@article{JoensuuAltimirHakolaetal.2016,
  author    = {Joensuu, Johanna and Altimir, Nuria and Hakola, Hannele and Rost{\´a}s, Michael and Raivonen, Maarit and Vestenius, Mika and Aaltonen, Hermanni and Riederer, Markus and B{\"a}ck, Jaana},
  title     = {Role of needle surface waxes in dynamic exchange of mono- and sesquiterpenes},
  series = {Atmospheric Chemistry and Physics},
  volume    = {16},
  journal   = {Atmospheric Chemistry and Physics},
  number    = {12},
  doi       = {10.5194/acp-2015-1024},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-171324},
  pages     = {7813-7823},
  year      = {2016},
  abstract  = {Biogenic volatile organic compounds (BVOCs) produced by plants have a major role in atmospheric chemistry. The different physicochemical properties of BVOCs affect their transport within and out of the plant as well as their reactions along the way. Some of these compounds may accumulate in or on the waxy surface layer of conifer needles and participate in chemical reactions on or near the foliage surface. The aim of this work was to determine whether terpenes, a key category of BVOCs produced by trees, can be found on the epicuticles of Scots pine (Pinus sylvestris L.) and, if so, how they compare with the terpenes found in shoot emissions of the same tree. We measured shoot-level emissions of pine seedlings at a remote outdoor location in central Finland and subsequently analysed the needle surface waxes for the same compounds. Both emissions and wax extracts were clearly dominated by monoterpenes, but the proportion of sesquiterpenes was higher in the wax extracts. There were also differences in the terpene spectra of the emissions and the wax extracts. The results, therefore, support the existence of BVOC associated to the epicuticular waxes. We briefly discuss the different pathways for terpenes to reach the needle surfaces and the implications for air chemistry.},
  language  = {en}
}
@article{LorenzBhattacharyyaFeileretal.2016,
  author    = {Lorenz, Sonja and Bhattacharyya, Moitrayee and Feiler, Christian and Rape, Michael and Kuriyan, John},
  title     = {Crystal Structure of a Ube2S-Ubiquitin Conjugate},
  series = {PLoS ONE},
  volume    = {11},
  journal   = {PLoS ONE},
  number    = {2},
  doi       = {10.1371/journal.pone.0147550},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-167265},
  pages     = {e0147550},
  year      = {2016},
  abstract  = {Protein ubiquitination occurs through the sequential formation and reorganization of specific protein-protein interfaces. Ubiquitin-conjugating (E2) enzymes, such as Ube2S, catalyze the formation of an isopeptide linkage between the C-terminus of a "donor" ubiquitin and a primary amino group of an "acceptor" ubiquitin molecule. This reaction involves an intermediate, in which the C-terminus of the donor ubiquitin is thioester-bound to the active site cysteine of the E2 and a functionally important interface is formed between the two proteins. A docked model of a Ube2S-donor ubiquitin complex was generated previously, based on chemical shift mapping by NMR, and predicted contacts were validated in functional studies. We now present the crystal structure of a covalent Ube2S-ubiquitin complex. The structure contains an interface between Ube2S and ubiquitin in trans that resembles the earlier model in general terms, but differs in detail. The crystallographic interface is more hydrophobic than the earlier model and is stable in molecular dynamics (MD) simulations. Remarkably, the docked Ube2S-donor complex converges readily to the configuration seen in the crystal structure in 3 out of 8 MD trajectories. Since the crystallographic interface is fully consistent with mutational effects, this indicates that the structure provides an energetically favorable representation of the functionally critical Ube2S-donor interface.},
  language  = {en}
}
@article{BahnikStrack2016,
  author    = {Bahn{\´i}k, Štěp{\´a}n and Strack, Fritz},
  title     = {Overlap of accessible information undermines the anchoring effect},
  series = {Judgment and Decision Making},
  volume    = {11},
  journal   = {Judgment and Decision Making},
  number    = {1},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-169287},
  pages     = {92-98},
  year      = {2016},
  abstract  = {According to the Selective Accessibility Model of anchoring, the comparison question in the standard anchoring paradigm activates information that is congruent with an anchor. As a consequence, this information will be more likely to become the basis for the absolute judgment which will therefore be assimilated toward the anchor. However, if the activated information overlaps with information that is elicited by the absolute judgment itself, the preceding comparative judgment should not exert an incremental effect and should fail to result in an anchoring effect. The present studies find this result when the comparative judgment refers to a general category and the absolute judgment refers to a subset of the general category that was activated by the anchor value. For example, participants comparing the average annual temperature in New York City to a high 102 °F judged the average winter, but not summer temperature to be higher than participants making no comparison. On the other hand, participants comparing the annual temperature to a low -4 °F judged the average summer, but not winter temperature to be lower than control participants. This pattern of results was shown also in another content domain. It is consistent with the Selective Accessibility Model but difficult to reconcile with other main explanations of the anchoring effect.},
  language  = {en}
}
@article{BekesFriedlKoehleretal.2016,
  author    = {Bekes, Inga and Friedl, Thomas W. P. and K{\"o}hler, Tanja and M{\"o}bus, Volker and Janni, Wolfgang and W{\"o}ckel, Achim and Wulff, Christine},
  title     = {Does VEGF facilitate local tumor growth and spread into the abdominal cavity by suppressing endothelial cell adhesion, thus increasing vascular peritoneal permeability followed by ascites production in ovarian cancer?},
  series = {Molecular Cancer},
  volume    = {15},
  journal   = {Molecular Cancer},
  number    = {13},
  doi       = {10.1186/s12943-016-0497-3},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-169298},
  year      = {2016},
  abstract  = {Background Ovarian cancer is mostly associated with pathologically regulated permeability of peritoneal vessels, leading to ascites. Here, we investigated the molecular regulation of endothelial permeability by the vascular endothelial growth factor (VEGF) and both tight and adherens junction proteins (VE-cadherin and claudin 5) with regards to the tumor biology of different ovarian cancer types. Methods Serum and ascites samples before and after surgery, as well as peritoneal biopsies of 68 ovarian cancer patients and 20 healthy controls were collected. In serum and ascites VEGF protein was measured by ELISA. In peritoneal biopsies co-localization of VE-cadherin and claudin 5 was investigated using immunohistochemical dual staining. In addition, the gene expression of VE-cadherin and claudin 5 was quantified by Real-time PCR. Differences in VEGF levels, VE-cadherin and claudin 5 gene expression were analyzed in relation to various tumor characteristics (tumor stage, grading, histological subtypes, resection status after surgery) and then compared to controls. Furthermore, human primary ovarian cancer cells were co-cultured with human umbilical vein endothelial cells (HUVEC) and changes in VE-cadherin and claudin 5 were investigated after VEGF inhibition. Results VEGF was significantly increased in tumor patients in comparison to controls and accumulates in ascites. The highest VEGF levels were found in patients diagnosed with advanced tumor stages, with tumors of poor differentiation, or in the group of solid / cystic-solid tumors. Patients with residual tumor after operation showed significantly higher levels of VEGF both before and after surgery as compared to tumor-free resected patients. Results of an immunohistochemical double-staining experiment indicated co-localization of VE-cadherin and claudin 5 in the peritoneal vasculature. Compared to controls, expression of VE-cadherin and claudin 5 was significantly suppressed in peritoneal vessels of tumor patients, but there were no significant differences regarding VE-cadherin and claudin 5 expression in relation to different tumor characteristics. A significant positive correlation was found between VE-cadherin and claudin 5 expression. VEGF inhibition in vitro was associated with significant increase in VE-cadherin and claudin 5. Conclusions Our results indicate that increased peritoneal permeability in ovarian cancer is due to down-regulation of adhesion proteins via tumor derived VEGF. Advanced ovarian cancer with aggressive tumor biology may be associated with early dysregulation of vascular permeability leading to ascites. These patients may benefit from therapeutic VEGF inhibition.},
  language  = {en}
}
@article{HuangSchrammHeilmannetal.2016,
  author    = {Huang, Guozheng and Schramm, Simon and Heilmann, J{\"o}rg and Biedermann, David and Kren, Vladim{\´i}r and Decker, Michael},
  title     = {Unconventional application of the Mitsunobu reaction: Selective flavonolignan dehydration yielding hydnocarpins},
  series = {Beilstein Journal of Organic Chemistry},
  volume    = {12},
  journal   = {Beilstein Journal of Organic Chemistry},
  doi       = {10.3762/bjoc.12.66},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-160986},
  pages     = {662-669},
  year      = {2016},
  abstract  = {Various Mitsunobu conditions were investigated for a series of flavonolignans (silybin A, silybin B, isosilybin A, and silychristin A) to achieve either selective esterification in position C-23 or dehydration in a one-pot reaction yielding the biologically important enantiomers of hydnocarpin D, hydnocarpin and isohydnocarpin, respectively. This represents the only one-pot semi-synthetic method to access these flavonolignans in high yields.},
  language  = {en}
}
@article{ZinnerKruegerReedetal.2016,
  author    = {Zinner, C. and Krueger, M. and Reed, J. L. and Kohl-Bareis, M. and Holmberg, H. C. and Sperlich, B.},
  title     = {Exposure to a combination of heat and hyperoxia during cycling at submaximal intensity does not alter thermoregulatory responses},
  series = {Biology of Sport},
  volume    = {33},
  journal   = {Biology of Sport},
  number    = {1},
  doi       = {10.5604/20831862.1192041},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-160993},
  pages     = {71-76},
  year      = {2016},
  abstract  = {In this study, we tested the hypothesis that breathing hyperoxic air (F\(_{in}\)O\(_2\) = 0.40) while exercising in a hot environment exerts negative effects on the total tissue level of haemoglobin concentration (tHb); core (T\(_{core}\)) and skin (T\(_{skin}\)) temperatures; muscle activity; heart rate; blood concentration of lactate; pH; partial pressure of oxygen (P\(_a\)O\(_2\)) and carbon dioxide; arterial oxygen saturation (S\(_a\)O\(_2\)); and perceptual responses. Ten well-trained male athletes cycled at submaximal intensity at 21°C or 33°C in randomized order: first for 20 min while breathing normal air (FinO\(_2\) = 0.21) and then 10 min with F\(_{in}\)O\(_2\) = 0.40 (HOX). At both temperatures, S\(_a\)O\(_2\) and P\(_a\)O\(_2\), but not tHb, were increased by HOX. Tskin and perception of exertion and thermal discomfort were higher at 33°C than 21°C (p < 0.01), but independent of F\(_{in}\)O\(_2\). T\(_{core}\) and muscle activity were the same under all conditions (p > 0.07). Blood lactate and heart rate were higher at 33°C than 21°C. In conclusion, during 30 min of submaximal cycling at 21°C or 33°C, T\(_{core}\), T\(_{skin}\) and T\(_{body}\), tHb, muscle activity and ratings of perceived exertion and thermal discomfort were the same under normoxic and hyperoxic conditions. Accordingly, breathing hyperoxic air (F\(_{in}\)O\(_2\) = 0.40) did not affect thermoregulation under these conditions.},
  language  = {en}
}
@article{JoukhadarWoeckelHerretal.2016,
  author    = {Joukhadar, R. and W{\"o}ckel, A. and Herr, D. and Paulus, V. and Radosa, J. and Hamza, A. and Solomayer, E. and Baum, S.},
  title     = {Challenges of Longevity: Safety of Vaginal and Laparoscopic Urogynecological Procedures in Septuagenarians and Older Patients},
  series = {BioMed Research International},
  volume    = {2016},
  journal   = {BioMed Research International},
  number    = {Article ID 5184595},
  doi       = {10.1155/2016/5184595},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-161005},
  pages     = {9},
  year      = {2016},
  abstract  = {Introduction. Pelvic organ prolapse (POP) and urinary incontinence (UI) have increasing prevalence in the elderly population. The aim of this study was to compare the comorbidities of these procedures between <70 y/o and ≥70 y/o patients. Materials and Methods. In our retrospective study over a period of 2.5 years, 407 patients had received an urogynecological procedure. All patients with POP were treated by reconstructive surgery. Complications were reported using the standardized classification of Clavien-Dindo (CD). The study can be assigned to stage 2b Exploration IDEAL (Idea, Development, Exploration, Assessment, Long-term study)-system of surgical innovation. Results. Operation time, blood loss, and intraoperative complications have not been more frequent in the elderly, whereas hospital stay was significantly longer in ≥70 y/o patients. Regarding postoperative complications, we noticed that ≥70 y/o patients had an almost threefold risk to develop mild early postoperative complications compared to younger patients (OR: 2.86; 95\% CI: 1.76-4.66). On the contrary, major complications were not more frequent. No case of life-threatening complication or the need for blood transfusion was reported. Conclusion. After urogynecological procedures, septuagenarians and older patients are more likely to develop mild postoperative complications but not more intraoperative or severe postoperative complications compared to younger patients.},
