@article{TsamadouFuerstVucinicetal.2017,
  author    = {Tsamadou, Chrysanthi and F{\"u}rst, Daniel and Vucinic, Vladan and Bunjes, Donald and Neuchel, Christine and Mytilineos, Daphne and Gramatzki, Martin and Arnold, Renate and Wagner, Eva Maria and Einsele, Hermann and M{\"u}ller, Carlheinz and Schrezenmeier, Hubert and Mytilineos, Joannis},
  title     = {Human leukocyte antigen-E mismatch is associated with better hematopoietic stem cell transplantation outcome in acute leukemia patients},
  series = {Haematologica},
  volume    = {102},
  journal   = {Haematologica},
  number    = {11},
  doi       = {10.3324/haematol.2017.169805},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-173325},
  pages     = {1947-1955},
  year      = {2017},
  abstract  = {The immunomodulatory role of human leukocyte antigen (HLA)-E in hematopoietic stem cell transplantation (HSCT) has not been extensively investigated. To this end, we genotyped 509 10/10 HLA unrelated transplant pairs for HLA-E, in order to study the effect of HLA-E as a natural killer (NK)-alloreactivity mediator on HSCT outcome in an acute leukemia (AL) setting. Overall survival (OS), disease free survival (DFS), relapse incidence (RI) and non-relapse mortality (NRM) were set as endpoints. Analysis of our data revealed a significant correlation between HLA-E mismatch and improved HSCT outcome, as shown by both univariate (53\% vs. 38\%, P=0.002, 5-year OS) and multivariate (hazard ratio (HR)=0.63, confidence interval (CI) 95\%=0.48-0.83, P=0.001) analyses. Further subgroup analysis demonstrated that the positive effect of HLA-E mismatch was significant and pronounced in advanced disease patients (n=120) (5-year OS: 50\% vs. 18\%, P=0.005; HR=0.40, CI 95\%=0.22-0.72, P=0.002; results from univariate and multivariate analyses, respectively). The study herein is the first to report an association between HLA-E incompatibility and improved post-transplant prognosis in AL patients who have undergone matched unrelated HSCT. Combined NK and T cell HLA-E-mediated mechanisms may account for the better outcomes observed. Notwithstanding the necessity for in vitro and confirmational studies, our findings highlight the clinical relevance of HLA-E matching and strongly support prospective HLA-E screening upon donor selection for matched AL unrelated HSCTs.},
  language  = {en}
}
@article{TriphanJobstAnjorinetal.2017,
  author    = {Triphan, Simon M. F. and Jobst, Bertram J. and Anjorin, Angela and Sedlaczek, Oliver and Wolf, Ursula and Terekhov, Maxim and Hoffmann, Christian and Ley, Sebastian and D{\"u}ber, Christoph and Biederer, J{\"u}rgen and Kauczor, Hans-Ulrich and Jakob, Peter M. and Wielp{\"u}tz, Mark O.},
  title     = {Reproducibility and comparison of oxygen-enhanced T\(_1\) quantification in COPD and asthma patients},
  series = {PLoS ONE},
  volume    = {12},
  journal   = {PLoS ONE},
  number    = {2},
  doi       = {10.1371/journal.pone.0172479},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-171833},
  year      = {2017},
  abstract  = {T\(_1\) maps have been shown to yield useful diagnostic information on lung function in patients with chronic obstructive pulmonary disease (COPD) and asthma, both for native T\(_1\) and ΔT\(_1\), the relative reduction while breathing pure oxygen. As parameter quantification is particularly interesting for longitudinal studies, the purpose of this work was both to examine the reproducibility of lung T\(_1\) mapping and to compare T\(_1\) found in COPD and asthma patients using IRSnapShotFLASH embedded in a full MRI protocol. 12 asthma and 12 COPD patients (site 1) and further 15 COPD patients (site 2) were examined on two consecutive days. In each patient, T\(_1\) maps were acquired in 8 single breath-hold slices, breathing first room air, then pure oxygen. Maps were partitioned into 12 regions each to calculate average values. In asthma patients, the average T\(_{1,RA}\) = 1206ms (room air) was reduced to T\(_{1,O2}\) = 1141ms under oxygen conditions (ΔT\(_1\) = 5.3\%, p < 5⋅10\(^{-4})\), while in COPD patients both native T\(_{1,RA}\) = 1125ms was significantly shorter (p < 10\(^{-3})\) and the relative reduction to T\(_{1,O2}\) = 1081ms on average ΔT\(_1\) = 4.2\%(p < 10\(^{-5}\)). On the second day, with T\(_{1,RA}\) = 1186ms in asthma and T\(_{1,RA}\) = 1097ms in COPD, observed values were slightly shorter on average in all patient groups. ΔT\(_1\) reduction was the least repeatable parameter and varied from day to day by up to 23\% in individual asthma and 30\% in COPD patients. While for both patient groups T\(_1\) was below the values reported for healthy subjects, the T\(_1\) and ΔT\(_1\) found in asthmatics lies between that of the COPD group and reported values for healthy subjects, suggesting a higher blood volume fraction and better ventilation. However, it could be demonstrated that lung T\(_1\) quantification is subject to notable inter-examination variability, which here can be attributed both to remaining contrast agent from the previous day and the increased dependency of lung T\(_1\) on perfusion and thus current lung state.},
  language  = {en}
}
@article{TiffeWagnerRueckeretal.2017,
  author    = {Tiffe, Theresa and Wagner, Martin and R{\"u}cker, Viktoria and Morbach, Caroline and Gelbrich, G{\"o}tz and St{\"o}rk, Stefan and Heuschmann, Peter U.},
  title     = {Control of cardiovascular risk factors and its determinants in the general population - findings from the STAAB cohort study},
  series = {BMC Cardiovascular Disorders},
  volume    = {17},
  journal   = {BMC Cardiovascular Disorders},
  number    = {276},
  doi       = {10.1186/s12872-017-0708-x},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-159391},
  year      = {2017},
  abstract  = {Background: While data from primary care suggest an insufficient control of vascular risk factors, little is known about vascular risk factor control in the general population. We therefore aimed to investigate the adoption of adequate risk factor control and its determinants in the general population free of cardiovascular disease (CVD). Methods: Data from the Characteristics and Course of Heart Failure Stages A-B and Determinants of Progression (STAAB) Cohort Study, a population-based study of inhabitants aged 30 to 79 years from the general population of W{\"u}rzburg (Germany), were used. Proportions of participants without established CVD meeting targets for risk factor control recommended by 2016 ESC guideline were identified. Determinants of the accumulation of insufficiently controlled vascular risk factors (three or more) were assessed. Results: Between December 2013 and April 2015, 1379 participants without CVD were included; mean age was 53.1 ± 11.9 years and 52.9\% were female; 30.8\% were physically inactive, 55.2\% overweight, 19.3\% current smokers. Hypertension, dyslipidemia, and diabetes mellitus were prevalent in 31.8\%, 57.6\%, and 3.9\%, respectively. Treatment goals were not reached despite medication in 52.7\% of hypertensive, in 37.3\% of hyperlipidemic and in 44.0\% of diabetic subjects. Insufficiently controlled risk was associated with male sex (OR 1.94, 95\%CI 1.44-2.61), higher age (OR for 30-39 years vs. 70-79 years 4.01, 95\%CI 1.94-8.31) and lower level of education (OR for primary vs. tertiary 2.15, 95\%CI 1.48-3.11). Conclusions: In the general population, prevalence of vascular risk factors was high. We found insufficient identification and control of vascular risk factors and a considerable potential to improve adherence to cardiovascular guidelines for primary prevention. Further studies are needed to identify and overcome patient- and physician-related barriers impeding successful control of vascular risk factors in the general population.},
  language  = {en}
}
@article{Thalhammer2017,
  author    = {Thalhammer, Johanna},
  title     = {L'art de bien chanter und Von der Kunst zierlich zu singen und zu spielen - Eine kontrastive Analyse von Texten der musikalischen Fachsprache im 18. Jahrhundert anhand von Ausz{\"u}gen aus Code de musique pratique, Rameau (1760) und Der vollkommene Capellmeister, Mattheson (1739)},
  series = {promptus - W{\"u}rzburger Beitr{\"a}ge zur Romanistik},
  volume    = {3},
  journal   = {promptus - W{\"u}rzburger Beitr{\"a}ge zur Romanistik},
  issn      = {2510-2613},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-172958},
  pages     = {203-224},
  year      = {2017},
