@article{TackeWuttkeHenke1992,
  author    = {Tacke, Reinhold and Wuttke, F. and Henke, H.},
  title     = {Zur Stereochemie der mikrobiellen Reduktion von rac-Acetyl( t-butyl)methylphenylsilan mit Trigonopsis variabilis (DSM 70714) und Corynebacterium dioxydans (ATCC 21766): Aufkl{\"a}rung der absoluten Konfiguration der Biotransformationsprodukte (SiR,CR)- und ( SiS ,CR)-t-Butyl( 1-hydroxyethyl)methylphenylsilan},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-64176},
  year      = {1992},
  abstract  = {No abstract available},
  subject      = {Anorganische Chemie},
  language  = {en}
}
@article{WittbrodtLammersMalitscheketal.1992,
  author    = {Wittbrodt, Joachim and Lammers, Reiner and Malitschek, Barbara and Ullrich, Axel and Schartl, Manfred},
  title     = {Xmrk receptor tyrosine kinase is activated in Xiphophorus malignant melanoma},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-61699},
  year      = {1992},
  abstract  = {Xmrk encodes a putative transmembrane glycoprotein of the tyrosine kinase family and is a melanoma-inducing gene in Xiphophorus. We attempted to investigate the biological function of the putative Xmrk receptor by characterizing its signalling properties. Since a potential Iigand for Xmrk has not yet been identified, it has been difficult to analyse the biochemical properlies and biological function of this cell surface protein. In an approach towards such analyses, the Xmrk extracellular domain was replaced by the closely related Iigand-binding domain sequences of the human epidennal growth factor receptor (HER) and the ligand-induced activity of the chimeric HER-Xmrk proteinwas examined. We show that the Xmrk protein is a functional receptor tyrosine kinase, is highly active in malignant melanoma and displays a constitutive autophosphorylation activity possibly due to an activating mutation in its extracellular or transmembrane domain. In the focus formation assay the HER-Xmrk chimera is a potent transfonning protein equivalent to other tyrosine kinase oncoproteins.},
  subject      = {Physiologische Chemie},
  language  = {en}
}
@inproceedings{HeiserUlrichsEcksteinetal.1992,
  author    = {Heiser, A. and Ulrichs, Karin and Eckstein, V. and M{\"u}ller-Ruchholtz, W.},
  title     = {Xenogeneic Cellular Response of Human Lymphocytes Against Porcine Lymphocytes and Isolated Pancreatic Islets},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-45479},
  year      = {1992},
  abstract  = {no abstract available},
  language  = {en}
}
@techreport{SendtnerKreutzbergJennekens1992,
  author    = {Sendtner, Michael and Kreutzberg, Georg W. and Jennekens, Frans G.},
  title     = {Workshop on trophic factors in the peripheral nervous system. Capri, October 1991.},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-31451},
  year      = {1992},
  abstract  = {No abstract available},
  language  = {en}
}
@article{PlakhutinZhidomirovArbuznikov1992,
  author    = {Plakhutin, B. N. and Zhidomirov, G. M. and Arbuznikov, Alexei V.},
  title     = {Vector coupling coefficients for calculations of transition-metal atoms and ions by the SCF coupling operator method},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-30702},
  year      = {1992},
  abstract  = {No abstract available},
  language  = {en}
}
@article{WuBeckerWaagetal.1992,
  author    = {Wu, Y. S. and Becker, Charles R. and Waag, A. and Bicknell-Tassius, R. N. and Landwehr, G.},
  title     = {Thermal effects on (100) CdZnTe substrates as studied by x-ray photoelectron spectroscopy and reflection high energy electron diffraction},
  issn      = {0003-6951},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-37801},
  year      = {1992},
  abstract  = {The influence of different CdZnTe substrate treatments prior to II-VI molecular beam epitaxial growth on surface stoichiometry, oxygen, and carbon contamination has been studied using x-ray photoelectron spectroscopy and reflection high energy electron diffraction. Heating the substrate at 300 °C can eliminate oxygen contamination, but cannot completely remove carbon from the surface. Heating at higher temperatures decreases the carbon contamination only slightly, while increasing the Zn-Cd ratio on the surface considerably. The magnitude of the latter effect is surprising and is crucial when one is using lattice matched CdZnTe (Zn 4\%) substrates.},
  language  = {en}
}
@article{KauppSchleyer1992,
  author    = {Kaupp, Martin and Schleyer, Paul von Rague},
  title     = {The Structure and Stability Trends Fluoro(methyl)plumbanes},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-60105},
  year      = {1992},
  abstract  = {No abstract available},
  subject      = {Anorganische Chemie},
  language  = {en}
}
@article{KauppSchleyer1992,
  author    = {Kaupp, Martin and Schleyer, Paul. von Rague},
  title     = {The Structural Variations of Monomeric Alkaline Earth MX\(_2\)-Compounds (M = Ca, Sr, Ba; X = Li, BeH, BH\(_2\), CH\(_3\), NH\(_2\),OH, F). An ab Initio Pseudopotential Study},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-60152},
  year      = {1992},
  abstract  = {No abstract available},
  subject      = {Anorganische Chemie},
  language  = {en}
}
@article{StoeberFranzekBeckmann1992,
  author    = {St{\"o}ber, Gerald and Franzek, E. and Beckmann, H.},
  title     = {The role of maternal infectious diseases during pregnancy in the etiology of schizophrenia in offspring},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-82216},
  year      = {1992},
  abstract  = {In 55 chronic schizophrenics, the occurrence of infectious diseases during their mothers' pregnancies was investigated. Different psychiatrie diagnostic systems were compared. Infections were reported by the mothers of familial and sporadic DSM I1I-R schizophrenics in equal proportion. However, applying Leonhard's classification, the frequency of infections was found to be significantly increased in 'systematic' schizophrenia (mainly exogenously induced in the view of Leonhard) compared to 'unsystematic' schizophrenia (mainly genetically determined according to Leonhard's findings). Most of the infections occurred during the second trimester (nine out of 13). Thus, in the 'systematic' forms of schizophrenia (low genetic loading), maternal infections in this crucial period of neurodevelopment would appear to be important causative factors in the cytoarchitectural deviance detected in the central nervous system of schizophrenics.},