  language  = {en}
}
@article{IsaiasTrujilloSummersetal.2016,
  author    = {Isaias, Ioannis U. and Trujillo, Paula and Summers, Paul and Marotta, Giorgio and Mainardi, Luca and Pezzoli, Gianni and Zecca, Luigi and Costa, Antonella},
  title     = {Neuromelanin Imaging and Dopaminergic Loss in Parkinson's Disease},
  series = {Frontiers in Aging Neuroscience},
  volume    = {8},
  journal   = {Frontiers in Aging Neuroscience},
  number    = {196},
  doi       = {10.3389/fnagi.2016.00196},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-164046},
  year      = {2016},
  abstract  = {Parkinson's disease (PD) is a progressive neurodegenerative disorder in which the major pathologic substrate is a loss of dopaminergic neurons from the substantia nigra. Our main objective was to determine the correspondence between changes in the substantia nigra, evident in neuromelanin and iron sensitive magnetic resonance imaging (MRI), and dopaminergic striatal innervation loss in patients with PD. Eighteen patients and 18 healthy control subjects were included in the study. Using neuromelanin-MRI, we measured the volume of the substantia nigra and the contrast-to-noise-ratio between substantia nigra and a background region. The apparent transverse relaxation rate and magnetic susceptibility of the substantia nigra were calculated from dual-echo MRI. Striatal dopaminergic innervation was measured as density of dopamine transporter (DAT) by means of single-photon emission computed tomography and [123I] N-ω-fluoropropyl-2b-carbomethoxy-3b-(4-iodophenyl) tropane. Patients showed a reduced volume of the substantia nigra and contrast-to-noise-ratio and both positively correlated with the corresponding striatal DAT density. The apparent transverse relaxation rate and magnetic susceptibility values of the substantia nigra did not differ between patients and healthy controls. The best predictor of DAT reduction was the volume of the substantia nigra. Clinical and imaging correlations were also investigated for the locus coeruleus. Our results suggest that neuromelanin-MRI can be used for quantifying substantia nigra pathology in PD where it closely correlates with dopaminergic striatal innervation loss. Longitudinal studies should further explore the role of Neuromelanin-MRI as an imaging biomarker of PD, especially for subjects at risk of developing the disease.},
  language  = {en}
}
@phdthesis{Lorenzin2016,
  author    = {Lorenzin, Francesca},
  title     = {Regulation of transcription by MYC - DNA binding and target genes},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-150766},
  school      = {Universit{\"a}t W{\"u}rzburg},
  year      = {2016},
  abstract  = {MYC is a transcription factor, whose expression is elevated or deregulated in many human cancers (up to 70\%) and is often associated with aggressive and poorly differentiated tumors. Although MYC is extensively studied, discrepancies have emerged about how this transcription factor works. In primary lymphocytes, MYC promotes transcriptional amplification of virtually all genes with an open promoter, whereas in tumor cells MYC regulates specific sets of genes that have significant prognostic value. Furthermore, the set of target genes that distinguish MYC's physiological function from the pathological/oncogenic one, whether it exists or not, has not been fully understood yet. In this study, it could be shown that MYC protein levels within a cell and promoter affinity (determined by E-box presence or interaction with other proteins) of target genes toward MYC are important factors that influence MYC activity. At low levels, MYC can amplify a certain transcriptional program, which includes high affinity binding sites, whereas at high levels MYC leads to the specific up- and down regulation of genes with low affinity. Moreover, the promoter affinity characterizes different sets of target genes which can be distinguished in the physiological or oncogenic MYC signatures. MYC-mediated repression requires higher MYC levels than activation and formation of a complex with MIZ1 is necessary for inhibiting expression of a subset of MYC target genes.},
  subject      = {MYC},
  language  = {en}
}
@incollection{Schmitz2016,
  author    = {Schmitz, Barbara},
  title     = {Space, Borders and Boundaries in the Letter of Aristeas},
  series = {Borders : Terminologies, Ideologies, and Performances},
  booktitle = {Borders : Terminologies, Ideologies, and Performances},
  publisher = {Mohr Siebeck},
  address   = {T{\"u}bingen},
  isbn      = {978-3-16-154375-3},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-151285},
  publisher      = {Universit{\"a}t W{\"u}rzburg},
  pages     = {142-154},
  year      = {2016},
  abstract  = {No abstract available.},
  subject      = {Aristeas, Epistolographus : Ad Philocratem},
  language  = {en}
}
@article{TiedeGrafe2016,
  author    = {Tiede, Jennifer and Grafe, Silke},
  title     = {Media Pedagogy in German and US Teacher Education},
  series = {Communicar},
  volume    = {XXIV},
  journal   = {Communicar},
  number    = {49},
  doi       = {10.3916/C49-2016-02},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-162600},
  pages     = {19-28},
  year      = {2016},
  abstract  = {Varios estudios de investigaci{\´o}n y de pr{\´a}ctica llegan a la conclusi{\´o}n de que la pedagog{\´i}a de los medios debe integrarse en la formaci{\´o}n de profesores para que estos futuros docentes puedan utilizar los medios de comunicaci{\´o}n en sus clases con eficacia y {\´e}xito. Sin embargo, estos resultados no se reflejan en los programas universitarios vigentes, de manera que en algunas instituciones los profesores en formaci{\´o}n pueden llegar al t{\´e}rmino de sus estudios sin haber abordado cuestiones de educaci{\´o}n en medios. Para comprender, evaluar y m{\´a}s adelante mejorar la situaci{\´o}n actual de la formaci{\´o}n del profesorado en el {\´a}mbito de la pedagog{\´i}a de los medios se necesitan extensas investigaciones. Teniendo en cuenta esta situaci{\´o}n, el siguiente art{\´i}culo presenta un resumen del «statu quo» de las competencias en pedagog{\´i}a de los medios de los futuros profesores, centr{\´a}ndose en los ejemplos de Alemania y EEUU. Para crear una base presentamos diferentes modelos de competencias pedag{\´o}gicas medi{\´a}ticas de ambos pa{\´i}ses e intentaremos responder a la pregunta si estas competencias son promovidas por los programas de formaci{\´o}n del profesorado. Despu{\´e}s, se describir{\´a}n el m{\´e}todo y resultados seleccionados de un estudio que midi{\´o} las competencias en pedagog{\´i}a de los medios de estudiantes de ambos pa{\´i}ses, estudio basado en un modelo generalizador de competencias pedag{\´o}gicas medi{\´a}ticas que conectan la investigaci{\´o}n alemana e internacional en este campo. La perspectiva internacional comparada ayuda a extender perspectivas y comprender diferencias y similitudes. Los datos de este estudio sirven para identificar diferentes formas de integrar la pedagog{\´i}a de los medios de comunicaci{\´o}n en la formaci{\´o}n del profesorado. Adem{\´a}s, se pueden sacar conclusiones sobre las consecuencias que implican estos procesos para profesores en formaci{\´o}n y sus competencias medi{\´a}ticas.},
  language  = {en}
}
@article{KaluzaWallaceHeardetal.2016,
  author    = {Kaluza, Benjamin F. and Wallace, Helen and Heard, Tim A. and Klein, Aelxandra-Maria and Leonhardt, Sara D.},
  title     = {Urban gardens promote bee foraging over natural habitats and plantations},
  series = {Ecology and Evolution},
  volume    = {6},
  journal   = {Ecology and Evolution},
  number    = {5},
  doi       = {10.1002/ece3.1941},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-162713},
  pages     = {1304-1316},
  year      = {2016},
  abstract  = {Increasing human land use for agriculture and housing leads to the loss of natural habitat and to widespread declines in wild bees. Bee foraging dynamics and fitness depend on the availability of resources in the surrounding landscape, but how precisely landscape related resource differences affect bee foraging patterns remains unclear. To investigate how landscape and its interaction with season and weather drive foraging and resource intake in social bees, we experimentally compared foraging activity, the allocation of foragers to different resources (pollen, nectar, and resin) and overall resource intake in the Australian stingless bee Tetragonula carbonaria (Apidae, Meliponini). Bee colonies were monitored in different seasons over two years. We compared foraging patterns and resource intake between the bees' natural habitat (forests) and two landscapes differently altered by humans (suburban gardens and agricultural macadamia plantations). We found foraging activity as well as pollen and nectar forager numbers to be highest in suburban gardens, intermediate in forests and low in plantations. Foraging patterns further differed between seasons, but seasonal variations strongly differed between landscapes. Sugar and pollen intake was low in plantations, but contrary with our predictions, it was even higher in gardens than in forests. In contrast, resin intake was similar across landscapes. Consequently, differences in resource availability between natural and altered landscapes strongly affect foraging patterns and thus resource intake in social bees. While agricultural monocultures largely reduce foraging success, suburban gardens can increase resource intake well above rates found in natural habitats of bees, indicating that human activities can both decrease and increase the availability of resources in a landscape and thus reduce or enhance bee fitness.},
  language  = {en}
}
@article{SeydelmannLiuKraemeretal.2016,
  author    = {Seydelmann, Nora and Liu, Dan and Kr{\"a}mer, Johannes and Drechsler, Christiane and Hu, Kai and Nordbeck, Peter and Schneider, Andreas and St{\"o}rk, Stefan and Bijnens, Bart and Ertl, Georg and Wanner, Christoph and Weidemann, Frank},
  title     = {High-Sensitivity Troponin: A Clinical Blood Biomarker for Staging Cardiomyopathy in Fabry Disease},
  series = {Journal of the American Heart Association},
  volume    = {5},
  journal   = {Journal of the American Heart Association},
  number    = {e002839},
  doi       = {10.1161/JAHA.115.002839},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-165682},
  year      = {2016},
  abstract  = {Background High-sensitivity troponin (hs-TNT), a biomarker of myocardial damage, might be useful for assessing fibrosis in Fabry cardiomyopathy. We performed a prospective analysis of hs-TNT as a biomarker for myocardial changes in Fabry patients and a retrospective longitudinal follow-up study to assess longitudinal hs-TNT changes relative to fibrosis and cardiomyopathy progression. Methods and Results For the prospective analysis, hs-TNT from 75 consecutive patients with genetically confirmed Fabry disease was analyzed relative to typical Fabry-associated echocardiographic findings and total myocardial fibrosis as measured by late gadolinium enhancement (LE) on magnetic resonance imaging. Longitudinal data (3.9±2.0 years), including hs-TNT, LE, and echocardiographic findings from 58 Fabry patients, were retrospectively collected. Hs-TNT level positively correlated with LE (linear correlation coefficient, 0.72; odds ratio, 32.81 [95\% CI, 3.56-302.59]; P=0.002); patients with elevated baseline hs-TNT (>14 ng/L) showed significantly increased LE (median: baseline, 1.9 [1.1-3.3] \%; follow-up, 3.2 [2.3-4.9] \%; P<0.001) and slightly elevated hs-TNT (baseline, 44.7 [30.1-65.3] ng/L; follow-up, 49.1 [27.6-69.5] ng/L; P=0.116) during follow-up. Left ventricular wall thickness and EF of patients with elevated hs-TNT were decreased during follow-up, indicating potential cardiomyopathy progression. Conclusions hs-TNT is an accurate, easily accessible clinical blood biomarker for detecting replacement fibrosis in patients with Fabry disease and a qualified predictor of cardiomyopathy progression. Thus, hs-TNT could be helpful for staging and follow-up of Fabry patients.},
  language  = {en}
}
@article{AlbersBernsteinBrachmannetal.2016,
  author    = {Albers, Gregory W. and Bernstein, Richard A. and Brachmann, Johannes and Camm, John and Easton, J. Donald and Fromm, Peter and Goto, Shinya and Granger, Christopher B. and Hohnloser, Stefan H. and Hylek, Elaine and Jaffer, Amir K. and Krieger, Derk W. and Passman, Rod and Pines, Jesse M. and Reed, Shelby D. and Rothwell, Peter M. and Kowey, Peter R.},
  title     = {Heart Rhythm Monitoring Strategies for Cryptogenic Stroke: 2015 Diagnostics and Monitoring Stroke Focus Group Report},
  series = {Journal of the American Heart Association},
  volume    = {5},
  journal   = {Journal of the American Heart Association},
  number    = {e00294},
  doi       = {10.1161/JAHA.115.002944},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-165709},
  pages     = {1-11},
  year      = {2016},
  abstract  = {No abstract available.},
  language  = {en}
}
@article{WawraFeselWidmeretal.2016,
  author    = {Wawra, Stephan and Fesel, Philipp and Widmer, Heidi and Timm, Malte and Seibel, J{\"u}rgen and Leson, Lisa and Kesseler, Leona and Nostadt, Robin and Hilbert, Magdalena and Langen, Gregor and Zuccaro, Alga},