  abstract  = {This article is an analysis and a comparison of German and French special language of music in the 18th century, more precisely about the terms used to describe the activity of singing. The analysis is based on two treatises about music theory. The first writing, Der Vollkommene Capellmeister, was written by Johann Mattheson in 1739 and the second, Code de musique pratique by Jean-Philippe Rameau was published in 1760. Both texts contain a chapter which gives explanations how to sing. The treatises include different types of technical words: specific terms easy identified as special language terms like names of ornaments in the music, special verbs standing for singing, and words and anaphors to describe tonality and dynamics. By having a look on the terms of music language, the influence of Italian and French words on German vocabulary of music becomes obvious. The vocabulary is often similar in both languages, but not always defined as a part of the special language of music.},
  language  = {de}
}
@article{TemmeFriebeSchmidtetal.2017,
  author    = {Temme, Sebastian and Friebe, Daniela and Schmidt, Timo and Poschmann, Gereon and Hesse, Julia and Steckel, Bodo and St{\"u}hler, Kai and Kunz, Meik and Dandekar, Thomas and Ding, Zhaoping and Akhyari, Payam and Lichtenberg, Artur and Schrader, J{\"u}rgen},
  title     = {Genetic profiling and surface proteome analysis of human atrial stromal cells and rat ventricular epicardium-derived cells reveals novel insights into their cardiogenic potential},
  series = {Stem Cell Research},
  volume    = {25},
  journal   = {Stem Cell Research},
  doi       = {10.1016/j.scr.2017.11.006},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-172716},
  pages     = {183-190},
  year      = {2017},
  abstract  = {Epicardium-derived cells (EPDC) and atrial stromal cells (ASC) display cardio-regenerative potential, but the molecular details are still unexplored. Signals which induce activation, migration and differentiation of these cells are largely unknown. Here we have isolated rat ventricular EPDC and rat/human ASC and performed genetic and proteomic profiling. EPDC and ASC expressed epicardial/mesenchymal markers (WT-1, Tbx18, CD73,CD90, CD44, CD105), cardiac markers (Gata4, Tbx5, troponin T) and also contained phosphocreatine. We used cell surface biotinylation to isolate plasma membrane proteins of rEPDC and hASC, Nano-liquid chromatography with subsequent mass spectrometry and bioinformatics analysis identified 396 rat and 239 human plasma membrane proteins with 149 overlapping proteins. Functional GO-term analysis revealed several significantly enriched categories related to extracellular matrix (ECM), cell migration/differentiation, immunology or angiogenesis. We identified receptors for ephrin and growth factors (IGF, PDGF, EGF, anthrax toxin) known to be involved in cardiac repair and regeneration. Functional category enrichment identified clusters around integrins, PI3K/Akt-signaling and various cardiomyopathies. Our study indicates that EPDC and ASC have a similar molecular phenotype related to cardiac healing/regeneration. The cell surface proteome repository will help to further unravel the molecular details of their cardio-regenerative potential and their role in cardiac diseases.},
  language  = {en}
}
@article{TemmeAdamAhnenetal.2017,
  author    = {Temme, Fabian and Adam, Jan and Ahnen, Max L. and Baack, Dominik and Balbo, Matteo and Bergmann, Matthias and Biland, Adrian and Blank, Michael and Bretz, Thomas and Br{\"u}gge, Kai A. and Buss, Jens and Dmytriiev, Anton and Dorner, Daniela and Einecke, Sabrina and Hempfling, Christina and Hildebrand, Dorothee and Hughes, Gareth and Linhoff, Lena and Mannheim, Karl and M{\"u}ller, Sebastian and Neise, Dominik and Neronov, Andrii and N{\"o}the, Max and Paravac, Aleksander and Pauss, Felicitas and Rhode, Wolfgang and Shukla, Amit and Thaele, Julia and Walter, Roland},
  title     = {Long-Term monitoring of bright blazars in the multi-GeV to TeV range with FACT},
  series = {Galaxies},
  volume    = {5},
  journal   = {Galaxies},
  number    = {1},
  publisher = {MDPI},
  issn      = {2075-4434},
  doi       = {10.3390/galaxies5010018},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-198088},
  pages     = {18},
  year      = {2017},
  abstract  = {Blazars like Markarian 421 or Markarian 501 are active galactic nuclei (AGN), with their jets orientated towards the observer. They are among the brightest objects in the very high energy (VHE) gamma ray regime (>100 GeV). Their emitted gamma-ray fluxes are extremely variable, with changing activity levels on timescales between minutes, months, and even years. Several questions are part of the current research, such as the question of the emission regions or the engine of the AGN and the particle acceleration. A dedicated longterm monitoring program is necessary to investigate the properties of blazars in detail. A densely sampled and unbiased light curve allows for observation of both high and low states of the sources, and the combination with multi-wavelength observation could contribute to the answer of several questions mentioned above. FACT (First G-APD Cherenkov Telescope) is the first operational telescope using silicon photomultiplier (SiPM, also known as Geigermode—Avalanche Photo Diode, G-APD) as photon detectors. SiPM have a very homogenous and stable longterm performance, and allow operation even during full moon without any filter, leading to a maximal duty cycle for an Imaging Air Cherenkov Telescope (IACT). Hence, FACT is an ideal device for such a longterm monitoring of bright blazars. A small set of sources (e.g., Markarian 421, Markarian 501, 1ES 1959+650, and 1ES 2344+51.4) is currently being monitored. In this contribution, the FACT telescope and the concept of longterm monitoring of bright blazars will be introduced. The results of the monitoring program will be shown, and the advantages of densely sampled and unbiased light curves will be discussed.},
  language  = {en}
}
@article{Teichmann2017,
  author    = {Teichmann, Christoph},
  title     = {Die GmbH im europ{\"a}ischen Wettbewerb der Rechtsformen},
  series = {Zeitschrift f{\"u}r Unternehmens- und Gesellschaftsrecht},
  volume    = {46},
  journal   = {Zeitschrift f{\"u}r Unternehmens- und Gesellschaftsrecht},
  number    = {5},
  issn      = {1612-7048},
  doi       = {10.1515/zgr-2017-0024},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-194060},
  pages     = {543 -- 582},
  year      = {2017},
  abstract  = {In den 125 Jahren seit ihrer Einf{\"u}hrung im Jahre 1892 hat die deutsche GmbH einerseits einen Siegeszug um die ganze Welt angetreten und musste sich andererseits im eigenen Heimatland der scharfen Konkurrenz der englischen Limited erwehren. Dieser Wettbewerb setzte im Internationalen Gesellschaftsrecht einen Wechsel von der Sitz- zur Gr{\"u}ndungstheorie voraus. Seine negativen Auswirkungen lassen sich, wie die j{\"u}ngere EuGH-Rechtsprechung zeigt, durch eine am Sachproblem orientierte Anwendung inl{\"a}ndischer Drittschutzregeln zielgerichtet eingrenzen. Im europ{\"a}ischen Ideenwettbewerb ist das deutsche GmbH-Recht derweil deutlich zur{\"u}ckgefallen. Das liegt weniger an der vermeintlichen Dominanz des englischen Rechts als am Ideenreichtum der kleineren EU-Staaten, denen es mit gut durchdachten Reformprojekten gelingt, international Aufmerksamkeit auf sich zu ziehen.},
  language  = {de}
}
@article{Teichmann2017,
  author    = {Teichmann, Christoph},
  title     = {Die grenz{\"u}berschreitende Unternehmensgruppe im Compliance-Zeitalter},
  series = {Zeitschrift f{\"u}r Unternehmens- und Gesellschaftsrecht},
  volume    = {46},
  journal   = {Zeitschrift f{\"u}r Unternehmens- und Gesellschaftsrecht},
  number    = {4},
  issn      = {1612-7048},
  doi       = {10.1515/zgr-2017-0021},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-194940},
  pages     = {485 -- 508},
  year      = {2017},
  abstract  = {Die europ{\"a}ische Konzernorganisation und die „Europa GmbH" (SPE) bilden zwei wichtige Forschungsschwerpunkte im Werk von Peter Hommelhoff. Beide Projekte haben sich {\"u}ber die Jahre als außerordentlich dicke Bretter erwiesen. Doch davon l{\"a}sst sich der Jubilar nicht beirren. R{\"u}ckschl{\"a}ge und Umwege geh{\"o}ren in der Wissenschaft zum kollektiven Lernprozess, der neue Erkenntnisse bringt. Ganz in diesem Sinne m{\"u}nden die Erfahrungen aus der Diskussion um ein europ{\"a}isches Konzernrecht und um die SPE im vorliegenden Beitrag in die Konzeption eines supranationalen Konzernbausteins f{\"u}r europ{\"a}ische Unternehmensgruppen.},
  language  = {de}
}
@article{TawkSharanEulalioetal.2017,
  author    = {Tawk, Caroline and Sharan, Malvika and Eulalio, Ana and Vogel, J{\"o}rg},
  title     = {A systematic analysis of the RNA-targeting potential of secreted bacterial effector proteins},
