@article{VainioValtonenHeberetal.2013,
  author    = {Vainio, Rami and Valtonen, Eino and Heber, Bernd and Malandraki, Olga E. and Papaioannou, Athanasios and Klein, Karl-Ludwig and Afanasiev, Alexander and Agueda, Neus and Aurass, Henry and Battarbee, Markus and Braune, Stephan and Dr{\"o}ge, Wolfgang and Ganse, Urs and Hamadache, Clarisse and Heynderickx, Daniel and Huttunen-Heikinmaa, Kalle and Kiener, J{\"u}rgen and Kilian, Patrick and Kopp, Andreas and Kouloumvakos, Athanasios and Maisala, Sami and Mishev, Alexander and Miteva, Rosita and Nindos, Alexander and Oittinen, Tero and Raukunen, Osku and Riihonen, Esa and Rodriguez-Gasen, Rosa and Saloniemi, Oskari and Sanahuja, Blai and Scherer, Renate and Spanier, Felix and Tatischeff, Vincent and Tziotziou, Kostas and Usoskin, Ilya G. and Vilmer, Nicole},
  title     = {The first SEPServer event catalogue similar to ~68-MeV solar proton events observed at 1 AU in 1996-2010},
  series = {Journal of Space Weather and Space Climate},
  volume    = {3},
  journal   = {Journal of Space Weather and Space Climate},
  number    = {A12},
  issn      = {2115-7251},
  doi       = {10.1051/swsc/2013030},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-122847},
  year      = {2013},
  abstract  = {SEPServer is a three-year collaborative project funded by the seventh framework programme (FP7-SPACE) of the European Union. The objective of the project is to provide access to state-of-the-art observations and analysis tools for the scientific community on solar energetic particle (SEP) events and related electromagnetic (EM) emissions. The project will eventually lead to better understanding of the particle acceleration and transport processes at the Sun and in the inner heliosphere. These processes lead to SEP events that form one of the key elements of space weather. In this paper we present the first results from the systematic analysis work performed on the following datasets: SOHO/ERNE, SOHO/EPHIN, ACE/EPAM, Wind/WAVES and GOES X-rays. A catalogue of SEP events at 1 AU, with complete coverage over solar cycle 23, based on high-energy (similar to 68-MeV) protons from SOHO/ERNE and electron recordings of the events by SOHO/EPHIN and ACE/EPAM are presented. A total of 115 energetic particle events have been identified and analysed using velocity dispersion analysis (VDA) for protons and time-shifting analysis (TSA) for electrons and protons in order to infer the SEP release times at the Sun. EM observations during the times of the SEP event onset have been gathered and compared to the release time estimates of particles. Data from those events that occurred during the European day-time, i.e., those that also have observations from ground-based observatories included in SEPServer, are listed and a preliminary analysis of their associations is presented. We find that VDA results for protons can be a useful tool for the analysis of proton release times, but if the derived proton path length is out of a range of 1 AU < s less than or similar to 3 AU, the result of the analysis may be compromised, as indicated by the anti-correlation of the derived path length and release time delay from the associated X-ray flare. The average path length derived from VDA is about 1.9 times the nominal length of the spiral magnetic field line. This implies that the path length of first-arriving MeV to deka-MeV protons is affected by interplanetary scattering. TSA of near-relativistic electrons results in a release time that shows significant scatter with respect to the EM emissions but with a trend of being delayed more with increasing distance between the flare and the nominal footpoint of the Earth-connected field line.},
  language  = {en}
}
@article{SchosseeVeitGitteletal.2022,
  author    = {Schossee, Nadine and Veit, Gabriele and Gittel, Julia and Viebahn, Johannes and Niklaus, Marius and Klingler, Philipp and {\"U}{\c{c}}eyler, Nurcan and Klinker, Erdwine and Kobsar, Anna and Boeck, Markus and Koessler, Juergen},
  title     = {Profile of the single-use, multiple-pass protein A adsorber column in immunoadsorption},
  series = {Vox Sanguinis},
  volume    = {117},
  journal   = {Vox Sanguinis},
  number    = {3},
  doi       = {10.1111/vox.13205},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-259689},
  pages     = {393-398},
  year      = {2022},
