@article{TonyLehrnbecherMerzetal.1991, author = {Tony, H. P. and Lehrnbecher, T. and Merz, H. and Sebald, Werner and Wilhelm, M.}, title = {Regulation of IL-4 responsiveness in lymphoma B cells}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-62520}, year = {1991}, abstract = {The responsiveness to IL-4 with and without costimulation with anti-IgM antibodies or phorbolester was studied in 35 cases of low grade non-Hodgkin Iymphoma by analyzing enhancement of CD23 and HLA dass li expression. The predominant phenotype responds directly to IL-4. Separate differentiation states can be distinguished according to coordinate or differential upregulation of CD23 and HLA dass II molecules by IL-4 alone, and differences in responsiveness to anti-IgM antibodies. A particular subgroup of B-lymphoma cells defines a separate stage of B-eeil differentiation. They fail to express high affinity binding sites for IL-4 and accordingly do not respond to IL-4- mediated signals. Cross-linking membrane lgM receptors or direct activation of protein kinase C via phorbolester induces IL-4 receptor expression and subsequent IL-4 reactivity.}, subject = {Biochemie}, language = {en} } @article{PreiserSchmartzVanderLindenetal.1991, author = {Preiser, J. C. and Schmartz, D. and Van der Linden, P. and Content, J. and Vanden Bussche, P. and Buurman, W. and Sebald, Werner and Dupont, E. and Pinsky, M. R. and Vincent, J. L.}, title = {Interleukin-6 administration has no acute hemodynamic or hematologic effect in the dog}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-62511}, year = {1991}, abstract = {To investigate the possible hemodynamic efl'ects of interleukin-6 (IL-6), a single dose of 15 mcg/kg of recombinant IL-6 isolated from Escherichia coli was injected intravenously in six pentobarbital-anesthetized dogs. After 30 min, saline infusion was performed to maintain the - pulmonary artery balloon-occluded pressure at baseline Ievel. The animals were observed for up to 5 hours. No other hemodynamic alteration was observed than a gradual decline in cardiac output attributed to anesthesia. Hematologic variables, blood glucose, and total serum proteins were also constant. IL-6 levels were markedly elevated in the blood, bot no tumor necrosis factor activity was detected. Thus a primary role for IL-6 in the early cardiovascular alterations associated with septic shock seems unlikely.}, subject = {Biochemie}, language = {en} } @article{WernerSebald1981, author = {Werner, S. and Sebald, Werner}, title = {Immunological techniques for studies on the biogenesis of mitochondrial membrane proteins}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-82044}, year = {1981}, abstract = {no abstract available}, subject = {Biochemie}, language = {en} }