  title     = {The fungal-specific beta-glucan-binding lectin FGB1 alters cell-wall composition and suppresses glucan-triggered immunity in plants},
  series = {Nature Communications},
  volume    = {7},
  journal   = {Nature Communications},
  doi       = {10.1038/ncomms13188},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-165945},
  pages     = {13188},
  year      = {2016},
  abstract  = {β-glucans are well-known modulators of the immune system in mammals but little is known about β-glucan triggered immunity in planta. Here we show by isothermal titration calorimetry, circular dichroism spectroscopy and nuclear magnetic resonance spectroscopy that the FGB1 gene from the root endophyte Piriformospora indica encodes for a secreted fungal-specific β-glucan-binding lectin with dual function. This lectin has the potential to both alter fungal cell wall composition and properties, and to efficiently suppress β-glucan-triggered immunity in different plant hosts, such as Arabidopsis, barley and Nicotiana benthamiana. Our results hint at the existence of fungal effectors that deregulate innate sensing of β-glucan in plants.},
  language  = {en}
}
@article{KnorrSokkarSchottetal.2016,
  author    = {Knorr, Johannes and Sokkar, Pandian and Schott, Sebastian and Costa, Paolo and Thiel, Walter and Sander, Wolfram and Sanchez-Garcia, Elsa and Nuernberger, Patrick},
  title     = {Competitive solvent-molecule interactions govern primary processes of diphenylcarbene in solvent mixtures},
  series = {Nature Communications},
  volume    = {7},
  journal   = {Nature Communications},
  doi       = {10.1038/ncomms12968},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-165954},
  pages     = {12968},
  year      = {2016},
  abstract  = {Photochemical reactions in solution often proceed via competing reaction pathways comprising intermediates that capture a solvent molecule. A disclosure of the underlying reaction mechanisms is challenging due to the rapid nature of these processes and the intricate identification of how many solvent molecules are involved. Here combining broadband femtosecond transient absorption and quantum mechanics/molecular mechanics simulations, we show for one of the most reactive species, diphenylcarbene, that the decision-maker is not the nearest solvent molecule but its neighbour. The hydrogen bonding dynamics determine which reaction channels are accessible in binary solvent mixtures at room temperature. In-depth analysis of the amount of nascent intermediates corroborates the importance of a hydrogen-bonded complex with a protic solvent molecule, in striking analogy to complexes found at cryogenic temperatures. Our results show that adjacent solvent molecules take the role of key abettors rather than bystanders for the fate of the reactive intermediate.},
  language  = {en}
}
@article{MitchellLiWeinholdetal.2016,
  author    = {Mitchell, Jonathan S. and Li, Ni and Weinhold, Niels and F{\"o}rsti, Asta and Ali, Mina and van Duin, Mark and Thorleifsson, Gudmar and Johnson, David C. and Chen, Bowang and Halvarsson, Britt-Marie and Gudbjartsson, Daniel F. and Kuiper, Rowan and Stephens, Owen W. and Bertsch, Uta and Broderick, Peter and Campo, Chiara and Einsele, Hermann and Gregory, Walter A. and Gullberg, Urban and Henrion, Marc and Hillengass, Jens and Hoffmann, Per and Jackson, Graham H. and Johnsson, Ellinor and J{\"o}ud, Magnus and Kristinsson, Sigurdur Y. and Lenhoff, Stig and Lenive, Oleg and Mellqvist, Ulf-Henrik and Migliorini, Gabriele and Nahi, Hareth and Nelander, Sven and Nickel, Jolanta and N{\"o}then, Markus M. and Rafnar, Thorunn and Ross, Fiona M. and da Silva Filho, Miguel Inacio and Swaminathan, Bhairavi and Thomsen, Hauke and Turesson, Ingemar and Vangsted, Annette and Vogel, Ulla and Waage, Anders and Walker, Brian A. and Wihlborg, Anna-Karin and Broyl, Annemiek and Davies, Faith E. and Thorsteinsdottir, Unnur and Langer, Christian and Hansson, Markus and Kaiser, Martin and Sonneveld, Pieter and Stefansson, Kari and Morgan, Gareth J. and Goldschmidt, Hartmut and Hemminki, Kari and Nilsson, Bj{\"o}rn and Houlston, Richard S.},
  title     = {Genome-wide association study identifies multiple susceptibility loci for multiple myeloma},
  series = {Nature Communications},
  volume    = {7},
  journal   = {Nature Communications},
  doi       = {10.1038/ncomms12050},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-165983},
  pages     = {12050},
  year      = {2016},
  abstract  = {Multiple myeloma (MM) is a plasma cell malignancy with a significant heritable basis. Genome-wide association studies have transformed our understanding of MM predisposition, but individual studies have had limited power to discover risk loci. Here we perform a meta-analysis of these GWAS, add a new GWAS and perform replication analyses resulting in 9,866 cases and 239,188 controls. We confirm all nine known risk loci and discover eight new loci at 6p22.3 (rs34229995, P=1.31 × 10-8), 6q21 (rs9372120, P=9.09 × 10-15), 7q36.1 (rs7781265, P=9.71 × 10-9), 8q24.21 (rs1948915, P=4.20 × 10-11), 9p21.3 (rs2811710, P=1.72 × 10-13), 10p12.1 (rs2790457, P=1.77 × 10-8), 16q23.1 (rs7193541, P=5.00 × 10-12) and 20q13.13 (rs6066835, P=1.36 × 10-13), which localize in or near to JARID2, ATG5, SMARCD3, CCAT1, CDKN2A, WAC, RFWD3 and PREX1. These findings provide additional support for a polygenic model of MM and insight into the biological basis of tumour development.},
  language  = {en}
}
@article{VanHauteDietmannKremeretal.2016,
  author    = {Van Haute, Lindsey and Dietmann, Sabine and Kremer, Laura and Hussain, Shobbir and Pearce, Sarah F. and Powell, Christopher A. and Rorbach, Joanna and Lantaff, Rebecca and Blanco, Sandra and Sauer, Sascha and Kotzaeridou, Urania and Hoffmann, Georg F. and Memari, Yasin and Kolb-Kokocinski, Anja and Durbin, Richard and Mayr, Johannes A. and Frye, Michaela and Prokisch, Holger and Minczuk, Michal},
  title     = {Deficient methylation and formylation of mt-tRNA(Met) wobble cytosine in a patient carrying mutations in NSUN3},
  series = {Nature Communications},
  volume    = {7},
  journal   = {Nature Communications},
  doi       = {10.1038/ncomms12039},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-165998},
  pages     = {12039},
  year      = {2016},
  abstract  = {Epitranscriptome modifications are required for structure and function of RNA and defects in these pathways have been associated with human disease. Here we identify the RNA target for the previously uncharacterized 5-methylcytosine (m5C) methyltransferase NSun3 and link m5C RNA modifications with energy metabolism. Using whole-exome sequencing, we identified loss-of-function mutations in NSUN3 in a patient presenting with combined mitochondrial respiratory chain complex deficiency. Patient-derived fibroblasts exhibit severe defects in mitochondrial translation that can be rescued by exogenous expression of NSun3. We show that NSun3 is required for deposition of m5C at the anticodon loop in the mitochondrially encoded transfer RNA methionine (mt-tRNAMet). Further, we demonstrate that m5C deficiency in mt-tRNAMet results in the lack of 5-formylcytosine (f5C) at the same tRNA position. Our findings demonstrate that NSUN3 is necessary for efficient mitochondrial translation and reveal that f5C in human mitochondrial RNA is generated by oxidative processing of m5C.},
  language  = {en}
}
@article{KernreiterGovernaleZuelickeetal.2016,
  author    = {Kernreiter, T. and Governale, M. and Z{\"u}licke, U. and Hankiewicz, E. M.},
  title     = {Anomalous Spin Response and Virtual-Carrier-Mediated Magnetism in a Topological Insulator},
  series = {Physical Review X},
  volume    = {6},
  journal   = {Physical Review X},
  number    = {021010},
  doi       = {10.1103/PhysRevX.6.021010},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-166582},
  year      = {2016},
  abstract  = {We present a comprehensive theoretical study of the static spin response in HgTe quantum wells, revealing distinctive behavior for the topologically nontrivial inverted structure. Most strikingly, the q=0 (long-wavelength) spin susceptibility of the undoped topological-insulator system is constant and equal to the value found for the gapless Dirac-like structure, whereas the same quantity shows the typical decrease with increasing band gap in the normal-insulator regime. We discuss ramifications for the ordering of localized magnetic moments present in the quantum well, both in the insulating and electron-doped situations. The spin response of edge states is also considered, and we extract effective Land{\´e} g factors for the bulk and edge electrons. The variety of counterintuitive spin-response properties revealed in our study arises from the system's versatility in accessing situations where the charge-carrier dynamics can be governed by ordinary Schr{\"o}dinger-type physics; it mimics the behavior of chiral Dirac fermions or reflects the material's symmetry-protected topological order.},
  language  = {en}
}
@article{KimZhangWangetal.2016,
  author    = {Kim, Seonghoon and Zhang, Bo and Wang, Zhaorong and Fischer, Julian and Brodbeck, Sebastian and Kamp, Martin and Schneider, Christian and H{\"o}fling, Sven and Deng, Hui},
  title     = {Coherent Polariton Laser},
  series = {Physical Review X},
  volume    = {6},
  journal   = {Physical Review X},
  number    = {011026},
  doi       = {10.1103/PhysRevX.6.011026},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-166597},
  year      = {2016},
  abstract  = {The semiconductor polariton laser promises a new source of coherent light, which, compared to conventional semiconductor photon lasers, has input-energy threshold orders of magnitude lower. However, intensity stability, a defining feature of a coherent state, has remained poor. Intensity noise many times the shot noise of a coherent state has persisted, attributed to multiple mechanisms that are difficult to separate in conventional polariton systems. The large intensity noise, in turn, limits the phase coherence. Thus, the capability of the polariton laser as a source of coherence light is limited. Here, we demonstrate a polariton laser with shot-noise-limited intensity stability, as expected from a fully coherent state. This stability is achieved by using an optical cavity with high mode selectivity to enforce single-mode lasing, suppress condensate depletion, and establish gain saturation. Moreover, the absence of spurious intensity fluctuations enables the measurement of a transition from exponential to Gaussian decay of the phase coherence of the polariton laser. It suggests large self-interaction energies in the polariton condensate, exceeding the laser bandwidth. Such strong interactions are unique to matter-wave lasers and important for nonlinear polariton devices. The results will guide future development of polariton lasers and nonlinear polariton devices.},
  language  = {en}
}
@article{IslesIngasonLowtheretal.2016,
  author    = {Isles, Anthony R. and Ingason, Andr{\´e}s and Lowther, Chelsea and Walters, James and Gawlick, Micha and St{\"o}ber, Gerald and Rees, Elliott and Martin, Joanna and Little, Rosie B. and Potter, Harry and Georgieva, Lyudmila and Pizzo, Lucilla and Ozaki, Norio and Aleksic, Branko and Kushima, Itaru and Ikeda, Masashi and Iwata, Nakao and Levinson, Douglas F. and Gejman, Pablo V. and Shi, Jianxin and Sanders, Alan R. and Duan, Jubao and Willis, Joseph and Sisodiya, Sanjay and Costain, Gregory and Werge, Thomas M. and Degenhardt, Franziska and Giegling, Ina and Rujescu, Dan and Hreidarsson, Stefan J. and Saemundsen, Evald and Ahn, Joo Wook and Ogilvie, Caroline and Girirajan, Santhosh D. and Stefansson, Hreinn and Stefansson, Kari and O'Donovan, Michael C. and Owen, Michael J. and Bassett, Anne and Kirov, George},
  title     = {Parental Origin of Interstitial Duplications at 15q11.2-q13.3 in Schizophrenia and Neurodevelopmental Disorders},
  series = {PLoS Genetics},
  volume    = {12},
  journal   = {PLoS Genetics},
  number    = {5},
  doi       = {10.1371/journal.pgen.1005993},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-166706},
  pages     = {e1005993},
  year      = {2016},
  abstract  = {Duplications at 15q11.2-q13.3 overlapping the Prader-Willi/Angelman syndrome (PWS/AS) region have been associated with developmental delay (DD), autism spectrum disorder (ASD) and schizophrenia (SZ). Due to presence of imprinted genes within the region, the parental origin of these duplications may be key to the pathogenicity. Duplications of maternal origin are associated with disease, whereas the pathogenicity of paternal ones is unclear. To clarify the role of maternal and paternal duplications, we conducted the largest and most detailed study to date of parental origin of 15q11.2-q13.3 interstitial duplications in DD, ASD and SZ cohorts. We show, for the first time, that paternal duplications lead to an increased risk of developing DD/ASD/multiple congenital anomalies (MCA), but do not appear to increase risk for SZ. The importance of the epigenetic status of 15q11.2-q13.3 duplications was further underlined by analysis of a number of families, in which the duplication was paternally derived in the mother, who was unaffected, whereas her offspring, who inherited a maternally derived duplication, suffered from psychotic illness. Interestingly, the most consistent clinical characteristics of SZ patients with 15q11.2-q13.3 duplications were learning or developmental problems, found in 76\% of carriers. Despite their lower pathogenicity, paternal duplications are less frequent in the general population with a general population prevalence of 0.0033\% compared to 0.0069\% for maternal duplications. This may be due to lower fecundity of male carriers and differential survival of embryos, something echoed in the findings that both types of duplications are de novo in just over 50\% of cases. Isodicentric chromosome 15 (idic15) or interstitial triplications were not observed in SZ patients or in controls. Overall, this study refines the distinct roles of maternal and paternal interstitial duplications at 15q11.2-q13.3, underlining the critical importance of maternally expressed imprinted genes in the contribution of Copy Number Variants (CNVs) at this interval to the incidence of psychotic illness. This work will have tangible benefits for patients with 15q11.2-q13.3 duplications by aiding genetic counseling.},
