer, 2005) wurden analysiert. Das Facial Action Coding System (Ekman, Friesen, \& Hager, 2002), die umfassendste und am weitesten verbreitete Methode zur objektiven Untersuchung von Mimik, wurde hierf{\"u}r verwendet. Die Ergebnisse zeigten, dass die Probanden Gesichtsausdr{\"u}cke (Action Unit [AU] 12 und AUs, die mit positiven Emotionen assoziiert sind, sowie AU 4 und AUs, die mit negativen Emotionen assoziiert sind) sowie selbstberichtete Gef{\"u}hle in {\"U}bereinstimmung mit der Valenz der in den Videos gezeigten Behandlung zeigten. Bei emotional expressiven Robotern konnten st{\"a}rkere emotionale Reaktionen beobachtet werden als bei nicht-expressiven Robotern. Der tier{\"a}hnliche Roboter Pleo erfuhr in der Misshandlungs-Bedingung am meisten Mitleid, Empathie, negative Gef{\"u}hle und Traurigkeit, gefolgt vom anthropomorphen Roboter Reeti und am wenigsten f{\"u}r den maschinenartigen Roboter Roomba. Roomba wurde am meisten Antipathie zugeschrieben. Die Ergebnisse kn{\"u}pfen an fr{\"u}here Forschungen an (z.B. Krach et al., 2008; Menne \& Schwab, 2018; Riek et al., 2009; Rosenthal-von der P{\"u}tten et al., 2013) und zeigen das Potenzial der Mimik f{\"u}r eine nat{\"u}rliche Mensch-Roboter Interaktion. Experiment 2 und Experiment 3 {\"u}bertrugen die klassischen Experimente von Milgram (1963; 1974) zum Thema Gehorsam in den Kontext der Mensch-Roboter Interaktion. Die Gehorsamkeitsstudien von Milgram wurden als sehr geeignet erachtet, um das Ausmaß der Empathie gegen{\"u}ber einem Roboter im Verh{\"a}ltnis zum Gehorsam gegen{\"u}ber einem Roboter zu untersuchen. Experiment 2 unterschied sich von Experiment 3 in der Ebene der „apparent reality" (Frijda, 2007): in Anlehnung an Milgram (1963) wurde eine rein text-basierte Studie (Experiment 2) einer live Mensch-Roboter Interaktion (Experiment 3) gegen{\"u}bergestellt. W{\"a}hrend die abh{\"a}ngigen Variablen von Experiment 2 aus den Selbstberichten emotionaler Gef{\"u}hle sowie Einsch{\"a}tzungen des hypothetischen Verhaltens bestand, erfasste Experiment 3 subjektive Gef{\"u}hle sowie reales Verhalten (Reaktionszeit: Dauer des Z{\"o}gerns; Gehorsamkeitsrate; Anzahl der Proteste; Mimik) der Teilnehmer. Beide Experimente untersuchten den Einfluss der Faktoren „Autorit{\"a}tsstatus" (hoch / niedrig) des Roboters, der die Befehle erteilt (Nao) und die emotionale Expressivit{\"a}t (an / aus) des Roboters, der die Strafen erh{\"a}lt (Pleo). Die subjektiven Gef{\"u}hle der Teilnehmer aus Experiment 2 unterschieden sich zwischen den Gruppen nicht. Dar{\"u}ber hinaus gaben nur wenige Teilnehmer (20.2\%) an, dass sie den „Opfer"-Roboter definitiv bestrafen w{\"u}rden. Ein {\"a}hnliches Ergebnis fand auch Milgram (1963). Das reale Verhalten von Versuchsteilnehmern in Milgrams' Labor-Experiment unterschied sich jedoch von Einsch{\"a}tzungen hypothetischen Verhaltens von Teilnehmern, denen Milgram das Experiment nur beschrieben hatte. Ebenso lassen Kommentare von Teilnehmern aus Experiment 2 darauf schließen, dass das beschriebene Szenario m{\"o}glicherweise als fiktiv eingestuft wurde und Einsch{\"a}tzungen von hypothetischem Verhalten daher kein realistisches Bild realen Verhaltens gegen{\"u}ber Roboter in einer live Interaktion zeichnen k{\"o}nnen. Daher wurde ein weiteres Experiment (Experiment 3) mit einer Live Interaktion mit einem Roboter als Autorit{\"a}tsfigur (hoher Autorit{\"a}tsstatus vs. niedriger) und einem weiteren Roboter als „Opfer" (emotional expressiv vs. nicht expressiv) durchgef{\"u}hrt. Es wurden Gruppenunterschiede in Frageb{\"o}gen {\"u}ber emotionale Reaktionen gefunden. Dem emotional expressiven Roboter wurde mehr Empathie entgegengebracht und es wurde mehr Freude und weniger Antipathie berichtet als gegen{\"u}ber einem nicht-expressiven Roboter. Außerdem konnten Gesichtsausdr{\"u}cke beobachtet werden, die mit negativen Emotionen assoziiert sind w{\"a}hrend Probanden Nao's Befehl ausf{\"u}hrten und Pleo bestraften. Obwohl Probanden tendenziell l{\"a}nger z{\"o}gerten, wenn sie einen emotional expressiven Roboter bestrafen sollten und der Befehl von einem Roboter mit niedrigem Autorit{\"a}tsstatus kam, wurde dieser Unterschied nicht signifikant. Zudem waren alle bis auf einen Probanden gehorsam und bestraften Pleo, wie vom Nao Roboter befohlen. Dieses Ergebnis steht in starkem Gegensatz zu dem selbstberichteten hypothetischen Verhalten der Teilnehmer aus Experiment 2 und unterst{\"u}tzt die Annahme, dass die Einsch{\"a}tzungen von hypothetischem Verhalten in einem Mensch-Roboter-Gehorsamkeitsszenario nicht zuverl{\"a}ssig sind f{\"u}r echtes Verhalten in einer live Mensch-Roboter Interaktion. Situative Variablen, wie z.B. der Gehorsam gegen{\"u}ber Autorit{\"a}ten, sogar gegen{\"u}ber einem Roboter, scheinen st{\"a}rker zu sein als Empathie f{\"u}r einen Roboter. Dieser Befund kn{\"u}pft an andere Studien an (z.B. Bartneck \& Hu, 2008; Geiskkovitch et al., 2016; Menne, 2017; Slater et al., 2006), er{\"o}ffnet neue Erkenntnisse zum Einfluss von Robotern, zeigt aber auch auf, dass die Wahl einer Methode um Empathie f{\"u}r einen Roboter zu evozieren eine nicht triviale Angelegenheit