@article{TackeBentlageSheldricketal.1982,
  author    = {Tacke, R. and Bentlage, A. and Sheldrick, W. S. and Ernst, L. and Towart, R. and Stoepel, K.},
  title     = {Sila-Pharmaka, 24. Mitt. [1]. Sila-Analoga von Nifedipin-{\"a}hnlichen 4-Aryl-2.6-dimethyl-1.4-dihydropyridin- 3.5-dicarbons{\"a}ure-dialkylestern, II.},
  series = {Zeitschrift f{\"u}r Naturforschung B},
  volume    = {37},
  journal   = {Zeitschrift f{\"u}r Naturforschung B},
  number    = {4},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-128381},
  pages     = {443-450},
  year      = {1982},
  abstract  = {In the course of systematic studies on sila-substituted drugs the nifedipine-like 1.4-dihydropyridine derivatives 4a, 4b and 4c were prepared and investigated with respect to sila-substitution effects. By X-ray diffraction analyses 4a, 4b and 4c were found to be isostructural. The C/Si-analogues exhibit similar spasmolytic activities (in vitro, guinea pig ileum), comparable with that of nifedipine. However, the compounds differ substantially in their in vivo activity, as measured by the antihypertensive effect on the renal-hypertensive rat. The experimental results are discussed with respect to the carbon/silicon exchange.},
  language  = {de}
}
@article{TackeLinohAttarBashietal.1982,
  author    = {Tacke, Reinhold and Linoh, Haryanto and Attar-Bashi, Moayad T. and Sheldrick, William S. and Ernst, Ludger and Niedner, Roland and Frohnecke, Joachim},
  title     = {Sila-Pharmaka, 26. Mitt. [1] Darstellung und Eigenschaften potentiell curarewirksamer Silicium-Verbindungen, III},
  series = {Zeitschrift f{\"u}r Naturforschung B},
  volume    = {37},
  journal   = {Zeitschrift f{\"u}r Naturforschung B},
  number    = {11},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-128402},
  pages     = {1461-1471},
  year      = {1982},
  abstract  = {The potentially curare-like silicon compounds 8a- 8f were synthesized and investigated with respect to their structure-activity relationships. The conformations of the compounds in the solid state and in solution were studied by X-ray diffraction analysis (8a- 8e) and IR NMR spectroscopy (8a- 8f), respectively. The muscle relaxing properties of 8a- 8f were investigated on the mouse. The observed structure-activity relationships are not in accordance with the classical "14 {\AA} model" for neuromuscular blocking agents.},
  language  = {de}
}