  language  = {en}
}
@article{VendelovadeLimaLorenzattoetal.2016,
  author    = {Vendelova, Emilia and de Lima, Jeferson Camargo and Lorenzatto, Karina Rodrigues and Monteiro, Karina Mariante and Mueller, Thomas and Veepaschit, Jyotishman and Grimm, Clemens and Brehm, Klaus and Hrčkov{\´a}, Gabriela and Lutz, Manfred B. and Ferreira, Henrique B. and Nono, Justin Komguep},
  title     = {Proteomic Analysis of Excretory-Secretory Products of Mesocestoides corti Metacestodes Reveals Potential Suppressors of Dendritic Cell Functions},
  series = {PLoS Neglected Tropical Diseases},
  volume    = {10},
  journal   = {PLoS Neglected Tropical Diseases},
  number    = {10},
  doi       = {10.1371/journal.pntd.0005061},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-166742},
  pages     = {e0005061},
  year      = {2016},
  abstract  = {Accumulating evidences have assigned a central role to parasite-derived proteins in immunomodulation. Here, we report on the proteomic identification and characterization of immunomodulatory excretory-secretory (ES) products from the metacestode larva (tetrathyridium) of the tapeworm Mesocestoides corti (syn. M. vogae). We demonstrate that ES products but not larval homogenates inhibit the stimuli-driven release of the pro-inflammatory, Th1-inducing cytokine IL-12p70 by murine bone marrow-derived dendritic cells (BMDCs). Within the ES fraction, we biochemically narrowed down the immunosuppressive activity to glycoproteins since active components were lipid-free, but sensitive to heat- and carbohydrate-treatment. Finally, using bioassay-guided chromatographic analyses assisted by comparative proteomics of active and inactive fractions of the ES products, we defined a comprehensive list of candidate proteins released by M. corti tetrathyridia as potential suppressors of DC functions. Our study provides a comprehensive library of somatic and ES products and highlight some candidate parasite factors that might drive the subversion of DC functions to facilitate the persistence of M. corti tetrathyridia in their hosts.},
  language  = {en}
}
@article{ShiKuaiLeietal.2016,
  author    = {Shi, Yaoyao and Kuai, Yue and Lei, Lizhen and Weng, Yuanyuan and Berberich-Siebelt, Friederike and Zhang, Xinxia and Wang, Jinjie and Zhou, Yuan and Jiang, Xin and Ren, Guoping and Pan, Hongyang and Mao, Zhengrong and Zhou, Ren},
  title     = {The feedback loop of LITAF and BCL6 is involved in regulating apoptosis in B cell non-Hodgkin's-lymphoma},
  series = {Oncotarget},
  volume    = {7},
  journal   = {Oncotarget},
  number    = {47},
  doi       = {10.18632/oncotarget.12680},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-166500},
  pages     = {77444-77456},
  year      = {2016},
  abstract  = {Dysregulation of the apoptotic pathway is widely recognized as a key step in lymphomagenesis. Notably, LITAF was initially identified as a p53-inducible gene, subsequently implicated as a tumor suppressor. Our previous study also showed LITAF to be methylated in 89.5\% B-NHL samples. Conversely, deregulated expression of BCL6 is a pathogenic event in many lymphomas. Interestingly, our study found an oppositional expression of LITAF and BCL6 in B-NHL. In addition, LITAF was recently identified as a novel target gene of BCL6. Therefore, we sought to explore the feedback loop between LITAF and BCL6 in B-NHL. Here, our data for the first time show that LITAF can repress expression of BCL6 by binding to Region A (-87 to +65) containing a putative LITAF-binding motif (CTCCC) within the BCL6 promoter. Furthermore, the regulation of BCL6 targets (PRDM1 or c-Myc) by LITAF may be associated with B-cell differentiation. Results also demonstrate that ectopic expression of LITAF induces cell apoptosis, activated by releasing cytochrome c, cleaving PARP and caspase 3 in B-NHL cells whereas knockdown of LITAF robustly protected cells from apoptosis. Interestingly, BCL6, in turn, could reverse cell apoptosis mediated by LITAF. Collectively, our findings provide a novel apoptotic regulatory pathway in which LITAF, as a transcription factor, inhibits the expression of BCL6, which leads to activation of the intrinsic mitochondrial pathway and tumor apoptosis. Our study is expected to provide a possible biomarker as well as a target for clinical therapies to promote tumor cell apoptosis.},
  language  = {en}
}
@article{VučićevićGehreDhamijaetal.2016,
  author    = {Vučićević, Dubravka and Gehre, Maja and Dhamija, Sonam and Friis-Hansen, Lennart and Meierhofer, David and Sauer, Sascha and {\O}rom, Ulf Andersson},
  title     = {The long non-coding RNA PARROT is an upstream regulator of c-Myc and affects proliferation and translation},
  series = {Oncotarget},
  volume    = {7},
  journal   = {Oncotarget},
  number    = {23},
  doi       = {10.18632/oncotarget.8985},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-166519},
  pages     = {33934-33947},
  year      = {2016},
  abstract  = {Long non-coding RNAs are important regulators of gene expression and signaling pathways. The expression of long ncRNAs is dysregulated in cancer and other diseases. The identification and characterization of long ncRNAs is often challenging due to their low expression level and localization to chromatin. Here, we identify a functional long ncRNA, PARROT (Proliferation Associated RNA and Regulator Of Translation) transcribed by RNA polymerase II and expressed at a relatively high level in a number of cell lines. The PARROT long ncRNA is associated with proliferation in both transformed and normal cell lines. We characterize the long ncRNA PARROT as an upstream regulator of c-Myc affecting cellular proliferation and translation using RNA sequencing and mass spectrometry following depletion of the long ncRNA. PARROT is repressed during senescence of human mammary epithelial cells and overexpressed in some cancers, suggesting an important association with proliferation through regulation of c-Myc. With this study, we add to the knowledge of cytoplasmic functional long ncRNAs and extent the long ncRNA-Myc regulatory network in transformed and normal cells.},
  language  = {en}
}
@article{EisenhardtSprengerRoeringetal.2016,
  author    = {Eisenhardt, Anja E. and Sprenger, Adrian and R{\"o}ring, Michael and Herr, Ricarda and Weinberg, Florian and K{\"o}hler, Martin and Braun, Sandra and Orth, Joachim and Diedrich, Britta and Lanner, Ulrike and Tscherwinski, Natalja and Schuster, Simon and Dumaz, Nicolas and Schmidt, Enrico and Baumeister, Ralf and Schlosser, Andreas and Dengjel, J{\"o}rn and Brummer, Tilman},
  title     = {Phospho-proteomic analyses of B-Raf protein complexes reveal new regulatory principles},
  series = {Oncotarget},
  volume    = {7},
  journal   = {Oncotarget},
  number    = {18},
  doi       = {10.18632/oncotarget.8427},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-166529},
  pages     = {26628-26652},
  year      = {2016},
  abstract  = {B-Raf represents a critical physiological regulator of the Ras/RAF/MEK/ERK-pathway and a pharmacological target of growing clinical relevance, in particular in oncology. To understand how B-Raf itself is regulated, we combined mass spectrometry with genetic approaches to map its interactome in MCF-10A cells as well as in B-Raf deficient murine embryonic fibroblasts (MEFs) and B-Raf/Raf-1 double deficient DT40 lymphoma cells complemented with wildtype or mutant B-Raf expression vectors. Using a multi-protease digestion approach, we identified a novel ubiquitination site and provide a detailed B-Raf phospho-map. Importantly, we identify two evolutionary conserved phosphorylation clusters around T401 and S419 in the B-Raf hinge region. SILAC labelling and genetic/biochemical follow-up revealed that these clusters are phosphorylated in the contexts of oncogenic Ras, sorafenib induced Raf dimerization and in the background of the V600E mutation. We further show that the vemurafenib sensitive phosphorylation of the T401 cluster occurs in trans within a Raf dimer. Substitution of the Ser/Thr-residues of this cluster by alanine residues enhances the transforming potential of B-Raf, indicating that these phosphorylation sites suppress its signaling output. Moreover, several B-Raf phosphorylation sites, including T401 and S419, are somatically mutated in tumors, further illustrating the importance of phosphorylation for the regulation of this kinase.},
  language  = {en}
}
@article{ChenariSeibelHauschildetal.2016,
  author    = {Chenari, Hossein Mahmoudi and Seibel, Christoph and Hauschild, Dirk and Reinert, Friedrich and Abdollahian, Hossein},
  title     = {Titanium Dioxide Nanoparticles: Synthesis, X-Ray Line Analysis and Chemical Composition Study},
  series = {Materials Research},
  volume    = {19},
  journal   = {Materials Research},
  number    = {6},
  doi       = {10.1590/1980-5373-MR-2016-0288},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-165807},
  pages     = {1319-1323},
  year      = {2016},
  abstract  = {TiO2 nanoparticleshave been synthesized by the sol-gel method using titanium alkoxide and isopropanolas a precursor. The structural properties and chemical composition of the TiO2 nanoparticles were studied usingX-ray diffraction, scanning electron microscopy, and X-ray photoelectron spectroscopy.The X-ray powder diffraction pattern confirms that the particles are mainly composed of the anatase phase with the preferential orientation along [101] direction. The physical parameters such as strain, stress and energy density were investigated from the Williamson- Hall (W-H) plot assuming a uniform deformation model (UDM), and uniform deformation energy density model (UDEDM). The W-H analysis shows an anisotropic nature of the strain in nanopowders. The scanning electron microscopy image shows clear TiO2 nanoparticles with particle sizes varying from 60 to 80nm. The results of mean particle size of TiO2 nanoparticles show an inter correlation with the W-H analysis and SEM results. Our X-ray photoelectron spectroscopy spectra show that nearly a complete amount of titanium has reacted to TiO2},
  language  = {en}
}
@article{DingemansMonsieursYuetal.2016,
  author    = {Dingemans, Josef and Monsieurs, Pieter and Yu, Sung-Huan and Crabb{\´e}, Aur{\´e}lie and F{\"o}rstner, Konrad U. and Malfroot, Anne and Cornelis, Pierre and Van Houdt, Rob},
  title     = {Effect of Shear Stress on Pseudomonas aeruginosa Isolated from the Cystic Fibrosis Lung},
  series = {mBio},
  volume    = {7},
  journal   = {mBio},
  number    = {4},
  doi       = {10.1128/mBio.00813-16},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-165821},
  pages     = {e00813-16},
  year      = {2016},
  abstract  = {Chronic colonization of the lungs by Pseudomonas aeruginosa is one of the major causes of morbidity and mortality in cystic fibrosis (CF) patients. To gain insights into the characteristic biofilm phenotype of P. aeruginosa in the CF lungs, mimicking the CF lung environment is critical. We previously showed that growth of the non-CF-adapted P. aeruginosa PAO1 strain in a rotating wall vessel, a device that simulates the low fluid shear (LS) conditions present in the CF lung, leads to the formation of in-suspension, self-aggregating biofilms. In the present study, we determined the phenotypic and transcriptomic changes associated with the growth of a highly adapted, transmissible P. aeruginosa CF strain in artificial sputum medium under LS conditions. Robust self-aggregating biofilms were observed only under LS conditions. Growth under LS conditions resulted in the upregulation of genes involved in stress response, alginate biosynthesis, denitrification, glycine betaine biosynthesis, glycerol metabolism, and cell shape maintenance, while genes involved in phenazine biosynthesis, type VI secretion, and multidrug efflux were downregulated. In addition, a number of small RNAs appeared to be involved in the response to shear stress. Finally, quorum sensing was found to be slightly but significantly affected by shear stress, resulting in higher production of autoinducer molecules during growth under high fluid shear (HS) conditions. In summary, our study revealed a way to modulate the behavior of a highly adapted P. aeruginosa CF strain by means of introducing shear stress, driving it from a biofilm lifestyle to a more planktonic lifestyle.},
  language  = {en}
}
@article{DrgonovaWaltherHartsteinetal.2016,
  author    = {Drgonova, Jana and Walther, Donna and Hartstein, G Luke and Bukhari, Mohammad O and Baumann, Michael H and Katz, Jonathan and Hall, F Scott and Arnold, Elizabeth R and Flax, Shaun and Riley, Anthony and Rivero, Olga and Lesch, Klaus-Peter and Troncoso, Juan and Ranscht, Barbara and Uhl, George R},
  title     = {Cadherin 13: Human cis-Regulation and Selectively Altered Addiction Phenotypes and Cerebral Cortical Dopamine in Knockout Mice},
  series = {Molecular Medicine},
  volume    = {22},
