@article{KerkauSchmittLandgrafSchimpletal.1989,
  author    = {Kerkau, Thomas and Schmitt-Landgraf, Renate and Schimpl, Anneliese and Wecker, Eberhard},
  title     = {Downregulation of HLA Class I Antigensin HIV-1-Infected Cells},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-47172},
  year      = {1989},
  abstract  = {By means of indirect immunofluorescence analysis we investigated the effect of HIV -1 infection on HLA class I surface antigens. We report here that in CD4\(^+\) HeLa cells, in H9 cells, and in peripheral T Iymphocytes HLA class I antigens are down regulated following infection with HIV -1. The downregulation is effected at a posttranscriptional level since the amounts of HLA class I specific mRNA are similar in infected and uninfected cells. This phenomenon is not only correlated with the state of infection, that is, the presence of P24 of HIV-l in the cells, but also depends on the time of infection. Upon HLA class I downregulation by HIV infection, the specific lysis of peripheral blood cells by allogeneic CTL is reduced.},
  language  = {en}
}