@article{Nord2017,
  author    = {Nord, Ilona},
  title     = {Wolfhard Schweiker, Prinzip Inklusion. Grundlagen einer interdisziplin{\"a}ren Metatheorie in religionsp{\"a}dagogischer Perspektive. G{\"o}ttingen: Vandenhoeck \& Ruprecht 2017.},
  series = {Zeitschrift f{\"u}r P{\"a}dagogik und Theologie},
  volume    = {69},
  journal   = {Zeitschrift f{\"u}r P{\"a}dagogik und Theologie},
  number    = {3},
  issn      = {2366-7796},
  doi       = {10.1515/zpt-2017-0032},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-194874},
  pages     = {284-287},
  year      = {2017},
  abstract  = {Kein Abstract verf{\"u}gbar.},
  language  = {de}
}
@article{Kraft2017,
  author    = {Kraft, Stephan},
  title     = {Wider den „Hauffen junger Schnautzhahnen" : Grimmelshausens Versuch, die Erinnerung an den Dreißigj{\"a}hrigen Krieg in der Gegenwart festzuhalten},
  series = {Internationales Archiv f{\"u}r Sozialgeschichte der deutschen Literatur},
  volume    = {42},
  journal   = {Internationales Archiv f{\"u}r Sozialgeschichte der deutschen Literatur},
  number    = {1},
  issn      = {1865-9128},
  doi       = {10.1515/iasl-2017-0005},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-193938},
  pages     = {122-134},
  year      = {2017},
  abstract  = {This paper retraces the specific conception of the 'present' as manifested in Satyrischer Pilgram, Grimmelshausen's first published work. In the face of progressively vanishing consciousness of the past terrors of the Thirty Years' War, the Pilgram devises a program for bringing the experience of a whole generation to the present, thereby saving it for the future. Instead of delivering a general reflection on the nature of war, it suggests to narrate individually experienced "particularities." It is crucial that all of these experiences are negative, not meant to prompt imitation, but instead rather to build and keep up a stronghold against attitudes and actions of the past.},
  language  = {de}
}
@article{Soder2017,
  author    = {Soder, Lisa},
  title     = {An den Grenzen der Pragmatik},
  series = {Zeitschrift f{\"u}r germanistische Linguistik},
  volume    = {45},
  journal   = {Zeitschrift f{\"u}r germanistische Linguistik},
  number    = {3},
  issn      = {1613-0626},
  doi       = {10.1515/zgl-2017-0024},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-195413},
  pages     = {428-434},
  year      = {2017},
  abstract  = {Kein Abstract verf{\"u}gbar.},
  language  = {de}
}
@article{Shehata2017,
  author    = {Shehata, Dahlia},
  title     = {Eine mannshohe Leier im altbabylonischen Ištar-Ritual aus Mari (FM 3, no. 2)},
  series = {Altorientalische Forschungen},
  volume    = {44},
  journal   = {Altorientalische Forschungen},
  number    = {1},
  issn      = {2196-6761},
  doi       = {10.1515/aofo-2017-0008},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-195422},
  pages     = {68-81},
  year      = {2017},
  abstract  = {The Old Babylonian Ištar ritual from Mari (FM 3, no. 2) has been the focus of much discussion since its primary edition in 1938 by G. Dossin. This article offers a new analysis of the passage mentioning the balaĝ-deity Ninigizibara, which leads to identifying this balaĝ as a huge upright lyre as tall as a human played by two persons from both sides. Similar musical instruments are known from Anatolia and Egypt. Especially the Egyptian examples, which are attested only for the time of Echnaton, show striking parallels to the musical performance described in the Old Babylonian Ištar ritual. After discussing the possible background of cultural exchange, this article closes with a revaluation and new interpretation of the term balaĝ.},
  language  = {de}
}
@article{KaluzaWallaceKelleretal.2017,
  author    = {Kaluza, Benjamin F. and Wallace, Helen and Keller, Alexander and Heard, Tim A. and Jeffers, Bradley and Drescher, Nora and Bl{\"u}thgen, Nico and Leonhardt, Sara D.},
  title     = {Generalist social bees maximize diversity intake in plant species-rich and resource-abundant environments},
  series = {Ecosphere},
  volume    = {8},
  journal   = {Ecosphere},
  number    = {3},
  doi       = {10.1002/ecs2.1758},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-171155},
  pages     = {e01758},
  year      = {2017},
  abstract  = {Numerous studies revealed a positive relationship between biodiversity and ecosystem functioning, suggesting that biodiverse environments may not only enhance ecosystem processes, but also benefit individual ecosystem members by, for example, providing a higher diversity of resources. Whether and how the number of available resources affects resource collection and subsequently consumers (e.g., through impacting functions associated with resources) have, however, been little investigated, although a better understanding of this relationship may help explain why the abundance and richness of many animal species typically decline with decreasing plant (resource) diversity. Using a social bee species as model (Tetragonula carbonaria), we investigated how plant species richness—recorded for study sites located in different habitats—and associated resource abundance affected the diversity and functionality (here defined as nutritional content and antimicrobial activity) of resources (i.e., pollen, nectar, and resin) collected by a generalist herbivorous consumer. The diversity of both pollen and resin collected strongly increased with increasing plant/tree species richness, while resource abundance was only positively correlated with resin diversity. These findings suggest that bees maximize resource diversity intake in (resource) diverse habitats. Collecting more diverse resources did, however, not increase their functionality, which appeared to be primarily driven by the surrounding (plant) source community in our study. In generalist herbivores, maximizing resource diversity intake may therefore primarily secure collection of sufficient amounts of resources across the entire foraging season, but it also ensures that the allocated resources meet all functional needs. Decreasing available resource diversity may thus impact consumers primarily by reduced resource abundance, but also by reduced resource functionality, particularly when resources of high functionality (e.g., from specific plant species) become scarce.},
  language  = {en}
}
@article{GiampaoloWojcikSerflingetal.2017,
  author    = {Giampaolo, Sabrina and W{\´o}jcik, Gabriela and Serfling, Edgar and Patra, Amiya K.},
  title     = {Interleukin-2-regulatory T cell axis critically regulates maintenance of hematopoietic stem cells},
  series = {Oncotarget},
  volume    = {8},
  journal   = {Oncotarget},
  number    = {18},
  doi       = {10.18632/oncotarget.16377},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-170947},
  pages     = {29625-29642},
  year      = {2017},
  abstract  = {The role of IL-2 in HSC maintenance is unknown. Here we show that Il2\(^{-/-}\) mice develop severe anomalies in HSC maintenance leading to defective hematopoiesis. Whereas, lack of IL-2 signaling was detrimental for lympho- and erythropoiesis, myelopoiesis was enhanced in Il2\(^{-/-}\) mice. Investigation of the underlying mechanisms of dysregulated hematopoiesis in Il2\(^{-/-}\) mice shows that the IL-2-T\(_{reg}\) cell axis is indispensable for HSC maintenance and normal hematopoiesis. Lack of T\(_{reg}\) activity resulted in increased IFN-γ production by activated T cells and an expansion of the HSCs in the bone marrow (BM). Though, restoring T\(_{reg}\) population successfully rescued HSC maintenance in Il2\(^{-/-}\) mice, preventing IFN-γ activity could do the same even in the absence of T\(_{reg}\) cells. Our study suggests that equilibrium in IL-2 and IFN-γ activity is critical for steady state hematopoiesis, and in clinical conditions of BM failure, IL-2 or anti-IFN-γ treatment might help to restore hematopoiesis.},
  language  = {en}
}
@article{DegenHovestadtMitesseretal.2017,
  author    = {Degen, Tobias and Hovestadt, Thomas and Mitesser, Oliver and H{\"o}lker, Franz},
  title     = {Altered sex-specific mortality and female mating success: ecological effects and evolutionary responses},
  series = {Ecosphere},
  volume    = {8},
  journal   = {Ecosphere},
  number    = {5},
  doi       = {10.1002/ecs2.1820},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-170953},
  pages     = {e01820},
  year      = {2017},
  abstract  = {Theory predicts that males and females should often join the mating pool at different times (sexual dimorphism in timing of emergence [SDT]) as the degree of SDT affects female mating success. We utilize an analytical model to explore (1) how important SDT is for female mating success, (2) how mating success might change if either sex's mortality (abruptly) increases, and (3) to what degree evolutionary responses in SDT may be able to mitigate the consequences of such mortality increase. Increasing male pre-mating mortality has a non-linear effect on the fraction of females mated: The effect is initially weak, but at some critical level a further increase in male mortality has a stronger effect than a similar increase in female mortality. Such a change is expected to impose selection for reduced SDT. Increasing mortality during the mating season has always a stronger effect on female mating success if the mortality affects the sex that emerges first. This bias results from the fact that enhancing mortality of the earlier emerging sex reduces female-male encounter rates. However, an evolutionary response in SDT may effectively mitigate such consequences. Further, if considered independently for females and males, the predicted evolutionary response in SDT could be quite dissimilar. The difference between female and male evolutionary response in SDT leads to marked differences in the fraction of fertilized females under certain conditions. Our model may provide general guidelines for improving harvesting of populations, conservation management of rare species under altered environmental conditions, or maintaining long-term efficiency of pest-control measures.},
  language  = {en}
}
@article{ZieglerWeissSchmittetal.2017,
  author    = {Ziegler, Sabrina and Weiss, Esther and Schmitt, Anna-Lena and Schlegel, Jan and Burgert, Anne and Terpitz, Ulrich and Sauer, Markus and Moretta, Lorenzo and Sivori, Simona and Leonhardt, Ines and Kurzai, Oliver and Einsele, Hermann and Loeffler, Juergen},
  title     = {CD56 Is a Pathogen Recognition Receptor on Human Natural Killer Cells},
  series = {Scientific Reports},
  volume    = {7},
  journal   = {Scientific Reports},
  number    = {6138},
  doi       = {10.1038/s41598-017-06238-4},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-170637},
  year      = {2017},
  abstract  = {Aspergillus (A.) fumigatus is an opportunistic fungal mold inducing invasive aspergillosis (IA) in immunocompromised patients. Although antifungal activity of human natural killer (NK) cells was shown in previous studies, the underlying cellular mechanisms and pathogen recognition receptors (PRRs) are still unknown. Using flow cytometry we were able to show that the fluorescence positivity of the surface receptor CD56 significantly decreased upon fungal contact. To visualize the interaction site of NK cells and A. fumigatus we used SEM, CLSM and dSTORM techniques, which clearly demonstrated that NK cells directly interact with A. fumigatus via CD56 and that CD56 is re-organized and accumulated at this interaction site time-dependently. The inhibition of the cytoskeleton showed that the receptor re-organization was an active process dependent on actin re-arrangements. Furthermore, we could show that CD56 plays a role in the fungus mediated NK cell activation, since blocking of CD56 surface receptor reduced fungal mediated NK cell activation and reduced cytokine secretion. These results confirmed the direct interaction of NK cells and A. fumigatus, leading to the conclusion that CD56 is a pathogen recognition receptor. These findings give new insights into the functional role of CD56 in the pathogen recognition during the innate immune response.},