  journal   = {Molecular Medicine},
  doi       = {10.2119/molmed.2015.00170},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-165842},
  pages     = {537-547},
  year      = {2016},
  abstract  = {The Cadherin 13 (CDH13) gene encodes a cell adhesion molecule likely to influence development and connections of brain circuits that modulate addiction, locomotion and cognition, including those that involve midbrain dopamine neurons. Human CDH13 mRNA expression differs by more than 80\% in postmortem cerebral cortical samples from individuals with different CDH13 genotypes, supporting examination of mice with altered CDH13 expression as models for common human variation at this locus. Constitutive CDH13 knockout mice display evidence for changed cocaine reward: shifted dose response relationship in tests of cocaine-conditioned place preference using doses that do not alter cocaine-conditioned taste aversion. Reduced adult CDH13 expression in conditional knockouts also alters cocaine reward in ways that correlate with individual differences in cortical CDH13 mRNA levels. In control and comparison behavioral assessments, knockout mice display modestly quicker acquisition of rotarod and water maze tasks, with a trend toward faster acquisition of 5-choice serial reaction time tasks that otherwise displayed no genotype-related differences. They display significant differences in locomotion in some settings, with larger effects in males. In assessments of brain changes that might contribute to these behavioral differences, there are selective alterations of dopamine levels, dopamine/metabolite ratios, dopaminergic fiber densities and mRNA encoding the activity dependent transcription factor npas4 in cerebral cortex of knockout mice. These novel data and previously reported human associations of CDH13 variants with addiction, individual differences in responses to stimulant administration and attention deficit hyperactivity disorder (ADHD) phenotypes suggest that levels of CDH13 expression, through mechanisms likely to include effects on mesocortical dopamine, influence stimulant reward and may contribute modestly to cognitive and locomotor phenotypes relevant to ADHD.},
  language  = {en}
}
@article{vandeKerkhofFekkesvanderHeijdenetal.2016,
  author    = {van de Kerkhof, Nora WA and Fekkes, Durk and van der Heijden, Frank MMA and Hoogendijk, Witte JG and St{\"o}ber, Gerald and Egger, Jos IM and Verhoeven, Willem MA},
  title     = {Cycloid psychoses in the psychosis spectrum: evidence for biochemical differences with schizophrenia},
  series = {Neuropsychiatric Disease and Treatment},
  volume    = {12},
  journal   = {Neuropsychiatric Disease and Treatment},
  doi       = {10.2147/NDT.S101317},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-166255},
  pages     = {1927-1933},
  year      = {2016},
  abstract  = {Cycloid psychoses (CP) differ from schizophrenia regarding symptom profile, course, and prognosis and over many decades they were thought to be a separate entity within the psychosis spectrum. As to schizophrenia, research into the pathophysiology has focused on dopamine, brain-derived neurotrophic factor, and glutamate signaling in which, concerning the latter, the N-methyl-d-aspartate receptor plays a crucial role. The present study aims to determine whether CP can biochemically be delineated from schizophrenia. Eighty patients referred for psychotic disorders were assessed with the Comprehensive Assessment of Symptoms and History, and (both at inclusion and after 6 weeks of antipsychotic treatment) with the Positive and Negative Syndrome Scale and Clinical Global Impression. From 58 completers, 33 patients were diagnosed with schizophrenia and ten with CP according to the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, and Leonhard criteria, respectively. Fifteen patients were diagnosed with other disorders within the psychosis spectrum. At both time points, blood levels of the dopamine metabolite homovanillic acid, brain-derived neurotrophic factor, and amino acids related to glutamate neurotransmission were measured and compared with a matched control sample. Patients with CP showed a significantly better response to antipsychotic treatment as compared to patients with schizophrenia. In CP, glycine levels were elevated and tryptophan levels were lowered as compared to schizophrenia. Glutamate levels were increased in both patient groups as compared to controls. These results, showing marked differences in both treatment outcome and glutamate-related variable parameters, may point at better neuroplasticity in CP, necessitating demarcation of this subgroup within the psychosis spectrum.},
  language  = {en}
}
@article{HargartRoyChoudhuryJohnetal.2016,
  author    = {Hargart, F and Roy-Choudhury, K and John, T and Portalupi, S L and Schneider, C and H{\"o}fling, S and Kamp, M and Hughes, S and Michler, P},
  title     = {Probing different regimes of strong field light-matter interaction with semiconductor quantum dots and few cavity photons},
  series = {New Journal of Physics},
  volume    = {18},
  journal   = {New Journal of Physics},
  doi       = {10.1088/1367-2630/aa5198},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-166278},
  year      = {2016},
  abstract  = {In this work we present an extensive experimental and theoretical investigation of different regimes of strong field light-matter interaction for cavity-driven quantum dot (QD) cavity systems. The electric field enhancement inside a high-Q micropillar cavity facilitates exceptionally strong interaction with few cavity photons, enabling the simultaneous investigation for a wide range of QD-laser detuning. In case of a resonant drive, the formation of dressed states and a Mollow triplet sideband splitting of up to 45 μeV is measured for amean cavity photon number <n\(_c\)>\(\leq\) 1. In the asymptotic limit of the linear ACStark effect we systematically investigate the power and detuning dependence of more than 400 QDs. Some QD-cavity systems exhibit an unexpected anomalous Stark shift, which can be explained by an extended dressed 4-levelQDmodel.Weprovide a detailed analysis of the QD-cavity systems properties enabling this novel effect. The experimental results are successfully reproduced using a polaron master equation approach for the QD-cavity system, which includes the driving laser field, exciton-cavity and exciton-phonon interactions},
  language  = {en}
}
@article{RedlichLingnauHolzingeretal.2016,
  author    = {Redlich, Christoph and Lingnau, Benjamin and Holzinger, Steffen and Schlottmann, Elisabeth and Kreinberg, S{\"o}ren and Schneider, Christian and Kamp, Martin and H{\"o}fling, Sven and Wolters, Janik and Reitzenstein, Stephan and L{\"u}dge, Kathy},
  title     = {Mode-switching induced super-thermal bunching in quantum-dot microlasers},
  series = {New Journal of Physics},
  volume    = {18},
  journal   = {New Journal of Physics},
  number    = {063011},
  doi       = {10.1088/1367-2630/18/6/063011},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-166286},
  year      = {2016},
  abstract  = {The super-thermal photon bunching in quantum-dot (QD) micropillar lasers is investigated both experimentally and theoretically via simulations driven by dynamic considerations. Using stochastic multi-mode rate equations we obtain very good agreement between experiment and theory in terms of intensity profiles and intensity-correlation properties of the examined QD micro-laser's emission. Further investigations of the time-dependent emission show that super-thermal photon bunching occurs due to irregular mode-switching events in the bimodal lasers. Our bifurcation analysis reveals that these switchings find their origin in an underlying bistability, such that spontaneous emission noise is able to effectively perturb the two competing modes in a small parameter region. We thus ascribe the observed high photon correlation to dynamical multistabilities rather than quantum mechanical correlations.},
  language  = {en}
}
@article{LisinetskayaBraunProchetal.2016,
  author    = {Lisinetskaya, Polina and Braun, Christian and Proch, Sebastian and Kim, Young Dok and Gantef{\"o}r, Gerd and Mitrić, Roland},
  title     = {Excited state nonadiabatic dynamics of bare and hydrated anionic gold clusters Au\(^-_3\)[H\(_2\)O]\(_n\) (n=0-2)},
  series = {Physical Chemistry Chemical Physics},
  volume    = {18},
  journal   = {Physical Chemistry Chemical Physics},
  number    = {9},
  issn      = {1463-9076},
  doi       = {10.1039/c5cp04297f},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-159176},
  pages     = {6411-6419},
  year      = {2016},
  abstract  = {We present a joint theoretical and experimental study of excited state dynamics in pure and hydrated anionic gold clusters Au\(^-_3\)[H\(_2\)O]\(_n\) (n = 0-2). We employ mixed quantum-classical dynamics combined with femtosecond time-resolved photoelectron spectroscopy in order to investigate the influence of hydration on excited state lifetimes and photo-dissociation dynamics. A gradual decrease of the excited state lifetime with the number of adsorbed water molecules as well as gold cluster fragmentation quenching by two or more water molecules are observed both in experiment and in simulations. Non-radiative relaxation and dissociation in excited states are found to be responsible for the excited state population depletion. Time constants of these two processes strongly depend on the number of water molecules leading to the possibility to modulate excited state dynamics and fragmentation of the anionic cluster by adsorption of water molecules.},
  language  = {en}
}
@article{LisinetskayaRoehrMitrić2016,
  author    = {Lisinetskaya, Polina and R{\"o}hr, Merle I. S. and Mitrić, Roland},
  title     = {First-principles simulation of light propagation and exciton dynamics in metal cluster nanostructures},
  series = {Applied Physics B},
  volume    = {122},
  journal   = {Applied Physics B},
  number    = {6},
  issn      = {0946-2171},
  doi       = {10.1007/s00340-016-6436-6},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-159193},
  pages     = {175},
  year      = {2016},
  abstract  = {We present a theoretical approach for the simulation of the electric field and exciton propagation in ordered arrays constructed of molecular-sized noble metal clusters bound to organic polymer templates. In order to describe the electronic coupling between individual constituents of the nanostructure we use the ab initio parameterized transition charge method which is more accurate than the usual dipole-dipole coupling. The electronic population dynamics in the nanostructure under an external laser pulse excitation is simulated by numerical integration of the time-dependent Schrodinger equation employing the fully coupled Hamiltonian. The solution of the TDSE gives rise to time-dependent partial point charges for each subunit of the nanostructure, and the spatio-temporal electric field distribution is evaluated by means of classical electrodynamics methods. The time-dependent partial charges are determined based on the stationary partial and transition charges obtained in the framework of the TDDFT. In order to treat large plasmonic nanostructures constructed of many constituents, the approximate self-consistent iterative approach presented in (Lisinetskaya and Mitric in Phys Rev B 89:035433, 2014) is modified to include the transition-charge-based interaction. The developed methods are used to study the optical response and exciton dynamics of Ag-3(+) and porphyrin-Ag-4 dimers. Subsequently, the spatio-temporal electric field distribution in a ring constructed of ten porphyrin-Ag-4 subunits under the action of circularly polarized laser pulse is simulated. The presented methodology provides a theoretical basis for the investigation of coupled light-exciton propagation in nanoarchitectures built from molecular size metal nanoclusters in which quantum confinement effects are important.},
  language  = {en}
}
@article{WohlgemuthMitric2016,
  author    = {Wohlgemuth, Matthias and Mitric, Roland},
  title     = {Photochemical Chiral Symmetry Breaking in Alanine},
  series = {Journal of Physical Chemistry A},
  volume    = {45},
  journal   = {Journal of Physical Chemistry A},
  number    = {120},
  doi       = {10.1021/acs.jpca.6b07611},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-158557},
  pages     = {8976-8982},
  year      = {2016},
  abstract  = {We introduce a general theoretical approach for the simulation of photochemical dynamics under the influence of circularly polarized light to explore the possibility of generating enantiomeric enrichment through polarized-light-selective photochemistry. The method is applied to the simulation of the photolysis of alanine, a prototype chiral amino acid. We show that a systematic enantiomeric enrichment can be obtained depending on the helicity of the circularly polarized light that induces the excited-state photochemistry of alanine. By analyzing the patterns of the photoinduced fragmentation of alanine we find an inducible enantiomeric enrichment up to 1.7\%, which is also in good correspondence to the experimental findings. Our method is generally applicable to complex systems and might serve to systematically explore the photochemical origin of homochirality.},
  language  = {en}
}
@article{RoehrLisinetskayaMitric2016,
  author    = {R{\"o}hr, Merle I. S. and Lisinetskaya, Polina G. and Mitric, Roland},
  title     = {Excitonic Properties of Ordered Metal Nanocluster Arrays: 2D Silver Clusters at Multiporphyrin Templates},
  series = {Journal of Physical Chemistry A},
  volume    = {120},
  journal   = {Journal of Physical Chemistry A},
