@article{PetritschKoestlerGassenmaieretal.2016,
  author    = {Petritsch, Bernhard and K{\"o}stler, Herbert and Gassenmaier, Tobias and Kunz, Andreas S and Bley, Thorsten A and Horn, Michael},
  title     = {An investigation into potential gender-specific differences in myocardial triglyceride content assessed by \(^{1}\)H-Magnetic Resonance Spectroscopy at 3Tesla},
  series = {Journal of International Medical Research},
  volume    = {44},
  journal   = {Journal of International Medical Research},
  number    = {3},
  doi       = {10.1177/0300060515603884},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-168808},
  pages     = {585-591},
  year      = {2016},
  abstract  = {Objective: Over the past decade, myocardial triglyceride content has become an accepted biomarker for chronic metabolic and cardiac disease. The purpose of this study was to use proton (hydrogen 1)-magnetic resonance spectroscopy (\(^{1}\)H-MRS) at 3Tesla (3 T) field strength to assess potential gender-related differences in myocardial triglyceride content in healthy individuals. Methods: Cardiac MR imaging was performed to enable accurate voxel placement and obtain functional and morphological information. Double triggered (i.e., ECG and respiratory motion gating) \(^{1}\)H-MRS was used to quantify myocardial triglyceride levels for each gender. Two-sample t-test and Mann-Whitney U-test were used for statistical analyses. Results: In total, 40 healthy volunteers (22 male, 18 female; aged >18 years and age matched) were included in the study. Median myocardial triglyceride content was 0.28\% (interquartile range [IQR] 0.17-0.42\%) in male and 0.24\% (IQR 0.14-0.45\%) in female participants, and no statistically significant difference was observed between the genders. Furthermore, no gender-specific difference in ejection fraction was observed, although on average, male participants presented with a higher mean ± SD left ventricular mass (136.3 ± 25.2 g) than female participants (103.9 ± 16.1 g). Conclusions: The study showed that \(^{1}\)H-MRS is a capable, noninvasive tool for acquisition of myocardial triglyceride metabolites. Myocardial triglyceride concentration was shown to be unrelated to gender in this group of healthy volunteers.},
  language  = {en}
}
@article{KurzKampfBuschleetal.2016,
  author    = {Kurz, Felix T. and Kampf, Thomas and Buschle, Lukas R. and Schlemmer, Heinz-Peter and Bendszus, Martin and Heiland, Sabine and Ziener, Christian H.},
  title     = {Generalized moment analysis of magnetic field correlations for accumulations of spherical and cylindrical magnetic perturbers},
  series = {Frontiers in Physics},
  volume    = {4},
  journal   = {Frontiers in Physics},
  issn      = {2296-424X},
  doi       = {10.3389/fphy.2016.00046},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-190604},
  year      = {2016},
  abstract  = {In biological tissue, an accumulation of similarly shaped objects with a susceptibility difference to the surrounding tissue generates a local distortion of the external magnetic field in magnetic resonance imaging. It induces stochastic field fluctuations that characteristically influence proton spin dephasing in the vicinity of these magnetic perturbers. The magnetic field correlation that is associated with such local magnetic field inhomogeneities can be expressed in the form of a dynamic frequency autocorrelation function that is related to the time evolution of the measured magnetization. Here, an eigenfunction expansion for two simple magnetic perturber shapes, that of spheres and cylinders, is considered for restricted spin diffusion in a simple model geometry. Then, the concept of generalized moment analysis, an approximation technique that is applied in the study of (non-)reactive processes that involve Brownian motion, allows deriving analytical expressions of the correlation function for different exponential decay forms. Results for the biexponential decay for both spherical and cylindrical magnetized objects are derived and compared with the frequently used (less accurate) monoexponential decay forms. They are in asymptotic agreement with the numerically exact value of the correlation function for long and short times.},
  language  = {en}
}