  language  = {en}
}
@article{KollmannsbergerKerschnitzkiReppetal.2017,
  author    = {Kollmannsberger, Philip and Kerschnitzki, Michael and Repp, Felix and Wagermaier, Wolfgang and Weinkamer, Richard and Fratzl, Peter},
  title     = {The small world of osteocytes: connectomics of the lacuno-canalicular network in bone},
  series = {New Journal of Physics},
  volume    = {19},
  journal   = {New Journal of Physics},
  number    = {073019},
  doi       = {10.1088/1367-2630/aa764b},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-170662},
  year      = {2017},
  abstract  = {Osteocytes and their cell processes reside in a large, interconnected network of voids pervading the mineralized bone matrix of most vertebrates. This osteocyte lacuno-canalicular network (OLCN) is believed to play important roles in mechanosensing, mineral homeostasis, and for the mechanical properties of bone. While the extracellular matrix structure of bone is extensively studied on ultrastructural and macroscopic scales, there is a lack of quantitative knowledge on how the cellular network is organized. Using a recently introduced imaging and quantification approach, we analyze the OLCN in different bone types from mouse and sheep that exhibit different degrees of structural organization not only of the cell network but also of the fibrous matrix deposited by the cells. We define a number of robust, quantitative measures that are derived from the theory of complex networks. These measures enable us to gain insights into how efficient the network is organized with regard to intercellular transport and communication. Our analysis shows that the cell network in regularly organized, slow-growing bone tissue from sheep is less connected, but more efficiently organized compared to irregular and fast-growing bone tissue from mice. On the level of statistical topological properties (edges per node, edge length and degree distribution), both network types are indistinguishable, highlighting that despite pronounced differences at the tissue level, the topological architecture of the osteocyte canalicular network at the subcellular level may be independent of species and bone type. Our results suggest a universal mechanism underlying the self-organization of individual cells into a large, interconnected network during bone formation and mineralization.},
  language  = {en}
}
@article{MemmelSisarioZoelleretal.2017,
  author    = {Memmel, Simon and Sisario, Dmitri and Z{\"o}ller, Caren and Fiedler, Vanessa and Katzer, Astrid and Heiden, Robin and Becker, Nicholas and Eing, Lorenz and Ferreira, F{\´a}bio L.R. and Zimmermann, Heiko and Sauer, Markus and Flentje, Michael and Sukhorukov, Vladimir L. and Djuzenova, Cholpon S.},
  title     = {Migration pattern, actin cytoskeleton organization and response to PI3K-, mTOR-, and Hsp90-inhibition of glioblastoma cells with different invasive capacities},
  series = {Oncotarget},
  volume    = {8},
  journal   = {Oncotarget},
  number    = {28},
  doi       = {10.18632/oncotarget.16847},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-170719},
  pages     = {45298-45310},
  year      = {2017},
  abstract  = {High invasiveness and resistance to chemo- and radiotherapy of glioblastoma multiforme (GBM) make it the most lethal brain tumor. Therefore, new treatment strategies for preventing migration and invasion of GBM cells are needed. Using two different migration assays, Western blotting, conventional and super-resolution (dSTORM) fluorescence microscopy we examine the effects of the dual PI3K/mTOR-inhibitor PI-103 alone and in combination with the Hsp90 inhibitor NVP-AUY922 and/or irradiation on the migration, expression of marker proteins, focal adhesions and F-actin cytoskeleton in two GBM cell lines (DK-MG and SNB19) markedly differing in their invasive capacity. Both lines were found to be strikingly different in morphology and migration behavior. The less invasive DK-MG cells maintained a polarized morphology and migrated in a directionally persistent manner, whereas the highly invasive SNB19 cells showed a multipolar morphology and migrated randomly. Interestingly, a single dose of 2 Gy accelerated wound closure in both cell lines without affecting their migration measured by single-cell tracking. PI-103 inhibited migration of DK-MG (p53 wt, PTEN wt) but not of SNB19 (p53 mut, PTEN mut) cells probably due to aberrant reactivation of the PI3K pathway in SNB19 cells treated with PI-103. In contrast, NVP-AUY922 exerted strong anti-migratory effects in both cell lines. Inhibition of cell migration was associated with massive morphological changes and reorganization of the actin cytoskeleton. Our results showed a cell line-specific response to PI3K/mTOR inhibition in terms of GBM cell motility. We conclude that anti-migratory agents warrant further preclinical investigation as potential therapeutics for treatment of GBM.},
  language  = {en}
}
@article{EffenbergerBommertKunzetal.2017,
  author    = {Effenberger, Madlen and Bommert, Kathryn S. and Kunz, Viktoria and Kruk, Jessica and Leich, Ellen and Rudelius, Martina and Bargou, Ralf and Bommert, Kurt},
  title     = {Glutaminase inhibition in multiple myeloma induces apoptosis via MYC degradation},
  series = {Oncotarget},
  volume    = {8},
  journal   = {Oncotarget},
  number    = {49},
  doi       = {10.18632/oncotarget.20691},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-170168},
  pages     = {85858-85867},
  year      = {2017},
  abstract  = {Multiple Myeloma (MM) is an incurable hematological malignancy affecting millions of people worldwide. As in all tumor cells both glucose and more recently glutamine have been identified as important for MM cellular metabolism, however there is some dispute as to the role of glutamine in MM cell survival. Here we show that the small molecule inhibitor compound 968 effectively inhibits glutaminase and that this inhibition induces apoptosis in both human multiple myeloma cell lines (HMCLs) and primary patient material. The HMCL U266 which does not express MYC was insensitive to both glutamine removal and compound 968, but ectopic expression of MYC imparted sensitivity. Finally, we show that glutamine depletion is reflected by rapid loss of MYC protein which is independent of MYC transcription and post translational modifications. However, MYC loss is dependent on proteasomal activity, and this loss was paralleled by an equally rapid induction of apoptosis. These findings are in contrast to those of glucose depletion which largely affected rates of proliferation in HMCLs, but had no effects on either MYC expression or viability. Therefore, inhibition of glutaminolysis is effective at inducing apoptosis and thus serves as a possible therapeutic target in MM.},
  language  = {en}
}
@article{AuerhammerArrowsmithBraunschweigetal.2017,
  author    = {Auerhammer, Dominic and Arrowsmith, Merle and Braunschweig, Holger and Dewhurst, Rian D. and Jim{\´e}nez-Halla, J. Oscar C. and Kupfer, Thomas},
  title     = {Nucleophilic addition and substitution at coordinatively saturated boron by facile 1,2-hydrogen shuttling onto a carbene donor},
  series = {Chemical Science},
  volume    = {8},
  journal   = {Chemical Science},
  number    = {10},
  doi       = {10.1039/c7sc03193a},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-170255},
  pages     = {7066-7071},
  year      = {2017},
  abstract  = {The reaction of [(cAAC\(^{Me}\))BH\(_{3}\)] (cAAC\(^{Me}\) = 1-(2,6-iPr\(_{2}\)C\(_{6}\)H\(_{3}\))-3,3,5,5-tetramethylpyrrolidin-2-ylidene) with a range of organolithium compounds led to the exclusive formation of the corresponding (dihydro)organoborates, Li\(^{+}\)[(cAAC\(^{Me}\)H)BH\(_{2}\)R]- (R = sp\(^{3}\)-, sp\(^{2}\)-, or sp-hybridised organic substituent), by migration of one boron-bound hydrogen atom to the adjacent carbene carbon of the cAAC ligand. A subsequent deprotonation/salt metathesis reaction with Me3SiCl or spontaneous LiH elimination yielded the neutral cAAC-supported mono(organo)boranes, [(cAAC\(^{Me}\)H)BH\(_{2}\)R]- (R]. Similarly the reaction of [cAAC\(^{Me}\))BH\(_{3}\)] with a neutral donor base L resulted in adduct formation by shuttling one boron-bound hydrogen to the cAAC ligand, to generate [(cAAC\(^{Me}\)H)BH\(_{2}\)L], either irreversibly (L = cAAC\(^{Me}\)) or reversibly (L = pyridine). Variable-temperature NMR data and DFT calculations on [(cAAC\(^{Me}\)H)BH\(_{2}\)(cAAC\(^{Me}\))] show that the hydrogen on the former carbene carbon atom exchanges rapidly with the boron-bound hydrides.},
  language  = {en}
}
@article{BrumbergKuestersAlMomanietal.2017,
  author    = {Brumberg, Joachim and K{\"u}sters, Sebastian and Al-Momani, Ehab and Marotta, Giorgio and Cosgrove, Kelly P. and van Dyck, Christopher H. and Herrmann, Ken and Homola, Gy{\"o}rgy A. and Pezzoli, Gianni and Buck, Andreas K. and Volkmann, Jens and Samnick, Samuel and Isaias, Ioannis U.},
  title     = {Cholinergic activity and levodopa-induced dyskinesia: a multitracer molecular imaging study},
  series = {Annals of Clinical and Translational Neurology},
  volume    = {4},
  journal   = {Annals of Clinical and Translational Neurology},
  number    = {9},
  doi       = {10.1002/acn3.438},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-170406},
  pages     = {632-639},
  year      = {2017},
  abstract  = {Objective: To investigate the association between levodopa-induced dyskinesias and striatal cholinergic activity in patients with Parkinson's disease. Methods: This study included 13 Parkinson's disease patients with peak-of-dose levodopa-induced dyskinesias, 12 nondyskinetic patients, and 12 healthy controls. Participants underwent 5-[\(^{123}\)I]iodo-3-[2(S)-2-azetidinylmethoxy]pyridine single-photon emission computed tomography, a marker of nicotinic acetylcholine receptors, [\(^{123}\)I]N-ω-fluoropropyl-2β-carbomethoxy-3β-(4-iodophenyl)nortropane single-photon emission computed tomography, to measure dopamine reuptake transporter density and 2-[\(^{18}\)F]fluoro-2-deoxyglucose positron emission tomography to assess regional cerebral metabolic activity. Striatal binding potentials, uptake values at basal ganglia structures, and correlations with clinical variables were analyzed. Results: Density of nicotinic acetylcholine receptors in the caudate nucleus of dyskinetic subjects was similar to that of healthy controls and significantly higher to that of nondyskinetic patients, in particular, contralaterally to the clinically most affected side. Interpretation: Our findings support the hypothesis that the expression of dyskinesia may be related to cholinergic neuronal excitability in a dopaminergic-depleted striatum. Cholinergic signaling would play a role in maintaining striatal dopaminergic responsiveness, possibly defining disease phenotype and progression.},
  language  = {en}
}
@article{LandmannHennigIgnat'evetal.2017,
  author    = {Landmann, Johannes and Hennig, Philipp T. and Ignat'ev, Nikolai V. and Finze, Maik},
  title     = {Borylation of fluorinated arenes using the boron centred nucleophile B(CN)\(_{3}\)\(^{2-}\) - a unique entry to aryltricyanoborates},
  series = {Chemical Science},
  volume    = {8},