  series = {Scientific Reports},
  volume    = {7},
  journal   = {Scientific Reports},
  doi       = {10.1038/s41598-017-09527-0},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-158815},
  pages     = {9328},
  year      = {2017},
  abstract  = {Many pathogenic bacteria utilize specialized secretion systems to deliver proteins called effectors into eukaryotic cells for manipulation of host pathways. The vast majority of known effector targets are host proteins, whereas a potential targeting of host nucleic acids remains little explored. There is only one family of effectors known to target DNA directly, and effectors binding host RNA are unknown. Here, we take a two-pronged approach to search for RNA-binding effectors, combining biocomputational prediction of RNA-binding domains (RBDs) in a newly assembled comprehensive dataset of bacterial secreted proteins, and experimental screening for RNA binding in mammalian cells. Only a small subset of effectors were predicted to carry an RBD, indicating that if RNA targeting was common, it would likely involve new types of RBDs. Our experimental evaluation of effectors with predicted RBDs further argues for a general paucity of RNA binding activities amongst bacterial effectors. We obtained evidence that PipB2 and Lpg2844, effector proteins of Salmonella and Legionella species, respectively, may harbor novel biochemical activities. Our study presenting the first systematic evaluation of the RNA-targeting potential of bacterial effectors offers a basis for discussion of whether or not host RNA is a prominent target of secreted bacterial proteins.},
  language  = {en}
}
@article{SanchezThierschmannMolenkamp2017,
  author    = {S{\´a}nchez, Rafael and Thierschmann, Holger and Molenkamp, Laurens W.},
  title     = {Single-electron thermal devices coupled to a mesoscopic gate},
  series = {New Journal of Physics},
  volume    = {19},
  journal   = {New Journal of Physics},
  doi       = {10.1088/1367-2630/aa8b94},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-172982},
  year      = {2017},
  abstract  = {We theoretically investigate the propagation of heat currents in a three-terminal quantum dot engine. Electron-electron interactions introduce state-dependent processes which can be resolved by energy-dependent tunneling rates. We identify the relevant transitions which define the operation of the system as a thermal transistor or a thermal diode. In the former case, thermal-induced charge fluctuations in the gate dot modify the thermal currents in the conductor with suppressed heat injection, resulting in huge amplification factors and the possible gating with arbitrarily low energy cost. In the latter case, enhanced correlations of the state-selective tunneling transitions redistribute heat flows giving high rectification coefficients and the unexpected cooling of one conductor terminal by heating the other one. We propose quantum dot arrays as a possible way to achieve the extreme tunneling asymmetries required for the different operations.},
  language  = {en}
}
@article{SyperekAndrzejewskiRudnoRudzińskietal.2017,
  author    = {Syperek, M. and Andrzejewski, J. and Rudno-Rudziński, W. and Maryński, A. and Sȩk, G. and Misiewicz, J. and Reithmaier, J. P. and Somers, A. and H{\"o}fling, S.},
  title     = {The issue of 0D-like ground state isolation in GaAs- and InP-based coupled quantum dots-quantum well systems},
  series = {Journal of Physics: Conference Series},
  volume    = {906},
  journal   = {Journal of Physics: Conference Series},
  number    = {1},
  issn      = {1742-6588},
  doi       = {10.1088/1742-6596/906/1/012019},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-262876},
  year      = {2017},
  abstract  = {The issue of quantum mechanical coupling between a semiconductor quantum dot and a quantum well is studied in two families of GaAs- and InP- based structures at cryogenic temperatures. It is shown that by tuning the quantum well parameters one can strongly disturb the 0D-character of the coupled system ground state, initially located in a dot. The out-coupling of either an electron or a hole state from the quantum dot confining potential is viewed by a significant elongation of the photoluminescence decay time constant. Band structure calculations show that in the GaAs-based coupled system at its ground state a hole remains isolated in the dot, whereas an electron gets delocalized towards the quantum well. The opposite picture is built for the ground state of a coupled system based on InP.},
  language  = {en}
}
@article{SunkavalliAguilarSilvaetal.2017,
  author    = {Sunkavalli, Ushasree and Aguilar, Carmen and Silva, Ricardo Jorge and Sharan, Malvika and Cruz, Ana Rita and Tawk, Caroline and Maudet, Claire and Mano, Miguel and Eulalio, Ana},
  title     = {Analysis of host microRNA function uncovers a role for miR-29b-2-5p in Shigella capture by filopodia},
  series = {PLoS Pathogens},
  volume    = {13},
  journal   = {PLoS Pathogens},
  number    = {4},
  doi       = {10.1371/journal.ppat.1006327},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-158204},
  pages     = {e1006327},
  year      = {2017},
  abstract  = {MicroRNAs play an important role in the interplay between bacterial pathogens and host cells, participating as host defense mechanisms, as well as exploited by bacteria to subvert host cellular functions. Here, we show that microRNAs modulate infection by Shigella flexneri, a major causative agent of bacillary dysentery in humans. Specifically, we characterize the dual regulatory role of miR-29b-2-5p during infection, showing that this microRNA strongly favors Shigella infection by promoting both bacterial binding to host cells and intracellular replication. Using a combination of transcriptome analysis and targeted high-content RNAi screening, we identify UNC5C as a direct target of miR-29b-2-5p and show its pivotal role in the modulation of Shigella binding to host cells. MiR-29b-2-5p, through repression of UNC5C, strongly enhances filopodia formation thus increasing Shigella capture and promoting bacterial invasion. The increase of filopodia formation mediated by miR-29b-2-5p is dependent on RhoF and Cdc42 Rho-GTPases. Interestingly, the levels of miR-29b-2-5p, but not of other mature microRNAs from the same precursor, are decreased upon Shigella replication at late times post-infection, through degradation of the mature microRNA by the exonuclease PNPT1. While the relatively high basal levels of miR-29b-2-5p at the start of infection ensure efficient Shigella capture by host cell filopodia, dampening of miR-29b-2-5p levels later during infection may constitute a bacterial strategy to favor a balanced intracellular replication to avoid premature cell death and favor dissemination to neighboring cells, or alternatively, part of the host response to counteract Shigella infection. Overall, these findings reveal a previously unappreciated role of microRNAs, and in particular miR-29b-2-5p, in the interaction of Shigella with host cells.},
  language  = {en}
}
@article{SuchomelBrodbeckLiewetal.2017,
  author    = {Suchomel, H. and Brodbeck, S. and Liew, T. C. H. and Amthor, M. and Klaas, M. and Klembt, S. and Kamp, M. and H{\"o}fling, S. and Schneider, C.},
  title     = {Prototype of a bistable polariton field-effect transistor switch},
  series = {Scientific Reports},
  volume    = {7},
  journal   = {Scientific Reports},
  number    = {5114},
  doi       = {10.1038/s41598-017-05277-1},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-158323},
  year      = {2017},
  abstract  = {Microcavity exciton polaritons are promising candidates to build a new generation of highly nonlinear and integrated optoelectronic devices. Such devices range from novel coherent light emitters to reconfigurable potential landscapes for electro-optical polariton-lattice based quantum simulators as well as building blocks of optical logic architectures. Especially for the latter, the strongly interacting nature of the light-matter hybrid particles has been used to facilitate fast and efficient switching of light by light, something which is very hard to achieve with weakly interacting photons. We demonstrate here that polariton transistor switches can be fully integrated in electro-optical schemes by implementing a one-dimensional polariton channel which is operated by an electrical gate rather than by a control laser beam. The operation of the device, which is the polariton equivalent to a field-effect transistor, relies on combining electro-optical potential landscape engineering with local exciton ionization to control the scattering dynamics underneath the gate. We furthermore demonstrate that our device has a region of negative differential resistance and features a completely new way to create bistable behavior.},