  subject      = {Psychiatrie},
  language  = {en}
}
@article{BjorklundSchneiderHarnishfegeretal.1992,
  author    = {Bjorklund, David F. and Schneider, Wolfgang and Harnishfeger, Katherine Kipp and Cassel, William S. and Bjorklund, Barbara R. and Bernholtz, Jean E.},
  title     = {The role of IQ, expertise, and motivation in the recall of familiar Information},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-62204},
  year      = {1992},
  abstract  = {High- and low-IQ children in the first, third, and fifth grades performed two free-recall tasks: a sort-recall task with sets of categorically related pictures, and a class-recall task, with children recalling the current members of their school class. All children were deemed to be experts concerning the composition of their school class, but, unlike experts in other domains, had no special motivation associated with their expertise. Recall and clustering on both tasks were high. The high-IQ children performed better than low-IQ children only on the sort-recall task. IQ was significantly correlated with measures of performance on the sort-recall task but not on the class-recall task. The results reflect the fact that the memory benefits associated with being an expert (here, elimination of IQ effects) are related to the greater knowledge the expert possesses and not to factors of motivation.},
  subject      = {Psychologie},
  language  = {en}
}
@article{GaultneyBjorklundSchneider1992,
  author    = {Gaultney, Jane F. and Bjorklund, David F. and Schneider, Wolfgang},
  title     = {The role of children's expertise in a Strategie memory task},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-62190},
  year      = {1992},
  abstract  = {In a study intended to replicate and extend the findings from a recent experiment by Schneider and Bjorklund (1992), the expert/novice paradigm was used with second- and fourth-grade children in a sort/recall task. Children were classified as experts or novices for their knowledge of baseball, then given two sort/recall tasks, with a list consisting of either baseball or nonbaseball terms. Experts recalled more than novices on the baseball list only. While both groups used organizational strategies at sorting on the nonbaseball list, experts were marginally more strategic than novices on the baseball list, and no differences were found between the groups on either list for clustering. Baseball experts used more adultlike categories, suggesting that their enhanced levels of recall were attributed in part to strategy use, although there was also evidence that most of the substantial recall difference between the groups was attributed to item-specific effects associated with a more elaborated knowledge base. A second experiment using fifth-grade children on a multitrial sort/recall task using the baseball list also found increased recall by experts, and also found evidence of strategic behavior at the sort phase for trials 3 and 4.},
  subject      = {Psychologie},
  language  = {en}
}
@article{ReuterEngelsPeyerimhoff1992,
  author    = {Reuter, W. and Engels, Bernd and Peyerimhoff, S.D.},
  title     = {The Reaction of Singlet and Triplet Methylen with Ethene - A Multi-Reference CI Study},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-58923},
  year      = {1992},
  abstract  = {Large-scale multireference configuration interaction (MRD-CI) calculations in a flexible atomic orbital (AO) basis are employed to study the reaction of C\(_2\)H\(_4\) with CH\(_2\) in its firSt triplet and singlet state. The minimum energy path (MEP) of both reactions is calculated, and different mechanisms are discussed. To examine the possible participation of the singlet state in the overall reaction starting from the triplet channel and terminating in the singlet-state c-C\(_3\)H\(_6\), various cuts through both hypersurfaces are calculated. lt is found that favorable interconversion from the trip1et to the singlet surface can only occur at !arge separations of the two fragments of CH2 and C\(_2\)H\(_4\). Experimental data considering the vibrational motion of CH\(_2\) in connection with the relative position of both surfaces are used to obtain an estimate for the overall barrier of the reaction. The height of the barrier is about 6 kcal/mol, while the barrier of the pure triplet reaction is calculated to be 7-9 kcal/mol.},
  subject      = {Organische Chemie},
  language  = {en}
}
@article{GesslerGrupeGrzeschiketal.1992,
  author    = {Gessler, Manfred and Grupe, Andrew and Grzeschik, Karl-Heinz and Pongs, Olaf},
  title     = {The potassium channel gene HK1 maps to human chromosome 11p14.1, close to the FSHB gene},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-59184},
  year      = {1992},
  abstract  = {Transiently activating (A-type) potassium (K) channels are important regulators of action potential and action potential firing frequencies. HK1 designates the firsthuman cDNA that is highly homologous to the rat RCK4 cDNA that codes for an A-type K-channel. The HK1 channel is expressed in heart. By somatic cell hybrid analysis, the HK1 gene has been assigned to human chromosome 11p13-pl4, the WAGR deletion region (Wilms tumor, aniridia, genito-urinary abnormalities and mental retardation). Subsequent pulsed field gel (PFG) analysis and comparison with the well-established PFG map of this region localized the gene to 11p14, 200-600 kb telomeric to the FSHB gene.},
  subject      = {Biochemie},
  language  = {en}
}
@article{SirenFeuerstein1992,
  author    = {Sir{\´e}n, Anna-Leena and Feuerstein, G.},
  title     = {The Opioid System in circulatory control},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-63045},
  year      = {1992},