  journal   = {Chemical Science},
  number    = {9},
  doi       = {10.1039/c7sc02249b},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-170417},
  pages     = {5962-5968},
  year      = {2017},
  abstract  = {The potassium salt of the boron-centred nucleophile B(CN)\(_{3}\)\(^{2-}\)(1) readily reacts with perfluorinated arenes, such as hexafluorobenzene, decafluorobiphenyl, octafluoronaphthalene and pentafluoropyridine, which results in KF and the K\(^{+}\) salts of the respective borate anions with one {B(CN)\(_{3}\)} unit bonded to the (hetero)arene. An excess of K\(_{2}\)1 leads to the successive reaction of two or, in the case of perfluoropyridine, even three C-F moieties and the formation of di- and trianions, respectively. Moreover, all of the 11 partially fluorinated benzene derivatives, C\(_{6}\)F\(_{6-n}\)H\(_{n}\) (n = 1-5), generally react with K\(_{2}\)1 to give new tricyano(phenyl)borate anions with high chemo- and regioselectivity. A decreasing number of fluorine substituents on benzene results in a decrease in the reaction rate. In the cases of partially fluorinated benzenes, the addition of LiCl is advantageous or even necessary to facilitate the reaction. Also, pentafluorobenzenes R-C\(_{6}\)F\(_{5}\) (R = -CN, -OMe, -Me, or -CF\(_{3}\)) react via C-F/C-B exchange that mostly occurs in the para position and to a lesser extent in the meta or ortho positions. Most of the reactions proceed via an S\(_{N}\)Ar mechanism. The reaction of 1,4-F\(_{2}\)C\(_{6}\)H\(_{4}\) with K\(_{2}\)1 shows that an aryne mechanism has to be considered in some cases as well. In summary, a wealth of new stable tricyano(aryl)borates have been synthesised and fully characterized using multi-NMR spectroscopy and most of them were characterised using single-crystal X-ray diffraction.},
  language  = {en}
}
@article{Ott2017,
  author    = {Ott, Christine},
  title     = {Literarisches Dorfleben in Maienfeld oder Wie Heidi lebte.},
  series = {kjl\&m - Kinder-/Jugendliteratur und Medien in Forschung, Literatur und Bibliothek},
  volume    = {69},
  journal   = {kjl\&m - Kinder-/Jugendliteratur und Medien in Forschung, Literatur und Bibliothek},
  number    = {3},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-210610},
  pages     = {14-22},
  year      = {2017},
  abstract  = {Kein Abstract verf{\"u}gbar.},
  language  = {de}
}
@article{DrenckhahnZonneveld2017,
  author    = {Drenckhahn, Detlev and Zonneveld, Ben},
  title     = {Rubus viridilucidus Drenckhahn, eine neue Brombeerart aus der Sektion Corylifolii, Serie Subcanescentes},
  series = {Forum Geobotanicum},
  volume    = {7},
  journal   = {Forum Geobotanicum},
  issn      = {1867-9315},
  doi       = {10.3264/FG.2017.1221},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-156257},
  pages     = {34-42},
  year      = {2017},
  abstract  = {Rubus viridilucidus Drenckhahn ist eine tetraploide Brombeerart (2n=28) aus der Sektion Corylifolii, Serie Subcanescentes mit einem Genomgewicht (2C-Wert) von 1,49 pg, das dem Genomgewicht verwandter Sippen der Serie Subcanescentes wie R. scabrosus, R. fasciculatiformis und R. fasciculatus (1,52-1,54 pg) aus Unterfranken entspricht. Charakteristische Merkmale sind 3-4(5)-z{\"a}hlige Bl{\"a}tter mit herab gekr{\"u}mmten rundlichen bis breit obovaten Endbl{\"a}ttchen und breitovalen Seitenbl{\"a}ttchen, die eine v{\"o}llig unbehaarte, lichtgr{\"u}ne, mattgl{\"a}nzende Blattoberfl{\"a}che besitzen mit kontrastierender hell gr{\"u}nlich-grauer, samtig behaarter Blattunterseite. Die {\"u}berwiegend rundlichen bis stumpf kantigen, lichtgr{\"u}nen bis r{\"o}tlich {\"u}berlaufenen Sch{\"o}sslinge sind unbehaart und sp{\"a}rlich mit kurzen (<4mm) nadelf{\"o}rmigen Stacheln und wenigen Stieldr{\"u}sen besetzt. R. viridilucidus entwickelt zus{\"a}tzlich zu den Bl{\"u}tenzweigen der zweij{\"a}hrigen Sch{\"o}sslinge (Ausbreitungssch{\"o}sslinge) einen besonderen bl{\"u}henden 0,8 bis 1,6 m langen Sch{\"o}sslingstyp aus, den Rispensch{\"o}ssling, der direkt aus dem Wurzelstock entspringt und terminal in eine Bl{\"u}tenrispe ausl{\"a}uft. Bei R. viridilucidus sind zwei verschiedene Typen von Rispensch{\"o}sslingen ausgebildet. Die Sippe w{\"a}chst bevorzugt auf gest{\"o}rten Fl{\"a}chen wie Brachen, Straßenr{\"a}ndern, Lagerpl{\"a}tzen, Weinbergr{\"a}ndern und kann sich mit 1-2 m j{\"a}hrlichem Zuwachs (Satellitenbildauswertung, Vermessungen vor Ort) schnell ausbreiten. Die bekannt gewordenen Fundstellen erstrecken sich vom n{\"o}rdlichen Baden-W{\"u}rttemberg bis in den n{\"o}rdlichsten Teil von Bayern (Rh{\"o}n).},
  subject      = {Brombeere},
  language  = {de}
}
@article{DrenckhahnBaumgartnerZonneveld2017,
  author    = {Drenckhahn, Detlev and Baumgartner, Werner and Zonneveld, Ben},
  title     = {Different genome sizes of Western and Eastern Ficaria verna lineages shed light on steps of Ficaria evolution},
  series = {Forum Geobotanicum},
  volume    = {7},
  journal   = {Forum Geobotanicum},
  issn      = {1867-9315},
  doi       = {10.3264/FG.2017.1122},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-155061},
  pages     = {27-33},
  year      = {2017},
  abstract  = {The genus Ficaria is now considered to comprize eight Eurasian species. The most widespread European species is the tetraploid F. verna Huds. The present study provides evidence for the existence of two main lineages of F. verna that differ considerably in their genomic size by about 3 pg. A Western F. verna lineage west of river Rhine displays a mean genome size (2C-value) of 34.2 pg and is almost precisely codistributed with the diploid F. ambigua Boreau (20 pg) north of the Mediterranean. The remaining part of Europe appears to be occupied by the Eastern F. verna lineage solely (mean genome size of 31.3 pg) which codistributes in South-Eastern Europe with the diploid F. calthifolia Rchb. (15 pg). There is little overlap at the boundary of Western and Eastern F. verna lineages with the occurrence of a separate intermediate group in the Netherlands (mean genomic size of 33.2 pg) that appears to result from hybridization of both lineages. On the basis of these observations and further considerations we propose development of F. ambigua and F. calthifolia south of the Alps with subsequent divergence to populate their current Western and Eastern European ranges, respectively. The Western F. verna lineage is proposed to originate from autotetraploidization of F. ambigua (precursor) with moderate genomic downsizing and the Eastern F. verna lineage from auto¬tetraploidization of F. calthifolia (precursor).},
  subject      = {Durchflusscytometrie},
  language  = {en}
}
@article{WohlgemuthMiyazakiTsukadaetal.2017,
  author    = {Wohlgemuth, Matthias and Miyazaki, Mitsuhiko and Tsukada, Kohei and Weiler, Martin and Dopfer, Otto and Fujii, Masaaki and Mitrić, Roland},
  title     = {Deciphering environment effects in peptide bond solvation dynamics by experiment and theory},
  series = {Physical Chemistry Chemical Physics},
  volume    = {19},
  journal   = {Physical Chemistry Chemical Physics},
  number    = {33},
  doi       = {10.1039/C7CP03992A},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-159647},
  pages     = {22564-22572},
  year      = {2017},
  abstract  = {Most proteins work in aqueous solution and the interaction with water strongly affects their structure and function. However, experimentally the motion of a specific single water molecule is difficult to trace by conventional methods, because they average over the heterogeneous solvation structure of bulk water surrounding the protein. Here, we provide a detailed atomistic picture of the water rearrangement dynamics around the -CONH- peptide linkage in the two model systems formanilide and acetanilide, which simply differ by the presence of a methyl group at the peptide linkage. The combination of picosecond pump-probe time-resolved infrared spectroscopy and molecular dynamics simulations demonstrates that the solvation dynamics at the molecular level is strongly influenced by this small structural difference. The effective timescales for solvent migration triggered by ionization are mainly controlled by the efficiency of the kinetic energy redistribution rather than the shape of the potential energy surface. This approach provides a fundamental understanding of protein hydration and may help to design functional molecules in solution with tailored properties.},
  language  = {en}
}
@article{KohlmorgenEliasSchoen2017,
  author    = {Kohlmorgen, Britta and Elias, Johannes and Schoen, Christoph},
  title     = {Improved performance of the artus Mycobacterium tuberculosis RG PCR kit in a low incidence setting: a retrospective monocentric study},
  series = {Scientific Reports},
  volume    = {7},
  journal   = {Scientific Reports},
  number    = {14127},
  doi       = {10.1038/s41598-017-14367-z},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-159248},
  year      = {2017},
  abstract  = {Tuberculosis (TB) and the spread of Mycobacterium tuberculosis complex (MTBC) strains resistant against rifampin (RIF) and isoniazid (INH) pose a serious threat to global health. However, rapid and reliable MTBC detection along with RIF/INH susceptibility testing are challenging in low prevalence countries due to the higher rate of false positives. Here, we provide the first performance data for the artus MTBC PCR assay in a low prevalence setting. We analyze 1323 respiratory and 311 non-respiratory samples with the artus MTBC PCR assay as well as by mycobacterial culture and microscopy. We propose retesting of specimens in duplicate and consideration of a determined cycle-threshold value cut-off greater than 34, as this significantly increases accuracy, specificity, and negative predictive value without affecting sensitivity. Furthermore, we tested fourteen MTBC positive samples with the GenoType MTBDRplus test and demonstrate that using an identical DNA extraction protocol for both assays does not impair downstream genotypic testing for RIF and INH susceptibility. In conclusion, our procedure optimizes the use of the artus MTB assay with workload efficient methods in a low incidence setting. Combining the modified artus MTB with the GenoType MTBDRplus assays allows rapid and accurate detection of MTBC and RIF/INH resistance.},
  language  = {en}
}
@article{LapaAriasLozaHayakawaetal.2017,
  author    = {Lapa, Constantin and Arias-Loza, Paula and Hayakawa, Nobuyuki and Wakabayashi, Hiroshi and Werner, Rudolf A. and Chen, Xinyu and Shinaji, Tetsuya and Herrmann, Ken and Pelzer, Theo and Higuchi, Takahiro},
  title     = {Whitening and impaired glucose utilization of brown adipose tissue in a rat model of type 2 diabetes mellitus},
  series = {Scientific Reports},
  volume    = {7},
  journal   = {Scientific Reports},
  doi       = {10.1038/s41598-017-17148-w},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-159066},
  pages     = {16795},
  year      = {2017},
  abstract  = {Brown adipose tissue (BAT) is an attractive therapeutic target to combat diabetes and obesity due to its ability to increase glucose expenditure. In a genetic rat model (ZDF fa/fa) of type-2 diabetes and obesity, we aimed to investigate glucose utilization of BAT by \(^{18}\)F-FDG PET imaging. Male Zucker diabetic fatty (ZDF) and Male Zucker lean (ZL) control rats were studied at 13 weeks. Three weeks prior to imaging, ZDF rats were randomized into a no-restriction (ZDF-ND) and a mild calorie restriction (ZDF-CR) group. Dynamic \(^{18}\)F-FDG PET using a dedicated small animal PET system was performed under hyperinsulinemic-euglycemic clamp. \(^{18}\)F-FDG PET identified intense inter-scapular BAT glucose uptake in all ZL control rats, while no focally increased \(^{18}\)F-FDG uptake was detected in all ZDF-ND rats. Mild but significant improved BAT tracer uptake was identified after calorie restriction in diabetic rats (ZDF-CR). The weight of BAT tissue and fat deposits were significantly increased in ZDF-CR and ZDF-ND rats as compared to ZL controls, while UCP-1 and mitochondrial concentrations were significantly decreased. Whitening and severely impaired insulin-stimulated glucose uptake in BAT was confirmed in a rat model of type-2 diabetes. Additionally, calorie restriction partially restored the impaired BAT glucose uptake.},
