@inproceedings{HeiserUlrichsEcksteinetal.1992,
  author    = {Heiser, A. and Ulrichs, Karin and Eckstein, V. and M{\"u}ller-Ruchholtz, W.},
  title     = {Xenogeneic Cellular Response of Human Lymphocytes Against Porcine Lymphocytes and Isolated Pancreatic Islets},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-45479},
  year      = {1992},
  abstract  = {no abstract available},
  language  = {en}
}
@article{EngemannUlrichsThiedeetal.1990,
  author    = {Engemann, R. and Ulrichs, Karin and Thiede, A. and M{\"u}ller-Ruchholtz, W. and Hamelmann, H.},
  title     = {Value of a physiological liver transplant model in rats. Induction of specific graft tolerance in a fully allogeneic strain combination},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-45622},
  year      = {1990},
  abstract  = {No abstract available},
  language  = {en}
}
@inproceedings{KaitschickUlrichsMuellerRuchholtz1991,
  author    = {Kaitschick, J. and Ulrichs, K. and M{\"u}ller-Ruchholtz, W.},
  title     = {The New Immunosuppressant Leflunomide Appears To Be a Potent Inhibitor of Humoral Xeno Sensitization},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-45727},
  year      = {1991},
  abstract  = {No abstract available},
  subject      = {Immunbiologie},
  language  = {en}
}
@inproceedings{HeiserUlrichsEcksteinetal.1992,
  author    = {Heiser, A. and Ulrichs, Karin and Eckstein, V. and M{\"u}ller-Ruchholtz, W.},
  title     = {The Human Cell Mediated Response to Xenogeneic (Porcine) Transplantation Antigen Depends on the Stimulator Cell Compartment},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-45670},
  year      = {1992},
  abstract  = {No abstract available},
  language  = {en}
}
@article{WinotoMorbachLeyhausenMuellerRuchholtzetal.1988,
  author    = {Winoto-Morbach, S. and Leyhausen, G. and M{\"u}ller-Ruchholtz, W. and Ulrichs, Karin},
  title     = {The Electromagnetic Separation Principle: A Basis for Human Pancreatic Islet Transplantation},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-82520},
  year      = {1988},
  abstract  = {No abstract available},
  subject      = {Allergie},
  language  = {en}
}
@article{UlrichsKaitschickBartlettetal.1992,
  author    = {Ulrichs, Karin and Kaitschick, J. and Bartlett, R. and M{\"u}ller-Ruchholtz, W.},
  title     = {Suppression of natural xenophile antibodies with the novel immunomodulating drug leflunomide},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-45202},
  year      = {1992},
  abstract  = {No abstract available},
  subject      = {Chirurgie},
  language  = {en}
}
@article{DickneiteSchorlemmerSedlaceketal.1987,
  author    = {Dickneite, G. and Schorlemmer, H. U. and Sedlacek, H. H. and Falk, W. and Ulrichs, Karin and M{\"u}ller-Ruchholtz, W.},
  title     = {Suppression of macrophage function and prolongation of graft survival by the new guanidinic-like structure, 15-deoxyspergualin},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-86991},
  year      = {1987},
  abstract  = {No abstract available.},
  subject      = {Makrophage},
  language  = {en}
}
@article{UlrichsMuellerRuchholtz1989,
  author    = {Ulrichs, Karin and M{\"u}ller-Ruchholtz, W.},
  title     = {Significant manipulative procedures to reduce immunogenicity of human islet allografts},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-45155},
  year      = {1989},
  abstract  = {No abstract available},
  subject      = {Chirurgie},
  language  = {en}
}
@article{UlrichsKellerMuellerRuchholtz1985,
  author    = {Ulrichs, Karin and Keller, R. and M{\"u}ller-Ruchholtz, W.},
  title     = {Serological demonstration and manipulation of passenger cells (PC) in pancreas islet grafts},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-72944},
  year      = {1985},
  abstract  = {No abstract available},
  subject      = {Immunobiologie},
  language  = {en}
}
@article{UlrichsSchangKelleretal.1984,
  author    = {Ulrichs, Karin and Schang, T. and Keller, R. and M{\"u}ller-Ruchholtz, W.},
  title     = {Reactivity of pancreas islet cells with antisera of known specificity},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-45466},
  year      = {1984},
  abstract  = {No abstract available},
  language  = {en}
}
@article{HeiserUlrichsMuellerRuchholtz1994,
  author    = {Heiser, A. and Ulrichs, Karin and M{\"u}ller-Ruchholtz, W.},
  title     = {Prophylactic trypsin inhibition during the isolation procedure guarantees reproducible, high porcine islet yields},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-45531},
  year      = {1994},
