@article{OPUS4-22542,
  title     = {Search for heavy \({ZZ}\) resonances in the l\(^+\)l\(^-\)l\(^+\)l\(^-\) and l\(^+\)l\(^-\) nu(nu)over-bar final states using proton-proton collisions at root s=13 TeV with the ATLAS detector},
  series = {The European Physical Journal C},
  volume    = {78},
  journal   = {The European Physical Journal C},
  number    = {293},
  organization    = {The ATLAS Collaboration},
  doi       = {10.1140/epjc/s10052-018-5686-3},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-225421},
  pages     = {1-34},
  year      = {2018},
  abstract  = {A search for heavy resonances decaying into a pair of Z bosons leading to l(+) l(-) l(+) l(-) and l(+) l(-) nu(nu) over bar final states, where l stands for either an electron or a muon, is presented. The search uses proton-proton collision data at a centre-of-mass energy of 13 TeV corresponding to an integrated luminosity of 36.1 fb(-1) collected with the ATLAS detector during 2015 and 2016 at the Large Hadron Collider. Different mass ranges for the hypothetical resonances are considered, depending on the final state and model. The different ranges span between 200 and 2000 GeV. The results are interpreted as upper limits on the production cross section of a spin-0 or spin-2 resonance. The upper limits for the spin-0 resonance are translated to exclusion contours in the context of Type-I and Type-II two-Higgs-doublet models, while those for the spin-2 resonance are used to constrain the Randall-Sundrum model with an extra dimension giving rise to spin-2 graviton excitations.},
  language  = {en}
}
@article{OPUS4-22559,
  title     = {Search for doubly charged Higgs boson production in multi-lepton final states with the ATLAS detector using proton-proton collisions at root s=13TeV},
  series = {The European Physical Journal C},
  volume    = {78},
  journal   = {The European Physical Journal C},
  number    = {199},
  organization    = {The ATLAS Collaboration},
  doi       = {10.1140/epjc/s10052-018-5661-z},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-225591},
  pages     = {1-34},
  year      = {2018},
  abstract  = {A search for doubly charged Higgs bosons with pairs of prompt, isolated, highly energetic leptons with the same electric charge is presented. The search uses a proton-proton collision data sample at a centre-of-mass energy of 13 TeV corresponding to 36.1 fb(-1) of integrated luminosity recorded in 2015 and 2016 by the ATLAS detector at the LHC. This analysis focuses on the decays H-+/-+/- -> e(+/-)e(+/-), H-+/-+/- -> e(+/-)mu(+/-) and H-+/-+/- -> mu(+/-)mu(+/-), fitting the dilepton mass spectra in several exclusive signal regions. No significant evidence of a signal is observed and corresponding limits on the production cross-section and consequently a lower limit on m(H-+/-+/-) are derived at 95\% confidence level. With l(+/-)l(+/-) = e(+/-)e(+/-)/mu(+/-)mu(+/-)/e(+/-)mu(+/-), the observed lower limit on the mass of a doubly charged Higgs boson only coupling to left-handed leptons varies from 770 to 870GeV (850GeV expected) for B(H-+/-+/- -> l(+/-)l(+/-)) = 100\% and both the expected and observed mass limits are above 450GeV for B(H-+/-+/- -> l(+/-)l(+/-)) = 10\% and any combination of partial branching ratios.},
  language  = {en}
}
@article{OPUS4-22561,
  title     = {Measurement of longitudinal flow decorrelations in Pb plus Pb collisions at root s(NN)=2.76 and 5.02 TeV with the ATLAS detector},
  series = {The European Physical Journal C},
  volume    = {78},
  journal   = {The European Physical Journal C},
  number    = {142},
  organization    = {The ATLAS Collaboration},
  doi       = {10.1140/epjc/s10052-018-5605-7},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-225610},
  pages     = {1-37},
  year      = {2018},
  abstract  = {Measurements of longitudinal flow correlations are presented for charged particles in the pseudorapidity range vertical bar eta vertical bar < 2.4 using 7 mu b(-1) and 470 mu b(-1) of Pb+Pb collisions at root s(NN) = 2.76 and 5.02 TeV, respectively, recorded by the ATLAS detector at the LHC. It is found that the correlation between the harmonic flow coefficients v(n) measured in two separated eta intervals does not factorise into the product of single-particle coefficients, and this breaking of factorisation, or flow decorrelation, increases linearly with the eta separation between the intervals. The flow decorrelation is stronger at 2.76 TeVthan at 5.02 TeV. Higher-order moments of the correlations are also measured, and the corresponding linear coefficients for the kth-moment of the v(n) are found to be proportional to k for v(3), but not for v(2). The decorrelation effect is separated into contributions from the magnitude of v(n) and the event-plane orientation, each as a function of eta. These two contributions are found to be comparable. The longitudinal flow correlations are also measured between v(n) of different order in n. The decorrelations of v(2) and v(3) are found to be independent of each other, while the decorrelations of v(4) and v(5) are found to be driven by the nonlinear contribution from v(2)(2) and v(2)v(3), respectively.},
  language  = {en}
}
@article{OPUS4-22560,
  title     = {Search for the direct production of charginos and neutralinos in final states with tau leptons in root s=13 TeV pp collisions with the ATLAS detector},
  series = {The European Physical Journal C},
  volume    = {78},
  journal   = {The European Physical Journal C},
  number    = {154},
  organization    = {The ATLAS Collaboration},
  doi       = {10.1140/epjc/s10052-018-5583-9},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-225602},
  pages     = {1-33},
  year      = {2018},
  abstract  = {A search for the direct production of charginos and neutralinos in final states with at least two hadronically decaying tau leptons is presented. The analysis uses a dataset of pp collisions corresponding to an integrated luminosity of 36.1 fb, recorded with the ATLAS detector at the Large Hadron Collider at a centre-of-mass energy of 13 TeV. No significant deviation from the expected Standard Model background is observed. Limits are derived in scenarios of pair production and of and production in simplified models where the neutralinos and charginos decay solely via intermediate left-handed staus and tau sneutrinos, and the mass of the state is set to be halfway between the masses of the and the (chi) over tilde (0.)(1) . Chargino masses up to 630 GeV are excluded at 95\% confidence level in the scenario of direct production of for a massless (chi) over tilde (0.)(1). Common and masses up to 760 GeV are excluded in the case of production of and assuming a massless . Exclusion limits for additional benchmark scenarios with large and small mass-splitting between the and the are also studied by varying the mass between the masses of the and the (chi) over tilde (0.)(1)},
  language  = {en}
}
@article{OPUS4-22588,
  title     = {Search for new phenomena in high-mass final states with a photon and a jet from \({pp}\) collisions at root s=13 TeV with the ATLAS detector},
  series = {The European Physical Journal C},
  volume    = {78},
  journal   = {The European Physical Journal C},
  number    = {102},
  organization    = {The ATLAS Collaboration},
  doi       = {10.1140/epjc/s10052-018-5553-2},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-225887},
  pages     = {1-25},
  year      = {2018},
  abstract  = {A search is performed for new phenomena in events having a photon with high transverse momentum and a jet collected in 36.7 fb(-1) of proton-proton collisions at a centre-of-mass energy of root s = 13 TeV recorded with the ATLAS detector at the Large Hadron Collider. The invariant mass distribution of the leading photon and jet is examined to look for the resonant production of new particles or the presence of new high-mass states beyond the Standard Model. No significant deviation from the background-only hypothesis is observed and cross-section limits for generic Gaussian-shaped resonances are extracted. Excited quarks hypothesized in quark compositeness models and high-mass states predicted in quantum black hole models with extra dimensions are also examined in the analysis. The observed data exclude, at 95\% confidence level, the mass range below 5.3 TeV for excited quarks and 7.1 TeV (4.4 TeV) for quantum black holes in the Arkani-Hamed-Dimopoulos-Dvali (Randall-Sundrum) model with six (one) extra dimensions.},
  language  = {en}
}
@article{OPUS4-22591,
  title     = {Search for heavy resonances decaying into \({WW}\) in the eνμν final state in \({pp}\) collisions at root s=13 TeV with the ATLAS detector},
  series = {European Physical Journal C},
  volume    = {78},
  journal   = {European Physical Journal C},
  number    = {24},
  organization    = {The ATLAS Collaboration},
  doi       = {10.1140/epjc/s10052-017-5491-4},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-225914},
  pages     = {1-34},
  year      = {2018},
  abstract  = {A search for neutral heavy resonances is performed in the WW -> e nu mu nu decay channel using pp collision data corresponding to an integrated luminosity of 36.1 fb(-1), collected at a centre-of-mass energy of 13 TeV by the ATLAS detector at the Large Hadron Collider. No evidence of such heavy resonances is found. In the search for production via the quark-antiquark annihilation or gluon-gluon fusion process, upper limits on sigma(X) x B(X -> WW) as a function of the resonance mass are obtained in the mass range between 200 GeV and up to 5 TeV for various benchmark models: a Higgs-like scalar in different width scenarios, a two-Higgs-doublet model, a heavy vector triplet model, and a warped extra dimensions model. In the vector-boson fusion process, constraints are also obtained on these resonances, as well as on a Higgs boson in the Georgi-Machacek model and a heavy tensor particle coupling only to gauge bosons.},
  language  = {en}
}
@article{OPUS4-22593,
  title     = {Search for dark matter produced in association with bottom or top quarks in root s=13 TeV \({pp}\) collisions with the ATLAS detector},
  series = {European Physical Journal C},
  volume    = {C 78},
  journal   = {European Physical Journal C},
  number    = {18},
  organization    = {The ATLAS Collaboration},
  doi       = {10.1140/epjc/s10052-017-5486-1},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-225937},
  pages     = {1-36},
  year      = {2018},
  abstract  = {A search for weakly interacting massive dark matter particles produced in association with bottom or top quarks is presented. Final states containing third-generation quarks and missing transverse momentum are considered. The analysis uses 36.1 fb(-1) of proton proton collision data recorded by the ATLAS experiment at root s = 13 TeV in 2015 and 2016. No significant excess of events above the estimated backgrounds is observed. The results are interpreted in the framework of simplified models of spin-0 dark-matter mediators. For colour-neutral spin-0 mediators produced in association with top quarks and decaying into a pair of dark matter particles, mediator masses below 50 GeV are excluded assuming a dark-matter candidate mass of 1 GeV and unitary couplings. For scalar and pseudoscalar mediators produced in association with bottom quarks, the search sets limits on the production cross-section of 300 times the predicted rate for mediators with masses between 10 and 50 GeV and assuming a dark-matter mass of 1 GeV and unitary coupling. Constraints on colour-charged scalar simplified models are also presented. Assuming a dark-matter particle mass of 35 GeV, mediator particles with mass below 1.1 TeV are excluded for couplings yielding a dark-matter relic density consistent with measurements.},