  language  = {en}
}
@article{HefnerBerberichLanversetal.2017,
  author    = {Hefner, Jochen and Berberich, Sara and Lanvers, Elena and Sanning, Maria and Steimer, Ann-Kathrin and Kunzmann, Volker},
  title     = {New insights into frequency and contents of fear of cancer progression/recurrence (FOP/FCR) in outpatients with colorectal carcinoma (CRC) receiving oral capecitabine: a pilot study at a comprehensive cancer center},
  series = {Patient Preference and Adherence},
  volume    = {11},
  journal   = {Patient Preference and Adherence},
  doi       = {10.2147/PPA.S142784},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-158476},
  pages     = {1907-1914},
  year      = {2017},
  abstract  = {Background: Fear of cancer progression/recurrence (FOP/FCR) is considered one of the most prevalent sources of distress in cancer survivors and associated with lower quality of life and functional impairment. Detailed measures of FOP/FCR are needed because little is known about the knowledge of FOP/FCR, its associations with the patient-doctor relationship, and the rate of adequate therapy. Colorectal cancer (CRC) is one of the most prevalent cancer entities, and oral capecitabine is widely prescribed as treatment. Therefore, we initiated a pilot study to expand the literature on FOP/FCR in CRC outpatients receiving capecitabine and to generate hypotheses for future investigations. Methods: This study included 58 patients treated at a comprehensive cancer center. FOP/FCR was assessed with the Fear of Progression Questionnaire (FOP-Q-SF). Satisfaction with the relationships with doctors was assessed with the Patient-Doctor Relationship Questionnaire-9 (PRDQ-9). Levels of side effects were rated by the patients on a visual analog scale. Clinical data were extracted from the charts. Results: A total of 19 out of 58 patients (36\%) suffered from FOP/FCR according to our assessment. Levels of FOP/FCR seemed to be mostly moderate to high. Only four out of the 19 distressed patients (21\%) were treated accordingly. Typical side effects of oncological treatment were associated with higher FOP/FCR. Satisfaction with doctor-patient relationships was not associated with FOP/FCR. Regarding single items of FOP/FCR, three out of the five most prevalent fears were associated with close relatives. Discussion: FOP/FCR occurred frequently in more than one in three patients, but was mostly untreated in this sample of consecutive outpatients with CRC receiving oral capecitabine. In detail, most fears were related to family and friends. In addition to an unmet need of patients, our data indicate sources of distress not considered thus far. If replicated in larger studies, results may help to inform intervention development and improve patient care.},
  language  = {en}
}
@article{HocheSchmittHumeniuketal.2017,
  author    = {Hoche, Joscha and Schmitt, Hans-Christian and Humeniuk, Alexander and Fischer, Ingo and Mitrić, Roland and R{\"o}hr, Merle I. S.},
  title     = {The mechanism of excimer formation: an experimental and theoretical study on the pyrene dimer},
  series = {Physical Chemistry Chemical Physics},
  volume    = {19},
  journal   = {Physical Chemistry Chemical Physics},
  number    = {36},
  doi       = {10.1039/C7CP03990E},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-159514},
  pages     = {25002-25015},
  year      = {2017},
  abstract  = {The understanding of excimer formation in organic materials is of fundamental importance, since excimers profoundly influence their functional performance in applications such as light-harvesting, photovoltaics or organic electronics. We present a joint experimental and theoretical study of the ultrafast dynamics of excimer formation in the pyrene dimer in a supersonic jet, which is the archetype of an excimer forming system. We perform simulations of the nonadiabatic photodynamics in the frame of TDDFT that reveal two distinct excimer formation pathways in the gas-phase dimer. The first pathway involves local excited state relaxation close to the initial Franck-Condon geometry that is characterized by a strong excitation of the stacking coordinate exhibiting damped oscillations with a period of 350 fs that persist for several picoseconds. The second excimer forming pathway involves large amplitude oscillations along the parallel shift coordinate with a period of ≈900 fs that after intramolecular vibrational energy redistribution leads to the formation of a perfectly stacked dimer. The electronic relaxation within the excitonic manifold is mediated by the presence of intermolecular conical intersections formed between fully delocalized excitonic states. Such conical intersections may generally arise in stacked π-conjugated aggregates due to the interplay between the long-range and short-range electronic coupling. The simulations are supported by picosecond photoionization experiments in a supersonic jet that provide a time-constant for the excimer formation of around 6-7 ps, in good agreement with theory. Finally, in order to explore how the crystal environment influences the excimer formation dynamics we perform large scale QM/MM nonadiabatic dynamics simulations on a pyrene crystal in the framework of the long-range corrected tight-binding TDDFT. In contrast to the isolated dimer, the excimer formation in the crystal follows a single reaction pathway in which the initially excited parallel slip motion is strongly damped by the interaction with the surrounding molecules leading to the slow excimer stabilization on a picosecond time scale.},
  language  = {en}
}
@article{Drenckhahn2017,
  author    = {Drenckhahn, Detlev},
  title     = {Vorkommen des Atlantischen Wildkohls (Brassica oleracea L. subsp. oleracea) an den Kreidefelsen der Ostseeinsel R{\"u}gen, Deutschland},
  series = {Forum Geobotanicum},
  volume    = {7},
  journal   = {Forum Geobotanicum},
  issn      = {1867-9315},
  doi       = {10.3264/FG.2017.0116},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-142963},
  pages     = {18-26},
  year      = {2017},
  abstract  = {Der Atlantische Wildkohl (Brassica oleracea L. subsp. oleracea) w{\"a}chst auf den K{\"u}stenfelsen des Atlantiks und der Nordsee zwischen Nord-Spanien, Schottland und der Nordseeinsel Helgoland. 2001 wurde auch ein Vorkommen des Wildkohls an den Kreidefelsen der Ostseeinsel R{\"u}gen nachgewiesen, das aus ungef{\"a}hr 50 Individuen besteht. Die Pflanzen unterscheiden sich ph{\"a}notypisch nicht von Wildpflanzen der Atlantikk{\"u}sten. Da alle verbreiteten Kultursorten des Gem{\"u}sekohls genetisch sehr eng mit dem Atlantischen Kohl verwandt sind, vom dem sie h{\"o}chstwahrscheinlich abstammen, wird die Frage er{\"o}rtert, ob eine spontane R{\"u}ckverwandlung (R{\"u}ckkreuzung) von in die Natur entwichenen Kultursorten in den Wildkohl-Ph{\"a}notyp m{\"o}glich ist. Dieses wird als wenig wahrscheinlich angesehen. Dagegen ist Introgression zwischen Kultursorten und Wildsorten gut belegt. Die Frage nach einer m{\"o}glichen Hybridisierung von Gr{\"u}nkohl mit Pflanzen vom Wildkohlph{\"a}notyp oder mit anderen Kultursorten an der Kreidek{\"u}ste der d{\"a}nischen Ostseeinsel Seeland wird anhand eigener Beobachtungen er{\"o}rtert. Die dortige Population besteht offensichtlich aus verwilderten Kulturkohlhybriden, die sich deutlich von den Wildpflanzen R{\"u}gens unterscheiden. Das neue Vorkommen des Atlantischen Wildkohls in der westlichen Ostsee kann im Zusammenhang mit der Ostausbreitung anderer atlantischer Sippen im Rahmen des Klimawandels gesehen werden.},
  subject      = {Kohl},
  language  = {de}
}
@article{Pordzik2017,
  author    = {Pordzik, Ralph},
  title     = {George Orwell's Imperial Bestiary: Totemism, Animal Agency and Cross-Species Interaction in "Shooting an Elephant", Burmese Days and "Marrakech"},
  series = {Anglia},
  volume    = {135},
  journal   = {Anglia},
  number    = {3},
  issn      = {1865-8938},
  doi       = {10.1515/ang-2017-0045},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-194200},
  pages     = {440-466},
  year      = {2017},
  abstract  = {This essay argues that Orwell's representation of animals as companion species offers a strikingly new, as-yet largely neglected view of animal agency and interiority in his work. In "Shooting an Elephant", Burmese Days and "Marrakech", the writer's focus on the social reject is supplemented by a marked sense of community implying human tragedy yet framing it within precariously situated human-animal, colonial or urban-imperial transitions that visualise animals as agents of change and co-shaping species interdependent with the lives of the humans that utilize and domineer them. Animals are required whenever Orwell aspires to shift from isolation to communality, from the self-conscious outsider to the larger realm of ideas framing the world in which his characters strive to overstep the accepted lines of social performance and conformity. Read in and around disciplinary structures of rationalization, Orwell's animals appear to secure themselves, quite paradoxically, a place within the normative anthropocentric framework excluding them. They extend beyond anthropomorphising or allegorical modes of description and open up bio-political perspectives within and across regimes of knowledge and empathy. Orwell's writings thus present a challenge to the culturally accredited fantasy of human exceptionalism, collapsing any epistemic space between humans and animals and burying the idea of sustaining radical species distinction.},
  language  = {en}
}
@article{Huettner2017,
  author    = {Huettner, Sabrina},
  title     = {Nelson Pressley. American Playwriting and the Anti-Political Prejudice: Twentieth- and Twenty-First Century Perspectives. Basingstoke: Palgrave Macmillan, 2014, ix + 185 pp, \$69.99.},
  series = {Journal of Contemporary Drama in English},
  volume    = {5},
  journal   = {Journal of Contemporary Drama in English},
  number    = {1},
  issn      = {2195-0164},
  doi       = {10.1515/jcde-2017-0019},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-194210},
  pages     = {217-222},
  year      = {2017},
  abstract  = {No abstract available},
  language  = {en}
}
@article{Teichmann2017,
  author    = {Teichmann, Christoph},
  title     = {Die GmbH im europ{\"a}ischen Wettbewerb der Rechtsformen},
  series = {Zeitschrift f{\"u}r Unternehmens- und Gesellschaftsrecht},
  volume    = {46},
  journal   = {Zeitschrift f{\"u}r Unternehmens- und Gesellschaftsrecht},
  number    = {5},
  issn      = {1612-7048},
  doi       = {10.1515/zgr-2017-0024},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-194060},
  pages     = {543 -- 582},
  year      = {2017},