  language  = {en}
}
@article{StrohmeierMontenegro2017,
  author    = {Strohmeier, Michael and Montenegro, Sergio},
  title     = {Coupled GPS/MEMS IMU Attitude Determination of Small UAVs with COTS},
  series = {Electronics},
  volume    = {6},
  journal   = {Electronics},
  number    = {1},
  doi       = {10.3390/electronics6010015},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-171179},
  pages     = {15},
  year      = {2017},
  abstract  = {This paper proposes an attitude determination system for small Unmanned Aerial Vehicles (UAV) with a weight limit of 5 kg and a small footprint of 0.5m x 0.5 m. The system is realized by coupling single-frequency Global Positioning System (GPS) code and carrier-phase measurements with the data acquired from a Micro-Electro-Mechanical System (MEMS) Inertial Measurement Unit (IMU) using consumer-grade Components-Off-The-Shelf (COTS) only. The sensor fusion is accomplished using two Extended Kalman Filters (EKF) that are coupled by exchanging information about the currently estimated baseline. With a baseline of 48 cm, the static heading accuracy of the proposed system is comparable to the one of a commercial single-frequency GPS heading system with an accuracy of approximately 0.25°/m. Flight testing shows that the proposed system is able to obtain a reliable and stable GPS heading estimation without an aiding magnetometer.},
  language  = {en}
}
@article{StrasserSchrauthDembskietal.2017,
  author    = {Straßer, Marion and Schrauth, Joachim H. X. and Dembski, Sofia and Haddad, Daniel and Ahrens, Bernd and Schweizer, Stefan and Christ, Bastian and Cubukova, Alevtina and Metzger, Marco and Walles, Heike and Jakob, Peter M. and Sextl, Gerhard},
  title     = {Calcium fluoride based multifunctional nanoparticles for multimodal imaging},
  series = {Beilstein Journal of Nanotechnology},
  volume    = {8},
  journal   = {Beilstein Journal of Nanotechnology},
  doi       = {10.3762/bjnano.8.148},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-170657},
  pages     = {1484-1493},
  year      = {2017},
  abstract  = {New multifunctional nanoparticles (NPs) that can be used as contrast agents (CA) in different imaging techniques, such as photoluminescence (PL) microscopy and magnetic resonance imaging (MRI), open new possibilities for medical imaging, e.g., in the fields of diagnostics or tissue characterization in regenerative medicine. The focus of this study is on the synthesis and characterization of CaF\(_{2}\):(Tb\(^{3+}\),Gd\(^{3+}\)) NPs. Fabricated in a wet-chemical procedure, the spherical NPs with a diameter of 5-10 nm show a crystalline structure. Simultaneous doping of the NPs with different lanthanide ions, leading to paramagnetism and fluorescence, makes them suitable for MR and PL imaging. Owing to the Gd\(^{3+}\) ions on the surface, the NPs reduce the MR T\(_{1}\) relaxation time constant as a function of their concentration. Thus, the NPs can be used as a MRI CA with a mean relaxivity of about r = 0.471 mL·mg\(^{-1}\)·s\(^{-1}\). Repeated MRI examinations of four different batches prove the reproducibility of the NP synthesis and determine the long-term stability of the CAs. No cytotoxicity of NP concentrations between 0.5 and 1 mg·mL\(^{-1}\) was observed after exposure to human dermal fibroblasts over 24 h. Overall this study shows, that the CaF\(_{2}\):(Tb\(^{3+}\),Gd\(^{3+}\)) NPs are suitable for medical imaging.},
  language  = {en}
}
@article{StoevesandtHospKerstanetal.2017,
  author    = {Stoevesandt, Johanna and Hosp, Christine and Kerstan, Andreas and Trautmann, Axel},
  title     = {Safety of 100 µg venom immunotherapy rush protocols in children compared to adults},
  series = {Allergy, Asthma \& Clinical Immunology},
  volume    = {13},
  journal   = {Allergy, Asthma \& Clinical Immunology},
  number    = {32},
  doi       = {10.1186/s13223-017-0204-y},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-157830},
  year      = {2017},
  abstract  = {Background: There is a paucity of studies examining the safety of venom immunotherapy (VIT) in children. We aimed to assess the incidence of anaphylactic side effects during rush VIT in a cohort of pediatric patients and adult controls. Methods: 72 consecutive cycles of VIT-buildup in 71 children/adolescents aged 7-17 years were retrospectively evaluated and compared to an adult control group (n = 981) with regard to baseline parameters (sex, causative venom, severity of index sting reaction, results of allergy testing, comorbidities) and the incidence of anaphylactic adverse reactions. Results: Compared to adults, severe index sting-induced anaphylaxis was significantly less common in children (P = .001). Children were more likely to suffer from bee venom allergy (P < .001) and showed higher levels of bee venom-specific IgE (P = .013), but lower serum tryptase concentrations (P = .014). The overall rate of VIT-induced anaphylactic reactions was higher in children than in adults (6.9\% vs 2.5\%, P = .046 by univariate analysis). In the final binary logistic regression model, however, only bee VIT (P = .039; odds ratio 2.25; confidence interval 1.04-4.87) and 5-day compared to 3-day buildup protocols (P = .011; odds ratio 2.64; confidence interval 1.25-5.57) were associated with an increased risk of treatment-induced anaphylaxis. All pediatric patients finally reached and tolerated the target maintenance dose of 100 µg. Conclusions: The higher anaphylactic reaction rate observed in pediatric patients may be attributed to a greater prevalence of bee venom allergy. VIT-induced anaphylaxis in children is usually mild and does not affect further updosing and maintenance of VIT.},
  language  = {en}
}
@article{SteinbornHuestegge2017,
  author    = {Steinborn, Michael B. and Huestegge, Lynn},
  title     = {Phone conversation while processing information: chronometric analysis of load effects in everyday-media multitasking},
  series = {Frontiers in Psychology},
  volume    = {8},
  journal   = {Frontiers in Psychology},
  number    = {896},
  doi       = {10.3389/fpsyg.2017.00896},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-158253},
  year      = {2017},
  abstract  = {This is a pilot study that examined the effect of cell-phone conversation on cognition using a continuous multitasking paradigm. Current theorizing argues that phone conversation affects behavior (e.g., driving) by interfering at a level of cognitive processes (not peripheral activity) and by implying an attentional-failure account. Within the framework of an intermittent spare-utilized capacity threading model, we examined the effect of aspects of (secondary-task) phone conversation on (primary-task) continuous arithmetic performance, asking whether phone use makes components of automatic and controlled information-processing (i.e., easy vs. hard mental arithmetic) run more slowly, or alternatively, makes processing run less reliably albeit with the same processing speed. The results can be summarized as follows: While neither expecting a text message nor expecting an impending phone call had any detrimental effects on performance, active phone conversation was clearly detrimental to primary-task performance. Crucially, the decrement imposed by secondary-task (conversation) was not due to a constant slowdown but is better be characterized by an occasional breakdown of information processing, which differentially affected automatic and controlled components of primary-task processing. In conclusion, these findings support the notion that phone conversation makes individuals not constantly slower but more vulnerable to commit attention failure, and in this way, hampers stability of (primary-task) information processing.},
  language  = {en}
}
@article{SteinCoulibalyStenchlyetal.2017,
  author    = {Stein, Katharina and Coulibaly, Drissa and Stenchly, Kathrin and Goetze, Dethardt and Porembski, Stefan and Lindner, Andr{\´e} and Konat{\´e}, Souleymane and Linsenmair, Eduard K.},
  title     = {Bee pollination increases yield quantity and quality of cash crops in Burkina Faso, West Africa},
  series = {Scientific Reports},
  volume    = {7},
  journal   = {Scientific Reports},
  number    = {17691},
  doi       = {10.1038/s41598-017-17970-2},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-169914},
  year      = {2017},