  abstract  = {Opioid peptidesandmultiple opioid receptors are found in brain cardiovascular nuclei, autonomic ganglia, the heart, and blood vessels, and opioids induce potent cardiovascular changes. The role of endogenaus opioids in normal cardiovascular homeostasis is unclear; however, current data suggest opioid involvement in stress.},
  subject      = {Neurobiologie},
  language  = {en}
}
@article{FrerichsSirenFeuersteinetal.1992,
  author    = {Frerichs, K. and Sir{\`e}n, Anna-Leena and Feuerstein, G. and Hallenbeck, JM},
  title     = {The onset of postischemic hypoperfusion in rats is precipitous and may be controlled by local neurons},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-47980},
  year      = {1992},
  abstract  = {Background and Purpose: Reperfusion following transient global cerebral ischemia is characterized by an initial hyperemic phase, which precedes hypo perfusion. The pathogenesis of these flow derangements remains obscure. Our study investigates the dynamics of postischemic cerebral blood flow changes, with particular attention to the role of local neurons. Metho(Js: We assessed local cortical blood flow continuously by laser Doppler flowmetry to permit observation of any rapid flow changes after forebrain ischemia induced by four-vessel occlusion for 20 minutes in rats. To investigate the role of local cortical neurons in the regulation of any blood flow fluctuations, five rats received intracortical microinjections of a neurotoxin (10 p,g ibotenic acid in 1 p,1; 1.5-mm-depth parietal cortex) 24 hours before ischemia to induce selective and localized neuronal depletion in an area corresponding to the sampie volume of the laser Doppler probe (1 mm3 ). Local cerebral blood flow was measured within the injection site and at an adjacent control site. Results: Ischemia was followed by marked hyperemia (235 ±23\% of control, n =7), followed by secondary hypoperfusion (45±3\% of control, n=7). The transition from hyperemia to hypoperfusioo occurred not gradually but precipitously (maximal slope of flow decay: 66±6\%/min; n=7). In ibotenic acid-injected rats, hyperemia was preserved at the injection site, but the sudden decline of blood flow was abolished (maximal slope of flow decay: 5±3\%/min compared with 53±8\%/min at the control site; n=5, p<O.OOI) and 00 significant hypoperfusion de\eloped (103±20\% of control at 60 minutes). Conclusions: These data suggest that the rapid transition to cortical hypo perfusion after forebrain ischemia may be triggered locally by a neuronal mechanism but that this mechanism does not underlie the initial hyperemia.},
  subject      = {Gehirn},
  language  = {en}
}
@article{KauppCharkinSchleyer1992,
  author    = {Kaupp, Martin and Charkin, Oleg P. and Schleyer, Paul von Rague},
  title     = {The Ions MCp\(^{2+}\) (M = Sc, La): Significantly Bent Sandwich Species},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-60082},
  year      = {1992},
  abstract  = {No abstract available},
  subject      = {Anorganische Chemie},
  language  = {en}
}
@inproceedings{HeiserUlrichsEcksteinetal.1992,
  author    = {Heiser, A. and Ulrichs, Karin and Eckstein, V. and M{\"u}ller-Ruchholtz, W.},
  title     = {The Human Cell Mediated Response to Xenogeneic (Porcine) Transplantation Antigen Depends on the Stimulator Cell Compartment},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-45670},
  year      = {1992},
  abstract  = {No abstract available},
  language  = {en}
}
@article{GesslerKoenigBruns1992,
  author    = {Gessler, Manfred and K{\"o}nig, A. and Bruns, G. A. P.},
  title     = {The genomic organization and expression of the WT1 gene},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-59195},
  year      = {1992},
  abstract  = {The Wilms tumor gene WTl, a proposed tumor suppressor gene, has been identifled based on its location within a homozygous deletion found in tumor tissue. The gene encodes a putative transcription factor containing a Cys/His zinc finger domain. The critical homozygous deletions, however, are rarely seen, suggesting that in many cases the gene may be inactivated by more subtle alterations. To facilitate the seareh for smaller deletions and point mutations we have established the genomic organization of the WTl gene and have determined the sequence of all 10 exons and flanking intron DNA. The pattern of alternative splicing in two regions has been characterized in detail. These results will form the basis for future studies of mutant alleles at this locus.},
  subject      = {Biochemie},
  language  = {en}
}
@article{KauppSchleyerDolgetal.1992,
  author    = {Kaupp, Martin and Schleyer, Paul von Rague and Dolg, Michael and Stoll, Hermann},
  title     = {The Equilibrium Structures of Monomeric Group 2 and Lanthanide(II) Metallocenes MCp2 (M = Ca, Sr, Ba, Sm, Eu, Yb) Studied by ab Initio Calculations},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-60139},
  year      = {1992},
  abstract  = {No abstract available},
  subject      = {Anorganische Chemie},
  language  = {en}
}
@article{EllgringSchneiderFriedrichetal.1992,
  author    = {Ellgring, Johann Heinrich and Schneider, F. and Friedrich, J. and Fus, I. and Beyer, T. and Heimann, H. and Himer, W.},
  title     = {The effects of neuroleptics on facial action in schizophrenic patients},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-43269},
  year      = {1992},
  abstract  = {This paper describes the influence of neuroleptic therapy on facial action in drug-naive schizophrenics. In a comparative study of medicated and unmedicated schizophrenic patients, the coordinates of 12 small light-reflecting points, attached to subjects' faces, were computer-recorded and analyzed automatically during a semistandardized clinical interview. In addition, facial activity in videotaped interviews was coded using the Facial Action Coding System (FACS). Each sample group comprised of eight patients with the DSMIII- R diagnostic criteria "schizophrenia" or "schizophreniform disorder". Subjects were studied on two occasions, one shortly after admission to the hospital, the other three weeks later. Group I was unmedicated during the first session, whereas group2 was medicated throughout the study. Three weeks after the start of medication, at the second interview, both recording methods showed a reduction in facial activity and facial expression across all subjects in group 1. The facial action of patients in group2, however, remained unchanged.},
