@article{PetrasekProkopovaSladeketal.2014,
  author    = {Petrasek, Tomas and Prokopova, Iva and Sladek, Martin and Weissova, Kamila and Vojtechova, Iveta and Bahnik, Stepan and Zemanova, Anna and Sch{\"o}nig, Kai and Berger, Stefan and Tews, Bjoern and Bartsch, Dusan and Schwab, Martin E. and Sumova, Alena and Stuchlik, Ales},
  title     = {Nogo-A-deficient transgenic rats show deficits in higher cognitive functions, decreased anxiety, and altered circadian activity patterns},
  series = {Frontiers in Behavioral Neuroscience},
  volume    = {8},
  journal   = {Frontiers in Behavioral Neuroscience},
  number    = {90},
  doi       = {10.3389/fnbeh.2014.00090},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-117073},
  year      = {2014},
  abstract  = {Decreased levels of Nogo-A-dependent signaling have been shown to affect behavior and cognitive functions. In Nogo-A knockout and knockdown laboratory rodents, behavioral alterations were observed, possibly corresponding with human neuropsychiatric diseases of neurodevelopmental origin, particularly schizophrenia. This study offers further insight into behavioral manifestations of Nogo-A knockdown in laboratory rats, focusing on spatial and non-spatial cognition, anxiety levels, circadian rhythmicity, and activity patterns. Demonstrated is an impairment of cognitive functions and behavioral flexibility in a spatial active avoidance task, while non-spatial memory in a step-through avoidance task was spared. No signs of anhedonia, typical for schizophrenic patients, were observed in the animals. Some measures indicated lower anxiety levels in the Nogo-A-deficient group. Circadian rhythmicity in locomotor activity was preserved in the Nogo-A knockout rats and their circadian period (tau) did not differ from controls. However, daily activity patterns were slightly altered in the knockdown animals. We conclude that a reduction of Nogo-A levels induces changes in CNS development, manifested as subtle alterations in cognitive functions, emotionality, and activity patterns.},
  language  = {en}
}