  abstract  = {Mutualistic biotic interactions as among flowering plants and their animal pollinators are a key component of biodiversity. Pollination, especially by insects, is a key element in ecosystem functioning, and hence constitutes an ecosystem service of global importance. Not only sexual reproduction of plants is ensured, but also yields are stabilized and genetic variability of crops is maintained, counteracting inbreeding depression and facilitating system resilience. While experiencing rapid environmental change, there is an increased demand for food and income security, especially in sub-Saharan communities, which are highly dependent on small scale agriculture. By combining exclusion experiments, pollinator surveys and field manipulations, this study for the first time quantifies the contribution of bee pollinators to smallholders' production of the major cash crops, cotton and sesame, in Burkina Faso. Pollination by honeybees and wild bees significantly increased yield quantity and quality on average up to 62\%, while exclusion of pollinators caused an average yield gap of 37\% in cotton and 59\% in sesame. Self-pollination revealed inbreeding depression effects on fruit set and low germination rates in the F1-generation. Our results highlight potential negative consequences of any pollinator decline, provoking risks to agriculture and compromising crop yields in sub-Saharan West Africa.},
  language  = {en}
}
@article{SteijvenSpaetheSteffanDewenteretal.2017,
  author    = {Steijven, Karin and Spaethe, Johannes and Steffan-Dewenter, Ingolf and H{\"a}rtel, Stephan},
  title     = {Learning performance and brain structure of artificially-reared honey bees fed with different quantities of food},
  series = {PeerJ},
  volume    = {5},
  journal   = {PeerJ},
  number    = {e3858},
  doi       = {10.7717/peerj.3858},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-170137},
  year      = {2017},
  abstract  = {Background Artificial rearing of honey bee larvae is an established method which enables to fully standardize the rearing environment and to manipulate the supplied diet to the brood. However, there are no studies which compare learning performance or neuroanatomic differences of artificially-reared (in-lab) bees in comparison with their in-hive reared counterparts. Methods Here we tested how different quantities of food during larval development affect body size, brain morphology and learning ability of adult honey bees. We used in-lab rearing to be able to manipulate the total quantity of food consumed during larval development. After hatching, a subset of the bees was taken for which we made 3D reconstructions of the brains using confocal laser-scanning microscopy. Learning ability and memory formation of the remaining bees was tested in a differential olfactory conditioning experiment. Finally, we evaluated how bees reared with different quantities of artificial diet compared to in-hive reared bees. Results Thorax and head size of in-lab reared honey bees, when fed the standard diet of 160 µl or less, were slightly smaller than hive bees. The brain structure analyses showed that artificially reared bees had smaller mushroom body (MB) lateral calyces than their in-hive counterparts, independently of the quantity of food they received. However, they showed the same total brain size and the same associative learning ability as in-hive reared bees. In terms of mid-term memory, but not early long-term memory, they performed even better than the in-hive control. Discussion We have demonstrated that bees that are reared artificially (according to the Aupinel protocol) and kept in lab-conditions perform the same or even better than their in-hive sisters in an olfactory conditioning experiment even though their lateral calyces were consistently smaller at emergence. The applied combination of experimental manipulation during the larval phase plus subsequent behavioral and neuro-anatomic analyses is a powerful tool for basic and applied honey bee research.},
  language  = {en}
}
@article{StegnervanEeuwijkAngayetal.2017,
  author    = {Stegner, David and van Eeuwijk, Judith M.M. and Angay, Oğuzhan and Gorelashvili, Maximilian G. and Semeniak, Daniela and Pinnecker, J{\"u}rgen and Schmithausen, Patrick and Meyer, Imke and Friedrich, Mike and D{\"u}tting, Sebastian and Brede, Christian and Beilhack, Andreas and Schulze, Harald and Nieswandt, Bernhard and Heinze, Katrin G.},
  title     = {Thrombopoiesis is spatially regulated by the bone marrow vasculature},
  series = {Nature Communications},
  volume    = {8},
  journal   = {Nature Communications},
  number    = {127},
  doi       = {10.1038/s41467-017-00201-7},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-170591},
  year      = {2017},
  abstract  = {In mammals, megakaryocytes (MKs) in the bone marrow (BM) produce blood platelets, required for hemostasis and thrombosis. MKs originate from hematopoietic stem cells and are thought to migrate from an endosteal niche towards the vascular sinusoids during their maturation. Through imaging of MKs in the intact BM, here we show that MKs can be found within the entire BM, without a bias towards bone-distant regions. By combining in vivo two-photon microscopy and in situ light-sheet fluorescence microscopy with computational simulations, we reveal surprisingly slow MK migration, limited intervascular space, and a vessel-biased MK pool. These data challenge the current thrombopoiesis model of MK migration and support a modified model, where MKs at sinusoids are replenished by sinusoidal precursors rather than cells from a distant periostic niche. As MKs do not need to migrate to reach the vessel, therapies to increase MK numbers might be sufficient to raise platelet counts.},
  language  = {en}
}
@article{SperlichWallmannSperlichZinneretal.2017,
  author    = {Sperlich, Billy and Wallmann-Sperlich, Birgit and Zinner, Christoph and Von Stauffenberg, Valerie and Losert, Helena and Holmberg, Hans-Christer},
  title     = {Functional High-intensity Circuit Training Improves Body Composition,Peak Oxygen Uptake, Strength, and Alters Certain Dimensions of Quality of Life in Overweight Women},
  series = {Frontiers in Physiology},
  volume    = {8},
  journal   = {Frontiers in Physiology},
  number    = {172},
  doi       = {10.3389/fphys.2017.00172},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-171015},
  year      = {2017},
  abstract  = {The effects of circuit-like functional high-intensity training (Circuit\(_{HIIT}\)) alone or in combination with high-volume low-intensity exercise (Circuit\(_{combined}\)) on selected cardio-respiratory and metabolic parameters, body composition, functional strength and the quality of life of overweight women were compared. In this single-center, two-armed randomized, controlled study, overweight women performed 9-weeks (3 sessions·wk\(^{-1}\)) of either Circuit\(_{HIIT}\) (n = 11), or Circuit\(_{combined}\) (n = 8). Peak oxygen uptake and perception of physical pain were increased to a greater extent (p < 0.05) by Circuit\(_{HIIT}\), whereas Circuit\(_{combined}\) improved perception of general health more (p < 0.05). Both interventions lowered body mass, body-mass-index, waist-to-hip ratio, fat mass, and enhanced fat-free mass; decreased ratings of perceived exertion during submaximal treadmill running; improved the numbers of push-ups, burpees, one-legged squats, and 30-s skipping performed, as well as the height of counter-movement jumps; and improved physical and social functioning, role of physical limitations, vitality, role of emotional limitations, and mental health to a similar extent (all p < 0.05). Either forms of these multi-stimulating, circuit-like, multiple-joint training can be employed to improve body composition, selected variables of functional strength, and certain dimensions of quality of life in overweight women. However, Circuit\(_{HIIT}\) improves peak oxygen uptake to a greater extent, but with more perception of pain, whereas Circuit\(_{Combined}\) results in better perception of general health.},
  language  = {en}
}
@article{SperlichHolmberg2017,
  author    = {Sperlich, Billy and Holmberg, Hans-Christer},
  title     = {The responses of elite athletes to exercise: an all-day, 24-h integrative view is required!},
  series = {Frontiers in Physiology},
  volume    = {8},
  journal   = {Frontiers in Physiology},
  number    = {564},
  doi       = {10.3389/fphys.2017.00564},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-158655},
  year      = {2017},
  abstract  = {No abstract available.},
  language  = {en}
}
@article{SperlichDuekingHolmberg2017,
  author    = {Sperlich, Billy and D{\"u}king, Peter and Holmberg, Hans-Christer},