  number    = {26},
  doi       = {10.1021/acs.jpca.6b04243},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-159464},
  pages     = {4465-4472},
  year      = {2016},
  abstract  = {The design of ordered arrays of metal nanoclusters such as for example 2D cluster organic frameworks might open a new route towards the development of materials with tailored optical properties. Such systems could serve as plasmonically enhanced light-harvesting materials, sensors or catalysts. We present here a theoretical approach for the simulation of the optical properties of ordered arrays of metal clusters that is based on the ab initio parametrized Frenkel exciton model. We demonstrate that small atomically precise silver clusters can be assembled in one- and two-dimensional arrays on suitably designed porphyrin templates exhibiting remarkable optical properties. By employing explicit TDDFT calculations on smaller homologs, we show that the intrinsic optical properties of metal clusters are largely preserved but undergo J- and H-type excitonic coupling that results in controllable splitting of their excited states. Furthermore, ab initio parameterized Frenkel exciton model calculations allow us to predict an energetic splitting of up to 0.77 eV in extended two-dimensional square arrays and 0.79 eV in tilted square aggregates containing up to 25 cluster-porphyrin subunits.},
  language  = {en}
}
@article{DomschkeZwanzgerRehbeinetal.2016,
  author    = {Domschke, Katharina and Zwanzger, Peter and Rehbein, Maimu A. and Steinberg, Christian and Knoke, Kathrin and Dobel, Christian and Klinkenberg, Isabelle and Kugel, Harald and Kersting, Anette and Arolt, Volker and Pantev, Christo and Junghofer, Markus},
  title     = {Magnetoencephalographic Correlates of Emotional Processing in Major Depression Before and After Pharmacological Treatment},
  series = {International Journal of Neuropsychopharmacology},
  volume    = {2016},
  journal   = {International Journal of Neuropsychopharmacology},
  doi       = {10.1093/ijnp/pyv093},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-165523},
  pages     = {1-9},
  year      = {2016},
  abstract  = {Background: In major depressive disorder (MDD), electrophysiological and imaging studies suggest reduced neural activity in the parietal and dorsolateral prefrontal cortex regions. In the present study, neural correlates of emotional processing in MDD were analyzed for the first time in a pre-/post-treatment design by means of magnetoencephalography (MEG), allowing for detecting temporal dynamics of brain activation. Methods: Twenty-five medication-free Caucasian in-patients with MDD and 25 matched controls underwent a baseline MEG session with passive viewing of pleasant, unpleasant, and neutral pictures. Fifteen patients were followed-up with a second MEG session after 4 weeks of antidepressant monopharmacotherapy with mirtazapine. The corresponding controls received no intervention between the measurements. The clinical course of depression was assessed using the Hamilton Depression scale. Results: Prior to treatment, an overall neocortical hypoactivation during emotional processing, particularly at the parietal regions and areas at the right temporoparietal junction, as well as abnormal valence-specific reactions at the right parietal and bilateral dorsolateral prefrontal cortex (dlPFC) regions were observed in patients compared to controls. These effects occurred <150ms, suggesting dysfunctional processing of emotional stimuli at a preconscious level. Successful antidepressant treatment resulted in a normalization of the hypoactivation at the right parietal and right temporoparietal regions. Accordingly, both dlPFC regions revealed an increase of activity after therapy. Conclusions: The present study provides neurophysiological evidence for dysfunctional emotional processing in a fronto-parieto-temporal network, possibly contributing to the pathogenesis of MDD. These activation patterns might have the potential to serve as biomarkers of treatment success.},
  language  = {en}
}
@article{PacheZimmermannMikolajczaketal.2016,
  author    = {Pache, Florence and Zimmermann, Hanna and Mikolajczak, Janine and Schumacher, Sophie and Lacheta, Anna and Oertel, Frederike C. and Bellmann-Strobl, Judith and Jarius, Sven and Wildemann, Brigitte and Reindl, Markus and Waldman, Amy and Soelberg, Kerstin and Asgari, Nasrin and Ringelstein, Marius and Aktas, Orhan and Gross, Nikolai and Buttmann, Mathias and Ach, Thomas and Ruprecht, Klemens and Paul, Friedemann and Brandt, Alexander U.},
  title     = {MOG-IgG in NMO and related disorders: a multicenter study of 50 patients. Part 4: Afferent visual system damage after optic neuritis in MOG-IgG-seropositive versus AQP4-IgG-seropositive patients},
  series = {Journal of Neuroinflammation},
  volume    = {13},
  journal   = {Journal of Neuroinflammation},
  number    = {282},
  doi       = {10.1186/s12974-016-0720-6},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-165551},
  year      = {2016},
  abstract  = {Background Antibodies against myelin oligodendrocyte glycoprotein (MOG-IgG) have been reported in patients with aquaporin-4 antibody (AQP4-IgG)-negative neuromyelitis optica spectrum disorders (NMOSD). The objective of this study was to describe optic neuritis (ON)-induced neuro-axonal damage in the retina of MOG-IgG-positive patients in comparison with AQP4-IgG-positive NMOSD patients. Methods Afferent visual system damage following ON was bilaterally assessed in 16 MOG-IgG-positive patients with a history of ON and compared with that in 16 AQP4-IgG-positive NMOSD patients. In addition, 16 healthy controls matched for age, sex, and disease duration were analyzed. Study data included ON history, retinal optical coherence tomography, visual acuity, and visual evoked potentials. Results Eight MOG-IgG-positive patients had a previous diagnosis of AQP4-IgG-negative NMOSD with ON and myelitis, and eight of (mainly recurrent) ON. Twenty-nine of the 32 eyes of the MOG-IgG-positive patients had been affected by at least one episode of ON. Peripapillary retinal nerve fiber layer thickness (pRNFL) and ganglion cell and inner plexiform layer volume (GCIP) were significantly reduced in ON eyes of MOG-IgG-positive patients (pRNFL = 59 ± 23 μm; GCIP = 1.50 ± 0.34 mm3) compared with healthy controls (pRNFL = 99 ± 6 μm, p < 0.001; GCIP = 1.97 ± 0.11 mm3, p < 0.001). Visual acuity was impaired in eyes after ON in MOG-IgG-positive patients (0.35 ± 0.88 logMAR). There were no significant differences in any structural or functional visual parameters between MOG-IgG-positive and AQP4-IgG-positive patients (pRNFL: 59 ± 21 μm; GCIP: 1.41 ± 0.27 mm3; Visual acuity = 0.72 ± 1.09 logMAR). Importantly, MOG-IgG-positive patients had a significantly higher annual ON relapse rate than AQP4-IgG-positive patients (median 0.69 vs. 0.29 attacks/year, p = 0.004), meaning that on average a single ON episode caused less damage in MOG-IgG-positive than in AQP4-IgG-positive patients. pRNFL and GCIP loss correlated with the number of ON episodes in MOG-IgG-positive patients (p < 0.001), but not in AQP4-IgG-positive patients. Conclusions Retinal neuro-axonal damage and visual impairment after ON in MOG-IgG-positive patients are as severe as in AQP4-IgG-positive NMOSD patients. In MOG-IgG-positive patients, damage accrual may be driven by higher relapse rates, whereas AQP4-IgG-positive patients showed fewer but more severe episodes of ON. Given the marked damage in some of our MOG-IgG-positive patients, early diagnosis and timely initiation and close monitoring of immunosuppressive therapy are important.},
  language  = {en}
}
@article{JariusRuprechtKleiteretal.2016,
  author    = {Jarius, Sven and Ruprecht, Klemens and Kleiter, Ingo and Borisow, Nadja and Asgari, Nasrin and Pitarokoili, Kalliopi and Pache, Florence and Stich, Oliver and Beume, Lena-Alexandra and H{\"u}mmert, Martin W. and Ringelstein, Marius and Trebst, Corinna and Winkelmann, Alexander and Schwarz, Alexander and Buttmann, Mathias and Zimmermann, Hanna and Kuchling, Joseph and Franciotta, Diego and Capobianco, Marco and Siebert, Eberhard and Lukas, Carsten and Korporal-Kuhnke, Mirjam and Haas, J{\"u}rgen and Fechner, Kai and Brandt, Alexander U. and Schanda, Kathrin and Aktas, Orhan and Paul, Friedemann and Reindl, Markus and Wildemann, Brigitte},
  title     = {MOG-IgG in NMO and related disorders: a multicenter study of 50 patients. Part 2: Epidemiology, clinical presentation, radiological and laboratory features, treatment responses, and long-term outcome},
  series = {Journal of Neuroinflammation},
  volume    = {13},
  journal   = {Journal of Neuroinflammation},
  number    = {280},
  doi       = {10.1186/s12974-016-0718-0},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-165570},
  year      = {2016},
  abstract  = {Background A subset of patients with neuromyelitis optica spectrum disorders (NMOSD) has been shown to be seropositive for myelin oligodendrocyte glycoprotein antibodies (MOG-IgG). Objective To describe the epidemiological, clinical, radiological, cerebrospinal fluid (CSF), and electrophysiological features of a large cohort of MOG-IgG-positive patients with optic neuritis (ON) and/or myelitis (n = 50) as well as attack and long-term treatment outcomes. Methods Retrospective multicenter study. Results The sex ratio was 1:2.8 (m:f). Median age at onset was 31 years (range 6-70). The disease followed a multiphasic course in 80\% (median time-to-first-relapse 5 months; annualized relapse rate 0.92) and resulted in significant disability in 40\% (mean follow-up 75 ± 46.5 months), with severe visual impairment or functional blindness (36\%) and markedly impaired ambulation due to paresis or ataxia (25\%) as the most common long-term sequelae. Functional blindness in one or both eyes was noted during at least one ON attack in around 70\%. Perioptic enhancement was present in several patients. Besides acute tetra-/paraparesis, dysesthesia and pain were common in acute myelitis (70\%). Longitudinally extensive spinal cord lesions were frequent, but short lesions occurred at least once in 44\%. Fourty-one percent had a history of simultaneous ON and myelitis. Clinical or radiological involvement of the brain, brainstem, or cerebellum was present in 50\%; extra-opticospinal symptoms included intractable nausea and vomiting and respiratory insufficiency (fatal in one). CSF pleocytosis (partly neutrophilic) was present in 70\%, oligoclonal bands in only 13\%, and blood-CSF-barrier dysfunction in 32\%. Intravenous methylprednisolone (IVMP) and long-term immunosuppression were often effective; however, treatment failure leading to rapid accumulation of disability was noted in many patients as well as flare-ups after steroid withdrawal. Full recovery was achieved by plasma exchange in some cases, including after IVMP failure. Breakthrough attacks under azathioprine were linked to the drug-specific latency period and a lack of cotreatment with oral steroids. Methotrexate was effective in 5/6 patients. Interferon-beta was associated with ongoing or increasing disease activity. Rituximab and ofatumumab were effective in some patients. However, treatment with rituximab was followed by early relapses in several cases; end-of-dose relapses occurred 9-12 months after the first infusion. Coexisting autoimmunity was rare (9\%). Wingerchuk's 2006 and 2015 criteria for NMO(SD) and Barkhof and McDonald criteria for multiple sclerosis (MS) were met by 28\%, 32\%, 15\%, 33\%, respectively; MS had been suspected in 36\%. Disease onset or relapses were preceded by infection, vaccination, or pregnancy/delivery in several cases. Conclusion Our findings from a predominantly Caucasian cohort strongly argue against the concept of MOG-IgG denoting a mild and usually monophasic variant of NMOSD. The predominantly relapsing and often severe disease course and the short median time to second attack support the use of prophylactic long-term treatments in patients with MOG-IgG-positive ON and/or myelitis.},
  language  = {en}
}
@article{JariusRuprechtKleiteretal.2016,
  author    = {Jarius, Sven and Ruprecht, Klemens and Kleiter, Ingo and Borisow, Nadja and Asgari, Nasrin and Pitarokoili, Kalliopi and Pache, Florence and Stich, Oliver and Beume, Lena-Alexandra and H{\"u}mmert, Martin W. and Trebst, Corinna and Ringelstein, Marius and Aktas, Orhan and Winkelmann, Alexander and Buttmann, Mathias and Schwarz, Alexander and Zimmermann, Hanna and Brandt, Alexander U. and Franciotta, Diego and Capobianco, Marco and Kuchling, Joseph and Haas, J{\"u}rgen and Korporal-Kuhnke, Mirjam and Lillevang, Soeren Thue and Fechner, Kai and Schanda, Kathrin and Paul, Friedemann and Wildemann, Brigitte and Reindl, Markus},
  title     = {MOG-IgG in NMO and related disorders: a multicenter study of 50 patients. Part 1: Frequency, syndrome specificity, influence of disease activity, long-term course, association with AQP4-IgG, and origin},
  series = {Journal of Neuroinflammation},
  volume    = {13},
  journal   = {Journal of Neuroinflammation},
  number    = {279},
  doi       = {10.1186/s12974-016-0717-1},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-165659},
  pages     = {1-16},
  year      = {2016},