  abstract  = {Abstract: For isolating islets from the porcine pancreas, we established a semiautomated digestion method. Although the isolation technique was standardized and collagenase of controlled quality was used, until now the reproducibility of high islet yields was unsatisfactory. Our hypothesis was that pancreatic trypsin was responsible for this failure. The aim of this study was to investigate the effect of endogenous trypsin on islet yield. Our results demonstrate that a high trypsin level correlates with poor islet yield, whereas low trypsin activity always correlates with high islet yield. Specific inhibition of trypsin results in low trypsin activity and reproducible, high islet yields.},
  language  = {en}
}
@inproceedings{HedkeEcksteinMayetal.1993,
  author    = {Hedke, K. and Eckstein, V. and May, G. and Kaden, J. and M{\"u}ller-Ruchholtz, W. and Ulrichs, Karin},
  title     = {Production of Xenophile Antibodies (XA) in Type I Diabetic Patients is Strongly Influenced by Diabetes and/or Dialysis},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-45642},
  year      = {1993},
  abstract  = {No abstract available},
  language  = {en}
}
@article{UlrichsKuhlencordtMuellerRuchholtz1979,
  author    = {Ulrichs, Karin and Kuhlencordt, KM and M{\"u}ller-Ruchholtz, W.},
  title     = {Plating inhibition assay (PIA): a new test for cell mediated cytotoxicity},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-45443},
  year      = {1979},
  abstract  = {No abstract available},
  language  = {en}
}
@article{KekowUlrichsMuellerRuchholtzetal.1987,
  author    = {Kekow, J. and Ulrichs, Karin and M{\"u}ller-Ruchholtz, W. and Gross, WL},
  title     = {Pancreas transplantation: a study of insulin secretion in isolated islets of Langerhans and in sera using a new enzyme-linked immunosorbent assay},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-45229},
  year      = {1987},
  abstract  = {No abstract available},
  subject      = {Chirurgie},
  language  = {en}
}
@inproceedings{WinotoMorbachUlrichsMuellerRuchholtz1991,
  author    = {Winoto-Morbach, S. and Ulrichs, Karin and M{\"u}ller-Ruchholtz, W.},
  title     = {New Developments in Biodegradable Microspheres For Magnetic Separation Techniques},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-45712},
  year      = {1991},
  abstract  = {No abstract available},
  subject      = {Immunbiologie},
  language  = {en}
}
@article{EcksteinUlrichsMeinckeetal.1992,
  author    = {Eckstein, V. and Ulrichs, K. and Meincke, G. and M{\"u}ller-Ruchholtz, W.},
  title     = {Natural xenophile antibodies from sera of type I diabetic patients differ strongly in their reactivity against various porcine pancreatic cells},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-45277},
  year      = {1992},
  abstract  = {No abstract available},
  subject      = {Chirurgie},
  language  = {en}
}
@article{LausUlrichsMuellerRuchholtz1986,
  author    = {Laus, R. and Ulrichs, Karin and M{\"u}ller-Ruchholtz, W.},
  title     = {Molecular Specificity of Human Heterophile Antibodies (HHA) in Normal Human Serum (NHS) Reacting with Xenogeneic Cells.},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-72921},
  year      = {1986},
  abstract  = {No abstract available},
  subject      = {Immunobiologie},
  language  = {en}
}
@article{UlrichsMuellerRuchholtz1990,
  author    = {Ulrichs, Karin and M{\"u}ller-Ruchholtz, W.},
  title     = {Mixed lymphocyte islet culture (MLIC) and its use in manipulation of human islet alloimmunogenicity},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-45515},
  year      = {1990},
  abstract  = {No abstract available},
  language  = {en}
}
@article{UlrichsDeltzThiedeetal.1982,
  author    = {Ulrichs, Karin and Deltz, E. and Thiede, A. and M{\"u}ller-Ruchholtz, W.},
  title     = {Lymphoid tissue transplantation in rats leads to a GVHR, inducing a specific T-cell mediated autoreactivity against MHC-antigens},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-45420},
  year      = {1982},
  abstract  = {No abstract available},
  language  = {en}
}
@article{WinotoMorbachUlrichsHeringetal.1990,
  author    = {Winoto-Morbach, S. and Ulrichs, Karin and Hering, BJ and Leyhausen, G. and M{\"u}ller-Ruchholtz, W.},
  title     = {Lectins for electromagnetic purification of islets from humans and large mammals},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-45430},
  year      = {1990},
  abstract  = {No abstract available},
  subject      = {Chirurgie},
  language  = {en}
}
@article{WinotoMorbachKroutHeiseretal.1994,
  author    = {Winoto-Morbach, S. and Krout, OS and Heiser, A. and Ulrichs, Karin and M{\"u}ller-Ruchholtz, W.},
  title     = {Lectin binding to acinar tissue for complete magnetophoretic purification of porcine pancreatic islets depends on the composition and pH of the incubation medium},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-45183},
  year      = {1994},
  abstract  = {No abstract available},
  subject      = {Chirurgie},
  language  = {en}
}
@article{HeiserMuellerRuchholtzUlrichs1994,