  title     = {A SWOT analysis of the use and potential misuse of implantable monitoring devices by athletes},
  series = {Frontiers in Physiology},
  volume    = {8},
  journal   = {Frontiers in Physiology},
  number    = {629},
  doi       = {10.3389/fphys.2017.00629},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-158742},
  year      = {2017},
  abstract  = {Kein Abstract vorhanden.},
  language  = {en}
}
@article{SperlichBeckerHothoetal.2017,
  author    = {Sperlich, Billy and Becker, Martin and Hotho, Andreas and Wallmann-Sperlich, Birgit and Sareban, Mahdi and Winkert, Kay and Steinacker, J{\"u}rgen M. and Treff, Gunnar},
  title     = {Sedentary behavior among national elite rowers during off-training — a pilot study},
  series = {Frontiers in Physiology},
  volume    = {8},
  journal   = {Frontiers in Physiology},
  number    = {655},
  doi       = {10.3389/fphys.2017.00655},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-158753},
  year      = {2017},
  abstract  = {The aim of this pilot study was to analyze the off-training physical activity (PA) profile in national elite German U23 rowers during 31 days of their preparation period. The hours spent in each PA category (i.e., sedentary: <1.5 metabolic equivalents (MET); light physical activity: 1.5-3 MET; moderate physical activity: 3-6 MET and vigorous intense physical activity: >6 MET) were calculated for every valid day (i.e., >480 min of wear time). The off-training PA during 21 weekdays and 10 weekend days of the final 11-week preparation period was assessed by the wrist-worn multisensory device Microsoft Band II (MSBII). A total of 11 rowers provided valid data (i.e., >480 min/day) for 11.6 week days and 4.8 weekend days during the 31 days observation period. The average sedentary time was 11.63 ± 1.25 h per day during the week and 12.49 ± 1.10 h per day on the weekend, with a tendency to be higher on the weekend compared to weekdays (p = 0.06; d = 0.73). The average time in light, moderate and vigorous PA during the weekdays was 1.27 ± 1.15, 0.76 ± 0.37, 0.51 ± 0.44 h per day, and 0.67 ± 0.43, 0.59 ± 0.37, 0.53 ± 0.32 h per weekend day. Light physical activity was higher during weekdays compared to the weekend (p = 0.04; d = 0.69). Based on our pilot study of 11 national elite rowers we conclude that rowers display a considerable sedentary off-training behavior of more than 11.5 h/day.},
  language  = {en}
}
@article{Soder2017,
  author    = {Soder, Lisa},
  title     = {An den Grenzen der Pragmatik},
  series = {Zeitschrift f{\"u}r germanistische Linguistik},
  volume    = {45},
  journal   = {Zeitschrift f{\"u}r germanistische Linguistik},
  number    = {3},
  issn      = {1613-0626},
  doi       = {10.1515/zgl-2017-0024},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-195413},
  pages     = {428-434},
  year      = {2017},
  abstract  = {Kein Abstract verf{\"u}gbar.},
  language  = {de}
}
@article{SkryabinKartashovEgorovetal.2017,
  author    = {Skryabin, D.V. and Kartashov, Y.V. and Egorov, O.A. and Sich, M. and Chana, J.K. and Tapia Rodriguez, L.E. and Walker, P.M. and Clarke, E. and Royall, B. and Skolnick, M.S. and Krizhanovskii, D.N.},
  title     = {Backward Cherenkov radiation emitted by polariton solitons in a microcavity wire},
  series = {Nature Communications},
  volume    = {8},
  journal   = {Nature Communications},
  doi       = {10.1038/s41467-017-01751-6},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-173046},
  year      = {2017},
  abstract  = {Exciton-polaritons in semiconductor microcavities form a highly nonlinear platform to study a variety of effects interfacing optical, condensed matter, quantum and statistical physics. We show that the complex polariton patterns generated by picosecond pulses in microcavity wire waveguides can be understood as the Cherenkov radiation emitted by bright polariton solitons, which is enabled by the unique microcavity polariton dispersion, which has momentum intervals with positive and negative group velocities. Unlike in optical fibres and semiconductor waveguides, we observe that the microcavity wire Cherenkov radiation is predominantly emitted with negative group velocity and therefore propagates backwards relative to the propagation direction of the emitting soliton. We have developed a theory of the microcavity wire polariton solitons and of their Cherenkov radiation and conducted a series of experiments, where we have measured polariton-soliton pulse compression, pulse breaking and emission of the backward Cherenkov radiation.},
  language  = {en}
}
@article{SilvaVilchesPletinckxLohnertetal.2017,
  author    = {Silva-Vilches, Cinthia and Pletinckx, Katrien and Lohnert, Miriam and Pavlovic, Vladimir and Ashour, Diyaaeldin and John, Vini and Vendelova, Emilia and Kneitz, Susanne and Zhou, Jie and Chen, Rena and Reinheckel, Thomas and Mueller, Thomas D. and Bodem, Jochen and Lutz, Manfred B.},
  title     = {Low doses of cholera toxin and its mediator cAMP induce CTLA-2 secretion by dendritic cells to enhance regulatory T cell conversion},
  series = {PLoS ONE},
  volume    = {12},
  journal   = {PLoS ONE},
  number    = {7},
  doi       = {10.1371/journal.pone.0178114},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-158244},
  pages     = {e0178114},
  year      = {2017},
  abstract  = {Immature or semi-mature dendritic cells (DCs) represent tolerogenic maturation stages that can convert naive T cells into Foxp3\(^{+}\) induced regulatory T cells (iTreg). Here we found that murine bone marrow-derived DCs (BM-DCs) treated with cholera toxin (CT) matured by up-regulating MHC-II and costimulatory molecules using either high or low doses of CT (CT\(^{hi}\), CT\(^{lo}\)) or with cAMP, a known mediator CT signals. However, all three conditions also induced mRNA of both isoforms of the tolerogenic molecule cytotoxic T lymphocyte antigen 2 (CTLA-2α and CTLA-2β). Only DCs matured under CT\(^{hi}\) conditions secreted IL-1β, IL-6 and IL-23 leading to the instruction of Th17 cell polarization. In contrast, CT\(^{lo}\)- or cAMP-DCs resembled semi-mature DCs and enhanced TGF-β-dependent Foxp3\(^{+}\) iTreg conversion. iTreg conversion could be reduced using siRNA blocking of CTLA-2 and reversely, addition of recombinant CTLA-2α increased iTreg conversion in vitro. Injection of CT\(^{lo}\)- or cAMP-DCs exerted MOG peptide-specific protective effects in experimental autoimmune encephalomyelitis (EAE) by inducing Foxp3\(^{+}\) Tregs and reducing Th17 responses. Together, we identified CTLA-2 production by DCs as a novel tolerogenic mediator of TGF-β-mediated iTreg induction in vitro and in vivo. The CT-induced and cAMP-mediated up-regulation of CTLA-2 also may point to a novel immune evasion mechanism of Vibrio cholerae.},
  language  = {en}
}
@article{ShityakovRoewerFoersteretal.2017,
  author    = {Shityakov, Sergey and Roewer, Norbert and F{\"o}rster, Carola and Broscheit, Jens-Albert},
  title     = {In silico modeling of indigo and Tyrian purple single-electron nano-transistors using density functional theory approach},
  series = {Nanoscale Research Letters},
  volume    = {12},
  journal   = {Nanoscale Research Letters},
  number    = {439},
  doi       = {10.1186/s11671-017-2193-7},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-158332},
  year      = {2017},
  abstract  = {The purpose of this study was to develop and implement an in silico model of indigoid-based single-electron transistor (SET) nanodevices, which consist of indigoid molecules from natural dye weakly coupled to gold electrodes that function in a Coulomb blockade regime. The electronic properties of the indigoid molecules were investigated using the optimized density-functional theory (DFT) with a continuum model. Higher electron transport characteristics were determined for Tyrian purple, consistent with experimentally derived data. Overall, these results can be used to correctly predict and emphasize the electron transport functions of organic SETs, demonstrating their potential for sustainable nanoelectronics comprising the biodegradable and biocompatible materials.},
  language  = {en}
}
@article{ShibanDiemerMuelleretal.2017,
  author    = {Shiban, Youssef and Diemer, Julia and M{\"u}ller, Jana and Br{\"u}tting-Schick, Johanna and Pauli, Paul and M{\"u}hlberger, Andreas},
  title     = {Diaphragmatic breathing during virtual reality exposure therapy for aviophobia: functional coping strategy or avoidance behavior? A pilot study},
  series = {BMC Psychiatry},
  volume    = {17},
  journal   = {BMC Psychiatry},
  doi       = {10.1186/s12888-016-1181-2},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-181007},
  pages     = {10},
