@article{RadakovicPenovLazarusetal.2023,
  author    = {Radakovic, Dejan and Penov, Kiril and Lazarus, Marc and Madrahimov, Nodir and Hamouda, Khaled and Schimmer, Christoph and Leyh, Rainer G. and Bening, Constanze},
  title     = {The completeness of the left atrial appendage amputation during routine cardiac surgery},
  series = {BMC Cardiovascular Disorders},
  volume    = {23},
  journal   = {BMC Cardiovascular Disorders},
  doi       = {10.1186/s12872-023-03330-8},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-357376},
  year      = {2023},
  abstract  = {Background Left atrial appendage (LAA) is the origin of most heart thrombi which can lead to stroke or other cerebrovascular event in patients with non-valvular atrial fibrillation (AF). This study aimed to prove safety and low complication rate of surgical LAA amputation using cut and sew technique with control of its effectiveness. Methods 303 patients who have undergone selective LAA amputation were enrolled in the study in a period from 10/17 to 08/20. The LAA amputation was performed concomitant to routine cardiac surgery on cardiopulmonary bypass with cardiac arrest with or without previous history of AF. The operative and clinical data were evaluated. Extent of LAA amputation was examined intraoperatively by transoesophageal echocardiography (TEE). Six months in follow up, the patients were controlled regarding clinical status and episodes of strokes. Results Average age of study population was 69.9 ± 19.2 and 81.9\% of patients were male. In only three patients was residual stump after LAA amputation larger than 1 cm with average stump size 0.28 ± 0.34 cm. 3 patients (1\%) developed postoperative bleeding. Postoperatively 77 (25.4\%) patients developed postoperative AF (POAF), of which 29 (9.6\%) still had AF at discharge. On 6 months follow up only 5 patients had NYHA class III and 1 NYHA class IV. Seven patients reported with leg oedema and no patient experienced any cerebrovascular event in early postoperative follow up. Conclusion LAA amputation can be performed safely and completely leaving minimal to no LAA residual stump.},
  language  = {en}
}
@article{PenovRadakovicMadrahimovetal.2022,
  author    = {Penov, Kiril and Radakovic, Dejan and Madrahimov, Nodir and Aleksic, Ivan},
  title     = {Subacute Aortic Rupture Due to Mechanical Chest Compression with Indwelling Impella},
  series = {The Thoracic and Cardiovascular Surgeon Reports},
  volume    = {11},
  journal   = {The Thoracic and Cardiovascular Surgeon Reports},
  number    = {1},
  issn      = {2194-7635},
  doi       = {10.1055/s-0042-1757873},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-300174},
  pages     = {e64 -- e66},
  year      = {2022},
  abstract  = {Mechanical cardiopulmonary resuscitation (CPR) devices like Lund University Cardiopulmonary Assist System (LUCAS) cause more skeletal and visceral injuries than standard CPR. A 62-year-old woman with ST-elevation myocardial infarction was resuscitated with LUCAS and Impella CP for refractory cardiogenic shock during percutaneous coronary intervention. She suffered delayed ascending aortic rupture necessitating supracommissural ascending aortic replacement plus triple bypass grafting. Prolonged mechanical CPR with concomitant Impella may lead to aortic rupture. The combined use of LUCAS and Impella may have disastrous consequences.},
  language  = {en}
}
@article{RadakovicPenovHamoudaetal.2022,
  author    = {Radakovic, Dejan and Penov, Kiril and Hamouda, Khaled and Madrahimov, Nodir and Radakovic, Darko and Bening, Constanze and Leyh, Rainer G. and Aleksic, Ivan},
  title     = {Benefits of intra-aortic balloon pump support in patients with postcardiotomy shock requiring venoarterial extracorporeal membrane oxygenation},
  series = {Life},
  volume    = {12},
  journal   = {Life},
  number    = {8},
  issn      = {2075-1729},
  doi       = {10.3390/life12081195},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-286241},
  year      = {2022},
  abstract  = {Background: The benefit of the combined use of an intra-aortic balloon pump (IABP) and venoarterial extracorporeal membrane oxygenation (VA-ECMO) for postcardiotomy shock remains unclear. We aimed to analyse the potential benefits and safety of combining these two devices. Methods: We enrolled 200 patients treated with either VA-ECMO only or in combination with IABP (ECMO-I group) between January 2012 and January 2021. To adjust the patients' backgrounds, we used propensity score matching for additional analyses, resulting in 57 pairs. The primary endpoint was 30-day survival. Secondary endpoints included successful weaning and complication rates. We also analysed hemodynamic parameters in both groups. Results: After propensity score matching, 30-day survival was better in the ECMO-I group (log-rank p = 0.004). The ECMO-I and ECMO-only groups differed regarding the secondary endpoints, including successful weaning (50.9\% and 26.3\%, respectively; p = 0.012) and the need for continuous renal replacement therapy (28.1\% and 50.9\%, p = 0.021). Complication rates were not statistically different between the two groups. Conclusion: Compared to VA-ECMO alone, the combined use of VA-ECMO and IABP is beneficial regarding 30-day survival in selected patients with postcardiotomy shock; successful ECMO weaning and freedom from renal replacement therapy is more common in patients supported with VA-ECMO plus IABP.},
  language  = {en}
}