@article{SchrueferBrockowStoevesandtetal.2020,
  author    = {Schr{\"u}fer, Philipp and Brockow, Knut and Stoevesandt, Johanna and Trautmann, Axel},
  title     = {Predominant patterns of beta-lactam hypersensitivity in a single German Allergy Center: exanthem induced by aminopenicillins, anaphylaxis by cephalosporins},
  series = {Allergy, Asthma \& Clinical Immunology},
  volume    = {16},
  journal   = {Allergy, Asthma \& Clinical Immunology},
  doi       = {10.1186/s13223-020-00488-0},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-231306},
  year      = {2020},
  abstract  = {Background Penicillins and other beta-lactam antibiotics are the most common elicitors of allergic drug reaction. However, data on the pattern of clinical reaction types elicited by specific beta-lactams are scarce and inconsistent. We aimed to determine patterns of beta-latam allergy, i.e. the association of a clinical reaction type with a specific beta-lactam antibiotic. Methods We retrospectively evaluated data from 800 consecutive patients with suspected beta-lactam hypersensitivity over a period of 11 years in a single German Allergy Center. Results beta-lactam hypersensitivity was definitely excluded in 595 patients, immediate-type (presumably IgE-mediated) hypersensitivity was diagnosed in 70 and delayed-type hypersensitivity in 135 cases. Most (59 out of 70, 84.3\%) immediate-type anaphylactic reactions were induced by a limited number of cephalosporins. Delayed reactions were regularly caused by an aminopenicillin (127 out of 135, 94.1\%) and usually manifested as a measles-like exanthem (117 out of 135, 86.7\%). Intradermal testing proved to be the most useful method for diagnosing beta-lactam allergy, but prick testing was already positive in 24 out of 70 patients with immediate-type hypersensitivity (34.3\%). Patch testing in addition to intradermal testing did not provide additional information for the diagnosis of delayed-type hypersensitivity. Almost all beta-lactam allergic patients tolerated at least one, usually several alternative substances out of the beta-lactam group. Conclusions We identified two patterns of beta-lactam hypersensitivity: aminopenicillin-induced exanthem and anaphylaxis triggered by certain cephalosporins. Intradermal skin testing was the most useful method to detect both IgE-mediated and delayed-type beta-lactam hypersensitivity.},
  language  = {en}
}
@article{TrautmannBrockowStoevesandt2020,
  author    = {Trautmann, Axel and Brockow, Knut and Stoevesandt, Johanna},
  title     = {Metamizole-induced reactions as a paradigm of drug hypersensitivity: Non-allergic reactions, anaphylaxis, and delayed-type allergy},
  series = {Clinical \& Experimental Allergy},
  volume    = {50},
  journal   = {Clinical \& Experimental Allergy},
  number    = {9},
  doi       = {10.1111/cea.13689},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-217997},
  pages     = {1103 -- 1106},
  year      = {2020},
  language  = {en}
}