@phdthesis{Engbers2022,
  author    = {Engbers, Sarah},
  title     = {Krankheitslast und Auftreten erkrankungsassoziierter Komplikationen bei Patienten mit chronischem Hypoparathyreoidismus - Patienten-Survey},
  doi       = {10.25972/OPUS-29073},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-290739},
  school      = {Universit{\"a}t W{\"u}rzburg},
  year      = {2022},
  abstract  = {Objective: To investigate general morbidity, hypocalcemic events, Subjective Health Status (SHS) and daily life performance in patients with chronic hypoparathyroidism (HPT). Methods: Patients with chronic HPT and pseudo-HPT (n=412) from several German Centers were contacted. 215 subjects responded (response rate 52\%) and 205 were included. Patients received a disease specific questionnaire asking for SHS, interference of HPT with daily life and work life, disease associated morbidity and emergency events. SHS was assessed by SF-36. Data was compared to sex- and age-matched controls. Results: SF-36 values indicated significantly impaired SHS in HPT patients compared to the general population. Rating of general health was significantly worse in HPT compared to controls. Lifetime prevalence of depression, anxiety and renal insufficiency was higher in patients with HPT (22\% vs. 15\%; 21\% vs. 6\%; 11\% vs. 2\%, respectively, all p<0.01). Significantly more patients received antihypertensive treatment or antiepileptic agents (44\% vs. 34\%, p=0.003; 5\% vs. 2\%, p=0.01, respectively). Prevalence of cataract, cardiac arrhythmia, renal stones and nephrocalcinosis was 18\%, 16\%, 8\% and 6\%, respectively. 37\% reported impaired work life and more HPT patients retired at age <65y (21\% vs. 10\%, p<0.001). HPT patients more frequently indicated impairment of daily life activities for health reasons (58\% vs. 32\%, p<0.001). Since primary diagnosis 36\% of patients had presented at least once at an emergency department or were admitted to hospital because of HPT. Overall frequency of hypocalcemic emergencies requiring i.v. calcium was 14.7 events per 100 patient years. Hospitalization rate within the previous 12 months was, however, not significantly different from controls. Conclusion: Despite established treatment, chronic HPT is associated with a significantly reduced subjective health status, a variety of complications and an impairment of daily life performance.},
  language  = {de}
}