ist (vgl. Geiskkovitch et al., 2016; vgl. Milgram, 1965). Insgesamt st{\"u}tzen die Ergebnisse die Annahme, dass die emotionalen Reaktionen auf Roboter tiefgreifend sind und sich sowohl auf der subjektiven Ebene als auch in der motorischen Komponente zeigen. Menschen reagieren emotional auf einen Roboter, der emotional expressiv ist und eher weniger wie eine Maschine aussieht. Sie empfinden Empathie und negative Gef{\"u}hle, wenn ein Roboter misshandelt wird und diese emotionalen Reaktionen spiegeln sich in der Mimik. Dar{\"u}ber hinaus unterscheiden sich die Einsch{\"a}tzungen von Menschen {\"u}ber ihr eigenes hypothetisches Verhalten von ihrem tats{\"a}chlichen Verhalten, weshalb videobasierte oder live Interaktionen zur Analyse realer Verhaltensreaktionen empfohlen wird. Die Ankunft sozialer Roboter in der Gesellschaft f{\"u}hrt zu nie dagewesenen Fragen und diese Dissertation liefert einen ersten Schritt zum Verst{\"a}ndnis dieser neuen Herausforderungen.},
  subject      = {Roboter},
  language  = {en}
}
@article{AboagyeWeberMerdianetal.2021,
  author    = {Aboagye, B. and Weber, T. and Merdian, H. L. and Bartsch, D. and Lesch, K. P. and Waider, J.},
  title     = {Serotonin deficiency induced after brain maturation rescues consequences of early life adversity},
  series = {Scientific Reports},
  volume    = {11},
  journal   = {Scientific Reports},
  number    = {1},
  issn      = {2045-2322},
  doi       = {10.1038/s41598-021-83592-4},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-258626},
  year      = {2021},
  abstract  = {Brain serotonin (5-HT) system dysfunction is implicated in depressive disorders and acute depletion of 5-HT precursor tryptophan has frequently been used to model the influence of 5-HT deficiency on emotion regulation. Tamoxifen (TAM)-induced Cre/loxP-mediated inactivation of the tryptophan hydroxylase-2 gene (Tph2) was used to investigate the effects of provoked 5-HT deficiency in adult mice (Tph2 icKO) previously subjected to maternal separation (MS). The efficiency of Tph2 inactivation was validated by immunohistochemistry and HPLC. The impact of Tph2 icKO in interaction with MS stress (Tph2 icKOxMS) on physiological parameters, emotional behavior and expression of 5-HT system-related marker genes were assessed. Tph2 icKO mice displayed a significant reduction in 5-HT immunoreactive cells and 5-HT concentrations in the rostral raphe region within four weeks following TAM treatment. Tph2 icKO and MS differentially affected food and water intake, locomotor activity as well as panic-like escape behavior. Tph2 icKO prevented the adverse effects of MS stress and altered the expression of the genes previously linked to stress and emotionality. In conclusion, an experimental model was established to study the behavioral and neurobiological consequences of 5-HT deficiency in adulthood in interaction with early-life adversity potentially affecting brain development and the pathogenesis of depressive disorders.},
  language  = {en}
}
@article{StegmannAndreattaWieser2023,
  author    = {Stegmann, Yannik and Andreatta, Marta and Wieser, Matthias J.},
  title     = {The effect of inherently threatening contexts on visuocortical engagement to conditioned threat},
  series = {Psychophysiology},
  volume    = {60},
  journal   = {Psychophysiology},
  number    = {4},
  doi       = {10.1111/psyp.14208},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-312465},
  year      = {2023},
  abstract  = {Fear and anxiety are crucial for adaptive responding in life-threatening situations. Whereas fear is a phasic response to an acute threat accompanied by selective attention, anxiety is characterized by a sustained feeling of apprehension and hypervigilance during situations of potential threat. In the current literature, fear and anxiety are usually considered mutually exclusive, with partially separated neural underpinnings. However, there is accumulating evidence that challenges this distinction between fear and anxiety, and simultaneous activation of fear and anxiety networks has been reported. Therefore, the current study experimentally tested potential interactions between fear and anxiety. Fifty-two healthy participants completed a differential fear conditioning paradigm followed by a test phase in which the conditioned stimuli were presented in front of threatening or neutral contextual images. To capture defense system activation, we recorded subjective (threat, US-expectancy), physiological (skin conductance, heart rate) and visuocortical (steady-state visual evoked potentials) responses to the conditioned stimuli as a function of contextual threat. Results demonstrated successful fear conditioning in all measures. In addition, threat and US-expectancy ratings, cardiac deceleration, and visuocortical activity were enhanced for fear cues presented in threatening compared with neutral contexts. These results are in line with an additive or interactive rather than an exclusive model of fear and anxiety, indicating facilitated defensive behavior to imminent danger in situations of potential threat.},
  language  = {en}
}