  language  = {en}
}
@article{OPUS4-22069,
  title     = {Measurement of the Soft-Drop Jet Mass in \({pp}\) Collisions at root s=13 TeV with the ATLAS Detector},
  series = {Physical Review Letters},
  volume    = {121},
  journal   = {Physical Review Letters},
  number    = {9},
  organization    = {The ATLAS Collaboration},
  doi       = {10.1103/PhysRevLett.121.092001},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-220694},
  pages     = {1-20},
  year      = {2018},
  abstract  = {Jet substructure observables have significantly extended the search program for physics beyond the standard model at the Large Hadron Collider. The state-of-the-art tools have been motivated by theoretical calculations, but there has never been a direct comparison between data and calculations of jet substructure observables that are accurate beyond leading-logarithm approximation. Such observables are significant not only for probing the collinear regime of QCD that is largely unexplored at a hadron collider, but also for improving the understanding of jet substructure properties that are used in many studies at the Large Hadron Collider. This Letter documents a measurement of the first jet substructure quantity at a hadron collider to be calculated at next-to-next-to-leading-logarithm accuracy. The normalized, differential cross section is measured as a function of log(10)rho(2), where rho is the ratio of the soft-drop mass to the ungroomed jet transverse momentum. This quantity is measured in dijet events from 32.9 fb(-1) of root s = 13 TeV proton-proton collisions recorded by the ATLAS detector. The data are unfolded to correct for detector effects and compared to precise QCD calculations and leading-logarithm particle-level Monte Carlo simulations.},
  language  = {en}
}
@article{OPUS4-22066,
  title     = {Measurement of dijet azimuthal decorrelations in \({pp}\) collisions at root s=8 TeV with the ATLAS detector and determination of the strong coupling},
  series = {Physical Review D},
  volume    = {98},
  journal   = {Physical Review D},
  number    = {9},
  organization    = {The ATLAS Collaboration},
  doi       = {10.1103/PhysRevD.98.092004},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-220665},
  pages     = {1-31},
  year      = {2018},
  abstract  = {measurement of the rapidity and transverse momentum dependence of dijet azimuthal decorrelations is presented, using the quantity R-Delta phi. The quantity R-Delta phi specifies the fraction of the inclusive dijet events in which the azimuthal opening angle of the two jets with the highest transverse momenta is less than a given value of the parameter Delta phi(max). The quantity R-Delta phi is measured in proton-proton collisions at root s = 8 TeV as a function of the dijet rapidity interval, the event total scalar transverse momentum, and Delta phi(max). The measurement uses an event sample corresponding to an integrated luminosity of 20.2 fb(-1) collected with the ATLAS detector at the CERN Large Hadron Collider. Predictions of a perturbative QCD calculation at next-to-leading order in the strong coupling with corrections for nonperturbative effects are compared to the data. The theoretical predictions describe the data in the whole kinematic region. The data are used to determine the strong coupling alpha(S) and to study its running for momentum transfers from 260 GeV to above 1.6 TeV. Analysis that combines data at all momentum transfers results in alpha(S) (m(Z)) = 0.1127(- 0.0027) (+0.0063).},
  language  = {en}
}
@article{OPUS4-22070,
  title     = {Search for supersymmetry in events with four or more leptons in root s=13 TeV \({pp}\) collisions with ATLAS},
  series = {Physical Review D},
  volume    = {98},
  journal   = {Physical Review D},
  number    = {3},
  organization    = {The ATLAS Collaboration},
  doi       = {10.1103/PhysRevD.98.032009},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-220705},
  pages     = {1-31},
  year      = {2018},
  abstract  = {Results from a search for supersymmetry in events with four or more charged leptons (electrons, muons and taus) are presented. The analysis uses a data sample corresponding to 36.1 fb(-1) of proton-proton collisions delivered by the Large Hadron Collider at root s = 13 TeV and recorded by the ATLAS detector. Four-lepton signal regions with up to two hadronically decaying taus are designed to target a range of supersymmetric scenarios that can be either enriched in or depleted of events involving the production and decay of a Z boson. Data yields are consistent with Standard Model expectations and results are used to set upper limits on the event yields from processes beyond the Standard Model. Exclusion limits are set at the 95\% confidence level in simplified models of general gauge mediated supersymmetry, where Higgsino masses are excluded up to 295 GeV. In R-parity-violating simplified models with decays of the lightest supersymmetric particle to charged leptons, lower limits of 1.46, 1.06, and 2.25 TeV are placed on wino, slepton and gluino masses, respectively.},
  language  = {en}
}
@article{OPUS4-22083,
  title     = {Search for squarks and gluinos in final states with jets and missing transverse momentum using 36 fb\(^{-1}\) of root s=13 TeV \({pp}\) collision data with the ATLAS detector},
  series = {Physical Review D},
  volume    = {97},
  journal   = {Physical Review D},
  number    = {11},
  organization    = {The ATLAS Collaboration},
  doi       = {10.1103/PhysRevD.97.112001},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-220835},
  pages     = {1-47},
  year      = {2018},
  abstract  = {A search for the supersymmetric partners of quarks and gluons (squarks and gluinos) in final states containing hadronic jets and missing transverse momentum, but no electrons or muons, is presented. The data used in this search were recorded in 2015 and 2016 by the ATLAS experiment in root s = 13 TeV proton-proton collisions at the Large Hadron Collider, corresponding to an integrated luminosity of 36.1 fb(-1). The results are interpreted in the context of various models where squarks and gluinos are pair produced and the neutralino is the lightest supersymmetric particle. An exclusion limit at the 95\% confidence level on the mass of the gluino is set at 2.03 TeV for a simplified model incorporating only a gluino and the lightest neutralino, assuming the lightest neutralino is massless. For a simplified model involving the strong production of mass-degenerate first-and second-generation squarks, squark masses below 1.55 TeVare excluded if the lightest neutralino is massless. These limits substantially extend the region of supersymmetric parameter space previously excluded by searches with the ATLAS detector.},
  language  = {en}
}
@article{OPUS4-22545,
  title     = {Search for long-lived, massive particles in events with displaced vertices and missing transverse momentum in root S=13 TeV \({pp}\) collisions with the ATLAS detector},
  series = {Physical Review D},
  volume    = {97},
  journal   = {Physical Review D},
  number    = {5},
  organization    = {The ATLAS Collaboration},
  doi       = {10.1103/PhysRevD.97.052012},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-225450},
  pages     = {1-29},
  year      = {2018},
  abstract  = {A search for long-lived, massive particles predicted by many theories beyond the Standard Model is presented. The search targets final states with large missing transverse momentum and at least one highmass displaced vertex with five or more tracks, and uses 32.8 fb(-1) of root s = 13 TeV pp collision data collected by the ATLAS detector at the LHC. The observed yield is consistent with the expected background. The results are used to extract 95\% C.L. exclusion limits on the production of long-lived gluinos with masses up to 2.37 TeV and lifetimes of O(10(-2)) - O(10) ns in a simplified model inspired by split supersymmetry.},
  language  = {en}
}
@article{OPUS4-22584,
  title     = {\({ZZ}\) -> l(+)l(-)l '(+)l '(-) cross-section measurements and search for anomalous triple gauge couplings in 13 TeV \({pp}\) collisions with the ATLAS detector},
  series = {Physical Review D},
  volume    = {97},
  journal   = {Physical Review D},
  number    = {3},
  organization    = {The ATLAS Collaboration},
  doi       = {10.1103/PhysRevD.97.032005},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-225844},
  pages     = {1-39},
  year      = {2018},
  abstract  = {Measurements of ZZ production in the l(+)l(-)l'(+)l'(-) channel in proton-proton collisions at 13 TeV center-of-mass energy at the Large Hadron Collider are presented. The data correspond to 36.1 fb(-1) of collisions collected by the ATLAS experiment in 2015 and 2016. Here l and l ' stand for electrons or muons. Integrated and differential ZZ -> l(+)l(-)l'(+)l'(-) cross sections with Z -> l(+)l(-) candidate masses in the range of 66 GeV to 116 GeV are measured in a fiducial phase space corresponding to the detector acceptance and corrected for detector effects. The differential cross sections are presented in bins of twenty observables, including several that describe the jet activity. The integrated cross section is also extrapolated to a total phase space and to all standard model decays of Z bosons with mass between 66 GeV and 116 GeV, resulting in a value of 17.3 +/- 0.9 [+/- 0.6(start) +/- 0.5 (syst) +/- 0.6 (lumi)] pb. The measurements are found to be in good agreement with the standard model. A search for neutral triple gauge couplings is performed using the transverse momentum distribution of the leading Z boson candidate. No evidence for such couplings is found and exclusion limits are set on their parameters.},
  language  = {en}
}
@article{OPUS4-22586,
  title     = {Search for \(B\) - \(L\) \(R\)-parity-violating top squarks in root s=13 TeV \({pp}\) collisions with the ATLAS experiment},
  series = {Physical Review D},
  volume    = {97},
  journal   = {Physical Review D},
  number    = {3},
  organization    = {The ATLAS Collaboration},
  doi       = {10.1103/PhysRevD.97.032003},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-225863},
  pages     = {1-42},
  year      = {2018},
  abstract  = {A search is presented for the direct pair production of the stop, the supersymmetric partner of the top quark, that decays through an R-parity-violating coupling to a final state with two leptons and two jets, at least one of which is identified as a b-jet. The data set corresponds to an integrated luminosity of 36.1 fb(-1) of proton-proton collisions at a center-of-mass energy of root s = 13 TeV, collected in 2015 and 2016 by the ATLAS detector at the LHC. No significant excess is observed over the Standard Model background, and exclusion limits are set on stop pair production at a 95\% confidence level. Lower limits on the stop mass are set between 600 GeV and 1.5 TeV for branching ratios above 10\% for decays to an electron or muon and a b-quark.},
  language  = {en}
}
@article{OPUS4-22562,
  title     = {Measurement of long-range multiparticle azimuthal correlations with the subevent cumulant method in \({pp}\) and \(p\)+Pb collisions with the ATLAS detector at the CERN Large Hadron Collider},
  series = {Physical Review C},
  volume    = {97},
  journal   = {Physical Review C},
  number    = {2},
  organization    = {The ATLAS Collaboration},
  doi       = {10.1103/PhysRevC.97.024904},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-225623},
  pages     = {024904, 1-25},
  year      = {2018},
