@article{MollRoellinghoff1990,
  author    = {Moll, Heidrun and R{\"o}llinghoff, Martin},
  title     = {Resistance to murine cutaneous leishmaniasis is mediated by T\(_H\)1 cells, but disease-promoting CD4\(^+\) cells are different from T\(_H\)2 cells},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-61305},
  year      = {1990},
  abstract  = {No abstract available},
  subject      = {Biologie},
  language  = {en}
}
@article{MollScollayMitchell1988,
  author    = {Moll, Heidrun and Scollay, R. and Mitchell, G. F.},
  title     = {Resistance to cutaneous leishmaniasis in nude mice injected with L3T4+ T cells but not with Ly-2+ T cells},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-61269},
  year      = {1988},
  abstract  = {No abstract available},
  subject      = {Biologie},
  language  = {en}
}
@article{MollScollay1989,
  author    = {Moll, Heidrun and Scollay, Roland},
  title     = {L3T4+ T cells promoting susceptibility to murine cutaneous leishmaniasis express the surface marker Ly-24 (Pgp-1)},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-61275},
  year      = {1989},
  abstract  = {No abstract available},
  subject      = {Biologie},
  language  = {en}
}
@article{MollMuellerGillitzeretal.1991,
  author    = {Moll, Heidrun and M{\"u}ller, Christoph and Gillitzer, Reinhard and Fuchs, Harald and R{\"o}llinghoff, Martin and Simon, Markus M. and Kramer, Michael D.},
  title     = {Expression of T-cell-associated serine proteinase-1 during murine Leishmania major infection correlates with susceptibility to disease},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-61311},
  year      = {1991},
  abstract  = {The expression of T-cell-associated serine proteinase 1 (MTSP-1) in vivo during Leishmania major infection was analyzed in genetically resistant C57BL/6 mice and in genetically susceptible BALB/c mice. Using a monoclonal antibody as well as an RNA probe specific for MTSP-1 to stain tissue sections, we found T cells expressing MTSP-1 in skin lesions and spleens of mice of both strains. In skin lesions, MTSP-1-positive T cells could be detected as early as 3 days after infection. Most importantly, the frequency of T cells expressing MTSP-1 was significantly higher in susceptible BALB/c mice than in resistant C57BL/6 mice. These findings suggest that MTSP-1 is associated with disease-promoting T cells and that it may be an effector molecule involved in the pathogenesis of cutaneous leishmaniasis.},
  subject      = {Biologie},
  language  = {en}
}
@article{MollMitchellMcConvilleetal.1989,
  author    = {Moll, Heidrun and Mitchell, Graham F. and McConville, Malcom J. and Handman, Emanuela},
  title     = {Evidence for T cell recognition in mice of a purified lipophosphoglycan from Leishmania major},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-61288},
  year      = {1989},
  abstract  = {We have previously reported that a Leishmania major lipophosphoglycan (LPG), given with killed Corynebacterium parvum as an adjuvant, can vaccinate mice against cutaneous leishmaniasis. In order to analyze whetber T cells are able to recognize this important parasite antigen, we have studied both humoral and cellular immune responses to L. major LPG that bad been isolated from promastigotes by sequential solvent extraction and bydrophobic chromatography. The data sbow that immunization of mice with highly purified LPG induced an increase in frequency of L. major-reactive T cells and the production of immunoglobulin G antibodies to LPG. Furthermore, genetically resistant mice infected with L. major were able to develop a specific delayed-type hypersensitivity response in the ear to L. major LPG. These findings strongly suggest that T cells can recognize and respond to glycolipid antigens, in this case a bost-protective Leishmania LPG, even though such antigens appear not to be potent T-cell stimulators in mice.},
  subject      = {Biologie},
  language  = {en}
}
@article{Moll1993,
  author    = {Moll, Heidrun},
  title     = {Epidermal Langerhans cells are critical for immunoregulation of cutaneous leishmaniasis},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-61323},
  year      = {1993},
  abstract  = {In leishmaniasis, macrophages are known to play a central role as modulators of the specific immune activity. In this article, Heidrun Moll presents evidence for the critical involvement of another component of the skin immune system, the epidermal Langerhans cell. She proposes that Langerhans cells take up parasites in the skin and transport them to the draining lymph node for presentation to T cells and initiation of the specific immune response.},
  subject      = {Biologie},
  language  = {en}
}
@article{KramerBinningerSchirrmacheretal.1986,
  author    = {Kramer, Michael D. and Binninger, Linda and Schirrmacher, Volker and Moll, Heidrun and Prester, Marlot and Nerz, Gaby and Simon, Markus M.},
  title     = {Characterization and isolation of a trypsin-like serine protease from a long-term culture cytolytic t cell line andits expression by functionally distinct T cells},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-31636},
  year      = {1986},
  abstract  = {No abstract available},
  subject      = {Biologie},
  language  = {en}
}
@article{PimentelElardoKozytskaBugnietal.2010,
  author    = {Pimentel-Elardo, Sheila Marie and Kozytska, Svitlana and Bugni, Tim S. and Ireland, Chris M. and Moll, Heidrun and Hentschel, Ute},
  title     = {Anti-Parasitic Compounds from Streptomyces sp. Strains Isolated from Mediterranean Sponges},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-68312},
  year      = {2010},
  abstract  = {Actinomycetes are prolific producers of pharmacologically important compounds accounting for about 70\% of the naturally derived antibiotics that are currently in clinical use. In this study, we report on the isolation of Streptomyces sp. strains from Mediterranean sponges, on their secondary metabolite production and on their screening for anti-infective activities. Bioassay-guided isolation and purification yielded three previously known compounds namely, cyclic depsipeptide valinomycin, indolocarbazole alkaloid staurosporine and butenolide. This is the first report of the isolation of valinomycin from a marine source. These compounds exhibited novel anti-parasitic activities specifically against Leishmania major (valinomycin IC50 < 0.11 μM; staurosporine IC50 5.30 μM) and Trypanosoma brucei brucei (valinomycin IC50 0.0032 μM; staurosporine IC50 0.022 μM; butenolide IC50 31.77 μM). These results underscore the potential of marine actinomycetes to produce bioactive compounds as well as the re-evaluation of previously known compounds for novel anti-infective activities.},
  subject      = {Biologie},
  language  = {en}
}