  year      = {2017},
  abstract  = {Background: Although there is solid evidence for the efficacy of in vivo and virtual reality (VR) exposure therapy for a specific phobia, there is a significant debate over whether techniques promoting distraction or relaxation have impairing or enhancing effects on treatment outcome. In the present pilot study, we investigated the effect of diaphragmatic breathing (DB) as a relaxation technique during VR exposure treatment. Method: Twenty-nine patients with aviophobia were randomly assigned to VR exposure treatment either with or without diaphragmatic breathing (six cycles per minute). Subjective fear ratings, heart rate and skin conductance were assessed as indicators of fear during both the exposure and the test session one week later. Results: The group that experienced VR exposure combined with diaphragmatic breathing showed a higher tendency to effectively overcome the fear of flying. Psychophysiological measures of fear decreased and self-efficacy increased in both groups with no significant difference between the groups. Conclusions: Our findings indicate that diaphragmatic breathing during VR exposure does not interfere with the treatment outcome and may even enhance treatment effects of VR exposure therapy for aviophobic patients.},
  language  = {en}
}
@article{Shehata2017,
  author    = {Shehata, Dahlia},
  title     = {Eine mannshohe Leier im altbabylonischen Ištar-Ritual aus Mari (FM 3, no. 2)},
  series = {Altorientalische Forschungen},
  volume    = {44},
  journal   = {Altorientalische Forschungen},
  number    = {1},
  issn      = {2196-6761},
  doi       = {10.1515/aofo-2017-0008},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-195422},
  pages     = {68-81},
  year      = {2017},
  abstract  = {The Old Babylonian Ištar ritual from Mari (FM 3, no. 2) has been the focus of much discussion since its primary edition in 1938 by G. Dossin. This article offers a new analysis of the passage mentioning the balaĝ-deity Ninigizibara, which leads to identifying this balaĝ as a huge upright lyre as tall as a human played by two persons from both sides. Similar musical instruments are known from Anatolia and Egypt. Especially the Egyptian examples, which are attested only for the time of Echnaton, show striking parallels to the musical performance described in the Old Babylonian Ištar ritual. After discussing the possible background of cultural exchange, this article closes with a revaluation and new interpretation of the term balaĝ.},
  language  = {de}
}
@article{SharanFoerstnerEulalioetal.2017,
  author    = {Sharan, Malvika and F{\"o}rstner, Konrad U. and Eulalio, Ana and Vogel, J{\"o}rg},
  title     = {APRICOT: an integrated computational pipeline for the sequence-based identification and characterization of RNA-binding proteins},
  series = {Nucleic Acids Research},
  volume    = {45},
  journal   = {Nucleic Acids Research},
  number    = {11},
  doi       = {10.1093/nar/gkx137},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-157963},
  pages     = {e96},
  year      = {2017},
  abstract  = {RNA-binding proteins (RBPs) have been established as core components of several post-transcriptional gene regulation mechanisms. Experimental techniques such as cross-linking and co-immunoprecipitation have enabled the identification of RBPs, RNA-binding domains (RBDs) and their regulatory roles in the eukaryotic species such as human and yeast in large-scale. In contrast, our knowledge of the number and potential diversity of RBPs in bacteria is poorer due to the technical challenges associated with the existing global screening approaches. We introduce APRICOT, a computational pipeline for the sequence-based identification and characterization of proteins using RBDs known from experimental studies. The pipeline identifies functional motifs in protein sequences using position-specific scoring matrices and Hidden Markov Models of the functional domains and statistically scores them based on a series of sequence-based features. Subsequently, APRICOT identifies putative RBPs and characterizes them by several biological properties. Here we demonstrate the application and adaptability of the pipeline on large-scale protein sets, including the bacterial proteome of Escherichia coli. APRICOT showed better performance on various datasets compared to other existing tools for the sequence-based prediction of RBPs by achieving an average sensitivity and specificity of 0.90 and 0.91 respectively. The command-line tool and its documentation are available at https://pypi.python.org/pypi/bio-apricot.},
  language  = {en}
}
@article{ShamimMahapatraScappuccietal.2017,
  author    = {Shamim, Saquib and Mahapatra, S. and Scappucci, G. and Klesse, W. M. and Simmons, M. Y. and Ghosh, Arindam},
  title     = {Dephasing rates for weak localization and universal conductance fluctuations in two dimensional Si: P and Ge: P δ-layers},
  series = {Scientific Reports},
  volume    = {7},
  journal   = {Scientific Reports},
  number    = {46670},
  doi       = {10.1038/srep46670},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-170934},
  year      = {2017},
  abstract  = {We report quantum transport measurements on two dimensional (2D) Si:P and Ge:P δ-layers and compare the inelastic scattering rates relevant for weak localization (WL) and universal conductance fluctuations (UCF) for devices of various doping densities (0.3-2.5 × 10\(^{18}\)m\(^{-2}\)) at low temperatures (0.3-4.2 K). The phase breaking rate extracted experimentally from measurements of WL correction to conductivity and UCF agree well with each other within the entire temperature range. This establishes that WL and UCF, being the outcome of quantum interference phenomena, are governed by the same dephasing rate.},
  language  = {en}
}
@article{ShadyElHossaryFouadetal.2017,
  author    = {Shady, Nourhan Hisham and El-Hossary, Ebaa M. and Fouad, Mostafa A. and Gulder, Tobias A. M. and Kamel, Mohamed Salah and Abdelmohsen, Usama Ramadan},
  title     = {Bioactive natural products of marine sponges from the Genus Hyrtios},
  series = {Molecules},
  volume    = {22},
  journal   = {Molecules},
  number    = {5},
  doi       = {10.3390/molecules22050781},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-158227},
  pages     = {781},
  year      = {2017},
  abstract  = {Marine sponges are known as a rich source for novel bioactive compounds with valuable pharmacological potential. One of the most predominant sponge genera is Hyrtios, reported to have various species such as Hyrtios erectus, Hyrtios reticulatus, Hyrtios gumminae, Hyrtios communis, and Hyrtios tubulatus and a number of undescribed species. Members of the genus Hyrtios are a rich source of natural products with diverse and valuable biological activities, represented by different chemical classes including alkaloids, sesterterpenes and sesquiterpenes. This review covers the literature until June 2016, providing a complete survey of all compounds isolated from the genus Hyrtios with their corresponding biological activities whenever applicable.},
  language  = {en}
}
@article{SelchoMillanPalaciosMunozetal.2017,
  author    = {Selcho, Mareike and Mill{\´a}n, Carola and Palacios-Mu{\~n}oz, Angelina and Ruf, Franziska and Ubillo, Lilian and Chen, Jiangtian and Bergmann, Gregor and Ito, Chihiro and Silva, Valeria and Wegener, Christian and Ewer, John},
  title     = {Central and peripheral clocks are coupled by a neuropeptide pathway in Drosophila},
  series = {Nature Communications},
  volume    = {8},
  journal   = {Nature Communications},
  number    = {15563},
  doi       = {10.1038/ncomms15563},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-170831},
  year      = {2017},
  abstract  = {Animal circadian clocks consist of central and peripheral pacemakers, which are coordinated to produce daily rhythms in physiology and behaviour. Despite its importance for optimal performance and health, the mechanism of clock coordination is poorly understood. Here we dissect the pathway through which the circadian clock of Drosophila imposes daily rhythmicity to the pattern of adult emergence. Rhythmicity depends on the coupling between the brain clock and a peripheral clock in the prothoracic gland (PG), which produces the steroid hormone, ecdysone. Time information from the central clock is transmitted via the neuropeptide, sNPF, to non-clock neurons that produce the neuropeptide, PTTH. These secretory neurons then forward time information to the PG clock. We also show that the central clock exerts a dominant role on the peripheral clock. This use of two coupled clocks could serve as a paradigm to understand how daily steroid hormone rhythms are generated in animals.},