  abstract  = {A detailed study of multiparticle azimuthal correlations is presented using pp data at root s = 5.02 and 13 TeV, and p+Pb data at root s(NN) = 5.02 TeV, recorded with the ATLAS detector at the CERN Large Hadron Collider. The azimuthal correlations are probed using four-particle cumulants c(n){4} and flow coefficients v(n){4} = (-c(n){4})(1/4) for n = 2 and 3, with the goal of extracting long-range multiparticle azimuthal correlation signals and suppressing the short-range correlations. The values of c(n){4} are obtained as a function of the average number of charged particles per event, < N-ch >, using the recently proposed two-subevent and three-subevent cumulant methods, and compared with results obtained with the standard cumulant method. The standard method is found to be strongly biased by short-range correlations, which originate mostly from jetswith a positive contribution to c(n){4}. The threesubevent method, on the other hand, is found to be least sensitive to short-range correlations. The three-subevent method gives a negative c(2){4}, and therefore a well-defined v(2){4}, nearly independent of < N-ch >, which implies that the long-range multiparticle azimuthal correlations persist to events with low multiplicity. Furthermore, v(2){4} is found to be smaller than the v(2){2} measured using the two-particle correlation method, as expected for long-range collective behavior. Finally, the measured values of v(2){4} and v(2){2} are used to estimate the number of sources relevant for the initial eccentricity in the collision geometry. The results based on the subevent cumulant technique provide direct evidence, in small collision systems, for a long-range collectivity involving many particles distributed across a broad rapidity interval.},
  language  = {en}
}
@article{OPUS4-22541,
  title     = {Measurement of the cross section for isolated-photon plus jet production in \({pp}\) collisions at root s=13 TeV using the ATLAS detector},
  series = {Physics Letters B},
  volume    = {780},
  journal   = {Physics Letters B},
  organization    = {The ATLAS Collaboration},
  doi       = {10.1016/j.physletb.2018.03.035},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-225412},
  pages     = {578-602},
  year      = {2018},
  abstract  = {The dynamics of isolated-photon production in association with a jet in proton-proton collisions at a centre-of-mass energy of 13 TeV are studied with the ATLAS detector at the LHC using a dataset with an integrated luminosity of 3.2 fb(-1). Photons are required to have transverse energies above 125 GeV. Jets are identified using the anti-k(t) algorithm with radius parameter R = 0.4 and required to have transverse momenta above 100 GeV. Measurements of isolated-photon plus jet cross sections are presented as functions of the leading-photon transverse energy, the leading-jet transverse momentum, the azimuthal angular separation between the photon and the jet, the photon-jet invariant mass and the scattering angle in the photon-jet centre-of-mass system. Tree-level plus parton-shower predictions from SHERPA and PYTHIA as well as next-to-leading-order QCD predictions from JETPHOX and SHERPA are compared to the measurements. (C) 2018 The Author. Published by Elsevier B.V.},
  language  = {en}
}
@article{OPUS4-22540,
  title     = {Measurement of the production cross-section of a single top quark in association with a \(Z\) boson in proton-proton collisions at 13 TeV with the ATLAS detector},
  series = {Physics letters B},
  volume    = {780},
  journal   = {Physics letters B},
  organization    = {The ATLAS Collaboration},
  doi       = {10.1016/j.physletb.2018.03.023},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-225406},
  pages     = {557-577},
  year      = {2018},
  abstract  = {The production of a top quark in association with a Z boson is investigated. The proton-proton collision data collected by the ATLAS experiment at the LHC in 2015 and 2016 at a centre-of-mass energy of root s = 13 TeV are used, corresponding to an integrated luminosity of 36.1 fb(-1). Events containing three identified leptons (electrons and/or muons) and two jets, one of which is identified as a b-quark jet are selected. The major backgrounds are diboson, tt(\$)over-bar and Z + jets production. A neural network is used to improve the background rejection and extract the signal. The resulting significance is 4.2 sigma in the data and the expected significance is 5.4 sigma. The measured cross-section for tZq production is 600 +/- 170(stat.)+/- 140(syst.)fb. (C) 2018 The Author(s). Published by Elsevier B.V.},
  language  = {en}
}
@article{OPUS4-22543,
  title     = {A search for resonances decaying into a Higgs boson and a new particle \(X\) in the \({XH}\) -> \({qqbb}\) final state with the ATLAS detector},
  series = {Physics letters B},
  volume    = {779},
  journal   = {Physics letters B},
  organization    = {The ATLAS Collaboration},
  doi       = {10.1016/j.physletb.2018.01.042},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-225435},
  pages     = {24-45},
  year      = {2018},
  abstract  = {A search for heavy resonances decaying into a Higgs boson (H) and a new particle (X) is reported, utilizing 36.1 fb(-1) of proton-proton collision data at root s = 13 TeV collected during 2015 and 2016 with the ATLAS detector at the CERN Large Hadron Collider. The particle Xis assumed to decay to a pair of light quarks, and the fully hadronic final state XH -> q (q) over bar 'b (b) over bar is analysed. The search considers the regime of high XH resonance masses, where the X and H bosons are both highly Lorentz-boosted and are each reconstructed using a single jet with large radius parameter. A two-dimensional phase space of XH mass versus X mass is scanned for evidence of a signal, over a range of XH resonance mass values between 1 TeV and 4 TeV, and for X particles with masses from 50 GeV to 1000 GeV. All search results are consistent with the expectations for the background due to Standard Model processes, and 95\% CL upper limits are set, as a function of XH and X masses, on the production cross-section of the XH -> q (q) over bar 'b (b) over bar resonance. (c) 2018 The Author(s). Published by Elsevier B.V.},
  language  = {en}
}
@article{OPUS4-22582,
  title     = {Measurement of the exclusive gamma gamma -> mu\(^+\)mu\(^-\) process in proton-proton collisions at root s=13 TeV with the ATLAS detector},
  series = {Physics Letters B},
  volume    = {777},
  journal   = {Physics Letters B},
  organization    = {The ATLAS Collaboration},
  doi       = {10.1016/j.physletb.2017.12.043},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-225825},
  pages     = {303-323},
  year      = {2018},
  abstract  = {The production of exclusive gamma gamma -> mu(+)mu(-) events in proton-proton collisions at a centre-of-mass energy of 13 TeV is measured with the ATLAS detector at the LHC, using data corresponding to an integrated luminosity of 3.2 fb(-1). The measurement is performed for a dimuon invariant mass of 12 GeV < m(mu+mu-) < 70 GeV. The integrated cross-section is determined within a fiducial acceptance region of the ATLAS detector and differential cross-sections are measured as a function of the dimuon invariant mass. The results are compared to theoretical predictions both with and without corrections for absorptive effects. (c) 2017 The Author(s). Published by Elsevier B.V.},
  language  = {en}
}
@article{OPUS4-22578,
  title     = {Search for diboson resonances with boson-tagged jets in \({pp}\) collisions at root S=13 TeV with the ATLAS detector},
  series = {Physics Letters B},
  volume    = {777},
  journal   = {Physics Letters B},
  organization    = {The ATLAS Collaboration},
  doi       = {10.1016/j.physletb.2017.12.011},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-225782},
  pages     = {91-113},
  year      = {2018},
  abstract  = {Narrow resonances decaying into WW, WZ or ZZ boson pairs are searched for in 36.7 fb(-1) of proton-proton collision data at a centre-of-mass energy of root s = 13 TeV recorded with the ATLAS detector at the Large Hadron Collider in 2015 and 2016. The diboson system is reconstructed using pairs of large-radius jets with high transverse momentum and tagged as compatible with the hadronic decay of high-momentum Wor Zbosons, using jet mass and substructure properties. The search is sensitive to diboson resonances with masses in the range 1.2-5.0 TeV. No significant excess is observed in any signal region. Exclusion limits are set at the 95\% confidence level on the production cross section times branching ratio to dibosons for a range of theories beyond the Standard Model. Model-dependent lower limits on the mass of new gauge bosons are set, with the highest limit set at 3.5 TeV in the context of mass-degenerate resonances that couple predominantly to bosons. (c) 2017 The Author(s). Published by Elsevier B.V.},
  language  = {en}
}
@article{OPUS4-22594,
  title     = {Search for an invisibly decaying Higgs boson or dark matter candidates produced in association with a Z boson in \({pp}\) collisions at root s=13 TeV with the ATLAS detector},
  series = {Physics Letters B},
  volume    = {776},
  journal   = {Physics Letters B},
  number    = {1},
  organization    = {The ATLAS Collaboration},
  doi       = {10.1016/j.physletb.2017.11.049},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-225947},
  pages     = {318-337},
  year      = {2018},
  abstract  = {A search for an invisibly decaying Higgs boson or dark matter candidates produced in association with a leptonically decaying Z boson in proton-proton collisions at root s = 13 TeV is presented. This search uses 36.1 fb(-1) of data collected by the ATLAS experiment at the Large Hadron Collider. No significant deviation from the expectation of the Standard Model backgrounds is observed. Assuming the Standard Model ZH production cross-section, an observed (expected) upper limit of 67\% (39\%) at the 95\% confidence level is set on the branching ratio of invisible decays of the Higgs boson with mass m(H) = 125 GeV. The corresponding limits on the production cross-section of the ZH process with the invisible Higgs boson decays are also presented. Furthermore, exclusion limits on the dark matter candidate and mediator masses are reported in the framework of simplified dark matter models. (c) 2017 The Author(s). Published by Elsevier B.V.},
  language  = {en}
}
@article{OPUS4-22067,
  title     = {Angular analysis of B-d(0) -> K* µ\(^+\)μ\(^-\) decays in \({pp}\) collisions at root s=8 TeV with the ATLAS detector},
  series = {Journal of High Energy Physics},
  volume    = {47},
  journal   = {Journal of High Energy Physics},
  organization    = {The ATLAS collaboration},
  doi       = {10.1007/JHEP10(2018)047},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-220670},
  pages     = {1-47},
  year      = {2018},
  abstract  = {An angular analysis of the decay B-d(0) -> K*mu(+)mu(-) is presented, based on proton-proton collision data recorded by the ATLAS experiment at the LHC. The study is using 20.3 fb(-1) of integrated luminosity collected during 2012 at centre-of-mass energy of root s = 8TeV. Measurements of the K* longitudinal polarisation fraction and a set of angular parameters obtained for this decay are presented. The results are compatible with the Standard Model predictions.},
  language  = {en}
}
@article{OPUS4-22071,
  title     = {Search for exclusive Higgs and Z boson decays to phi gamma and rho gamma with the ATLAS detector},
  series = {Journal of High Energy Physics},
  volume    = {127},
  journal   = {Journal of High Energy Physics},
  number    = {7},
  organization    = {The ATLAS collaboration},
  doi       = {10.1007/JHEP07(2018)127},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-220717},