  language  = {en}
}
@inproceedings{Schneider1992,
  author    = {Schneider, Wolfgang},
  title     = {The "what" and "how" of development: Really two separate research agendas?},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-86630},
  year      = {1992},
  abstract  = {No abstract available.},
  subject      = {Entwicklungspsychologie},
  language  = {en}
}
@article{SendtnerStoeckliThoenen1992,
  author    = {Sendtner, Michael and St{\"o}ckli, K. A. and Thoenen, Hans},
  title     = {Synthesis and localization of ciliary neurotrophic factor in the sciatic nerve of the adult rat after lesion and during regeneration},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-31738},
  year      = {1992},
  abstract  = {Ciliary neurotrophic factor (CNTF) is expressed in high quantities in Schwann cells of peripheral nerves during postnatal development of the rat. The absence of a hydrophobic leader sequence and the immunohistochemical localization of CNTF within the cytoplasm of these cells indicate that the factor might not be available to responsive neurons under physiological conditions. However, CNTF supports the survival of a variety of embryonic neurons, including spinal motoneurons in culture. Moreover we have recently demonstrated that the exogenous application of CNTF protein to the lesioned facial nerve of the newborn rat rescued these motoneurons from cell death. These results indicate that CNTF might indeed play a major role in assisting the survival of lesioned neurons in the adult peripheral nervous system. Here we demonstrate that the CNTF mRNA and protein levels and the manner in which they are regulated are compatible with such a function in lesioned peripheral neurons. In particular, immunohistochemical analysis showed significant quantities of CNTF at extracellular sites after sciatic nerve lesion. Western blots and determination of CNTF biological activity of the same nerve segments indicate that extracellular CNTF seems to be biologically active. After nerve lesion CNTF mRNA levels were reduced to <5 \% in distal regions of the sciatic nerve whereas CNTF bioactivity decreased to only one third of the original before-lesion levels. A gradual reincrease in Schwann cells occurred concomitant with regeneration.},
  language  = {en}
}
@article{UlrichsKaitschickBartlettetal.1992,
  author    = {Ulrichs, Karin and Kaitschick, J. and Bartlett, R. and M{\"u}ller-Ruchholtz, W.},
  title     = {Suppression of natural xenophile antibodies with the novel immunomodulating drug leflunomide},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-45202},
  year      = {1992},
  abstract  = {No abstract available},
  subject      = {Chirurgie},
  language  = {en}
}
@misc{DandekarArgos1992,
  author    = {Dandekar, Thomas and Argos, Patrick},
  title     = {Successive action of DnaK, DnaJ and GroEL along the pathway of chaperone-mediated protein folding},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-29814},
  year      = {1992},
  abstract  = {No abstract available},
  language  = {en}
}
@article{EngelsPericReuteretal.1992,
  author    = {Engels, Bernd and Peric, M. and Reuter, W. and Peyerimhoff, S.D. and Grein, F.},
  title     = {Study of the hyperfine coupling constants \(^{14}\)N and \(^1\)H) of the NH\(_2\) molecule in the X\(^2\)B\(_1\) ground state and the A\(^2\)A\(_1\) excited state},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-58937},
  year      = {1992},
  abstract  = {The hyperfine coupling constants (hfcc) A\(_{iso}\) and A\(_{ij}\) are calculated for the atoms of NH\(_2\) in its, two lowest-lying electronk states at various molecular geometries by means of the ab initio multireference configuration interaction .method. The vibronically averaged values of the hfccs for the K = 0 and 1 levels in \(^{14}\)N \(^1\)H\(_2\) in the energy range up to 20 000 cm\(^{-1}\) are computed. Polarization elfects which determine A\(_{iso}\) as well as a simple model to describe the dipolar hfccs are discussed. All resrilts are in excellent agreement with experimental data.},
  subject      = {Organische Chemie},
  language  = {en}
}
@article{KauppSchleyer1992,
  author    = {Kaupp, Martin and Schleyer, Paul von Rague},
  title     = {Struktur- und Stabilit{\"a}tstrends bei Fluor(methyl)plumbanen},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-60091},
  year      = {1992},
  abstract  = {No abstract available},
  subject      = {Anorganische Chemie},
  language  = {en}
}
@article{HongSchartl1992,
  author    = {Hong, Yunhan and Schartl, Manfred},
  title     = {Structure of the rainbow trout metallothionein A gene},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-61679},
  year      = {1992},
  abstract  = {To investigate the regulation of metallothionein-encoding genes in fish, we have isolated and sequenced the rainbow trout metallothionein-A-encoding gene (tMT-A) by polymerase chain reaction. This gene spans about 1.1 kb, consists of three exons and two introns, and has an A+ T-rieb 5' -region which contains a TATAAA signal, and two metal responsive elements (MREs). The transcription start point is centered around an A residue 81 nt upstream of the ATG codon.},
  subject      = {Physiologische Chemie},
  language  = {en}
}
@article{WaelbroeckCamusTastenoyetal.1992,
  author    = {Waelbroeck, M. and Camus, J. and Tastenoy, M. and Mutschler, E. and Strohmann, C. and Tacke, Reinhold and Schjelderup, L. and Aasen, A. and Lambrecht, G. and Christophe, J.},
  title     = {Stereoselective interaction of procyclidine, hexahydro-difenidol, hexbutinol and oxyphencyclimine, and of related antagonists, with four muscarinic receptors},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-64237},
  year      = {1992},