  abstract  = {In den 125 Jahren seit ihrer Einf{\"u}hrung im Jahre 1892 hat die deutsche GmbH einerseits einen Siegeszug um die ganze Welt angetreten und musste sich andererseits im eigenen Heimatland der scharfen Konkurrenz der englischen Limited erwehren. Dieser Wettbewerb setzte im Internationalen Gesellschaftsrecht einen Wechsel von der Sitz- zur Gr{\"u}ndungstheorie voraus. Seine negativen Auswirkungen lassen sich, wie die j{\"u}ngere EuGH-Rechtsprechung zeigt, durch eine am Sachproblem orientierte Anwendung inl{\"a}ndischer Drittschutzregeln zielgerichtet eingrenzen. Im europ{\"a}ischen Ideenwettbewerb ist das deutsche GmbH-Recht derweil deutlich zur{\"u}ckgefallen. Das liegt weniger an der vermeintlichen Dominanz des englischen Rechts als am Ideenreichtum der kleineren EU-Staaten, denen es mit gut durchdachten Reformprojekten gelingt, international Aufmerksamkeit auf sich zu ziehen.},
  language  = {de}
}
@article{NordPalkowitschKuehl2017,
  author    = {Nord, Ilona and Palkowitsch-K{\"u}hl, Jens},
  title     = {RELab digital: Ein Projekt zu religi{\"o}ser Bildung in einer mediatisierten Welt},
  series = {Zeitschrift f{\"u}r P{\"a}dagogik und Theologie},
  volume    = {69},
  journal   = {Zeitschrift f{\"u}r P{\"a}dagogik und Theologie},
  number    = {3},
  issn      = {2366-7796},
  doi       = {10.1515/zpt-2017-0031},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-194880},
  pages     = {270-283},
  year      = {2017},
  abstract  = {Schule als Lern- und Lebensort zuk{\"u}nftiger Generationen partizipiert an global sich vollziehenden medialen Transformationsprozessen. Religionsp{\"a}dagogik und -didaktik sind, wie alle anderen Fachwissenschaften auch, herausgefordert, die Integration digitaler Medien in Theorie und Praxis zu reflektieren und konzeptionieren. Dies hat in mindestens drei Dimensionen zu erfolgen: beim Lernen mit digitalen Medien, beim Lernen {\"u}ber digitale Medien sowie in der Ein{\"u}bung in eine konstruktiv-kritische Medienbildung. Das Projekt ist der Entwicklung, Erprobung und Evaluation von Lernszenarien im Religionsunterricht und im Austausch mit außerschulischen religi{\"o}sen Bildungsorten gewidmet.},
  language  = {de}
}
@article{Teichmann2017,
  author    = {Teichmann, Christoph},
  title     = {Die grenz{\"u}berschreitende Unternehmensgruppe im Compliance-Zeitalter},
  series = {Zeitschrift f{\"u}r Unternehmens- und Gesellschaftsrecht},
  volume    = {46},
  journal   = {Zeitschrift f{\"u}r Unternehmens- und Gesellschaftsrecht},
  number    = {4},
  issn      = {1612-7048},
  doi       = {10.1515/zgr-2017-0021},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-194940},
  pages     = {485 -- 508},
  year      = {2017},
  abstract  = {Die europ{\"a}ische Konzernorganisation und die „Europa GmbH" (SPE) bilden zwei wichtige Forschungsschwerpunkte im Werk von Peter Hommelhoff. Beide Projekte haben sich {\"u}ber die Jahre als außerordentlich dicke Bretter erwiesen. Doch davon l{\"a}sst sich der Jubilar nicht beirren. R{\"u}ckschl{\"a}ge und Umwege geh{\"o}ren in der Wissenschaft zum kollektiven Lernprozess, der neue Erkenntnisse bringt. Ganz in diesem Sinne m{\"u}nden die Erfahrungen aus der Diskussion um ein europ{\"a}isches Konzernrecht und um die SPE im vorliegenden Beitrag in die Konzeption eines supranationalen Konzernbausteins f{\"u}r europ{\"a}ische Unternehmensgruppen.},
  language  = {de}
}
@article{KalbheimZiebertz2017,
  author    = {Kalbheim, Boris and Ziebertz, Hans-Georg},
  title     = {S{\"a}kular - mehr als „nichtreligi{\"o}s"?},
  series = {International Journal of Practical Theology},
  volume    = {21},
  journal   = {International Journal of Practical Theology},
  number    = {1},
  issn      = {1612-9768},
  doi       = {10.1515/ijpt-2015-0005},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-194408},
  pages     = {58-88},
  year      = {2017},
  abstract  = {There is hardly an autonomous description of those who do not belong to a religious denomination and who don't regard themselves as religious in a traditional way. The terms "non-denominational" and "non-religious" implicate a dissociation from the historically traditional concept of religion, but they do not offer any alternative ideological communalities. This article discusses the option of a "secular worldview" and investigates whether religious and non-religious respondents differ in their attitudes on selected human rights - and if so, to what extent. The empirical study (N=2244) shows that human rights are supported by all young people, athough in some cases with differing emphases. In basic terms, we can discern a common worldview or 'Weltanschauung' of secular respondents. This is recognizable as an approval of the intrinsic value of the Other as well as a recognition of norms set by public society.},
  language  = {de}
}
@article{Rupp2017,
  author    = {Rupp, Caroline S.},
  title     = {What's New in European Property Law? An Overview of Publications in 2015/2016},
  series = {European Property Law Journal},
  volume    = {6},
  journal   = {European Property Law Journal},
  number    = {1},
  issn      = {2190-8362},
  doi       = {10.1515/eplj-2017-0004},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-194449},
  pages     = {87-110},
  year      = {2017},
  abstract  = {No abstract available.},
  language  = {en}
}
@article{NeuchelFuerstNiederwieseretal.2017,
  author    = {Neuchel, Christine and F{\"u}rst, Daniel and Niederwieser, Dietger and Bunjes, Donald and Tsamadou, Chrysanthi and Wulf, Gerald and Pfreundschuh, Michael and Wagner, Eva and Stuhler, Gernot and Einsele, Hermann and Schrezenmeier, Hubert and Mytilineos, Joannis},
  title     = {Impact of donor activating KIR genes on HSCT outcome in C1-ligand negative myeloid disease patients transplanted with unrelated donors - a retrospective study},
  series = {PLOS One},
  volume    = {12},
  journal   = {PLOS One},
  number    = {1},
  doi       = {10.1371/journal.pone.0169512},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-180995},
  pages     = {39},
  year      = {2017},
  abstract  = {Natural Killer cells (NK) are lymphocytes with the potential to recognize and lyse cells which escaped T-cell mediated lysis due to their aberrant HLA expression profiles. Killer cell immunoglobulin-like receptors (KIR) influence NK-cell activity by mediation of activating or inhibitory signals upon interaction with HLA-C (C1, C2) ligands. Therefore, absence of ligands for donor inhibitory KIRs following hematopoietic stem cell transplantation (HSCT) may have an influence on its outcome. Previous studies showed that C1 negative patients have a decreased HSCT outcome. Our study, based on a cohort of 200 C1-negative patients, confirmed these findings for the endpoints: overall survival (OS: HR = 1.41, CI = 1.14-1.74, p = 0.0012), disease free survival (DFS: HR = 1.27, CI = 1.05-1.53, p = 0.015), treatment related mortality (TRM: HR = 1.41, CI = 1.01-1.96, p = 0.04), and relapse incidence (RI: HR = 1.33, CI = 1.01-1.75, p = 0.04) all being inferior when compared to C1-positive patients (n = 1246). Subsequent analysis showed that these findings applied for patients with myeloid malignancies but not for patients with lymphoproliferative diseases (OS: myeloid: HR = 1.51, CI = 1.15-1.99, p = 0.003; lymphoblastic: HR = 1.26, CI = 0.91-1.75, p = 0.16; DFS: myeloid: HR = 1.31, CI = 1.01-1.70, p = 0.04; lymphoblastic: HR = 1.21, CI = 0.90-1.61, p = 0.21; RI: myeloid: HR = 1.31, CI = 1.01-1.70, p = 0.04; lymphoblastic: HR = 1.21, CI = 0.90-1.61, p = 0.21). Interestingly, within the C1-negative patient group, transplantation with KIR2DS2 resulted in better OS (9/10 matched: HR = 0.24, CI = 0.08-0.67, p = 0.007) as well as DFS (9/10 matched: HR = 0,26, CI = 0.11-0.60, p = 0.002), and transplantation with KIR2DS1 positive donors was associated with a decreased RI (HR = 0.30, CI = 0.13-0.69, p = 0.005). TRM was increased when the donor was positive for KIR2DS1 (HR = 2.61, CI = 1.26-5.41, p = 0.001). Our findings suggest that inclusion of KIR2DS1/2/5 and KIR3DS1-genotyping in the unrelated donor search algorithm of C1-ligand negative patients with myeloid malignancies may prove to be of clinical relevance.},
  language  = {en}
}
@article{LapaKircherSchirbeletal.2017,
  author    = {Lapa, Constantin and Kircher, Stefan and Schirbel, Andreas and Rosenwald, Andreas and Kropf, Saskia and Pelzer, Theo and Walles, Thorsten and Buck, Andreas K. and Weber, Wolfgang A. and Wester, Hans-Juergen and Herrmann, Ken and L{\"u}ckerath, Katharina},
  title     = {Targeting CXCR4 with [\(^{68}\)Ga]Pentixafor: a suitable theranostic approach in pleural mesothelioma?},
  series = {Oncotarget},
  volume    = {8},
  journal   = {Oncotarget},
  number    = {57},
  doi       = {10.18632/oncotarget.18235},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-169989},
  pages     = {96732-96737},
  year      = {2017},
  abstract  = {C-X-C motif chemokine receptor 4 (CXCR4) is a key factor for tumor growth and metastasis in several types of human cancer. This study investigated the feasibility of CXCR4-directed imaging with positron emission tomography/computed tomography (PET/CT) using [\(^{68}\)Ga]Pentixafor in malignant pleural mesothelioma. Six patients with pleural mesothelioma underwent [\(^{68}\)Ga]Pentixafor-PET/CT. 2′-[\(^{18}\)F]fluoro-2′-deoxy-D-glucose ([\(^{18}\)F]FDG)-PET/CT (4/6 patients) and immunohistochemistry obtained from biopsy or surgery (all) served as standards of reference. Additionally, 9 surgical mesothelioma samples were available for histological work-up. Whereas [\(^{18}\)F]FDG-PET depicted active lesions in all patients, [\(^{68}\)Ga]Pentixafor-PET/CT recorded physiologic tracer distribution and none of the 6 patients presented [\(^{68}\)Ga]Pentixafor-positive lesions. This finding paralleled results of immunohistochemistry which also could not identify relevant CXCR4 surface expression in the samples analyzed. In contrast to past reports, our data suggest widely absence of CXCR4 expression in pleural mesothelioma. Hence, robust cell surface expression should be confirmed prior to targeting this chemokine receptor for diagnosis and/or therapy.},
  language  = {en}
}
@article{SunkavalliAguilarSilvaetal.2017,
  author    = {Sunkavalli, Ushasree and Aguilar, Carmen and Silva, Ricardo Jorge and Sharan, Malvika and Cruz, Ana Rita and Tawk, Caroline and Maudet, Claire and Mano, Miguel and Eulalio, Ana},
  title     = {Analysis of host microRNA function uncovers a role for miR-29b-2-5p in Shigella capture by filopodia},
  series = {PLoS Pathogens},
  volume    = {13},
  journal   = {PLoS Pathogens},
  number    = {4},
  doi       = {10.1371/journal.ppat.1006327},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-158204},
  pages     = {e1006327},
  year      = {2017},
  abstract  = {MicroRNAs play an important role in the interplay between bacterial pathogens and host cells, participating as host defense mechanisms, as well as exploited by bacteria to subvert host cellular functions. Here, we show that microRNAs modulate infection by Shigella flexneri, a major causative agent of bacillary dysentery in humans. Specifically, we characterize the dual regulatory role of miR-29b-2-5p during infection, showing that this microRNA strongly favors Shigella infection by promoting both bacterial binding to host cells and intracellular replication. Using a combination of transcriptome analysis and targeted high-content RNAi screening, we identify UNC5C as a direct target of miR-29b-2-5p and show its pivotal role in the modulation of Shigella binding to host cells. MiR-29b-2-5p, through repression of UNC5C, strongly enhances filopodia formation thus increasing Shigella capture and promoting bacterial invasion. The increase of filopodia formation mediated by miR-29b-2-5p is dependent on RhoF and Cdc42 Rho-GTPases. Interestingly, the levels of miR-29b-2-5p, but not of other mature microRNAs from the same precursor, are decreased upon Shigella replication at late times post-infection, through degradation of the mature microRNA by the exonuclease PNPT1. While the relatively high basal levels of miR-29b-2-5p at the start of infection ensure efficient Shigella capture by host cell filopodia, dampening of miR-29b-2-5p levels later during infection may constitute a bacterial strategy to favor a balanced intracellular replication to avoid premature cell death and favor dissemination to neighboring cells, or alternatively, part of the host response to counteract Shigella infection. Overall, these findings reveal a previously unappreciated role of microRNAs, and in particular miR-29b-2-5p, in the interaction of Shigella with host cells.},