  pages     = {1-36},
  year      = {2018},
  abstract  = {A search for the exclusive decays of the Higgs and Z bosons to a phi or rho meson and a photon is performed with a pp collision data sample corresponding to an integrated luminosity of up to 35.6 fb(-1) collected at root s = 13 TeV with the ATLAS detector at the CERN Large Hadron Collider. These decays have been suggested as a probe of the Higgs boson couplings to light quarks. No significant excess of events is observed above the background, as expected from the Standard Model. Upper limits at 95\% confidence level were obtained on the branching fractions of the Higgs boson decays to phi gamma and rho gamma of 4.8 x 10(-4) and 8.8 x 10(-4), respectively. The corresponding 95\% confidence level upper limits for the Z boson decays are 0.9 x 10(-6) and 25 x 10(-6) for phi gamma and rho gamma, respectively.},
  language  = {en}
}
@article{OPUS4-22072,
  title     = {Search for Higgs boson decays to beyond-the-Standard-Model light bosons in four-lepton events with the ATLAS detector at root s=13 TeV},
  series = {Journal of High Energy Physics},
  volume    = {166},
  journal   = {Journal of High Energy Physics},
  number    = {6},
  organization    = {The ATLAS collaboration},
  doi       = {10.1007/JHEP06(2018)166},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-220721},
  pages     = {1-50},
  year      = {2018},
  abstract  = {A search is conducted for a beyond-the-Standard-Model boson using events where a Higgs boson with mass 125 GeV decays to four leptons (l = e or mu). This decay is presumed to occur via an intermediate state which contains one or two on-shell, promptly decaying bosons: H -> ZX/XX -> 4l , where X is a new vector boson Z(d) or pseudoscalar a with mass between 1 and 60 GeV. The search uses pp collision data collected with the ATLAS detector at the LHC with an integrated luminosity of 36.1 fb(-1) at a centre-of-mass energy root s = 13TeV. No significant excess of events above Standard Model background predictions is observed; therefore, upper limits at 95\% confidence level are set on model-independent fiducial cross-sections, and on the Higgs boson decay branching ratios to vector and pseudoscalar bosons in two benchmark models.},
  language  = {en}
}
@article{OPUS4-22073,
  title     = {Search for top-squark pair production in final states with one lepton, jets, and missing transverse momentum using 36 fb\(^{-1}\) of root s=13 TeV \({pp}\) collision data with the ATLAS detector},
  series = {Journal of High Energy Physics},
  volume    = {108},
  journal   = {Journal of High Energy Physics},
  number    = {6},
  organization    = {The ATLAS collaboration},
  doi       = {10.1007/JHEP06(2018)108},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-220733},
  pages     = {1-95},
  year      = {2018},
  abstract  = {The results of a search for the direct pair production of top squarks, the supersymmetric partner of the top quark, in final states with one isolated electron or muon, several energetic jets, and missing transverse momentum are reported. The analysis also targets spin-0 mediator models, where the mediator decays into a pair of dark-matter particles and is produced in association with a pair of top quarks. The search uses data from proton-proton collisions delivered by the Large Hadron Collider in 2015 and 2016 at a centre-of-mass energy of root s = 13TeV and recorded by the ATLAS detector, corresponding to an integrated luminosity of 36 fb(-1). A wide range of signal scenarios with different mass-splittings between the top squark, the lightest neutralino and possible intermediate supersymmetric particles are considered, including cases where the W bosons or the top quarks produced in the decay chain are off-shell. No significant excess over the Standard Model prediction is observed. The null results are used to set exclusion limits at 95\% confidence level in several supersymmetry benchmark models. For pair-produced top-squarks decaying into top quarks, top-squark masses up to 940 GeV are excluded. Stringent exclusion limits are also derived for all other considered top-squark decay scenarios. For the spin-0 mediator models, upper limits are set on the visible cross-section.},
  language  = {en}
}
@article{OPUS4-22074,
  title     = {Search for supersymmetry in final states with missing transverse momentum and multiple b-jets in proton-proton collisions at root s=13 TeV with the ATLAS detector},
  series = {Journal of High Energy Physics},
  volume    = {107},
  journal   = {Journal of High Energy Physics},
  number    = {6},
  organization    = {The ATLAS collaboration},
  doi       = {10.1007/JHEP06(2018)107},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-220748},
  pages     = {1-55},
  year      = {2018},
  abstract  = {A search for supersymmetry involving the pair production of gluinos decaying via third-generation squarks into the lightest neutralino ((chi) over tilde (0)(1)) is reported. It uses LHC proton-proton collision data at a centre-of-mass energy root s = 13TeV with an integrated luminosity of 36.1 fb(-1) collected with the ATLAS detector in 2015 and 2016. The search is performed in events containing large missing transverse momentum and several energetic jets, at least three of which must be identified as originating from b-quarks. To increase the sensitivity, the sample is divided into subsamples based on the presence or absence of electrons or muons. No excess is found above the predicted background. For (chi) over tilde (0)(1) masses below approximately 300 GeV, gluino masses of less than 1.97 (1.92) TeV are excluded at 95\% confidence level in simplified models involving the pair production of gluinos that decay via top (bottom) squarks. An interpretation of the limits in terms of the branching ratios of the gluinos into third-generation squarks is also provided. These results improve upon the exclusion limits obtained with the 3.2 fb(-1) of data collected in 2015.},
  language  = {en}
}
@article{OPUS4-22084,
  title     = {Search for long-lived charginos based on a disappearing-track signature in pp collisions at root s=13 TeV with the ATLAS detector},
  series = {Journal of High Energy Physics},
  volume    = {22},
  journal   = {Journal of High Energy Physics},
  number    = {6},
  organization    = {The ATLAS collaboration},
  doi       = {10.1007/JHEP06(2018)022},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-220847},
  pages     = {1-46},
  year      = {2018},
  abstract  = {This paper presents a search for direct electroweak gaugino or gluino pair production with a chargino nearly mass-degenerate with a stable neutralino. It is based on an integrated luminosity of 36.1 fb(-1) of pp collisions at root s = 13 TeV collected by the ATLAS experiment at the LHC. The final state of interest is a disappearing track accompanied by at least one jet with high transverse momentum from initial-state radiation or by four jets from the gluino decay chain. The use of short track segments reconstructed from the innermost tracking layers significantly improves the sensitivity to short chargino lifetimes. The results are found to be consistent with Standard Model predictions. Exclusion limits are set at 95\% confidence level on the mass of charginos and gluinos for different chargino lifetimes. For a pure wino with a lifetime of about 0.2 ns, chargino masses up to 460 GeV are excluded. For the strong production channel, gluino masses up to 1.65 TeV are excluded assuming a chargino mass of 460 GeV and lifetime of 0.2 ns.},
  language  = {en}
}
@article{OPUS4-22085,
  title     = {Measurement of inclusive jet and dijet cross-sections in proton-proton collisions at root s=13 TeV with the ATLAS detector},
  series = {Journal of High Energy Physics},
  volume    = {195},
  journal   = {Journal of High Energy Physics},
  number    = {5},
  organization    = {The ATLAS collaboration},
  doi       = {10.1007/JHEP05(2018)195},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-220853},
  pages     = {1-48},
  year      = {2018},
  abstract  = {Inclusive jet and dijet cross-sections are measured in proton-proton collisions at a centre-of-mass energy of 13 TeV. The measurement uses a dataset with an integrated luminosity of 3.2 fb(-1) recorded in 2015 with the ATLAS detector at the Large Hadron Collider. Jets are identified using the anti-lit algorithm with a radius parameter value of R = 0.4. The inclusive jet cross-sections are measured double-differentially as a function of the jet transverse momentum, covering the range from 100 GeV to 3.5 TeV, and the absolute jet rapidity up to vertical bar y vertical bar = 3. The double-differential dijet production cross-sections are presented as a function of the dijet mass, covering the range from 300 GeV to 9 TeV, and the half absolute rapidity separation between the two leading jets within vertical bar y vertical bar < 3, y*, up to y* = 3. Next-to-leading-order, and next-to-next-to-leading-order for the inclusive jet measurement, perturbative QCD calculations corrected for non-perturbative and electroweak effects are compared to the measured cross-sections.},
  language  = {en}
}
@article{OPUS4-22087,
  title     = {Measurement of differential cross sections and W\(^+\)/W\(^-\) cross-section ratios for W boson production in association with jets at root s=8 TeV with the ATLAS detector},
  series = {Journal of High Energy Physics},
  volume    = {77},
  journal   = {Journal of High Energy Physics},
  number    = {5},
  organization    = {The ATLAS collaboration},
  doi       = {10.1007/JHEP05(2018)077},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-220872},
  pages     = {1-61},
  year      = {2018},
  abstract  = {This paper presents a measurement of the W boson production cross section and the W+/W- cross-section ratio, both in association with jets, in proton-proton collisions at root s = 8 TeV with the ATLAS experiment at the Large Hadron Collider. The measurement is performed in final states containing one electron and missing transverse momentum using data corresponding to an integrated luminosity of 20.2 fb(-1). Differential cross sections for events with at least one or two jets are presented for a range of observables, including jet transverse momenta and rapidities, the scalar sum of transverse momenta of the visible particles and the missing transverse momentum in the event, and the transverse momentum of the W boson. For a subset of the observables, the differential cross sections of positively and negatively charged W bosons are measured separately. In the cross-section ratio of W+/W- the dominant systematic uncertainties cancel out, improving the measurement precision by up to a factor of nine. The observables and ratios selected for this paper provide valuable input for the up quark, down quark, and gluon parton distribution functions of the proton.},
  language  = {en}
}
@article{OPUS4-22544,
  title     = {Search for heavy resonances decaying into a W or Z boson and a Higgs boson in final states with leptons and b-jets in 36 fb\(^{-1}\) of root s=13 TeV pp collisions with the ATLAS detector},
  series = {Journal of High Energy Physics},
  volume    = {174},
  journal   = {Journal of High Energy Physics},
  number    = {3},
  organization    = {The ATLAS collaboration},
  doi       = {10.1007/JHEP03(2018)174},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-225446},
  pages     = {1-52},
  year      = {2018},