  abstract  = {Wc invcstigatcd thc binding properlies of thc (R)- and (Sl-cnantiomcrs of thc muscarinic antagonists trihcxyphcnidyl, procyclidinc, hcxahydro-difcnidol. p-fluoro-hcxahydro-difcnidol. hcxbutinol, p-fluoro-hcxbutinnl. and thcir corrcsponding methiodidcs at muscarinic M\(_1\), M\(_2\)• M\(_3\) and M\(_4\) receptor subtypes. In addition. binding properlies of thc (R)- and (S)-cnantiomcrs of oxyphcncycliminc wcrc studicd. The {R)- cnantiomcrs (cutomcrs} of all the compounds had a grcatcr affinity than the (S)-isomcrs for thc four muscarinic rcccptor subtypcs. Thc binding pattcrns of thc (R)- and (S)-enantiomers wcrc gcncrally different. We did not obscrvc any gcncral corrclation hctwccn thc potcncy of thc high-affinity enantiomer and Lhc affinity ratio (cudismic ratio) of the two cnantiomcrs. Thc rcsuhs arc discusscd in tcrms of a 'four suhsitcs' binding modcl.},
  subject      = {Anorganische Chemie},
  language  = {en}
}
@article{KruegerBoneradDennleretal.1992,
  author    = {Kr{\"u}ger, H.-P. and Bonerad, E. M. and Dennler, H. J. and Dunkl, E. and Friese, H. J. and Hain, C. and Kazenwadel, J. and Kohnen, Ralf and Maier, W. and Menzel, M.},
  title     = {Speech chronemics in drug evaluation},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-41213},
  year      = {1992},
  abstract  = {No abstract available},
  language  = {en}
}
@article{DummerPosseckertNestleetal.1992,
  author    = {Dummer, R. and Posseckert, G. and Nestle, F. and Witzgall, R. and Burger, M. and Becker, J. C. and Sch{\"a}fer, E. and Wiede, J. and Sebald, Walter and Burg, G.},
  title     = {Soluble interleukin-2 receptors inhibit interleukin 2-dependent proliferation and cytotoxicity: explanation for diminished natural killer cell activity in cutaneous T-cell lymphomas in vivo?},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-62473},
  year      = {1992},
  abstract  = {No abstract available},
  subject      = {Biochemie},
  language  = {en}
}
@article{GowSimpsonSchliephakeetal.1992,
  author    = {Gow, J. W. and Simpson, K. and Schliephake, Andreas and Behan, W. M. and Morrison, L. J. and Cavanagh, H. and Rethwilm, Axel and Behan, P. O.},
  title     = {Search for retrovirus in the chronic fatigue syndrome},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-61436},
  year      = {1992},
  abstract  = {Aim: To examine peripheral blood and skeletal muscle from patients with chronic fadgue syndrome for exogenous retrovirus. Methods: Blood samples from 30 patients and muscle biopsy specimens of 15 patients were examined for retroviral sequences by DNA extraction, polymerase chain reacdon (PCR), and Southern blotting hybridisation. Sera were examined for human foamy virus by western immunoblotting and indirect immunofluorescence techniques. Results: No difference between the padent and control populations was found for any of the PCR primer sets used (gag, pol, env, and tax regions of HTLV VII). An endogenous gag band was observed in both the padent and control groups. All sera were negative for antibody to human foamy virus. Conclusion: The results indicate that there is no evidence of retroviral involvement in the chronic fatigue syndrome.},
  subject      = {Virologie},
  language  = {en}
}
@article{SchrotenSteinigPlogmannetal.1992,
  author    = {Schroten, H. and Steinig, M. and Plogmann, R. and Hanisch, F. G. and Hacker, J{\"o}rg and Herzig, P. and Wahn, V},
  title     = {S-fimbriae mediated adhesin of Escherichia coli to human buccal epithelial cells is age independent},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-59830},
  year      = {1992},
  abstract  = {S-fimbriated Escherichia coli, which cause sepsis and meningitis in the newbom, bind to sialic acid-containing glycoprotein structures on the surface of human buccal epithelial cells. The dependence of · this binding on host age was examined. S-fimbriated · E. coli adhered in comparable numbers to cells in newborns, infants, children and adults (23.0 ± 8.6; 23.1 ± 11.5; 24.7 ± 7.9; 28.9 ± 8.8). Thus, the increased susceptibility of neonates to infections caused by S-fimbriated E. coli cannot be explained by enhanced · adhesion to epithelial cells},
  subject      = {Infektionsbiologie},
  language  = {en}
}
@article{JaffeyChanShaoetal.1992,
  author    = {Jaffey, P. and Chan, L.-N. L. and Shao, J. and Schneider-Schaulies, J{\"u}rgen and Chan, T.-S.},
  title     = {Retinoic acid inhibition of serum-induced c-fos transcription in a fibrosarcoma cell line},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-54863},
  year      = {1992},
  abstract  = {No abstract available},
  subject      = {Immunologie},
  language  = {en}
}
@article{TschaepeBenderOttetal.1992,
  author    = {Tsch{\"a}pe, Helmut and Bender, Larisa and Ott, Manfred and Wittig, Walter and Hacker, J{\"o}rg},
  title     = {Restriction fragments length polymorphism and virulence pattern of the veterinary pathogen Escherichia coli O139:K82:H1},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-86131},
  year      = {1992},
  abstract  = {Escherichia coli 0139: K82: H1 strains originating from outbreaks and single cases of oedema disease in pigs were characterized by their genomic restriction fragment length polymorphism (RFLP), their virulence pattern, and by the occurrence as well as the genomic distribution of the determinants for hemolysin (hly) and verotoxins (shiga-like toxins; sltI, sltII). Whereas the RFLPs revealed considerable variation among the E. coli 0139: K82: H1 isolates depending the origin and epidemic source of the strains, the virulence gene slt II was found to be present in nearly all strains in a particular chromosomal region. Similar to RFLPs, the plasmid profiles are useful for epidemiological analysis.},
  subject      = {Escherichia coli},
  language  = {en}
}
@article{GrafeSchmuckLinsenmair1992,
  author    = {Grafe, T. Ulmar and Schmuck, Richard and Linsenmair, Karl Eduard},
  title     = {Reproductive energetics of the African Reed Frogs, Hyperolius viridiflavus and Hyperolius marmoratus},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-31187},
  year      = {1992},