  abstract  = {Background and Objectives Immunoadsorptions (IA) are used to remove autoantibodies from the plasma in autoimmune disorders. In this study, we evaluated the effects of a single-use, recombinant staphylococcal protein A-based immunoadsorber on blood composition of the patient. Materials and Methods In a cohort of patients with myasthenia gravis or stiff-person syndrome, essential parameters of blood cell count, coagulation, clinical chemistry or plasma proteins and immunoglobulins (Ig) were measured before and after IA (n = 11). Results In average, IA reduced the levels of total IgG, IgG1, IgG2 and IgG4 by approximately 60\%, the acetylcholine receptor autoantibody levels by more than 70\%. IgG3, IgA or IgM were diminished to a lower extent. In contrast to fibrinogen or other coagulation factors, the column markedly removed vitamin K-dependent coagulation factors II, VII, IX and X by approximately 40\%-70\%. Accordingly, international normalized ratio and activated partial thromboplastin time were increased after IA by 59.1\% and 32.7\%, respectively. Coagulation tests almost returned to baseline values within 24 h. Blood cell count, electrolytes, total protein or albumin were not essentially affected. No clinical events occurred. Conclusion The single-use, multiple-pass protein A adsorber column is highly efficient to remove IgG1, IgG2 and IgG4 or specific acetylcholine receptor autoantibodies from the plasma. Coagulation parameters should be monitored, since the column has the capacity to largely reduce vitamin K-dependent factors.},
  language  = {en}
}
@article{BliziotisKluijtmansSotoetal.2022,
  author    = {Bliziotis, Nikolaos G. and Kluijtmans, Leo A. J. and Soto, Sebastian and Tinnevelt, Gerjen H. and Langton, Katharina and Robledo, Mercedes and Pamporaki, Christina and Engelke, Udo F. H. and Erlic, Zoran and Engel, Jasper and Deutschbein, Timo and N{\"o}lting, Svenja and Prejbisz, Aleksander and Richter, Susan and Prehn, Cornelia and Adamski, Jerzy and Januszewicz, Andrzej and Reincke, Martin and Fassnacht, Martin and Eisenhofer, Graeme and Beuschlein, Felix and Kroiss, Matthias and Wevers, Ron A. and Jansen, Jeroen J. and Deinum, Jaap and Timmers, Henri J. L. M.},
  title     = {Pre- versus post-operative untargeted plasma nuclear magnetic resonance spectroscopy metabolomics of pheochromocytoma and paraganglioma},
  series = {Endocrine},
  volume    = {75},
  journal   = {Endocrine},
  number    = {1},
  doi       = {10.1007/s12020-021-02858-z},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-326574},
  pages     = {254-265},
  year      = {2022},
  abstract  = {Purpose Pheochromocytomas and Paragangliomas (PPGL) result in chronic catecholamine excess and serious health complications. A recent study obtained a metabolic signature in plasma from PPGL patients; however, its targeted nature may have generated an incomplete picture and a broader approach could provide additional insights. We aimed to characterize the plasma metabolome of PPGL patients before and after surgery, using an untargeted approach, and to broaden the scope of the investigated metabolic impact of these tumors. Design A cohort of 36 PPGL patients was investigated. Blood plasma samples were collected before and after surgical tumor removal, in association with clinical and tumor characteristics. Methods Plasma samples were analyzed using untargeted nuclear magnetic resonance (NMR) spectroscopy metabolomics. The data were evaluated using a combination of uni- and multi-variate statistical methods. Results Before surgery, patients with a nonadrenergic tumor could be distinguished from those with an adrenergic tumor based on their metabolic profiles. Tyrosine levels were significantly higher in patients with high compared to those with low BMI. Comparing subgroups of pre-operative samples with their post-operative counterparts, we found a metabolic signature that included ketone bodies, glucose, organic acids, methanol, dimethyl sulfone and amino acids. Three signals with unclear identities were found to be affected. Conclusions Our study suggests that the pathways of glucose and ketone body homeostasis are affected in PPGL patients. BMI-related metabolite levels were also found to be altered, potentially linking muscle atrophy to PPGL. At baseline, patient metabolomes could be discriminated based on their catecholamine phenotype.},
  language  = {en}
}