  abstract  = {A search is conducted for new resonances decaying into a W or Z boson and a 125 GeV Higgs boson in the nu(nu) over barb (b) over bar, l(+/-)nu b (b) over bar, and l(+)l(-)b (b) over bar final states, where l(+/-) = e(+/-) or mu(+/-), in pp collisions at root s = 13 TeV. The data used correspond to a total integrated luminosity of 36.1 fb(-1) collected with the ATLAS detector at the Large Hadron Collider during the 2015 and 2016 data-taking periods. The search is conducted by examining the reconstructed invariant or transverse mass distributions of Wh and Zh candidates for evidence of a localised excess in the mass range of 220 GeV up to 5 TeV. No significant excess is observed and the results are interpreted in terms of constraints on the production cross-section times branching fraction of heavy W' and Z' resonances in heavy-vector-triplet models and the CP-odd scalar boson A in two-Higgs-doublet models. Upper limits are placed at the 95\% confidence level and range between 9.0 x 10(-4) pb and 7.3 x 10(-1) pb depending on the model and mass of the resonance.},
  language  = {en}
}
@article{RangerBiedermannPhuntumartetal.2018,
  author    = {Ranger, Christopher M. and Biedermann, Peter HW and Phuntumart, Vipaporn and Beligala, Gayathri U. and Ghosh, Satyaki and Palmquist, Debra E. and Mueller, Robert and Barnett, Jenny and Schultz, Peter B. and Reding, Michael E. and Benz, J. Philipp},
  title     = {Symbiont selection via alcohol benefits fungus farming by ambrosia beetles},
  series = {Proceedings of the National Academy of Sciences},
  volume    = {115},
  journal   = {Proceedings of the National Academy of Sciences},
  number    = {17},
  doi       = {10.1073/pnas.1716852115},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-224953},
  pages     = {4447-4452},
  year      = {2018},
  abstract  = {Animal-microbe mutualisms are typically maintained by vertical symbiont transmission or partner choice. A third mechanism, screening of high-quality symbionts, has been predicted in theory, but empirical examples are rare. Here we demonstrate that ambrosia beetles rely on ethanol within host trees for promoting gardens of their fungal symbiont and producing offspring. Ethanol has long been known as the main attractant for many of these fungus-farming beetles as they select host trees in which they excavate tunnels and cultivate fungal gardens. More than 300 attacks by Xylosandrus germanus and other species were triggered by baiting trees with ethanol lures, but none of the foundresses established fungal gardens or produced broods unless tree tissues contained in vivo ethanol resulting from irrigation with ethanol solutions. More X. germanus brood were also produced in a rearing substrate containing ethanol. These benefits are a result of increased food supply via the positive effects of ethanol on food-fungus biomass. Selected Ambrosiella and Raffaelea fungal isolates from ethanol-responsive ambrosia beetles profited directly and indirectly by (i) a higher biomass on medium containing ethanol, (ii) strong alcohol dehydrogenase enzymatic activity, and (iii) a competitive advantage over weedy fungal garden competitors (Aspergillus, Penicillium) that are inhibited by ethanol. As ambrosia fungi both detoxify and produce ethanol, they may maintain the selectivity of their alcohol-rich habitat for their own purpose and that of other ethanol-resistant/producing microbes. This resembles biological screening of beneficial symbionts and a potentially widespread, unstudied benefit of alcohol-producing symbionts (e.g., yeasts) in other microbial symbioses.},
  language  = {en}
}
@article{SaudekCahovaHavrdovaetal.2018,
  author    = {Saudek, František and Cahov{\´a}, Monika and Havrdov{\´a}, Terezie and Zacharovov{\´a}, Kl{\´a}ra and Daňkov{\´a}, Helena and Voska, Luděk and L{\´a}nsk{\´a}, Věra and {\"U}{\c{c}}eyler, Nurcan and Sommer, Claudia},
  title     = {Preserved Expression of Skin Neurotrophic Factors in Advanced Diabetic Neuropathy Does Not Lead to Neural Regeneration despite Pancreas and Kidney Transplantation},
  series = {Journal of Diabetes Research},
  volume    = {2018},
  journal   = {Journal of Diabetes Research},
  number    = {2309108},
  doi       = {10.1155/2018/2309108},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-227469},
  pages     = {1-11},
  year      = {2018},
  abstract  = {Diabetic peripheral neuropathy (DPN) is a common complication of diabetes with potential severe consequences. Its pathogenesis involves hyperglycemia-linked mechanisms, which may include changes in the expression of neurotrophic growth factors. We analyzed the expression of 29 factors potentially related to nerve degeneration and regeneration in skin biopsies from 13 type 1 diabetic pancreas and kidney recipients with severe DPN including severe depletion of intraepidermal nerve fibers (IENF) in lower limb skin biopsies (group Tx1 1st examination). The investigation was repeated after a median 28-month period of normoglycemia achieved by pancreas transplantation (group Tx1 2nd examination). The same tests were performed in 13 stable normoglycemic pancreas and kidney recipients 6-12 years posttransplantation (group Tx2), in 12 matched healthy controls (group HC), and in 12 type 1 diabetic subjects without severe DPN (group DM). Compared to DM and HC groups, we found a significantly higher (p < 0.05-0.001) expression of NGF (nerve growth factor), NGFR (NGF receptor), NTRK1 (neurotrophic receptor tyrosine kinase 1), GDNF (glial cell-derived neurotrophic factor), GFRA1 (GDNF family receptor alpha 1), and GFAP (glial fibrillary acidic protein) in both transplant groups (Tx1 and Tx2). Enhanced expression of these factors was not normalized following the median 28-month period of normoglycemia (Tx1 2nd examination) and negatively correlated with IENF density and with electrophysiological indices of DPN (vibration perception threshold, electromyography, and autonomic tests). In contrast to our expectation, the expression of most of 29 selected factors related to neural regeneration was comparable in subjects with severe peripheral nerve fiber depletion and healthy controls and the expression of six factors was significantly upregulated. These findings may be important for better understanding the pathophysiology of nerve regeneration and for the development of intervention strategies.},
  language  = {en}
}
@article{RietjensDussortGuentheretal.2018,
  author    = {Rietjens, Ivonne M. C. M. and Dussort, P. and G{\"u}nther, Helmut and Hanlon, Paul and Honda, Hiroshi and Mally, Angela and O'Hagan, Sue and Scholz, Gabriele and Seidel, Albrecht and Swenberg, James and Teeguarden, Justin and Eisenbrand, Gerhard},
  title     = {Exposure assessment of process-related contaminants in food by biomarker monitoring},
  series = {Archives of Toxicology},
  volume    = {92},
  journal   = {Archives of Toxicology},
  number    = {1},
  doi       = {10.1007/s00204-017-2143-2},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-226268},
  pages     = {15-40},
  year      = {2018},
  abstract  = {Exposure assessment is a fundamental part of the risk assessment paradigm, but can often present a number of challenges and uncertainties. This is especially the case for process contaminants formed during the processing, e.g. heating of food, since they are in part highly reactive and/or volatile, thus making exposure assessment by analysing contents in food unreliable. New approaches are therefore required to accurately assess consumer exposure and thus better inform the risk assessment. Such novel approaches may include the use of biomarkers, physiologically based kinetic (PBK) modelling-facilitated reverse dosimetry, and/or duplicate diet studies. This review focuses on the state of the art with respect to the use of biomarkers of exposure for the process contaminants acrylamide, 3-MCPD esters, glycidyl esters, furan and acrolein. From the overview presented, it becomes clear that the field of assessing human exposure to process-related contaminants in food by biomarker monitoring is promising and strongly developing. The current state of the art as well as the existing data gaps and challenges for the future were defined. They include (1) using PBK modelling and duplicate diet studies to establish, preferably in humans, correlations between external exposure and biomarkers; (2) elucidation of the possible endogenous formation of the process-related contaminants and the resulting biomarker levels; (3) the influence of inter-individual variations and how to include that in the biomarker-based exposure predictions; (4) the correction for confounding factors; (5) the value of the different biomarkers in relation to exposure scenario's and risk assessment, and (6) the possibilities of novel methodologies. In spite of these challenges it can be concluded that biomarker-based exposure assessment provides a unique opportunity to more accurately assess consumer exposure to process-related contaminants in food and thus to better inform risk assessment.},
  language  = {en}
}
@article{BatzkeBuechelHansenetal.2018,
  author    = {Batzke, Katharina and B{\"u}chel, Gabriele and Hansen, Wiebke and Schramm, Alexander},
  title     = {TrkB-target Galectin-1 impairs immune activation and radiation responses in neuroblastoma: implications for tumour therapy},
  series = {International Journal of Molecular Sciences},
  volume    = {19},
  journal   = {International Journal of Molecular Sciences},
  number    = {3},
  issn      = {1422-0067},
  doi       = {10.3390/ijms19030718},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-285097},
  year      = {2018},
  abstract  = {Galectin-1 (Gal-1) has been described to promote tumour growth by inducing angiogenesis and to contribute to the tumour immune escape. We had previously identified up-regulation of Gal-1 in preclinical models of aggressive neuroblastoma (NB), the most common extracranial tumour of childhood. While Gal-1 did not confer a survival advantage in the absence of exogenous stressors, Gal-1 contributed to enhanced cell migratory and invasive properties. Here, we review these findings and extend them by analyzing Gal-1 mediated effects on immune cell regulation and radiation resistance. In line with previous results, cell autonomous effects as well as paracrine functions contribute to Gal-1 mediated pro-tumourigenic functions. Interfering with Gal-1 functions in vivo will add to a better understanding of the role of the Gal-1 axis in the complex tumour-host interaction during immune-, chemo- and radiotherapy of neuroblastoma.},
  language  = {en}
}
@article{KaiserBurekBritzetal.2018,
  author    = {Kaiser, Mathias and Burek, Malgorzata and Britz, Stefan and Lankamp, Frauke and Ketelhut, Steffi and Kemper, Bj{\"o}rn and F{\"o}rster, Carola and Gorzelanny, Christian and Goycoolea, Francisco M.},
  title     = {The influence of capsaicin on the integrity of microvascular endothelial cell monolayers},
  series = {International Journal of Molecular Sciences},
  volume    = {20},
  journal   = {International Journal of Molecular Sciences},
  number    = {1},
  issn      = {1422-0067},
  doi       = {10.3390/ijms20010122},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-284865},
  year      = {2018},
  abstract  = {Microvascular endothelial cells are an essential part of many biological barriers, such as the blood-brain barrier (BBB) and the endothelium of the arteries and veins. A reversible opening strategy to increase the permeability of drugs across the BBB could lead to improved therapies due to enhanced drug bioavailability. Vanilloids, such as capsaicin, are known to reversibly open tight junctions of epithelial and endothelial cells. In this study, we used several in vitro assays with the murine endothelial capillary brain cells (line cEND) as a BBB model to characterize the interaction between capsaicin and endothelial tight junctions.},