  abstract  = {No abstract available},
  language  = {en}
}
@article{SirenHeldmanDoronetal.1992,
  author    = {Sir{\´e}n, Anna-Leena and Heldman, Eliahu and Doron, David and Yue, Tian-Li and Liu, Yong and Feuerstein, G. and Hallenbeck, JM},
  title     = {Release of proinflammatory and prothrombbtic mediators in the brain and peripheral circulation in spontaneously hypertensive and normotensive Wistar-Kyoto rats},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-47469},
  year      = {1992},
  abstract  = {Background and Purpose: We reported previously that stroke risk factors prepared the brain stem for the development of ischemia and hemorrhage and induced the production of tumor necrosis factor following an intrathecal injection of Iipopolysaccharide, a prototypic monocyte-activating stimulus. This study evaluates whether blood or brain cells of hypertensive rats produce more proinflammatory and prothrombotic mediators than do blood or brain cells of normotensive rats. MethotJs: Levels of tumor necrosis factor, platelet-activating factor, 6-ketoprostaglandin F1a, and thromboxane B2 in the cerebrospinal fluid and blood of spontaneously hypertensive and normotensive Wistar-Kyoto rats were monitored before and after achallenge with Iipopolysaccharide. Results: Little or no activity from these media tors was found in the cerebrospinal fluid or blood of saline-injected control animals. Intravenous administration of Iipopolysaccharide (0.001, 0.1, and 1.8 mg/kg) produced dose-dependent increases in blood levels of all mediators in hypertensive rats. In normotensive rats the levels were less than in hypertensive rats and were not c1early dose-related. When Iipopolysaccharide was injected intracerebroventricularly, more tumor necrosis factor was measured in the cerebrospinal fluid than in the blood, suggesting local synthesis of this cytokine. Levels of tumor necrosis factor and platelet-activating factor in the cerebrospinal fluid were higher in hypertensive than in normotensive rats. The thromboxane A2/prostacyclin ratio was not aItered significantly between the two rat strains. Conclusions: It is suggested that the higher incidence of brain stem ischemia and hemorrhage after the intrathecal injection oflipopolysaccharide in hypertensive rats than in normotensive rats might be related to the higher levels of the two cytotoxic factors tumor necrosis factor and platelet-activating factor produced in response to such challenge.},
  subject      = {Gehirn},
  language  = {en}
}
@article{SchleyerKauppHampeletal.1992,
  author    = {Schleyer, Paul von Rague and Kaupp, Martin and Hampel, Frank and Bremer, Matthias and Mislow, Kurt},
  title     = {Relationships in the Rotational Barriers of Group 14 Ethane Congeners H\(_3\)X-YH\(_3\) (X, Y = C, Si, Ge, Sn, Pb). Comparisons of ab Initio Pseudopotential and All-Electron Results},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-60147},
  year      = {1992},
  abstract  = {No abstract available},
  subject      = {Anorganische Chemie},
  language  = {en}
}
@article{NolteLorenzenLehretal.1992,
  author    = {Nolte, D. and Lorenzen, A. and Lehr, H.-A. and Zimmer, F.-J. and Klotz, Karl-Norbert and Messmer, K.},
  title     = {Reduction of postischemic leukocyte-endothelium interaction by adenosine via A\(_2\) receptor},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-60424},
  year      = {1992},
  abstract  = {The adhesion of leukocytes to the endothelium of postcapillary venules hallmarks a key event in ischemia-reperfusion injury. Adenosine has been shown to protect from postischemic reperfusion injury, presumably through inhibition of postischemic leukocyte-endothelial interaction. This study was performed to investigate in vivo by which receptors the effect of adenosine on postischemic leukocyte-endothelium interaction is mediated. The hamster dorsal skinfold model and fluorescence microscopy were used for intravital investigation of red cell velocity, vessel diameter, and leukocyte-endothelium interaction in postcapillary venules of a thin striated skin muscle. leukocytes were stained in vivo with acridine orange (0.5 mg kg\(^{-1}\) min\(^{-1}\) i.v. ). Parameters were assessed prior to induction of 4 h ischemia to the muscle tissue and 0.5 h, 2 h, and 24 h after reperfusion. ·Adenosine, the adenosine A1-selective agonist 2-chloro-N\(^6\) -cyclopentyladenosine (CCPA), the Arselective agonist CGS 21,680, the non-selective adenosine receptor antagonist xanthine amine congener {XAC), and the adenosine uptake blocker S-(p-nitrobenzyl)-6-thioinosine (NBTI) were infused viajugular vein starting 15 min priortorelease of ischemia until 0.5 h after reperfusion. Adenosine and CGS 21,680 significantly reduced postischemic leukocyte-endothelium interaction 0.5 h after reperfusion (p< 0.01), while no inhibitory effect was observed with CCPA. Coadministration of XAC blocked the inhibitory effects of adenosine. Infusion of NBTI alone effectively decreased postischemic leukocyte-endothelium interaction. These findings indicate that adenosine reduces postischemic leukocyte-endothelium interaction via A\(_2\) receptor and suggest a protective role of endogenous adenosine during ischemia-reperfusion.},
  subject      = {Toxikologie},
  language  = {en}
}
@article{BommakantiBokochTolleyetal.1992,
  author    = {Bommakanti, R. and Bokoch, G. M. and Tolley, J. O. and Schreiber, R. E. and Siemsen, D. W. and Klotz, Karl-Norbert and Jesaitis, A. J.},
  title     = {Reconstitution of a physical complex between the N-formyl chemotactic peptide receptor and G protein: Inhibition by pertussis toxin-catalyzed ADP ribosylation},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-60406},
  year      = {1992},