  language  = {en}
}
@article{PieczykolanHuestegge2017,
  author    = {Pieczykolan, Aleks and Huestegge, Lynn},
  title     = {Cross-modal Action Complexity: Action- and Rule-related Memory Retrieval in Dual-response Control},
  series = {Frontiers in Psychology},
  volume    = {8},
  journal   = {Frontiers in Psychology},
  number    = {529},
  doi       = {10.3389/fpsyg.2017.00529},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-157794},
  year      = {2017},
  abstract  = {Normally, we do not act within a single effector system only, but rather coordinate actions across several output modules (cross-modal action). Such cross-modal action demands can vary substantially with respect to their complexity in terms of the number of task-relevant response combinations and to-be-retrieved stimulus-response (S-R) mapping rules. In the present study, we study the impact of these two types of cross-modal action complexity on dual-response costs (i.e., performance differences between single- and dual-action demands). In Experiment 1, we combined a manual and an oculomotor task, each involving four response alternatives. Crucially, one (unconstrained) condition involved all 16 possible combinations of response alternatives, whereas a constrained condition involved only a subset of possible response combinations. The results revealed that preparing for a larger number of response combinations yielded a significant, but moderate increase in dual-response costs. In Experiment 2, we utilized one common lateralized auditory (e.g., left) stimulus to trigger incompatible response compounds (e.g., left saccade and right key press or vice versa). While one condition only involved one set of task-relevant S-R rules, another condition involved two sets of task-relevant rules (coded by stimulus type: noise/tone), while the number of task-relevant response combinations was the same in both conditions. Here, an increase in the number of to-be-retrieved S-R rules was associated with a substantial increase in dual-response costs that were also modulated on a trial-by-trial basis when switching between rules. Taken together, the results shed further light on the dependency of cross-modal action control on both action- and rule-related memory retrieval processes.},
  language  = {en}
}
@article{SchmidtSkafGavriletal.2017,
  author    = {Schmidt, Marianne and Skaf, Josef and Gavril, Georgiana and Polednik, Christine and Roller, Jeanette and Kessler, Michael and Holzgrabe, Ulrike},
  title     = {The influence of Osmunda regalis root extract on head and neck cancer cell proliferation, invasion and gene expression},
  series = {BMC Complementary and Alternative Medicine},
  volume    = {17},
  journal   = {BMC Complementary and Alternative Medicine},
  number    = {518},
  doi       = {10.1186/s12906-017-2009-4},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-158704},
  year      = {2017},
  abstract  = {Background: According to only a handful of historical sources, Osmunda regalis, the royal fern, has been used already in the middle age as an anti-cancer remedy. To examine this ancient cancer cure, an ethanolic extract of the roots was prepared and analysed in vitro on its effectiveness against head and neck cancer cell lines. Methods: Proliferation inhibition was measured with the MTT assay. Invasion inhibition was tested in a spheroid-based 3-D migration assay on different extracellular matrix surfaces. Corresponding changes in gene expression were analysed by qRT-PCR array. Induction of apoptosis was measured by fluorescence activated cell sorting (FACS) with the Annexin V binding method. The plant extract was analysed by preliminary phytochemical tests, liquid chromatography/mass spectroscopy (LC-MS) and thin layer chromatography (TLC). Anti-angiogenetic activity was determined by the tube formation assay. Results: O. regalis extract revealed a growth inhibiting effect on the head and neck carcinoma cell lines HLaC78 and FaDu. The toxic effect seems to be partially modulated by p-glycoprotein, as the MDR-1 expressing HLaC79-Tax cells were less sensitive. O. regalis extract inhibited the invasion of cell lines on diverse extracellular matrix substrates significantly. Especially the dispersion of the highly motile cell line HlaC78 on laminin was almost completely abrogated. Motility inhibition on laminin was accompanied by differential gene regulation of a variety of genes involved in cell adhesion and metastasis. Furthermore, O. regalis extract triggered apoptosis in HNSCC cell lines and inhibited tube formation of endothelial cells. Preliminary phytochemical analysis proved the presence of tannins, glycosides, steroids and saponins. Liquid chromatography/mass spectroscopy (LC-MS) revealed a major peak of an unknown substance with a molecular mass of 864.15 Da, comprising about 50\% of the total extract. Thin layer chromatography identified ferulic acid to be present in the extract. Conclusion: The presented results justify the use of royal fern extracts as an anti-cancer remedy in history and imply a further analysis of ingredients.},
  language  = {en}
}
@article{WernerWeichHiguchietal.2017,
  author    = {Werner, Rudolf A. and Weich, Alexander and Higuchi, Takahiro and Schmid, Jan S. and Schirbel, Andreas and Lassmann, Michael and Wild, Vanessa and Rudelius, Martina and Kudlich, Theodor and Herrmann, Ken and Scheurlen, Michael and Buck, Andreas K. and Kropf, Saskia and Wester, Hans-J{\"u}rgen and Lapa, Constantin},
  title     = {Imaging of Chemokine Receptor 4 Expression in Neuroendocrine Tumors - a Triple Tracer Comparative Approach},
  series = {Theranostics},
  volume    = {7},
  journal   = {Theranostics},
  number    = {6},
  doi       = {10.7150/thno.18754},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-158008},
  pages     = {1489-1498},
  year      = {2017},
  abstract  = {C-X-C motif chemokine receptor 4 (CXCR4) and somatostatin receptors (SSTR) are overexpressed in gastro-entero-pancreatic neuroendocrine tumors (GEP-NET). In this study, we aimed to elucidate the feasibility of non-invasive CXCR4 positron emission tomography/computed tomography (PET/CT) imaging in GEP-NET patients using [\(^{68}\)Ga]Pentixafor in comparison to \(^{68}\)Ga-DOTA-D-Phe-Tyr3-octreotide ([\(^{68}\)Ga]DOTATOC) and \(^{18}\)F-fluorodeoxyglucose ([\(^{18}\)F]FDG). Twelve patients with histologically proven GEP-NET (3xG1, 4xG2, 5xG3) underwent [\(^{68}\)Ga]DOTATOC, [\(^{18}\)F]FDG, and [\(^{68}\)Ga]Pentixafor PET/CT for staging and planning of the therapeutic management. Scans were analyzed on a patient as well as on a lesion basis and compared to immunohistochemical staining patterns of CXCR4 and somatostatin receptors SSTR2a and SSTR5. [\(^{68}\)Ga]Pentixafor visualized tumor lesions in 6/12 subjects, whereas [\(^{18}\)F]FDG revealed sites of disease in 10/12 and [\(^{68}\)Ga]DOTATOC in 11/12 patients, respectively. Regarding sensitivity, SSTR-directed PET was the superior imaging modality in all G1 and G2 NET. CXCR4-directed PET was negative in all G1 NET. In contrast, 50\% of G2 and 80\% of G3 patients exhibited [\(^{68}\)Ga]Pentixafor-positive tumor lesions. Whereas CXCR4 seems to play only a limited role in detecting well-differentiated NET, increasing receptor expression could be non-invasively observed with increasing tumor grade. Thus, [\(^{68}\)Ga]Pentixafor PET/CT might serve as non-invasive read-out for evaluating the possibility of CXCR4-directed endoradiotherapy in advanced dedifferentiated SSTR-negative tumors.},
  subject      = {Positronen-Emissions-Tomografie},
  language  = {en}
}
@article{EmmertKneisel2017,
  author    = {Emmert, Adrian and Kneisel, Christof},
  title     = {Internal structure of two alpine rock glaciers investigated by quasi-3-D electrical resistivity imaging},
  series = {The Cryosphere},
  volume    = {11},
  journal   = {The Cryosphere},
  doi       = {10.5194/tc-11-841-2017},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-157569},
  pages     = {841-855},
  year      = {2017},
  abstract  = {Interactions between different formative processes are reflected in the internal structure of rock glaciers. Therefore, the detection of subsurface conditions can help to enhance our understanding of landform development. For an assessment of subsurface conditions, we present an analysis of the spatial variability of active layer thickness, ground ice content and frost table topography for two different rock glaciers in the Eastern Swiss Alps by means of quasi-3-D electrical resistivity imaging (ERI). This approach enables an extensive mapping of subsurface structures and a spatial overlay between site-specific surface and subsurface characteristics. At Nair rock glacier, we discovered a gradual descent of the frost table in a downslope direction and a constant decrease of ice content which follows the observed surface topography. This is attributed to ice formation by refreezing meltwater from an embedded snow bank or from a subsurface ice patch which reshapes the permafrost layer. The heterogeneous ground ice distribution at Uertsch rock glacier indicates that multiple processes on different time domains were involved in the development. Resistivity values which represent frozen conditions vary within a wide range and indicate a successive formation which includes several advances, past glacial overrides and creep processes on the rock glacier surface. In combination with the observed topography, quasi-3-D ERI enables us to delimit areas of extensive and compressive flow in close proximity. Excellent data quality was provided by a good coupling of electrodes to the ground in the pebbly material of the investigated rock glaciers. Results show the value of the quasi-3-D ERI approach but advise the application of complementary geophysical methods for interpreting the results.},
  language  = {en}
}
@article{OPUS4-17335,
  title     = {Measurement of the inclusive cross-sections of single top-quark and top-antiquark \(t\)-channel production in \(pp\) collisions at \(\sqrt{s}\) = 13 TeV with the ATLAS detector},
  series = {Journal of High Energy Physics},
  volume    = {2017},
  journal   = {Journal of High Energy Physics},
  number    = {04},
  organization    = {The ATLAS Collaboration},
  doi       = {https://doi.org/10.1007/JHEP04(2017)086},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-173357},
  year      = {2017},
  abstract  = {A measurement of the \(t\)-channel single-top-quark and single-top-antiquark production cross-sections in the lepton+jets channel is presented, using 3.2 fb\(^{-1}\) of proton-proton collision data at a centre-of-mass energy of 13 TeV, recorded with the ATLAS detector at the LHC in 2015. Events are selected by requiring one charged lepton (electron or muon), missing transverse momentum, and two jets with high transverse momentum, exactly one of which is required to be \(b\)-tagged. Using a binned maximum-likelihood fit to the discriminant distribution of a neural network, the cross-sections are determined to be \({σ(tq)}\) = 156 ± 5 (stat.) ± 27 (syst.) ± 3 (lumi.) pb for single top-quark production and \(σ(\overline{t}q)\) = 91 ± 4 (stat.) ± 18 (syst.) ± 2 (lumi.) pb for single top-antiquark production, assuming a top-quark mass of 172.5 GeV. The cross-section ratio is measured to be \(R_{t}\) = \(σ(tq)/σ(\overline{t}q)\) = 1.72 ± 0.09 (stat.) ± 0.18 (syst.). All results are in agreement with Standard Model predictions.},