  language  = {en}
}
@article{AdamDeimelPardoMedinaetal.2018,
  author    = {Adam, Alexander and Deimel, Stephan and Pardo-Medina, Javier and Garc{\´i}a-Mart{\´i}nez, Jorge and Konte, Tilen and Lim{\´o}n, M. Carmen and Avalos, Javier and Terpitz, Ulrich},
  title     = {Protein activity of the \(Fusarium\) \(fujikuroi\) rhodopsins CarO and OpsA and their relation to fungus-plant interaction},
  series = {International Journal of Molecular Sciences},
  volume    = {19},
  journal   = {International Journal of Molecular Sciences},
  number    = {1},
  issn      = {1422-0067},
  doi       = {10.3390/ijms19010215},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-285125},
  year      = {2018},
  abstract  = {Fungi possess diverse photosensory proteins that allow them to perceive different light wavelengths and to adapt to changing light conditions in their environment. The biological and physiological roles of the green light-sensing rhodopsins in fungi are not yet resolved. The rice plant pathogen Fusarium fujikuroi exhibits two different rhodopsins, CarO and OpsA. CarO was previously characterized as a light-driven proton pump. We further analyzed the pumping behavior of CarO by patch-clamp experiments. Our data show that CarO pumping activity is strongly augmented in the presence of the plant hormone indole-3-acetic acid and in sodium acetate, in a dose-dependent manner under slightly acidic conditions. By contrast, under these and other tested conditions, the Neurospora rhodopsin (NR)-like rhodopsin OpsA did not exhibit any pump activity. Basic local alignment search tool (BLAST) searches in the genomes of ascomycetes revealed the occurrence of rhodopsin-encoding genes mainly in phyto-associated or phytopathogenic fungi, suggesting a possible correlation of the presence of rhodopsins with fungal ecology. In accordance, rice plants infected with a CarO-deficient F. fujikuroi strain showed more severe bakanae symptoms than the reference strain, indicating a potential role of the CarO rhodopsin in the regulation of plant infection by this fungus.},
  language  = {en}
}
@article{UngernSternbergZerneckeSeizer2018,
  author    = {Ungern-Sternberg, Saskia N. I. von and Zernecke, Alma and Seizer, Peter},
  title     = {Extracellular matrix metalloproteinase inducer EMMPRIN (CD147) in cardiovascular disease},
  series = {International Journal of Molecular Sciences},
  volume    = {19},
  journal   = {International Journal of Molecular Sciences},
  number    = {2},
  issn      = {1422-0067},
  doi       = {10.3390/ijms19020507},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-285014},
  year      = {2018},
  abstract  = {The receptor EMMPRIN is involved in the development and progression of cardiovascular diseases and in the pathogenesis of myocardial infarction. There are several binding partners of EMMPRIN mediating the effects of EMMPRIN in cardiovascular diseases. EMMPRIN interaction with most binding partners leads to disease progression by mediating cytokine or chemokine release, the activation of platelets and monocytes, as well as the formation of monocyte-platelet aggregates (MPAs). EMMPRIN is also involved in atherosclerosis by mediating the infiltration of pro-inflammatory cells. There is also evidence that EMMPRIN controls energy metabolism of cells and that EMMPRIN binding partners modulate intracellular glycosylation and trafficking of EMMPRIN towards the cell membrane. In this review, we systematically discuss these multifaceted roles of EMMPRIN and its interaction partners, such as Cyclophilins, in cardiovascular disease.},
  language  = {en}
}
@article{SalingerHuLiuetal.2018,
  author    = {Salinger, Tim and Hu, Kai and Liu, Dan and Taleh, Scharoch and Herrmann, Sebastian and Oder, Daniel and Gensler, Daniel and M{\"u}ntze, Jonas and Ertl, Georg and Lorenz, Kristina and Frantz, Stefan and Weidemann, Frank and Nordbeck, Peter},
  title     = {Association between Comorbidities and Progression of Transvalvular Pressure Gradients in Patients with Moderate and Severe Aortic Valve Stenosis},
  series = {Cardiology Research and Practice},
  journal   = {Cardiology Research and Practice},
  doi       = {10.1155/2018/3713897},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-227291},
  pages     = {3713897, 1-7},
  year      = {2018},
  abstract  = {Background. Fast progression of the transaortic mean gradient (P-mean) is relevant for clinical decision making of valve replacement in patients with moderate and severe aortic stenosis (AS) patients. However, there is currently little knowledge regarding the determinants affecting progression of transvalvular gradient in AS patients. Methods. This monocentric retrospective study included consecutive patients presenting with at least two transthoracic echocardiography examinations covering a time interval of one year or more between April 2006 and February 2016 and diagnosed as moderate or severe aortic stenosis at the final echocardiographic examination. Laboratory parameters, medication, and prevalence of eight known cardiac comorbidities and risk factors (hypertension, diabetes, coronary heart disease, peripheral artery occlusive disease, cerebrovascular disease, renal dysfunction, body mass index >= 30 Kg/m(2), and history of smoking) were analyzed. Patients were divided into slow (P-mean < 5 mmHg/year) or fast (P-mean >= 5 mmHg/year) progression groups. Results. A total of 402 patients (mean age 78 +/- 9.4 years, 58\% males) were included in the study. Mean follow-up duration was 3.4 +/- 1.9 years. The average number of cardiac comorbidities and risk factors was 3.1 +/- 1.6. Average number of cardiac comorbidities and risk factors was higher in patients in slow progression group than in fast progression group (3.3 +/- 1.5 vs 2.9 +/- 1.7; P = 0.036). Patients in slow progression group had more often coronary heart disease (49.2\% vs 33.6\%; P = 0.003) compared to patients in fast progression group. LDL-cholesterol values were lower in the slow progression group (100 +/- 32.6 mg/dl vs 110.8 +/- 36.6 mg/dl; P = 0.005). Conclusion. These findings suggest that disease progression of aortic valve stenosis is faster in patients with fewer cardiac comorbidities and risk factors, especially if they do not have coronary heart disease. Further prospective studies are warranted to investigate the outcome of patients with slow versus fast progression of transvalvular gradient with regards to comorbidities and risk factors.},
  language  = {en}
}
@article{ScherpfSchwarzScharfetal.2018,
  author    = {Scherpf, Thorsten and Schwarz, Christopher and Scharf, Lennart T. and Zur, Jana-Alina and Helbig, Andeas and Gessner, Viktoria H.},
  title     = {Ylide-Functionalized Phosphines: Strong Donor Ligands for Homogeneous Catalysis},
  series = {Angewandte Chemie - International Edition},
  volume    = {57},
  journal   = {Angewandte Chemie - International Edition},
  number    = {39},
  doi       = {10.1002/anie.201805372},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-228551},
  pages     = {12859-12864},
  year      = {2018},
  abstract  = {Phosphines are important ligands in homogenous catalysis and have been crucial for many advances, such as in cross-coupling, hydrofunctionalization, or hydrogenation reactions. Herein we report the synthesis and application of a novel class of phosphines bearing ylide substituents. These phosphines are easily accessible via different synthetic routes from commercially available starting materials. Owing to the extra donation from the ylide group to the phosphorus center the ligands are unusually electron-rich and can thus function as strong electron donors. The donor capacity surpasses that of commonly used phosphines and carbenes and can easily be tuned by changing the substitution pattern at the ylidic carbon atom. The huge potential of ylide-functionalized phosphines in catalysis is demonstrated by their use in gold catalysis. Excellent performance at low catalyst loadings under mild reaction conditions is thus seen in different types of transformations.},
  language  = {en}
}
@article{WeberLassalleHaukeRamseretal.2018,
  author    = {Weber-Lassalle, Nana and Hauke, Jan and Ramser, Juliane and Richters, Lisa and Groß, Eva and Bl{\"u}mcke, Britta and Gehrig, Andrea and Kahlert, Anne-Karin and M{\"u}ller, Clemens R. and Hackmann, Karl and Honisch, Ellen and Weber-Lassalle, Konstantin and Niederacher, Dieter and Borde, Julika and Thiele, Holger and Ernst, Corinna and Altm{\"u}ller, Janine and Neidhardt, Guido and N{\"u}rnberg, Peter and Klaschik, Kristina and Schroeder, Christopher and Platzer, Konrad and Volk, Alexander E. and Wang-Gohrke, Shan and Just, Walter and Auber, Bernd and Kubisch, Christian and Schmidt, Gunnar and Horvath, Judit and Wappenschmidt, Barbara and Engel, Christoph and Arnold, Norbert and Dworniczak, Bernd and Rhiem, Kerstin and Meindl, Alfons and Schmutzler, Rita K. and Hahnen, Eric},
  title     = {BRIP1 loss-of-function mutations confer high risk for familial ovarian cancer, but not familial breast cancer},
  series = {Breast Cancer Research},
  volume    = {20},
  journal   = {Breast Cancer Research},
  doi       = {10.1186/s13058-018-0935-9},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-233433},
  year      = {2018},
  abstract  = {Background Germline mutations in the BRIP1 gene have been described as conferring a moderate risk for ovarian cancer (OC), while the role of BRIP1 in breast cancer (BC) pathogenesis remains controversial. Methods To assess the role of deleterious BRIP1 germline mutations in BC/OC predisposition, 6341 well-characterized index patients with BC, 706 index patients with OC, and 2189 geographically matched female controls were screened for loss-of-function (LoF) mutations and potentially damaging missense variants. All index patients met the inclusion criteria of the German Consortium for Hereditary Breast and Ovarian Cancer for germline testing and tested negative for pathogenic BRCA1/2 variants. Results BRIP1 LoF mutations confer a high OC risk in familial index patients (odds ratio (OR) = 20.97, 95\% confidence interval (CI) = 12.02-36.57, P < 0.0001) and in the subgroup of index patients with late-onset OC (OR = 29.91, 95\% CI = 14.99-59.66, P < 0.0001). No significant association of BRIP1 LoF mutations with familial BC was observed (OR = 1.81 95\% CI = 1.00-3.30, P = 0.0623). In the subgroup of familial BC index patients without a family history of OC there was also no apparent association (OR = 1.42, 95\% CI = 0.70-2.90, P = 0.3030). In 1027 familial BC index patients with a family history of OC, the BRIP1 mutation prevalence was significantly higher than that observed in controls (OR = 3.59, 95\% CI = 1.43-9.01; P = 0.0168). Based on the negative association between BRIP1 LoF mutations and familial BC in the absence of an OC family history, we conclude that the elevated mutation prevalence in the latter cohort was driven by the occurrence of OC in these families. Compared with controls, predicted damaging rare missense variants were significantly more prevalent in OC (P = 0.0014) but not in BC (P = 0.0693) patients. Conclusions To avoid ambiguous results, studies aimed at assessing the impact of candidate predisposition gene mutations on BC risk might differentiate between BC index patients with an OC family history and those without. In familial cases, we suggest that BRIP1 is a high-risk gene for late-onset OC but not a BC predisposition gene, though minor effects cannot be excluded.},
  language  = {en}
}
@article{KoepingShehataDielerSchneideretal.2018,