  abstract  = {Photoaffinity-labeled N-formyl chemotactic peptide receptors from human neutrophils solubilized in octyl glucoside exhibit two forms upon sucrose density gradient sedimentation, with apparent Sedimentation coefficients of approximately 4 and 7 S. Tbe 7 S form can be converted to the 4 S form by guanosine 5' -0- (3-thiotriphosphate) (GTP-yS) with an EC\&o of -20 nM, suggesting that the 7 S form may represent a physical complex of the receptor with endogenous G protein (Jesaitis, A. J., Tolley, J. 0., Bokoch, G. M., and Allen, R. A. (1989) J. Cell Biol. 109, 2783-2790). To probe the nature of the 7 S form, we reconstituted the 7 S form from the 4 S form by adding purified G protein. The 4 S form, obtained by solubilizing GTP-yS-treated neutrophil plasma membranes, was incubated with purified (>95\%) G. protein from bovine brain (containing both G\(_{ia1}\) and G\(_{ia2}\)) or with neutrophil G protein (G\(_a\)), and formation of the 7 S complex was analyzed on sucrose density gradients. The EC\(_{50}\) of 7 S complex formation induced by the two G proteins was 70 \(\pm\) 25 and 170 \(\pm\) 40 DM for G\(_a\) and G\(_1\), respectively. No complexation was measurable when bovine transducin (G\(_t\)) was used up to 30 times the EC\(_{50\) for G\(_a\). The EC\(_{50}\) for G\(_t\) was the same for receptors, obtained from formyl peptide-stimulated or unstimulated cells. The addition of 10 \(\mu\)M GTP-yS to the reconstituted 7 S complex caused a complete reversion of the receptor to the 4 S form, and anti-G\(_1\) peptide antisera immunosedimented the 7 S form. ADP-ribosylation of Gt prevented formation of the 7 S form even at 20 times the concentration of unribosylated G. normally used to attain 50\% conversion to the 7 S form. These observations suggest that the 7 S species is a pbysical complex containing N-formyl chemotactic peptide receptor and G protein.},
  subject      = {Toxikologie},
  language  = {en}
}
@article{LinhardtZiebuhrMeyeretal.1992,
  author    = {Linhardt, F. and Ziebuhr, W. and Meyer, P. and Witte, W. and Hacker, J{\"o}rg},
  title     = {Pulsed-field gel electrophoresis of genomic restriction fragments as a tool for the epidemiological analysis of Staphylococcus aureus and coagulase-negative Staphylococci},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-59811},
  year      = {1992},
  abstract  = {Thirtccn StttJ1hylococcus dw·eus and s: <'pid<'l'· midis strains ohtaincd from nnsc and hand nf twn cmployccs and onc paticnt uf a mcdical ward as weil as two S. hemol.\"licus strains wcrc analyscd according to thcir rcstrktion fmgmcnt lcngth pattcrns ( RFLP) hy pulscd-ficld gcl clcctrophorcsis (PFGE) using thc rcslriction cnzymcs SmaJ and s.. .· tll. Spccics idcntification nf thc isolatcs was pcrformcd hy a systcm which includcs :!O hiochcmical rc"ctions. Furthcrmorc. thc antillintic resistancc pattcrns of thc stmins wcrc dctcrmincd. Whilc scvcral isolatcs cxhihitcd idcnticaf antihiotic susccptihilitics and hiochcmical prnfilcs. diffcrences in thc RFLP wcrc ohtaincd. ln thrcc cascs, S. epiderm{\"u}lis strains colonizing thc skin showcd an idcntical rcstriction profilc as isollltcs from thc mucous mcmhrancs of thc samc pcrson. Wc C(mcludcd that thc analysis of staphylococcal strains hy PFGE is an important cpidcmiolngical tnnl with high discrimination power.},
  subject      = {Infektionsbiologie},
  language  = {en}
}
@article{SchluppParzefallEpplenetal.1992,
  author    = {Schlupp, Ingo and Parzefall, Jakob and Epplen, J{\"o}rg T. and Nanda, Indrajit and Schmid, Michael and Schartl, Manfred},
  title     = {Pseudomale behaviour and spontaneous masculinization in the all-female teleost Poecilia formosa (Teleostei: Poeciliidae)},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-61688},
  year      = {1992},
  abstract  = {Pseudosexual behaviour is a rare phenomenon associated with unisexuality in vertebrates. In the gynogenetic, all-female teleost Poecilia formosa, rare individuals occur that resemble males of closely related gonochoristic species both in behaviour and external morphology. These masculinized gynogens and normal gynogens are members of the same clone, as demonstrated by DNA-fingerprinting. The behaviour of these masculinized gynogens is described and compared to the behaviour of the gonochoristic species Poecilia mexicana, P. latipinna and their hybrid as weil as androgen-treated individuals of P. formosa. No statistically significant difTerences were found between masculinized gynogens and hormonetreated individuals nor between the gonochoristic P. mexicana and P. latipinna males. Differences exist between gonochoristic and unisexual species. Passihle causes and effects of masculinized gynogens are discussed.},
  subject      = {Physiologische Chemie},
  language  = {en}
}
@inproceedings{VollmerEllgringFerstl1992,
  author    = {Vollmer, H. C. and Ellgring, Johann Heinrich and Ferstl, R.},
  title     = {Prediction of premature termination of therapy in the treatment of drug addicts},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-50274},
  year      = {1992},
  abstract  = {No abstract available},
  subject      = {Psychologie},
  language  = {en}
}
@article{EllgringOertelUlmetal.1992,
  author    = {Ellgring, Johann Heinrich and Oertel, W. H. and Ulm, G. and Gasser, T. and Perleth, B. and Seiler, S.},
  title     = {Partnership and depression in Parkinson's Disease},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-42516},
  year      = {1992},
  abstract  = {In this study, the influence of partnership on depression and coping with Parkinson's disease has been investigated. Twentythree single female patients, 46 married patients (23 female, 23 male) with unimpaired partnership and 42 patients (21 female, 21 male) whose partnership had worsened since the onset of disease, were compared with regard to depression and self reported extent of psychosocial distress. Single female patients tended to have higher depression scores than patients in a stable partnership, especially in items concerning personal worthlessness and senselessness of life. Patients differed in the extent of distress concerning social behavior, psychological problems/anxiety and efficiency. Within the group of single female patients two subgroups emerged: (1) patients with low extent of distress in all aspects; (2) patients who were highly distressed by psychological problems and physical disability but weakly distressed from social interaction. Male and female patients living in a stable partnership reported only a generally low to moderate extent of distress. More than half of the male and female patients who reported an impairment of their relationship also had scores of moderate to severe depression. These patients also had the h~ghest extent of distress in each ofthe aspects assessed. The results are dicussed with regard to possible interactive effects ofthe disease, quality of the partnership and availability of coping strategies.},
