@phdthesis{Dakroub2022,
  author    = {Dakroub, Mohamad},
  title     = {Coarsened Exact Matching of Excisional to Plasma-Ablative Ab Interno Trabeculectomy},
  doi       = {10.25972/OPUS-29680},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-296805},
  school      = {Universit{\"a}t W{\"u}rzburg},
  year      = {2022},
  abstract  = {Abstract Purpose: To compare ab interno trabeculectomy by trabecular meshwork excision to plasma-mediated ablation in primary open-angle glaucoma. Methods: Retrospectively collected data of TrabEx+ (n=56) and Trabectome (n=99) were compared by coarsened exact matching to reduce confounding and matched based on baseline intraocular pressure and age. Primary outcomes were intraocular pressure and the number of glaucoma medications. Complications and the need for additional glaucoma surgery were assessed. Patients were followed for up to one year. Results: 53 TrabEx+ could be matched to Trabectome. Baseline intraocular pressure was 16.5 ± 4.6 mmHg in both; age was 73.7 ± 8.8 years and 71.5 ± 9.9 years in TrabEx+ and Trabectome, respectively. TrabEx+ were taking more medications than Trabectome (p<0.001). Intraocular pressure was reduced to 14.8±4.3 in TrabEx+ and 13.4±3.4 in Trabectome at 6 months, and to 14.9±6.0 (p=0.13) in TrabEx+ and to 14.1±3.8 mmHg (all p<0.05) in Trabectome at 12 months. Medications were reduced at both 6 and 12 months (p< 0.05). No differences were seen between both groups at 6 and 12 months. In TrabEx+, only one serious complication occurred, and two patients required further glaucoma surgery. Conclusion: Although both groups had a baseline intraocular pressure considered low for ab interno trabeculectomy, intraocular pressure and medications were reduced further at 6 and 12 months. Intraocular pressure reduction did not reach significance in TrabEx+ at 12 months. The inter-group comparison did not reveal any significant differences. Both had a low complication rate.},
  subject      = {Glaukom},
  language  = {en}
}
@phdthesis{VermaFuehring2022,
  author    = {Verma-F{\"u}hring, Raoul},
  title     = {Die Trabekulopunktion als Pr{\"a}diktiver Test f{\"u}r den Erfolg der Ab Interno Trabekulektomie im Schweineaugenmodell},
  doi       = {10.25972/OPUS-28263},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-282633},
  school      = {Universit{\"a}t W{\"u}rzburg},
  year      = {2022},
  abstract  = {To investigate trabeculopuncture (TP) for predicting the outcome of ab interno trabeculectomy (AIT). Ex vivo porcine anterior segments were perfused and sequentially underwent two procedures, TP and AIT. We concluded that a 10\% reduction in IOP after TP can be used to predict the success (>20\% IOP decrease) of AIT in porcine eyes. As porcine eyes share many similarities with human eyes, our findings may have implications on the validity of this test as a predictor for surgical outcomes of AITs in humans.},
  subject      = {Glaukom},
  language  = {en}
}