  author    = {K{\"o}ping, Maria and Shehata-Dieler, Wafaa and Schneider, Dieter and Cebulla, Mario and Oder, Daniel and M{\"u}ntze, Jonas and Nordbeck, Peter and Wanner, Christoph and Hagen, Rudolf and Schraven, Sebastian P.},
  title     = {Characterization of vertigo and hearing loss in patients with Fabry disease},
  series = {Orphanet Journal of Rare Diseases},
  volume    = {13},
  journal   = {Orphanet Journal of Rare Diseases},
  doi       = {10.1186/s13023-018-0882-7},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-222818},
  year      = {2018},
  abstract  = {Background Fabry Disease (FD) is an X-linked hereditary lysosomal storage disorder which leads to a multisystemic intralysosomal accumulation of globotriaosylceramid (Gb3). Besides prominent renal and cardiac organ involvement, patients commonly complain about vestibulocochlear symptoms like high-frequency hearing loss, tinnitus and vertigo. However, comprehensive data especially on vertigo remain scarce. The aim of this study was to examine the prevalence and characteristics of vertigo and hearing loss in patients with FD, depending on renal and cardiac parameters and get hints about the site and the pattern of the lesions. Methods Single-center study with 57 FD patients. Every patient underwent an oto-rhino-laryngological examination as well as videonystagmography and vestibular evoked myogenic potentials (VEMPs) and audiological measurements using pure tone audiometry and auditory brainstem response audiometry (ABR). Renal function was measured by eGFR, cardiac impairment was graduated by NYHA class. Results More than one out of three patients (35.1\%) complained about hearing loss, 54.4\% about vertigo and 28.1\% about both symptom. In 74\% a sensorineural hearing loss of at least 25 dB was found, ABR could exclude any retrocochlear lesion. Caloric testing showed abnormal values in 71.9\%, VEMPs were pathological in 68\%. A correlation between the side or the shape of hearing loss and pathological vestibular testing could not be revealed. Conclusions Hearing loss and vertigo show a high prevalence in FD. While hearing loss seems due to a cochlear lesion, peripheral vestibular as well as central nervous pathologies cause vertigo. Thus, both the site of lesion and the pathophysiological patterns seem to differ.},
  language  = {en}
}
@article{QamarAzmatAbbasetal.2018,
  author    = {Qamar, Muhammad Uzair and Azmat, Muhammad and Abbas, Azhar and Usman, Muhammad and Shahid, Muhammad Adnan and Khan, Zahid Mahmood},
  title     = {Water Pricing and Implementation Strategies for the Sustainability of an Irrigation System: A Case Study within the Command Area of the Rakh Branch Canal},
  series = {Water},
  volume    = {10},
  journal   = {Water},
  number    = {4, 509},
  doi       = {10.3390/w10040509},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-224711},
  pages     = {1-24},
  year      = {2018},
  abstract  = {The command area of the Rakh branch canal grows wheat, sugarcane, and rice crops in abundance. The canal water, which is trivial for irrigating these crops, is conveyed to the farms through the network of canals and distributaries. For the maintenance of this vast infrastructure; the end users are charged on a seasonal basis. The present water charges are severely criticized for not being adequate to properly manage the entire infrastructure. We use the residual value to determine the value of the irrigation water and then based on the quantity of irrigation water supplied to farm land coupled with the infrastructure maintenance cost, full cost recovery figures are executed for the study area, and policy recommendations are made for the implementation of the full cost recovery system. The approach is unique in the sense that the pricings are based on the actual quantity of water conveyed to the field for irrigating crops. The results of our analysis showed that the canal water is severely under charged in the culturable command area of selected distributaries, thus negating the plan of having a self-sustainable irrigation system.},
  language  = {en}
}
@article{SantoroLabopinGiannottietal.2018,
  author    = {Santoro, Nicole and Labopin, Myriam and Giannotti, Federica and Ehninger, Gerard and Niederwieser, Dietger and Brecht, Arne and Stelljes, Matthias and Kr{\"o}ger, Nicolaus and Einsele, Herman and Eder, Matthias and Hallek, Michael and Glass, Bertram and Finke, J{\"u}rgen and Ciceri, Fabio and Mohty, Mohamad and Ruggeri, Annalisa and Nagler, Arnon},
  title     = {Unmanipulated haploidentical in comparison with matched unrelated donor stem cell transplantation in patients 60 years and older with acute myeloid leukemia: a comparative study on behalf of the ALWP of the EBMT},
  series = {Journal of Hematology \& Oncology},
  volume    = {11},
  journal   = {Journal of Hematology \& Oncology},
  doi       = {10.1186/s13045-018-0598-0},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-227315},
  pages     = {55, 1-10},
  year      = {2018},
  abstract  = {Background: Acute myeloid leukemia (AML) is both more common and with more biologically aggressive phenotype in the elderly. Allogenic stem cell transplantation (allo-SCT) is the best treatment option in fit patients. Either HLA-matched unrelated donor (MUD) or haploidentical (Haplo) donor are possible alternative for patients in need. Methods: We retrospectively compared non-T-cell-depleted Haplo (n = 250) to 10/10 MUD (n = 2589) in AML patients >= 60 years. Results: Median follow-up was 23 months. Disease status at transplant differs significantly between the two groups (p < 10(-4)). Reduced intensity conditioning (RIC) was administrated to 73 and 77\% of Haplo and MUD, respectively (p = 0.23). Stem cell source was the bone marrow (BM) in 52\% of the Haplo and 6\% of MUD (p < 10(-4)). Anti-thymocyte globulin (ATG) was most frequently used in MUD (p < 10(-4)) while post-Tx cyclophosphamide (PT-Cy) was given in 62\% of Haplo. Engraftment was achieved in 90\% of the Haplo vs 97\% of MUD (p < 10(-4)). In multivariate analysis, no significant difference was found between Haplo and MUD for acute (a) graft versus host disease (GVHD) grade II-IV, relapse incidence (RI), non-relapse mortality (NRM), leukemia free survival (LFS), graft-versus-host-free-relapse free survival (GRFS), and overall survival (OS). Extensive chronic (c) GVHD was significantly higher for MUD as compared to Haplo (HR 2, p = 0.01, 95\% CI 1.17-3.47). A propensity score analysis confirmed the higher risk of extensive cGVHD for MUD without differences for other outcomes. Conclusions: Allo-SCT from both Haplo and MUD are valid option for AML patients >= 60 years of age with similar results. Transplantation from MUD was associated with higher extensive cGVHD. Our findings suggest that Haplo is a suitable and attractive graft source for patients >= 60 with AML in need of allo-SCT.},
  language  = {en}
}
@article{BuellesbachVetterSchmitt2018,
  author    = {Buellesbach, Jan and Vetter, Sebastian G. and Schmitt, Thomas},
  title     = {Differences in the reliance on cuticular hydrocarbons as sexual signaling and species discrimination cues in parasitoid wasps},
  series = {Frontiers in Zoology},
  volume    = {15},
  journal   = {Frontiers in Zoology},
  doi       = {10.1186/s12983-018-0263-z},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-221702},
  year      = {2018},
  abstract  = {Background Cuticular hydrocarbons (CHC) have been documented to play crucial roles as species- and sex-specific cues in the chemical communication systems of a wide variety of insects. However, whether they are sufficient by themselves as the sole cue triggering sexual behavior as well as preference of con- over heterospecific mating partners is rarely assessed. We conducted behavioral assays in three representative species of parasitoid wasps (Hymenoptera: Pteromalidae) to determine their reliance on CHC as species-specific sexual signaling cues. Results We found a surprising degree of either unspecific or insufficient sexual signaling when CHC are singled out as recognition cues. Most strikingly, the cosmopolitan species Nasonia vitripennis, expected to experience enhanced selection pressure to discriminate against other co-occurring parasitoids, did not discriminate against CHC of a partially sympatric species from another genus, Trichomalopsis sarcophagae. Focusing on the latter species, in turn, it became apparent that CHC are even insufficient as the sole cue triggering conspecific sexual behavior, hinting at the requirement of additional, synergistic sexual cues particularly important in this species. Finally, in the phylogenetically and chemically most divergent species Muscidifurax uniraptor, we intriguingly found both CHC-based sexual signaling as well as species discrimination behavior intact although this species is naturally parthenogenetic with sexual reproduction only occurring under laboratory conditions. Conclusions Our findings implicate a discrepancy in the reliance on and specificity of CHC as sexual cues in our tested parasitioid wasps. CHC profiles were not sufficient for unambiguous discrimination and preference behavior, as demonstrated by clear cross-attraction between some of our tested wasp genera. Moreover, we could show that only in T. sarcophagae, additional behavioral cues need to be present for triggering natural mating behavior, hinting at an interesting shift in signaling hierarchy in this particular species. This demonstrates the importance of integrating multiple, potentially complementary signaling modalities in future studies for a better understanding of their individual contributions to natural sexual communication behavior.},
  language  = {en}
}
@article{SonntagHashimotoEyrichetal.2018,
  author    = {Sonntag, Katja and Hashimoto, Hisayoshi and Eyrich, Matthias and Menzel, Moritz and Schubach, Max and D{\"o}cker, Dennis and Battke, Florian and Courage, Carolina and Lambertz, Helmut and Handgretinger, Rupert and Biskup, Saskia and Schilbach, Karin},
  title     = {Immune monitoring and TCR sequencing of CD4 T cells in a long term responsive patient with metastasized pancreatic ductal carcinoma treated with individualized, neoepitope-derived multipeptide vaccines: a case report},
  series = {Journal of Translational Medicine},
  volume    = {16},
  journal   = {Journal of Translational Medicine},
  doi       = {10.1186/s12967-018-1382-1},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-239276},
  year      = {2018},
  abstract  = {Background Cancer vaccines can effectively establish clinically relevant tumor immunity. Novel sequencing approaches rapidly identify the mutational fingerprint of tumors, thus allowing to generate personalized tumor vaccines within a few weeks from diagnosis. Here, we report the case of a 62-year-old patient receiving a four-peptide-vaccine targeting the two sole mutations of his pancreatic tumor, identified via exome sequencing. Methods Vaccination started during chemotherapy in second complete remission and continued monthly thereafter. We tracked IFN-γ+ T cell responses against vaccine peptides in peripheral blood after 12, 17 and 34 vaccinations by analyzing T-cell receptor (TCR) repertoire diversity and epitope-binding regions of peptide-reactive T-cell lines and clones. By restricting analysis to sorted IFN-γ-producing T cells we could assure epitope-specificity, functionality, and TH1 polarization. Results A peptide-specific T-cell response against three of the four vaccine peptides could be detected sequentially. Molecular TCR analysis revealed a broad vaccine-reactive TCR repertoire with clones of discernible specificity. Four identical or convergent TCR sequences could be identified at more than one time-point, indicating timely persistence of vaccine-reactive T cells. One dominant TCR expressing a dual TCRVα chain could be found in three T-cell clones. The observed T-cell responses possibly contributed to clinical outcome: The patient is alive 6 years after initial diagnosis and in complete remission for 4 years now. Conclusions Therapeutic vaccination with a neoantigen-derived four-peptide vaccine resulted in a diverse and long-lasting immune response against these targets which was associated with prolonged clinical remission. These data warrant confirmation in a larger proof-of concept clinical trial.},