  language  = {en}
}
@article{BringmannHartungGoebeletal.1992,
  author    = {Bringmann, Gerhard and Hartung, Thomas and Goebel, Lothar and Schupp, Olaf and Ewers, Christian L. J. and Schoener, Bernd and Zagst, Rainer and Peters, Karl and Von Schnering, Hans Georg and Burschka, Christian},
  title     = {Novel concepts in directed biaryl synthesis, IX: Synthesis and structure of benzonaphthopyranones, useful bridged model precursors for stereoselective biaryl syntheses},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-46635},
  year      = {1992},
  abstract  = {A practicable two-step procedure for the preparation of a series of lactone-type bridged biaryls 7 as favorable substrates for subsequent atropisomer-selective ring-opening reactions is described. Due to the efficiency of the coupling step, which tolerates even a telt·butyl group next to the biaryl axis and avoids problems of regioselectivity, a variety of differently substituted representatives is prepared. These cover a broad range of steric hindrance and thus molecular distortion. The structures are investigated mainly by NMR spectroscopy and X-ray diffraction, showing the lactones 7 to be helically distorted, depending on the size of the residues R.},
  subject      = {Chemie},
  language  = {en}
}
@article{EcksteinUlrichsMeinckeetal.1992,
  author    = {Eckstein, V. and Ulrichs, K. and Meincke, G. and M{\"u}ller-Ruchholtz, W.},
  title     = {Natural xenophile antibodies from sera of type I diabetic patients differ strongly in their reactivity against various porcine pancreatic cells},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-45277},
  year      = {1992},
  abstract  = {No abstract available},
  subject      = {Chirurgie},
  language  = {en}
}
@article{DandekarTollervey1992,
  author    = {Dandekar, Thomas and Tollervey, David},
  title     = {Mutational analysis of Schizosaccharomyces pombe U4 snRNA by plasmid exchange},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-29969},
  year      = {1992},
  abstract  = {No abstract available},
  language  = {en}
}
@article{OttilieRaulfBarnekowetal.1992,
  author    = {Ottilie, S. and Raulf, F. and Barnekow, A. and Hannig, G. and Schartl, Manfred},
  title     = {Multiple src-related kinase genes, srk1-4, in the fresh water sponge Spongilla lacustris},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-80282},
  year      = {1992},
  abstract  = {In one of the simplest metazoan organisms, the sponge Spongilla lacustris, at least four different src-related kin ase genes (srkl-4) are expressed, aD of which show a high degree of similarity to the c-src genes of vertebrates. Whereas srk2 and srk3 are c1early unrelated at the nucleic acid level, srkl and srk4 share identical sequences in the 5' parts of their cDNAs. The cloning of several primer extension clones and genomic polymerase chain re action experiments confirmed the hypo thesis of an alternative splicing of tandemly arranged carboxyterminal parts of srkl and srk4. The genomic sequence encoding both proteins was found to be interrupted at the splice point by an intron which is located in the same position as one of the introns in the chicken src gene, which is the only gene conserved in invertebrates and vertebrates. All four srk genes are expressed in adult sponges as mRNA transcripts of about 2.2 kb. Tyrosine kin ase activity of a src-related kin ase could be detected in adult sponges but not in their resting form (gemmulae), and may reflect the activity of the srk protein products. Spongilla lacustris is the simplest organism from which a pro tein tyrosine kinase gene has been isolated. The presence of at least four such genes in the evolutionary ancient and primitive phylum Porifera suggests that tyrosine kinase genes arose concomitantly with or shortly after the appearance of multicellular organisms and that their activity may be involved in aggregation and cell-cell recognition.},
  subject      = {Spongilla lacustris},
  language  = {en}
}
@article{SendtnerStoeckliCarrolletal.1992,
  author    = {Sendtner, Michael and St{\"o}ckli, Kurt A. and Carroll, Patrick and Kreutzberg, Georg W. and Thoenen, Hans},
  title     = {More on motor neurons},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-42598},
  year      = {1992},
  abstract  = {No abstract available},
  language  = {en}
}
@article{SchartlAdam1992,
  author    = {Schartl, Manfred and Adam, Dieter},
  title     = {Molecular cloning, structural characterization, and analysis of transcription of the melanoma oncogene of xiphophorus},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-61989},
  year      = {1992},
  abstract  = {No abstract available},
  subject      = {Physiologische Chemie},
  language  = {en}
}
@article{GorboulevAkhundovaLuziusetal.1992,
  author    = {Gorboulev, Valentin and Akhundova, Aida and Luzius, Heike and Fahrenholz, Falk},
  title     = {Molecular cloning of substance P receptor cDNA from guinea-pig uterus},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-59293},
  year      = {1992},
  abstract  = {A cDNA encoding guinea-pig uterine substance P (SP) receptor has been isolated using the homology screening approach. Northern blot analysis reveals that the corresponding mRNA, of approx. 4.8 kb, is expressed in all tissues tested, but predominantly in the uteri of non-pregnant animals; during pregnancy its expression is reduced. The guinea-pig SP receptor was expressed in COS-7 cells and demonstrated relative Iigand affinity in the order: SP >> neurokinin A > neurokinin B.},
  subject      = {Biologie},
  language  = {en}
}