  language  = {en}
}
@article{OPUS4-17336,
  title     = {Measurement of charged-particle distributions sensitive to the underlying event in \(\sqrt{s}\) = 13 TeV proton-proton collisions with the ATLAS detector at the LHC},
  series = {Journal of High Energy Physics},
  volume    = {2017},
  journal   = {Journal of High Energy Physics},
  number    = {03},
  organization    = {The ATLAS Collaboration},
  doi       = {https://doi.org/10.1007/JHEP03(2017)157},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-173361},
  year      = {2017},
  abstract  = {We present charged-particle distributions sensitive to the underlying event, measured by the ATLAS detector in proton-proton collisions at a centre-of-mass energy of 13 TeV, in low-luminosity Large Hadron Collider fills corresponding to an integrated luminosity of 1.6 nb\(^{-1}\). The distributions were constructed using charged particles with absolute pseudorapidity less than 2.5 and with transverse momentum greater than 500 MeV, in events with at least one such charged particle with transverse momentum above 1 GeV. These distributions characterise the angular distribution of energy and particle flows with respect to the charged particle with highest transverse momentum, as a function of both that momentum and of charged-particle multiplicity. The results have been corrected for detector effects and are compared to the predictions of various Monte Carlo event generators, experimentally establishing the level of underlying-event activity at LHC Run 2 energies and providing inputs for the development of event generator modelling. The current models in use for UE modelling typically describe this data to 5\% accuracy, compared with data uncertainties of less than 1\%.},
  language  = {en}
}
@article{BettsNagelSchatzschneideretal.2017,
  author    = {Betts, Jonathan and Nagel, Christopher and Schatzschneider, Ulrich and Poole, Robert and La Ragione, Robert M.},
  title     = {Antimicrobial activity of carbon monoxide-releasing molecule [Mn(CO)\(_3\)(tpa-\(\kappa^{3}N\))]Br versus multidrug-resistant isolates of Avian Pathogenic \(Escherichia\) \(coli\) and its synergy with colistin},
  series = {PLoS ONE},
  volume    = {12},
  journal   = {PLoS ONE},
  number    = {10},
  doi       = {10.1371/journal.pone.0186359},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-173687},
  year      = {2017},
  abstract  = {Antimicrobial resistance is a growing global concern in human and veterinary medicine, with an ever-increasing void in the arsenal of clinicians. Novel classes of compounds including carbon monoxoide-releasing molecules (CORMs), for example the light-activated metal complex [Mn(CO)\(_3\)(tpa-\(\kappa^{3}N\))]Br, could be used as alternatives/to supplement traditional antibacterials. Avian pathogenic \(Escherichia\) \(coli\) (APEC) represent a large reservoir of antibiotic resistance and can cause serious clinical disease in poultry, with potential as zoonotic pathogens, due to shared serotypes and virulence factors with human pathogenic \(E.\) \(coli\). The \(in\) \(vitro\) activity of [Mn(CO)\(_3\)(tpa-\(\kappa^{3}N\))]Br against multidrug-resistant APECs was assessed via broth microtitre dilution assays and synergy testing with colistin performed using checkerboard and time-kill assays. \(In\) \(vivo\) antibacterial activity of [Mn(CO)\(_3\)(tpa-\(\kappa^{3}N\))]Br alone and in combination with colistin was determined using the \(Galleria\) \(mellonella\) wax moth larvae model. Animals were monitored for life/death, melanisation and bacterial numbers enumerated from larval haemolymph. \(In\) \(vitro\) testing produced relatively high [Mn(CO)\(_3\)(tpa-\(\kappa^{3}N\))]Br minimum inhibitory concentrations (MICs) of 1024 mg/L. However, its activity was significantly increased with the addition of colistin, bringing MICs down to \(\geq\)32 mg/L. This synergy was confirmed in time-kill assays. \(In\) \(vivo\) assays showed that the combination of [Mn(CO)\(_3\)(tpa-\(\kappa^{3}N\))]Br with colistin produced superior bacterial killing and significantly increased larval survival. In both \(in\) \(vitro\) and \(in\) \(vivo\) assays light activation was not required for antibacterial activity. This data supports further evaluation of [Mn(CO)\(_3\)(tpa-\(\kappa^{3}N\))]Br as a potential agent for treatment of systemic infections in humans and animals, when used with permeabilising agents such as colistin.},
  language  = {en}
}
@article{ErdmengerFernandezFloryetal.2017,
  author    = {Erdmenger, Johanna and Fern{\´a}ndez, Daniel and Flory, Mario and Meg{\´i}as, Eugenio and Straub, Ann-Kathrin and Witkowski, Piotr},
  title     = {Time evolution of entanglement for holographic steady state formation},
  series = {Journal of High Energy Physics},
  volume    = {2017},
  journal   = {Journal of High Energy Physics},
  number    = {10},
  doi       = {10.1007/JHEP10(2017)034},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-173798},
  year      = {2017},
  abstract  = {Within gauge/gravity duality, we consider the local quench-like time evolution obtained by joining two 1+1-dimensional heat baths at different temperatures at time \(t\) = 0. A steady state forms and expands in space. For the 2+1-dimensional gravity dual, we find that the "shockwaves" expanding the steady-state region are of spacelike nature in the bulk despite being null at the boundary. However, they do not transport information. Moreover, by adapting the time-dependent Hubeny-Rangamani-Takayanagi prescription, we holographically calculate the entanglement entropy and also the mutual information for different entangling regions. For general temperatures, we find that the entanglement entropy increase rate satisfies the same bound as in the 'entanglement tsunami' setups. For small temperatures of the two baths, we derive an analytical formula for the time dependence of the entanglement entropy. This replaces the entanglement tsunami-like behaviour seen for high temperatures. Finally, we check that strong subadditivity holds in this time-dependent system, as well as further more general entanglement inequalities for five or more regions recently derived for the static case.},
  language  = {en}
}
@article{WolterHanselmannPattschulletal.2017,
  author    = {Wolter, Patrick and Hanselmann, Steffen and Pattschull, Grit and Schruf, Eva and Gaubatz, Stefan},
  title     = {Central spindle proteins and mitotic kinesins are direct transcriptional targets of MuvB, B-MYB and FOXM1 in breast cancer cell lines and are potential targets for therapy},
  series = {Oncotarget},
  volume    = {8},
  journal   = {Oncotarget},
  number    = {7},
  doi       = {10.18632/oncotarget.14466},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-171851},
  pages     = {11160-11172},
  year      = {2017},
  abstract  = {The MuvB multiprotein complex, together with B-MYB and FOXM1 (MMB-FOXM1), plays an essential role in cell cycle progression by regulating the transcription of genes required for mitosis and cytokinesis. In many tumors, B-MYB and FOXM1 are overexpressed as part of the proliferation signature. However, the transcriptional targets that are important for oncogenesis have not been identified. Given that mitotic kinesins are highly expressed in cancer cells and that selected kinesins have been reported as target genes of MMB-FOXM1, we sought to determine which mitotic kinesins are directly regulated by MMB-FOXM1. We demonstrate that six mitotic kinesins and two microtubule-associated non-motor proteins (MAPs) CEP55 and PRC1 are direct transcriptional targets of MuvB, B-MYB and FOXM1 in breast cancer cells. Suppression of KIF23 and PRC1 strongly suppressed proliferation of MDA-MB-231 cells. The set of MMB-FOXM1 regulated kinesins genes and 4 additional kinesins which we referred to as the mitotic kinesin signature (MKS) is linked to poor outcome in breast cancer patients. Thus, mitotic kinesins could be used as prognostic biomarker and could be potential therapeutic targets for the treatment of breast cancer.},
  language  = {en}
}
@article{SanderXuEilersetal.2017,
  author    = {Sander, Bodo and Xu, Wenshan and Eilers, Martin and Popov, Nikita and Lorenz, Sonja},
  title     = {A conformational switch regulates the ubiquitin ligase HUWE1},
  series = {eLife},
  volume    = {6},
  journal   = {eLife},
  doi       = {10.7554/eLife.21036},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-171862},
  year      = {2017},
  abstract  = {The human ubiquitin ligase HUWE1 has key roles in tumorigenesis, yet it is unkown how its activity is regulated. We present the crystal structure of a C-terminal part of HUWE1, including the catalytic domain, and reveal an asymmetric auto-inhibited dimer. We show that HUWE1 dimerizes in solution and self-associates in cells, and that both occurs through the crystallographic dimer interface. We demonstrate that HUWE1 is inhibited in cells and that it can be activated by disruption of the dimer interface. We identify a conserved segment in HUWE1 that counteracts dimer formation by associating with the dimerization region intramolecularly. Our studies reveal, intriguingly, that the tumor suppressor p14ARF binds to this segment and may thus shift the conformational equilibrium of HUWE1 toward the inactive state. We propose a model, in which the activity of HUWE1 underlies conformational control in response to physiological cues—a mechanism that may be exploited for cancer therapy.},
  language  = {en}
}
@article{AltieriSbieraDellaCasaetal.2017,
  author    = {Altieri, Barbara and Sbiera, Silviu and Della Casa, Silvia and Weigand, Isabel and Wild, Vanessa and Steinhauer, Sonja and Fadda, Guido and Kocot, Arkadius and Bekteshi, Michaela and Mambretti, Egle M. and Rosenwald, Andreas and Pontecorvi, Alfredo and Fassnacht, Martin and Ronchi, Cristina L.},
  title     = {Livin/BIRC7 expression as malignancy marker in adrenocortical tumors},
  series = {Oncotarget},
  volume    = {8},
  journal   = {Oncotarget},
  number    = {6},
  doi       = {10.18632/oncotarget.14067},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-171887},
  pages     = {9323-9338},
  year      = {2017},
  abstract  = {Livin/BIRC7 is a member of the inhibitors of apoptosis proteins family, which are involved in tumor development through the inhibition of caspases. Aim was to investigate the expression of livin and other members of its pathway in adrenocortical tumors and in the adrenocortical carcinoma (ACC) cell line NCI-H295R. The mRNA expression of livin, its isoforms α and β, XIAP, CASP3 and DIABLO was evaluated by qRT-PCR in 82 fresh-frozen adrenal tissues (34 ACC, 25 adenomas = ACA, 23 normal adrenal glands = NAG). Livin protein expression was assessed by immunohistochemistry in 270 paraffin-embedded tissues (192 ACC, 58 ACA, 20 NAG). Livin, CASP3 and cleaved caspase-3 were evaluated in NCI-H295R after induction of livin overexpression. Relative livin mRNA expression was significantly higher in ACC than in ACA and NAG (0.060 ± 0.116 vs 0.004 ± 0.014 and 0.002 ± 0.009, respectively, p < 0.01), being consistently higher in tumors than in adjacent NAG and isoform β more expressed than α. No significant differences in CASP3, XIAP and DIABLO levels were found among these groups. In immunohistochemistry, livin was localized in both cytoplasm and nuclei. The ratio between cytoplasmic and nuclear staining was significantly higher in ACC (1.51 ± 0.66) than in ACA (0.80 ± 0.35) and NAG (0.88 ± 0.27; p < 0.0001). No significant correlations were observed between livin expression and histopathological parameters or clinical outcome. In NCI-H295R cells, the livin overexpression slightly reduced the activation of CASP3, but did not correlate with cell viability. In conclusion, livin is specifically over-expressed in ACC, suggesting that it might be involved in adrenocortical tumorigenesis and represent a new molecular marker of malignancy.},