  author    = {Heiser, A. and M{\"u}ller-Ruchholtz, W. and Ulrichs, Karin},
  title     = {Isolation of Islets of Langerhans: Improvement of the Isolation Technique Using the Pig Model.},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-87765},
  year      = {1994},
  abstract  = {During the last view years, interest in pancreatic islet transplantation for the cure of type I diabetes has increased markedly. A serious barrier to clinical islet transplantation is the isolation of a sufficient mass of viable and functional islets. We used a porcine islet isolation model to examine various parameters of the isolation procedure and to improve isolation technique.},
  subject      = {Langerhans-Inseln},
  language  = {en}
}
@article{HeiserUlrichsMuellerRuchholtz1994,
  author    = {Heiser, A. and Ulrichs, Karin and M{\"u}ller-Ruchholtz, W.},
  title     = {Influence of porcine strain, age, and pH of the isolation medium on porcine pancreatic islet isolation success},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-45171},
  year      = {1994},
  abstract  = {No abstract available},
  subject      = {Chirurgie},
  language  = {en}
}
@article{UlrichsYuDunckeretal.1984,
  author    = {Ulrichs, Karin and Yu, MY and Duncker, D. and M{\"u}ller-Ruchholtz, W.},
  title     = {Immunosuppression by cytostatic drugs?},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-45574},
  year      = {1984},
  abstract  = {In the present study, an attempt was made to characterize the immunomodulating abilities of the cytostatic drugs cydophosphamide, ifosfamide, vinblastine, vincristine, procarbazine, dacarbazine, 6-mercaptopurine, methotrexate, 5-f/uor-uracil and adriamycine in a defined experimental model. Varying combinations of drug plus transplantation alloantigen, (C3H-lymphocytes) were injected into Balb/c mice at different time intervals in vivo. The resulting T-effector cell reactivity was determined in vitro with the microcytotoxicity assay on day + 5 for primary (r) and day + 7 for secondary (2°) sensitized mice. According to the type of drug (alkylating agent vs. vinca alkaloid vs. antimetabolite vs. cytostatic antibiotic), the dosage (20\% LD50 vs. 60\% LD50), the state of sensitization (r vs. 2° sensitized recipients), and the time of drug application in relation to the antigen treatment on day 0 (in varying steps from day -6 to day +4), so-called "pharmaconantigen- variation-effects" (PA VE) were established for each of the investigated drugs in form of reaction profiles. The results were as folIows: (1) For almost alt substances, characteristic reaction profiles involving immunostimulation and/or immunosuppression could be established. Similarities in the profiles of different substances made it possible to classify the drugs according to different reaction types. The reaction type however is not definitely correlated to the biochemical mechanism of drug action. (2) The PA VE are decisively inf/uenced by so me of the biological parameters, such as the time of drug application in relation to the antigen treatment and the state of sensitization but relatively !ittle by the dosage of the drug. (3) Considering the different processes occurring du ring primary and secondary immune responses, the PAVE may give hints for a distinct manipulation of the immunoregulation and thus information on the immunobiological mechanism of drug action.},
  subject      = {Immunologie},
  language  = {en}
}
@misc{UlrichsMuellerRuchholtz1989,
  author    = {Ulrichs, Karin and M{\"u}ller-Ruchholtz, W.},
  title     = {Identification and Manipulation of Human Islet Alloimmunogenicity: Morphologic and Functional in Vitro Studies with Various Islet Preparations},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-45584},
  year      = {1989},
  abstract  = {No abstract available},
  subject      = {Immunbiologie},
  language  = {en}
}
@article{UlrichsBosseWackeretal.1994,
  author    = {Ulrichs, Karin and Bosse, M. and Wacker, HH and Heiser, A. and M{\"u}ller-Ruchholtz, W.},
  title     = {Histologic analysis of the porcine pancreas to improve islet yield and integrity after collagenase digestion},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-45166},
  year      = {1994},
  abstract  = {No abstract available},
  subject      = {Chirurgie},
  language  = {en}
}
@article{UlrichsMuellerRuchholtz1985,
  author    = {Ulrichs, Karin and M{\"u}ller-Ruchholtz, W.},
  title     = {Further Analyses of Pancreas Islet Immunogenicity, a Major Barrier to Successful Islet Transplantation},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-45563},
  year      = {1985},
  abstract  = {No abstract available},
  subject      = {Chirurgie},
  language  = {en}
}
@inproceedings{UlrichsEcksteinKorsgrenetal.1993,
  author    = {Ulrichs, Karin and Eckstein, V. and Korsgren, O. and M{\"u}ller-Ruchholtz, W.},