  abstract  = {Background Antibodies to myelin oligodendrocyte glycoprotein (MOG-IgG) have been suggested to play a role in a subset of patients with neuromyelitis optica and related disorders. Objective To assess (i) the frequency of MOG-IgG in a large and predominantly Caucasian cohort of patients with optic neuritis (ON) and/or myelitis; (ii) the frequency of MOG-IgG among AQP4-IgG-positive patients and vice versa; (iii) the origin and frequency of MOG-IgG in the cerebrospinal fluid (CSF); (iv) the presence of MOG-IgG at disease onset; and (v) the influence of disease activity and treatment status on MOG-IgG titers. Methods 614 serum samples from patients with ON and/or myelitis and from controls, including 92 follow-up samples from 55 subjects, and 18 CSF samples were tested for MOG-IgG using a live cell-based assay (CBA) employing full-length human MOG-transfected HEK293A cells. Results MOG-IgG was detected in 95 sera from 50 patients with ON and/or myelitis, including 22/54 (40.7\%) patients with a history of both ON and myelitis, 22/103 (21.4\%) with a history of ON but no myelitis and 6/45 (13.3\%) with a history of longitudinally extensive transverse myelitis but no ON, and in 1 control patient with encephalitis and a connective tissue disorder, all of whom were negative for AQP4-IgG. MOG-IgG was absent in 221 further controls, including 83 patients with AQP4-IgG-seropositive neuromyelitis optica spectrum disorders and 85 with multiple sclerosis (MS). MOG-IgG was found in 12/18 (67\%) CSF samples from MOG-IgG-seropositive patients; the MOG-IgG-specific antibody index was negative in all cases, indicating a predominantly peripheral origin of CSF MOG-IgG. Serum and CSF MOG-IgG belonged to the complement-activating IgG1 subclass. MOG-IgG was present already at disease onset. The antibodies remained detectable in 40/45 (89\%) follow-up samples obtained over a median period of 16.5 months (range 0-123). Serum titers were higher during attacks than during remission (p < 0.0001), highest during attacks of simultaneous myelitis and ON, lowest during acute isolated ON, and declined following treatment. Conclusions To date, this is the largest cohort studied for IgG to human full-length MOG by means of an up-to-date CBA. MOG-IgG is present in a substantial subset of patients with ON and/or myelitis, but not in classical MS. Co-existence of MOG-IgG and AQP4-IgG is highly uncommon. CSF MOG-IgG is of extrathecal origin. Serum MOG-IgG is present already at disease onset and remains detectable in the long-term course. Serum titers depend on disease activity and treatment status.},
  language  = {en}
}
@article{KilianWehmeierWahletal.2016,
  author    = {Kilian, Yvonne and Wehmeier, Udo F. and Wahl, Patrick and Mester, Joachim and Hilberg, Thomas and Sperlich, Billy},
  title     = {Acute Response of Circulating Vascular Regulating MicroRNAs during and after High-Intensity and High-Volume Cycling in Children},
  series = {Frontiers in Physiology},
  volume    = {7},
  journal   = {Frontiers in Physiology},
  number    = {92},
  doi       = {10.3389/fphys.2016.00092},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-165261},
  year      = {2016},
  abstract  = {Aim: The aim of the present study was to analyze the response of vascular circulating microRNAs (miRNAs; miR-16, miR-21, miR-126) and the VEGF mRNA following an acute bout of HIIT and HVT in children. Methods: Twelve healthy competitive young male cyclists (14.4 ± 0.8 years; 57.9 ± 9.4 ml•min-1•kg-1 peak oxygen uptake) performed one session of high intensity 4 × 4 min intervals (HIIT) at 90-95\% peak power output (PPO), each interval separated by 3 min of active recovery, and one high volume session (HVT) consisting of a constant load exercise for 90 min at 60\% PPO. Capillary blood from the earlobe was collected under resting conditions, during exercise (d1 = 20 min, d2 = 30 min, d3 = 60 min), and 0, 30, 60, 180 min after the exercise to determine miR-16, -21, -126, and VEGF mRNA. Results: HVT significantly increased miR-16 and miR-126 during and after the exercise compared to pre-values, whereas HIIT showed no significant influence on the miRNAs compared to pre-values. VEGF mRNA significantly increased during and after HIIT (d1, 30′, 60′, 180′) and HVT (d3, 0′, 60′). Conclusion: Results of the present investigation suggest a volume dependent exercise regulation of vascular regulating miRNAs (miR-16, miR-21, miR-126) in children. In line with previous data, our data show that acute exercise can alter circulating miRNAs profiles that might be used as novel biomarkers to monitor acute and chronic changes due to exercise in various tissues.},
  language  = {en}
}
@article{KempertGoetzBlatteretal.2016,
  author    = {Kempert, Sebastian and G{\"o}tz, Regina and Blatter, Kristine and Tibken, Catharina and Artelt, Cordula and Schneider, Wolfgang and Stanat, Petra},
  title     = {Training Early Literacy Related Skills: To Which Degree Does a Musical Training Contribute to Phonological Awareness Development?},
  series = {Frontiers in Psychology},
  volume    = {7},
  journal   = {Frontiers in Psychology},
  number    = {1803},
  doi       = {10.3389/fpsyg.2016.01803},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-165272},
  year      = {2016},
  abstract  = {Well-developed phonological awareness skills are a core prerequisite for early literacy development. Although effective phonological awareness training programs exist, children at risk often do not reach similar levels of phonological awareness after the intervention as children with normally developed skills. Based on theoretical considerations and first promising results the present study explores effects of an early musical training in combination with a conventional phonological training in children with weak phonological awareness skills. Using a quasi-experimental pretest-posttest control group design and measurements across a period of 2 years, we tested the effects of two interventions: a consecutive combination of a musical and a phonological training and a phonological training alone. The design made it possible to disentangle effects of the musical training alone as well the effects of its combination with the phonological training. The outcome measures of these groups were compared with the control group with multivariate analyses, controlling for a number of background variables. The sample included N = 424 German-speaking children aged 4-5 years at the beginning of the study. We found a positive relationship between musical abilities and phonological awareness. Yet, whereas the well-established phonological training produced the expected effects, adding a musical training did not contribute significantly to phonological awareness development. Training effects were partly dependent on the initial level of phonological awareness. Possible reasons for the lack of training effects in the musical part of the combination condition as well as practical implications for early literacy education are discussed.},
  language  = {en}
}
@article{WunschPfisterHenningetal.2016,
  author    = {Wunsch, Kathrin and Pfister, Roland and Henning, Anne and Aschersleben, Gisa and Weigelt, Matthias},
  title     = {No Interrelation of Motor Planning and Executive Functions across Young Ages},
  series = {Frontiers in Psychology},
  volume    = {7},
  journal   = {Frontiers in Psychology},
  number    = {1031},
  doi       = {10.3389/fpsyg.2016.01031},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-165281},
  year      = {2016},
  abstract  = {The present study examined the developmental trajectories of motor planning and executive functioning in children. To this end, we tested 217 participants with three motor tasks, measuring anticipatory planning abilities (i.e., the bar-transport-task, the sword-rotation-task and the grasp-height-task), and three cognitive tasks, measuring executive functions (i.e., the Tower-of-Hanoi-task, the Mosaic-task, and the D2-attention-endurance-task). Children were aged between 3 and 10 years and were separated into age groups by 1-year bins, resulting in a total of eight groups of children and an additional group of adults. Results suggested (1) a positive developmental trajectory for each of the sub-tests, with better task performance as children get older; (2) that the performance in the separate tasks was not correlated across participants in the different age groups; and (3) that there was no relationship between performance in the motor tasks and in the cognitive tasks used in the present study when controlling for age. These results suggest that both, motor planning and executive functions are rather heterogeneous domains of cognitive functioning with fewer interdependencies than often suggested.},
  language  = {en}
}
@article{GressmannJanczyk2016,
  author    = {Gressmann, Marcel and Janczyk, Markus},
  title     = {The (Un)Clear Effects of Invalid Retro-Cues},
  series = {Frontiers in Psychology},
  volume    = {7},
  journal   = {Frontiers in Psychology},
  number    = {244},
  doi       = {10.3389/fpsyg.2016.00244},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-165296},
  year      = {2016},
  abstract  = {Studies with the retro-cue paradigm have shown that validly cueing objects in visual working memory long after encoding can still benefit performance on subsequent change detection tasks. With regard to the effects of invalid cues, the literature is less clear. Some studies reported costs, others did not. We here revisit two recent studies that made interesting suggestions concerning invalid retro-cues: One study suggested that costs only occur for larger set sizes, and another study suggested that inclusion of invalid retro-cues diminishes the retro-cue benefit. New data from one experiment and a reanalysis of published data are provided to address these conclusions. The new data clearly show costs (and benefits) that were independent of set size, and the reanalysis suggests no influence of the inclusion of invalid retro-cues on the retro-cue benefit. Thus, previous interpretations may be taken with some caution at present.},
  language  = {en}
}
@article{PeperkornDiemerAlpersetal.2016,
  author    = {Peperkorn, Henrik M. and Diemer, Julia E. and Alpers, Georg W. and M{\"u}hlberger, Andreas},
  title     = {Representation of Patients' Hand Modulates Fear Reactions of Patients with Spider Phobia in Virtual Reality},
  series = {frontiers in Psychology},
  volume    = {7},
  journal   = {frontiers in Psychology},
  number    = {268},
  doi       = {10.3389/fpsyg.2016.00268},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-165307},
  year      = {2016},
  abstract  = {Embodiment (i.e., the involvement of a bodily representation) is thought to be relevant in emotional experiences. Virtual reality (VR) is a capable means of activating phobic fear in patients. The representation of the patient's body (e.g., the right hand) in VR enhances immersion and increases presence, but its effect on phobic fear is still unknown. We analyzed the influence of the presentation of the participant's hand in VR on presence and fear responses in 32 women with spider phobia and 32 matched controls. Participants sat in front of a table with an acrylic glass container within reaching distance. During the experiment this setup was concealed by a head-mounted display (HMD). The VR scenario presented via HMD showed the same setup, i.e., a table with an acrylic glass container. Participants were randomly assigned to one of two experimental groups. In one group, fear responses were triggered by fear-relevant visual input in VR (virtual spider in the virtual acrylic glass container), while information about a real but unseen neutral control animal (living snake in the acrylic glass container) was given. The second group received fear-relevant information of the real but unseen situation (living spider in the acrylic glass container), but visual input was kept neutral VR (virtual snake in the virtual acrylic glass container). Participants were instructed to touch the acrylic glass container with their right hand in 20 consecutive trials. Visibility of the hand was varied randomly in a within-subjects design. We found for all participants that visibility of the participant's hand increased presence independently of the fear trigger. However, in patients, the influence of the virtual hand on fear depended on the fear trigger. When fear was triggered perceptually, i.e., by a virtual spider, the virtual hand increased fear. When fear was triggered by information about a real spider, the virtual hand had no effect on fear. Our results shed light on the significance of different fear triggers (visual, conceptual) in interaction with body representations.},
  language  = {en}
}
@article{CitronAbugaberHerbert2016,
  author    = {Citron, Francesca M. M. and Abugaber, David and Herbert, Cornelia},
  title     = {Approach and Withdrawal Tendencies during Written Word Processing: Effects of Task, Emotional Valence, and Emotional Arousal},
  series = {frontiers in Psychology},
  volume    = {6},
  journal   = {frontiers in Psychology},
  number    = {1935},
  doi       = {10.3389/fpsyg.2015.01935},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-165318},
  year      = {2016},