  language  = {en}
}
@article{JiGriesbeckMarder2017,
  author    = {Ji, Lei and Griesbeck, Stefanie and Marder, Todd B.},
  title     = {Recent developments in and perspectives on three-coordinate boron materials: a bright future},
  series = {Chemical Science},
  volume    = {8},
  journal   = {Chemical Science},
  number    = {2},
  doi       = {10.1039/c6sc04245g},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-171912},
  pages     = {846-863},
  year      = {2017},
  abstract  = {The empty p\(_z\)-orbital of a three-coordinate organoboron compound leads to its electron-deficient properties, which make it an excellent π-acceptor in conjugated organic chromophores. The empty p-orbital in such Lewis acids can be attacked by nucleophiles, so bulky groups are often employed to provide air-stable materials. However, many of these can still bind fluoride and cyanide anions leading to applications as anion-selective sensors. One electron reduction generates radical anions. The π-acceptor strength can be easily tuned by varying the organic substituents. Many of these compounds show strong two-photon absorption (TPA) and two-photon excited fluorescence (TPEF) behaviour, which can be applied for e.g. biological imaging. Furthermore, these chromophores can be used as emitters and electron transporters in OLEDs, and examples have recently been found to exhibit efficient thermally activated delayed fluorescence (TADF). The three-coordinate organoboron unit can also be incorporated into polycyclic aromatic hydrocarbons. Such boron-doped compounds exhibit very interesting properties, distinct from their all-carbon analogues. Significant developments have been made in all of these areas in recent years and new applications are rapidly emerging for this class of boron compounds.},
  language  = {en}
}
@article{PollingerSchmittSanderetal.2017,
  author    = {Pollinger, Florian and Schmitt, Stefan and Sander, Dirk and Tian, Zhen and Kirschner, J{\"u}rgen and Vrdoljak, Pavo and Stadler, Christoph and Maier, Florian and Marchetto, Helder and Schmidt, Thomas and Sch{\"o}ll, Achim and Umbach, Eberhard},
  title     = {Nanoscale patterning, macroscopic reconstruction, and enhanced surface stress by organic adsorption on vicinal surfaces},
  series = {New Journal of Physics},
  volume    = {19},
  journal   = {New Journal of Physics},
  doi       = {10.1088/1367-2630/aa55b8},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-171947},
  year      = {2017},
  abstract  = {Self-organization is a promising method within the framework of bottom-up architectures to generate nanostructures in an efficient way. The present work demonstrates that self- organization on the length scale of a few to several tens of nanometers can be achieved by a proper combination of a large (organic) molecule and a vicinal metal surface if the local bonding of the molecule on steps is significantly stronger than that on low-index surfaces. In this case thermal annealing may lead to large mass transport of the subjacent substrate atoms such that nanometer-wide and micrometer-long molecular stripes or other patterns are being formed on high-index planes. The formation of these patterns can be controlled by the initial surface orientation and adsorbate coverage. The patterns arrange self-organized in regular arrays by repulsive mechanical interactions over long distances accompanied by a significant enhancement of surface stress. We demonstrate this effect using the planar organic molecule PTCDA as adsorbate and Ag(10 8 7) and Ag(775)surfaces as substrate. The patterns are directly observed by STM, the formation of vicinal surfaces is monitored by highresolution electron diffraction, the microscopic surface morphology changes are followed by spectromicroscopy, and the macroscopic changes of surface stress are measured by a cantilever bending method. The in situ combination of these complementary techniques provides compelling evidence for elastic interaction and a significant stress contribution to long-range order and nanopattern formation.},
  language  = {en}
}
@article{ElsaesserSchieblMukhinetal.2017,
  author    = {Els{\"a}sser, S. and Schiebl, M. and Mukhin, A. A. and Balbashov, A. M. and Pimenov, A. and Geurts, J.},
  title     = {Impact of temperature-dependent local and global spin order in \(R\)MnO\(_3\) compounds for spin-phonon coupling and electromagnon activity},
  series = {New Journal of Physics},
  volume    = {19},
  journal   = {New Journal of Physics},
  doi       = {10.1088/1367-2630/aa55ed},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-171978},
  year      = {2017},
  abstract  = {The orthorhombic rare-earth manganite compounds \(R\)MnO\(_3\) show a global magnetic order for \(T\) < \(T\)\(_N\), and several representatives are multiferroic with a cycloidal spin ground state order for \(T\) < \(T\)\(_c\)\(_y\)\(_c\)\(_l\) < \(T\)\(_N\) \(\approx\) 40 K. We deduce from the temperature dependence of spin-phonon coupling in Raman spectroscopy for a series of \(R\)MnO\(_3\) compounds that their spin order locally persists up to about twice \(T\)\(_N\). Along the same line, our observation of the persistence of the electromagnon in GdMnO\(_3\) up to \(T\) \(\approx\) 100 K is attributed to a local cycloidal spin order for \(T\) > \(T\)\(_c\)\(_y\)\(_c\)\(_l\), in contrast to the hitherto assumed incommensurate sinusoidal phase in the intermediate temperature range. The development of the magnetization pattern can be described in terms of an order-disorder transition at \(T\)\(_c\)\(_y\)\(_c\)\(_l\) within a pseudospin model of localized spin cycloids with opposite chirality.},
  language  = {en}
}
@article{KraftStanglKrauseetal.2017,
  author    = {Kraft, Andreas and Stangl, Johannes and Krause, Ana-Maria and M{\"u}ller-Buschbaum, Klaus and Beuerle, Florian},
  title     = {Supramolecular frameworks based on [60]fullerene hexakisadducts},
  series = {Beilstein Journal of Organic Chemistry},
  volume    = {13},
  journal   = {Beilstein Journal of Organic Chemistry},
  doi       = {10.3762/bjoc.13.1},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-171996},
  pages     = {1-9},
  year      = {2017},
  abstract  = {[60]Fullerene hexakisadducts possessing 12 carboxylic acid side chains form crystalline hydrogen-bonding frameworks in the solid state. Depending on the length of the linker between the reactive sites and the malonate units, the distance of the [60]fullerene nodes and thereby the spacing of the frameworks can be controlled and for the most elongated derivative, continuous channels are obtained within the structure. Stability, structural integrity and porosity of the material were investigated by powder X-ray diffraction, thermogravimetry and sorption measurements.},
  language  = {en}
}
@article{FayezFeineisMudogoetal.2017,
  author    = {Fayez, Shaimaa and Feineis, Doris and Mudogo, Virima and Awale, Suresh and Bringmann, Gerhard},
  title     = {Ancistrolikokines E-H and related 5,8\('\)-coupled naphthylisoquinoline alkaloids from the Congolese liana \(Ancistrocladus\) \(likoko\) with antiausterity activities against PANC-1 human pancreatic cancer cells},
  series = {RSC Advances},
  volume    = {7},
  journal   = {RSC Advances},
  number    = {85},
  doi       = {10.1039/c7ra11200a},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-172008},
  pages     = {53740-53751},
  year      = {2017},
  abstract  = {A striking feature of the metabolite profile of \(Ancistrocladus\) \(likoko\) (Ancistrocladaceae) is the exclusive production of 5,8\('\)-linked naphthylisoquinoline alkaloids varying in their OMe/OH substitution patterns and in the hydrogenation degree in their isoquinoline portions. Here we present nine new compounds of this coupling type isolated from the twigs of this remarkable Central African liana. Three of them, the ancistrolikokines E (9), E\(_2\) (10), and F (11), are the first 5,8\('\)-linked naphthyldihydroisoquinolines found in nature with \(R\)-configuration at C-3. The fourth new metabolite, ancistrolikokine G (12), is so far the only representative of the 5,8\('\)-coupling type that belongs to the very rare group of alkaloids with a fully dehydrogenated isoquinoline portion. Moreover, five new \(N\)-methylated naphthyltetrahydroisoquinolines, named ancistrolikokines A\(_2\) (13), A\(_3\) (14), C\(_2\) (5), H (15), and H\(_2\) (16) are presented, along with six known 5,8\('\)-linked alkaloids, previously identified in related African \(Ancistrocladus\) species, now found for the first time in \(A.\) \(likoko\). The structural elucidation was achieved by spectroscopic analysis (HRESIMS, 1D and 2D NMR) and by chemical (oxidative degradation) and chiroptical (electronic circular dichroism) methods. The new ancistrolikokines showed moderate to good preferential cytotoxic activities towards pancreatic PANC-1 cells in nutrient-deprived medium (NDM), without causing toxicity under normal, nutrient-rich conditions, with ancistrolikokine H\(_2\) (16) being the most potent compound.},
  language  = {en}
}
@article{PaethPaxianSeinetal.2017,
  author    = {Paeth, Heiko and Paxian, Andreas and Sein, Dimitry V. and Jacob, Daniela and Panitz, Hans-J{\"u}rgen and Warscher, Michael and Fink, Andreas H. and Kunstmann, Harald and Breil, Marcus and Engel, Thomas and Krause, Andreas and Toedter, Julian and Ahrens, Bodo},
  title     = {Decadal and multi-year predictability of the West African monsoon and the role of dynamical downscaling},
  series = {Meteorologische Zeitschrift},
  volume    = {26},
  journal   = {Meteorologische Zeitschrift},
  number    = {4},
  doi       = {10.1127/metz/2017/0811},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-172018},
  pages     = {363-377},
  year      = {2017},
  abstract  = {West African summer monsoon precipitation is characterized by distinct decadal variability. Due to its welldocumented link to oceanic boundary conditions in various ocean basins it represents a paradigm for decadal predictability. In this study, we reappraise this hypothesis for several sub-regions of sub-Saharan West Africa using the new German contribution to the coupled model intercomparison project phase 5 (CMIP5) near-term prediction system. In addition, we assume that dynamical downscaling of the global decadal predictions leads to an enhanced predictive skill because enhanced resolution improves the atmospheric response to oceanic forcing and landsurface feedbacks. Based on three regional climate models, a heterogeneous picture is drawn: none of the regional climate models outperforms the global decadal predictions or all other regional climate models in every region nor decade. However, for every test case at least one regional climate model was identified which outperforms the global predictions. The highest predictive skill is found in the western and central Sahel Zone with correlation coefficients and mean-square skill scores exceeding 0.9 and 0.8, respectively.},
  language  = {en}
}