@article{HalderRufFurdeaetal.2013,
  author    = {Halder, Sebastian and Ruf, Carolin Anne and Furdea, Adrian and Pasqualotto, Emanuele and De Massari, Daniele and van der Heiden, Linda and Bogdan, Martin and Rosenstiel, Wolfgang and Birbaumer, Niels and K{\"u}bler, Andrea and Matuz, Tamara},
  title     = {Prediction of P300 BCI Aptitude in Severe Motor Impairment},
  series = {PLoS ONE},
  journal   = {PLoS ONE},
  doi       = {10.1371/journal.pone.0076148},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-97268},
  year      = {2013},
  abstract  = {Brain-computer interfaces (BCIs) provide a non-muscular communication channel for persons with severe motor impairments. Previous studies have shown that the aptitude with which a BCI can be controlled varies from person to person. A reliable predictor of performance could facilitate selection of a suitable BCI paradigm. Eleven severely motor impaired participants performed three sessions of a P300 BCI web browsing task. Before each session auditory oddball data were collected to predict the BCI aptitude of the participants exhibited in the current session. We found a strong relationship of early positive and negative potentials around 200 ms (elicited with the auditory oddball task) with performance. The amplitude of the P2 (r = -0.77) and of the N2 (r = -0.86) had the strongest correlations. Aptitude prediction using an auditory oddball was successful. The finding that the N2 amplitude is a stronger predictor of performance than P3 amplitude was reproduced after initially showing this effect with a healthy sample of BCI users. This will reduce strain on the end-users by minimizing the time needed to find suitable paradigms and inspire new approaches to improve performance.},
  language  = {en}
}
@article{PohGreenAgostinellietal.2022,
  author    = {Poh, Eugenia Z. and Green, Courtney and Agostinelli, Luca and Penrose-Menz, Marissa and Karl, Ann-Kathrin and Harvey, Alan R. and Rodger, Jennifer},
  title     = {Manipulating the level of sensorimotor stimulation during LI-rTMS can improve visual circuit reorganisation in adult ephrin-A2A5\(^{-/-}\) Mice},
  series = {International Journal of Molecular Sciences},
  volume    = {23},
  journal   = {International Journal of Molecular Sciences},
  number    = {5},
  issn      = {1422-0067},
  doi       = {10.3390/ijms23052418},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-284090},
  year      = {2022},
  abstract  = {Repetitive transcranial magnetic stimulation (rTMS) is a non-invasive brain stimulation technique that has the potential to treat a variety of neurologic and psychiatric disorders. The extent of rTMS-induced neuroplasticity may be dependent on a subject's brain state at the time of stimulation. Chronic low intensity rTMS (LI-rTMS) has previously been shown to induce beneficial structural and functional reorganisation within the abnormal visual circuits of ephrin-A2A5\(^{-/-}\) mice in ambient lighting. Here, we administered chronic LI-rTMS in adult ephrin-A2A5\(^{-/-}\) mice either in a dark environment or concurrently with voluntary locomotion. One day after the last stimulation session, optokinetic responses were assessed and fluorescent tracers were injected to map corticotectal and geniculocortical projections. We found that LI-rTMS in either treatment condition refined the geniculocortical map. Corticotectal projections were improved in locomotion+LI-rTMS subjects, but not in dark + LI-rTMS and sham groups. Visuomotor behaviour was not improved in any condition. Our results suggest that the beneficial reorganisation of abnormal visual circuits by rTMS can be significantly influenced by simultaneous, ambient visual input and is enhanced by concomitant physical exercise. Furthermore, the observed pathway-specific effects suggest that regional molecular changes and/or the relative proximity of terminals to the induced electric fields influence the outcomes of LI-rTMS on abnormal circuitry.},
  language  = {en}
}
@article{SchottdorfEglenWolfetal.2014,
  author    = {Schottdorf, Manuel and Eglen, Stephen J. and Wolf, Fred and Keil, Wolfgang},
  title     = {Can Retinal Ganglion Cell Dipoles Seed Iso-Orientation Domains in the Visual Cortex?},
  series = {PLOS ONE},
  volume    = {9},
  journal   = {PLOS ONE},
  number    = {1},
  issn      = {1932-6203},
  doi       = {10.1371/journal.pone.0086139},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-117558},
  pages     = {e86139},
  year      = {2014},
  abstract  = {It has been argued that the emergence of roughly periodic orientation preference maps (OPMs) in the primary visual cortex (V1) of carnivores and primates can be explained by a so-called statistical connectivity model. This model assumes that input to V1 neurons is dominated by feed-forward projections originating from a small set of retinal ganglion cells (RGCs). The typical spacing between adjacent cortical orientation columns preferring the same orientation then arises via Moire 'Interference between hexagonal ON/OFF RGC mosaics. While this Moire-Interference critically depends on long-range hexagonal order within the RGC mosaics, a recent statistical analysis of RGC receptive field positions found no evidence for such long-range positional order. Hexagonal order may be only one of several ways to obtain spatially repetitive OPMs in the statistical connectivity model. Here, we investigate a more general requirement on the spatial structure of RGC mosaics that can seed the emergence of spatially repetitive cortical OPMs, namely that angular correlations between so-called RGC dipoles exhibit a spatial structure similar to that of OPM autocorrelation functions. Both in cat beta cell mosaics as well as primate parasol receptive field mosaics we find that RGC dipole angles are spatially uncorrelated. To help assess the level of these correlations, we introduce a novel point process that generates mosaics with realistic nearest neighbor statistics and a tunable degree of spatial correlations of dipole angles. Using this process, we show that given the size of available data sets, the presence of even weak angular correlations in the data is very unlikely. We conclude that the layout of ON/OFF ganglion cell mosaics lacks the spatial structure necessary to seed iso-orientation domains in the primary visual cortex.},
  language  = {en}
}