  abstract  = {The affective dimensions of emotional valence and emotional arousal affect processing of verbal and pictorial stimuli. Traditional emotional theories assume a linear relationship between these dimensions, with valence determining the direction of a behavior (approach vs. withdrawal) and arousal its intensity or strength. In contrast, according to the valence-arousal conflict theory, both dimensions are interactively related: positive valence and low arousal (PL) are associated with an implicit tendency to approach a stimulus, whereas negative valence and high arousal (NH) are associated with withdrawal. Hence, positive, high-arousal (PH) and negative, low-arousal (NL) stimuli elicit conflicting action tendencies. By extending previous research that used several tasks and methods, the present study investigated whether and how emotional valence and arousal affect subjective approach vs. withdrawal tendencies toward emotional words during two novel tasks. In Study 1, participants had to decide whether they would approach or withdraw from concepts expressed by written words. In Studies 2 and 3 participants had to respond to each word by pressing one of two keys labeled with an arrow pointing upward or downward. Across experiments, positive and negative words, high or low in arousal, were presented. In Study 1 (explicit task), in line with the valence-arousal conflict theory, PH and NL words were responded to more slowly than PL and NH words. In addition, participants decided to approach positive words more often than negative words. In Studies 2 and 3, participants responded faster to positive than negative words, irrespective of their level of arousal. Furthermore, positive words were significantly more often associated with "up" responses than negative words, thus supporting the existence of implicit associations between stimulus valence and response coding (positive is up and negative is down). Hence, in contexts in which participants' spontaneous responses are based on implicit associations between stimulus valence and response, there is no influence of arousal. In line with the valence-arousal conflict theory, arousal seems to affect participants' approach-withdrawal tendencies only when such tendencies are made explicit by the task, and a minimal degree of processing depth is required.},
  language  = {en}
}
@article{WittmannSiebervonStengeletal.2016,
  author    = {Wittmann, Katharina and Sieber, Cornel and von Stengel, Simon and Kohl, Matthias and Freiberger, Ellen and Jakob, Franz and Lell, Michael and Engelke, Klaus and Kemmler, Wolfgang},
  title     = {Impact of whole body electromyostimulation on cardiometabolic risk factors in older women with sarcopenic obesity: the randomized controlled FORMOsA-sarcopenic obesity study},
  series = {Clinical Interventions in Aging},
  volume    = {11},
  journal   = {Clinical Interventions in Aging},
  doi       = {10.2147/CIA.S116430},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-164930},
  pages     = {1697—1706},
  year      = {2016},
  abstract  = {Background: Sarcopenic obesity (SO) is characterized by a combination of low muscle and high fat mass with an additive negative effect of both conditions on cardiometabolic risk. The aim of the study was to determine the effect of whole-body electromyostimulation (WB-EMS) on the metabolic syndrome (MetS) in community-dwelling women aged ≥70 years with SO. Methods: The study was conducted in an ambulatory university setting. Seventy-five community-dwelling women aged ≥70 years with SO living in Northern Bavaria, Germany, were randomly allocated to either 6 months of WB-EMS application with (WB-EMS\&P) or without (WB-EMS) dietary supplementation (150 kcal/day, 56\% protein) or a non-training control group (CG). WB-EMS included one session of 20 min (85 Hz, 350 µs, 4 s of strain-4 s of rest) per week with moderate-to-high intensity. The primary study endpoint was the MetS Z-score with the components waist circumference (WC), mean arterial pressure (MAP), triglycerides, fasting plasma glucose, and high-density lipoprotein cholesterol (HDL-C); secondary study endpoints were changes in these determining variables. Results: MetS Z-score decreased in both groups; however, changes compared with the CG were significant (P=0.001) in the WB-EMS\&P group only. On analyzing the components of the MetS, significant positive effects for both WB-EMS groups (P≤0.038) were identified for MAP, while the WB-EMS group significantly differed for WC (P=0.036), and the WB-EMS\&P group significantly differed for HDL-C (P=0.006) from the CG. No significant differences were observed between the WB-EMS groups. Conclusion: The study clearly confirms the favorable effect of WB-EMS application on the MetS in community-dwelling women aged ≥70 years with SO. However, protein-enriched supplements did not increase effects of WB-EMS alone. In summary, we considered this novel technology an effective and safe method to prevent cardiometabolic risk factors and diseases in older women unable or unwilling to exercise conventionally.},
  language  = {en}
}
@article{PalamidesJodeleitFoehlingeretal.2016,
  author    = {Palamides, Pia and Jodeleit, Henrika and F{\"o}hlinger, Michael and Beigel, Florian and Herbach, Nadja and Mueller, Thomas and Wolf, Eckhard and Siebeck, Matthias and Gropp, Roswitha},
  title     = {A mouse model for ulcerative colitis based on NOD-scid IL2R gamma(null) mice reconstituted with peripheral blood mononuclear cells from affected individuals},
  series = {Disease Models \& Mechanisms},
  volume    = {9},
  journal   = {Disease Models \& Mechanisms},
  doi       = {10.1242/dmm.025452},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-164946},
  pages     = {985-997},
  year      = {2016},
  abstract  = {Animal models reflective of ulcerative colitis (UC) remain a major challenge, and yet are crucial to understand mechanisms underlying the onset of disease and inflammatory characteristics of relapses and remission. Mouse models in which colitis-like symptoms are induced through challenge with toxins such as oxazolone, dextran sodium sulfate (DSS) or 2,4,6-trinitrobenzenesulfonic acid (TNBS) have been instrumental in understanding the inflammatory processes of UC. However, these neither reflect the heterogeneous symptoms observed in the UC-affected population nor can they be used to test the efficacy of inhibitors developed against human targets where high sequence and structural similarity of the respective ligands is lacking. In an attempt to overcome these problems, we have developed a mouse model that relies on NOD-scid IL2R γnull mice reconstituted with peripheral blood mononuclear cells derived from UC-affected individuals. Upon challenge with ethanol, mice developed colitis-like symptoms and changes in the colon architecture, characterized by influx of inflammatory cells, edema, crypt loss, crypt abscesses and epithelial hyperplasia, as previously observed in immune-competent mice. TARC, TGFβ1 and HGF expression increased in distal parts of the colon. Analysis of human leucocytes isolated from mouse spleen revealed an increase in frequencies of CD1a+, CD64+, CD163+ and TSLPR+ CD14+ monocytes, and antigen-experienced CD44+ CD4+ and CD8+ T-cells in response to ethanol. Analysis of human leucocytes from the colon of challenged mice identified CD14+ monocytes and CD11b+ monocytes as the predominant populations. Quantitative real-time PCR (RT-PCR) analysis from distal parts of the colon indicated that IFNγ might be one of the cytokines driving inflammation. Treatment with infliximab ameliorated symptoms and pathological manifestations, whereas pitrakinra had no therapeutic benefit. Thus, this model is partially reflective of the human disease and might help to increase the translation of animal and clinical studies.},
  language  = {en}
}
@article{JonesFrucianoKelleretal.2016,
  author    = {Jones, Julia C. and Fruciano, Carmelo and Keller, Anja and Schartl, Manfred and Meyer, Axel},
  title     = {Evolution of the elaborate male intromittent organ of Xiphophorus fishes},
  series = {Ecology and Evolution},
  volume    = {6},
  journal   = {Ecology and Evolution},
  number    = {20},
  doi       = {10.1002/ece3.2396},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-164956},
  pages     = {7207-7220},
  year      = {2016},
  abstract  = {Internally fertilizing animals show a remarkable diversity in male genital morphology that is associated with sexual selection, and these traits are thought to be evolving particularly rapidly. Male fish in some internally fertilizing species have "gonopodia," highly modified anal fins that are putatively important for sexual selection. However, our understanding of the evolution of genital diversity remains incomplete. Contrary to the prediction that male genital traits evolve more rapidly than other traits, here we show that gonopodial traits and other nongonopodial traits exhibit similar evolutionary rates of trait change and also follow similar evolutionary models in an iconic genus of poeciliid fish (Xiphophorus spp.). Furthermore, we find that both mating and nonmating natural selection mechanisms are unlikely to be driving the diverse Xiphophorus gonopodial morphology. Putative holdfast features of the male genital organ do not appear to be influenced by water flow, a candidate selective force in aquatic habitats. Additionally, interspecific divergence in gonopodial morphology is not significantly higher between sympatric species, than between allopatric species, suggesting that male genitals have not undergone reproductive character displacement. Slower rates of evolution in gonopodial traits compared with a subset of putatively sexually selected nongenital traits suggest that different selection mechanisms may be acting on the different trait types. Further investigations of this elaborate trait are imperative to determine whether it is ultimately an important driver of speciation.},
  language  = {en}
}
@article{DrakulićFeldhaarLisičićetal.2016,
  author    = {Drakulić, Sanja and Feldhaar, Heike and Lisičić, Duje and Mioč, Mia and Cizelj, Ivan and Seiler, Michael and Spatz, Theresa and R{\"o}del, Mark-Oliver},
  title     = {Population-specific effects of developmental temperature on body condition and jumping performance of a widespread European frog},
  series = {Ecology and Evolution},
  volume    = {6},
  journal   = {Ecology and Evolution},
  number    = {10},
  doi       = {10.1002/ece3.2113},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-164960},
  pages     = {3115-3128},
  year      = {2016},
  abstract  = {All physiological processes of ectotherms depend on environmental temperature. Thus, adaptation of physiological mechanisms to the thermal environments is important for achieving optimal performance and fitness. The European Common Frog, Rana temporaria, is widely distributed across different thermal habitats. This makes it an exceptional model for studying the adaptations to different thermal conditions. We raised tadpoles from Germany and Croatia at two constant temperature treatments (15°C, 20°C), and under natural temperature fluctuations (in outdoor treatments), and tested how different developmental temperatures affected developmental traits, that is, length of larval development, morphometrics, and body condition, as well as jumping performance of metamorphs. Our results revealed population-specific differences in developmental time, body condition, and jumping performance. Croatian frogs developed faster in all treatments, were heavier, in better body condition, and had longer hind limbs and better jumping abilities than German metamorphs. The populations further differed in thermal sensitivity of jumping performance. While metamorphs from Croatia increased their jumping performance with higher temperatures, German metamorphs reached their performance maximum at lower temperatures. These population-specific differences in common environments indicate local genetic adaptation, with southern populations being better adapted to higher temperatures than those from north of the Alps.},
  language  = {en}
}
@article{vanToorNewmanTakekawaetal.2016,
  author    = {van Toor, Mari{\"e}lle L. and Newman, Scott H. and Takekawa, John Y. and Wegmann, Martin and Safi, Kamran},
  title     = {Temporal segmentation of animal trajectories informed by habitat use},
  series = {Ecosphere},
  volume    = {7},
  journal   = {Ecosphere},
  number    = {10},
  doi       = {10.1002/ecs2.1498},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-164970},
  pages     = {e01498},
  year      = {2016},
  abstract  = {Most animals live in seasonal environments and experience very different conditions throughout the year. Behavioral strategies like migration, hibernation, and a life cycle adapted to the local seasonality help to cope with fluctuations in environmental conditions. Thus, how an individual utilizes the environment depends both on the current availability of habitat and the behavioral prerequisites of the individual at that time. While the increasing availability and richness of animal movement data has facilitated the development of algorithms that classify behavior by movement geometry, changes in the environmental correlates of animal movement have so far not been exploited for a behavioral annotation. Here, we suggest a method that uses these changes in individual-environment associations to divide animal location data into segments of higher ecological coherence, which we term niche segmentation. We use time series of random forest models to evaluate the transferability of habitat use over time to cluster observational data accordingly. We show that our method is able to identify relevant changes in habitat use corresponding to both changes in the availability of habitat and how it was used using simulated data, and apply our method to a tracking data set of common teal (Anas crecca). The niche segmentation proved to be robust, and segmented habitat suitability outperformed models neglecting the temporal dynamics of habitat use. Overall, we show that it is possible to classify animal trajectories based on changes of habitat use similar to geometric segmentation algorithms. We conclude that such an environmentally informed classification of animal trajectories can provide new insights into an individuals' behavior and enables us to make sensible predictions of how suitable areas might be connected by movement in space and time.},
  language  = {en}
}