  title     = {Expression of Porcine Pancreatic Islet Antigens Varies and Determines Binding of Human Natural Xenophile Antibodies (NXA)},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-45655},
  year      = {1993},
  abstract  = {No abstract available},
  subject      = {Immunbiologie},
  language  = {en}
}
@article{UlrichsMuellerRuchholtz1988,
  author    = {Ulrichs, Karin and M{\"u}ller-Ruchholtz, W.},
  title     = {Expression of MHC Structures on Immunologically Reactive and Non Reactive Cells in Islets of Langerhans and Other Tissues},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-45557},
  year      = {1988},
  abstract  = {No abstract available},
  subject      = {Chirurgie},
  language  = {en}
}
@inproceedings{HeiserUlrichsMuellerRuchholtz1994,
  author    = {Heiser, A. and Ulrichs, Karin and M{\"u}ller-Ruchholtz, W.},
  title     = {Enzyme Kinetics of Commercial Collagenases and their Influence on Porcine Islet Isolation},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-45488},
  year      = {1994},
  abstract  = {No abstract available},
  subject      = {Heterotransplantation},
  language  = {en}
}
@inproceedings{HeiserUlrichsMuellerRuchholtz1994,
  author    = {Heiser, A. and Ulrichs, Karin and M{\"u}ller-Ruchholtz, W.},
  title     = {Enzyme Activities in Commercial Collagenase Preparations and Their Kinetics During Islet Isolation Procedure},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-45633},
  year      = {1994},
  abstract  = {No abstract available},
  subject      = {Transplantation},
  language  = {en}
}
@inproceedings{WangUlrichsMuellerRuchholtz1993,
  author    = {Wang, HY and Ulrichs, Karin and M{\"u}ller-Ruchholtz, W.},
  title     = {Down-Regulation of Xenophile Antibodies by Specific Immunosuppressive Protocols to Facilitate Xenogeneic Organ Transplantation},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-45669},
  year      = {1993},
  abstract  = {No abstract available},
  subject      = {Immunbiologie},
  language  = {en}
}
@article{DeltzMuellerHermelinkUlrichsetal.1981,
  author    = {Deltz, E. and M{\"u}ller-Hermelink, HK and Ulrichs, Karin and Thiede, A. and M{\"u}ller-Ruchholtz, W.},
  title     = {Development of graft-versus-host reaction in various target organs after small intestine transplantation},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-45459},
  year      = {1981},
  abstract  = {The GVHRIL foHowing transplantation of small intestine are different from those found after bone marrow transplantation or spleen cell injections in that they show a remarka ble, significant prevalence of lesions within the intestinal mucosa. These findings are consistent with the observation that jntestinal lymphocytes newly formed in mesenteric lymph nodes predominantly home in on the intestine again.\& The degree of histologic alteration within different tissues indicates that the graft and the host may survive the lesions of the lymphatic tissues, whereas the severe intestinal lesions following GVHR may easily cause death of the recipient. With regard to clinical sman bowel transplantation two statements can be made: (l) GVHRIL play a significant role in small bowel trans~ plantation. (2) To minimize their biologic importance, a selective elimination of the graft's Jymph nodes by irradiation or surgical resection should be considered in view of the remarkable difference between GVHRIL in lymph nodes and in the graft's intestinal wall itself.},
  subject      = {Chirurgie},
  language  = {en}
}
@article{UlrichsWinotoMorbachHeringetal.1990,
  author    = {Ulrichs, Karin and Winoto-Morbach, S. and Hering, B. and M{\"u}ller-Ruchholtz, W.},
  title     = {A Useful Biotechnological Approach to Solve the Problem of Graft Purity in Human Pancreatic Islet Transplantation},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-45619},
  year      = {1990},
  abstract  = {No abstract available},
  subject      = {Chirurgie},
  language  = {en}
}
@inproceedings{UlrichsEulerMuellerRuchholtz1991,
  author    = {Ulrichs, Karin and Euler, HH and M{\"u}ller-Ruchholtz, W.},
  title     = {A Clinically Successful Protocol to Suppress Autoantibody Production in SLE Patients Is Analyzed For Its Efficacy To Inhibit Natural Xenophile Antibodies (NXA)},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-45693},
  year      = {1991},
  abstract  = {No abstract available},
  language  = {en}
}
@article{FalkUlrichsMuellerRuchholtz1987,
  author    = {Falk, W. and Ulrichs, Karin and M{\"u}ller-Ruchholtz, W.},
  title     = {15-Deoxyspergualin (a new guanidine-like drug) blocks T lymphocyte proliferation},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-45215},
  year      = {1987},
  abstract  = {No abstract available},
  subject      = {Chirurgie},
  language  = {en}
}