  language  = {en}
}
@article{KuaiGongDingetal.2018,
  author    = {Kuai, Yue and Gong, Xin and Ding, Liya and Li, Fang and Lei, Lizhen and Gong, Yuqi and Liu, Qingmeng and Tan, Huajiao and Zhang, Xinxia and Liu, Dongyu and Ren, Guoping and Pan, Hongyang and Shi, Yaoyao and Berberich-Siebelt, Friederike and Ma, Zhengrong and Zhou, Ren},
  title     = {Wilms' tumor 1-associating protein plays an aggressive role in diffuse large B-cell lymphoma and forms a complex with BCL6 via Hsp90},
  series = {Cell Communication and Signaling},
  volume    = {16},
  journal   = {Cell Communication and Signaling},
  doi       = {10.1186/s12964-018-0258-6},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-230168},
  year      = {2018},
  abstract  = {Background Wilms' tumor 1-associating protein (WTAP) is a nuclear protein, which is ubiquitously expressed in many tissues. Furthermore, in various types of malignancies WTAP is overexpressed and plays a role as an oncogene. The function of WTAP in diffuse large B-cell lymphoma (DLBCL), however, remains unclear. Methods Immunohistochemistry was applied to evaluate the levels of WTAP expression in DLBCL tissues and normal lymphoid tissues. Overexpression and knock-down of WTAP in DLBCL cell lines, verified on mRNA and protein level served to analyze cell proliferation and apoptosis in DLBCL cell lines by flow cytometry. Finally, co-immunoprecipitation (Co-IP), IP, and GST-pull down assessed the interaction of WTAP with Heat shock protein 90 (Hsp90) and B-cell lymphoma 6 (BCL6) as well as determined the extend of its ubiquitinylation. Results WTAP protein levels were consistently upregulated in DLBCL tissues. WTAP promoted DLBCL cell proliferation and improved the ability to confront apoptosis, while knockdown of WTAP in DLBCL cell lines allowed a significant higher apoptosis rate after treatment with Etoposide, an anti-tumor drug. The stable expression of WTAP was depended on Hsp90. In line, we demonstrated that WTAP could form a complex with BCL6 via Hsp90 in vivo and in vitro. Conclusion WTAP is highly expressed in DLBCL, promoting growth and anti-apoptosis in DLBCL cell lines. WTAP is a client protein of Hsp90 and can appear in a complex with BCL6 and Hsp90 in DLBCL. Down-regulation of WTAP could improve the chemotherapeutic treatments in DLBCL.},
  language  = {en}
}
@article{DietlPrieschenkEckertetal.2018,
  author    = {Dietl, Alexander and Prieschenk, Christine and Eckert, Franziska and Birner, Christoph and Luchner, Andreas and Maier, Lars S. and Buchner, Stefan},
  title     = {3D vena contracta area after MitraClip© procedure: precise quantification of residual mitral regurgitation and identification of prognostic information},
  series = {Cardiovascular Ultrasound},
  volume    = {16},
  journal   = {Cardiovascular Ultrasound},
  doi       = {10.1186/s12947-017-0120-9},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-225318},
  year      = {2018},
  abstract  = {Background Percutaneous mitral valve repair (PMVR) is increasingly performed in patients with severe mitral regurgitation (MR). Post-procedural MR grading is challenging and an unsettled issue. We hypothesised that the direct planimetry of vena contracta area (VCA) by 3D-transoesophageal echocardiography allows quantifying post-procedural MR and implies further prognostic relevance missed by the usual ordinal scale (grade I-IV). Methods Based on a single-centre PMVR registry containing 102 patients, the association of VCA reduction and patients' functional capacity measured as six-minute walk distance (6 MW) was evaluated. 3D-colour-Doppler datasets were available before, during and 4 weeks after PMVR. Results Twenty nine patients (age 77.0 ± 5.8 years) with advanced heart failure (75.9\% NYHA III/IV) and severe degenerative (34\%) or functional (66\%) MR were eligible. VCA was reduced in all patients by PMVR (0.99 ± 0.46 cm\(^2\) vs. 0.22 ± 0.15 cm\(^2\), p < 0.0001). It remained stable after median time of 33 days (p = 0.999). 6 MW improved after the procedure (257.5 ± 82.5 m vs. 295.7 ± 96.3 m, p < 0.01). Patients with a decrease in VCA less than the median VCA reduction showed a more distinct improvement in 6 MW than patients with better technical result (p < 0.05). This paradoxical finding was driven by inferior results in very large functional MR. Conclusions VCA improves the evaluation of small residual MR. Its post-procedural values remain stable during a short-term follow-up and imply prognostic information for the patients' physical improvement. VCA might contribute to a more substantiated estimation of treatment success in the heterogeneous functional MR group.},
  language  = {en}
}
@article{HautmannDoepfnerKatzmannetal.2018,
  author    = {Hautmann, Christopher and D{\"o}pfner, Manfred and Katzmann, Josepha and Sch{\"u}rmann, Stephanie and Wolff Metternich-Kaizman, Tanja and Jaite, Charlotte and Kappel, Viola and Geissler, Julia and Warnke, Andreas and Jacob, Christian and Hennighausen, Klaus and Haack-Dees, Barbara and Schneider-Momm, Katja and Philipsen, Alexandra and Matthies, Swantje and R{\"o}sler, Michael and Retz, Wolfgang and Gontard, Alexander von and Sobanski, Esther and Alm, Barbara and Hohmann, Sarah and H{\"a}ge, Alexander and Poustka, Luise and Colla, Michael and Gentschow, Laura and Freitag, Christine M. and Becker, Katja and Jans, Thomas},
  title     = {Sequential treatment of ADHD in mother and child (AIMAC study): importance of the treatment phases for intervention success in a randomized trial},
  series = {BMC Psychiatry},
  volume    = {18},
  journal   = {BMC Psychiatry},
  doi       = {10.1186/s12888-018-1963-9},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-227930},
  year      = {2018},
  abstract  = {Background The efficacy of parent-child training (PCT) regarding child symptoms may be reduced if the mother has attention-deficit/hyperactivity disorder (ADHD). The AIMAC study (ADHD in Mothers and Children) aimed to compensate for the deteriorating effect of parental psychopathology by treating the mother (Step 1) before the beginning of PCT (Step 2). This secondary analysis was particularly concerned with the additional effect of the Step 2 PCT on child symptoms after the Step 1 treatment. Methods The analysis included 143 mothers and children (aged 6-12 years) both diagnosed with ADHD. The study design was a two-stage, two-arm parallel group trial (Step 1 treatment group [TG]: intensive treatment of the mother including psychotherapy and pharmacotherapy; Step 1 control group [CG]: supportive counseling only for mother; Step 2 TG and CG: PCT). Single- and multi-group analyses with piecewise linear latent growth curve models were applied to test for the effects of group and phase. Child symptoms (e.g., ADHD symptoms, disruptive behavior) were rated by three informants (blinded clinician, mother, teacher). Results Children in the TG showed a stronger improvement of their disruptive behavior as rated by mothers than those in the CG during Step 1 (Step 1: TG vs. CG). In the CG, according to reports of the blinded clinician and the mother, the reduction of children's disruptive behavior was stronger during Step 2 than during Step 1 (CG: Step 1 vs. Step 2). In the TG, improvement of child outcome did not differ across treatment steps (TG: Step 1 vs. Step 2). Conclusions Intensive treatment of the mother including pharmacotherapy and psychotherapy may have small positive effects on the child's disruptive behavior. PCT may be a valid treatment option for children with ADHD regarding disruptive behavior, even if mothers are not intensively treated beforehand. Trial registration ISRCTN registry ISRCTN73911400. Registered 29 March 2007.},
  language  = {en}
}
@article{RatHeibyBunzetal.2018,
  author    = {Rat, Charlotte and Heiby, Julia C. and Bunz, Jessica P. and Neuweiler, Hannes},
  title     = {Two-step self-assembly of a spider silk molecular clamp},
  series = {Nature Communications},
  volume    = {9},
  journal   = {Nature Communications},
  doi       = {10.1038/s41467-018-07227-5},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-225016},
  pages     = {4779, 1-11},
  year      = {2018},
  abstract  = {Web spiders synthesize silk fibers of unique strength and extensibility through the controlled self-assembly of protein building blocks, so-called spidroins. The spidroin C-terminal domain is highly conserved and connects two polypeptide chains through formation of an all-helical, intertwined dimer. Here we use contact-induced fluorescence self-quenching and resonance energy transfer in combination with far-UV circular dichroism spectroscopy as three orthogonal structural probes to dissect the mechanism of folding and dimerization of a spidroin C-terminal domain from the major ampullate gland of the nursery web spider Euprosthenops australis. We show that helices forming the dimer core assemble very rapidly and fold on association. Subsequently, peripheral helices fold and dock slowly onto the preformed core. Lability of outer helices facilitates formation of a highly expanded, partially folded dimer. The high end-to-end distance of chain termini in the partially folded dimer suggests an extensibility module that contributes to elasticity of spider silk.},
  language  = {en}
}
@article{RubioCosialsSchulzLambertsenetal.2018,
  author    = {Rubio-Cosials, Anna and Schulz, Eike C. and Lambertsen, Lotte and Smyshlyaev, Georgy and Rojas-Cordova, Carlos and Forslund, Kristoffer and Karaca, Ezgi and Bebel, Aleksandra and Bork, Peer and Barabas, Orsolya},
  title     = {Transposase-DNA Complex Structures Reveal Mechanisms for Conjugative Transposition of Antibiotic Resistance},
  series = {Cell},
  volume    = {173},
  journal   = {Cell},
  number    = {1},
  doi       = {10.1016/j.cell.2018.02.032},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-227085},
  pages     = {e20, 208-220},
  year      = {2018},
  abstract  = {Conjugative transposition drives the emergence of multidrug resistance in diverse bacterial pathogens, yet the mechanisms are poorly characterized. The Tn1549 conjugative transposon propagates resistance to the antibiotic vancomycin used for severe drug-resistant infections. Here, we present four high-resolution structures of the conserved Y-transposase of Tn1549 complexed with circular transposon DNA intermediates. The structures reveal individual transposition steps and explain how specific DNA distortion and cleavage mechanisms enable DNA strand exchange with an absolute minimum homology requirement. This appears to uniquely allow Tn916-like conjugative transposons to bypass DNA homology and insert into diverse genomic sites, expanding gene transfer. We further uncover a structural regulatory mechanism that prevents premature cleavage of the transposon DNA before a suitable target DNA is found and generate a peptide antagonist that interferes with the transposase-DNA structure to block transposition. Our results reveal mechanistic principles of conjugative transposition that could help control the spread of antibiotic resistance genes.},
  language  = {en}
}