  language  = {en}
}
@article{SeherLaglerStuehmeretal.2017,
  author    = {Seher, Axel and Lagler, Charlotte and St{\"u}hmer, Thorsten and M{\"u}ller-Richter, Urs Dietmar Achim and K{\"u}bler, Alexander Christian and Sebald, Walter and M{\"u}ller, Thomas Dieter and Nickel, Joachim},
  title     = {Utilizing BMP-2 muteins for treatment of multiple myeloma},
  series = {PLoS ONE},
  volume    = {12},
  journal   = {PLoS ONE},
  number    = {5},
  doi       = {10.1371/journal.pone.0174884},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-158144},
  pages     = {e0174884},
  year      = {2017},
  abstract  = {Multiple myeloma (MM) represents a haematological cancer characterized by the pathological hyper proliferation of antibody-producing B-lymphocytes. Patients typically suffer from kidney malfunction and skeletal disorders. In the context of MM, the transforming growth factor β (TGFβ) member Activin A was recently identified as a promoter of both accompanying symptoms. Because studies have shown that bone morphogenetic protein (BMP)-2-mediated activities are counteracted by Activin A, we analysed whether BMP2, which also binds to the Activin A receptors ActRII and ActRIIB but activates the alternative SMAD-1/5/8 pathway, can be used to antagonize Activin A activities, such as in the context of MM. Therefore three BMP2 derivatives were generated with modified binding activities for the type II (ActRIIB) and/or type I receptor (BMPRIA) showing either increased or decreased BMP2 activity. In the context of MM these BMP2 muteins show two functionalities since they act as a) an anti-proliferative/apoptotic agent against neoplastic B-cells, b) as a bone-formation promoting growth factor. The molecular basis of both activities was shown in two different cellular models to clearly rely on the properties of the investigated BMP2 muteins to compete for the binding of Activin A to the Activin type II receptors. The experimental outcome suggests new therapeutic strategies using BMP2 variants in the treatment of MM-related pathologies.},
  language  = {en}
}
@article{SchoeneggeGallionPicardetal.2017,
  author    = {Sch{\"o}negge, Anne-Marie and Gallion, Jonathan and Picard, Louis-Philippe and Wilkins, Angela D. and Le Gouill, Christian and Audet, Martin and Stallaert, Wayne and Lohse, Martin J. and Kimmel, Marek and Lichtarge, Olivier and Bouvier, Michel},
  title     = {Evolutionary action and structural basis of the allosteric switch controlling β\(_2\)AR functional selectivity},
  series = {Nature Communications},
  volume    = {8},
  journal   = {Nature Communications},
  doi       = {10.1038/s41467-017-02257-x},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-172268},
  year      = {2017},
  abstract  = {Functional selectivity of G-protein-coupled receptors is believed to originate from ligand-specific conformations that activate only subsets of signaling effectors. In this study, to identify molecular motifs playing important roles in transducing ligand binding into distinct signaling responses, we combined in silico evolutionary lineage analysis and structure-guided site-directed mutagenesis with large-scale functional signaling characterization and non-negative matrix factorization clustering of signaling profiles. Clustering based on the signaling profiles of 28 variants of the β\(_2\)-adrenergic receptor reveals three clearly distinct phenotypical clusters, showing selective impairments of either the Gi or βarrestin/endocytosis pathways with no effect on Gs activation. Robustness of the results is confirmed using simulation-based error propagation. The structural changes resulting from functionally biasing mutations centered around the DRY, NPxxY, and PIF motifs, selectively linking these micro-switches to unique signaling profiles. Our data identify different receptor regions that are important for the stabilization of distinct conformations underlying functional selectivity.},
  language  = {en}
}
@article{SchaeferBauerDonhauseretal.2017,
  author    = {Sch{\"a}fer, Kristina and Bauer, Boris and Donhauser, Julian and Kerstan, Andreas and Hamm, Henning},
  title     = {Becker Naevus Syndrome of the Lower Body: A New Case and Review of the Literature},
  series = {Acta Dermato-Venereologica},
  volume    = {97},
  journal   = {Acta Dermato-Venereologica},
  number    = {4},
  doi       = {10.2340/00015555-2589},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-171057},
  pages     = {499-504},
  year      = {2017},
  abstract  = {Becker naevus syndrome is a rare epidermal naevus syndrome defined by the co-occurrence of a Becker naevus with various cutaneous, muscular and skeletal anomalies. In the majority of cases, abnormalities exclusively consist of ipsilateral hypoplasia of the breast, areola and/or nipple in addition to the naevus. Here, we report on a 42-year-old woman with an extensive Becker naevus reaching from the left buttock to the left calf verified on histological examination. In addition, there was marked hypoplasia of the fatty tissue of the left thigh confirmed by magnetic resonance imaging in contrast to hyperplasia of the fatty tissue of the left gluteal area. Underlying muscles and bones were not affected. There was no difference in leg lengths. In addition, we review and discuss the features of Becker naevus syndrome with emphasis on 10 reported cases with involvement of the lower body.},
  language  = {en}
}
@article{Schaefer2017,
  author    = {Sch{\"a}fer, Elena},
  title     = {Veo veo. ?'Qu{\´e} ves? Durch H{\"o}r-Seh-Verstehen zu Mehrsprachigkeitskompetenz},
  series = {promptus - W{\"u}rzburger Beitr{\"a}ge zur Romanistik},
  volume    = {3},
  journal   = {promptus - W{\"u}rzburger Beitr{\"a}ge zur Romanistik},
  issn      = {2510-2613},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-172946},
  pages     = {183-201},
  year      = {2017},
  abstract  = {Multilingualism is part of our everyday lives and has recently entered the medium of film. Based on the linguistic diversity of Spanish-speaking countries, the present paper explores multilingualism as a key competence of foreign language learning. Since film provides students with audiovisual access to multilingual situations, a selection of educational videos that form parts of German textbooks will be critically explored concerning the presentation of multilingual phenomena. The results will be discussed in order to contribute to the systematic acquisition of multilingual skills in the sense of language and cultural awareness during classroom learning.},
  language  = {de}
}
@article{SchwabMeeuwsenEhlickeetal.2017,
  author    = {Schwab, Andrea and Meeuwsen, Annick and Ehlicke, Franziska and Hansmann, Jan and Mulder, Lars and Smits, Anthal and Walles, Heike and Kock, Linda},
  title     = {Ex vivo culture platform for assessment of cartilage repair treatment strategies},
  series = {ALTEX - Alternatives to animal experimentation},
  volume    = {34},
  journal   = {ALTEX - Alternatives to animal experimentation},
  number    = {2},
  doi       = {10.14573/altex.1607111},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-181665},
  pages     = {267-277},
  year      = {2017},
  abstract  = {There is a great need for valuable ex vivo models that allow for assessment of cartilage repair strategies to reduce the high number of animal experiments. In this paper we present three studies with our novel ex vivo osteochondral culture platform. It consists of two separated media compartments for cartilage and bone, which better represents the in vivo situation and enables supply of factors pecific to the different needs of bone and cartilage. We investigated whether separation of the cartilage and bone compartments and/or culture media results in the maintenance of viability, structural and functional properties of cartilage tissue. Next, we valuated for how long we can preserve cartilage matrix stability of osteochondral explants during long-term culture over 84 days. Finally, we determined the optimal defect size that does not show spontaneous self-healing in this culture system. It was demonstrated that separated compartments for cartilage and bone in combination with tissue-specific medium allow for long-term culture of osteochondral explants while maintaining cartilage viability, atrix tissue content, structure and mechanical properties for at least 56 days. Furthermore, we could create critical size cartilage defects of different sizes in the model. The osteochondral model represents a valuable preclinical ex vivo tool for studying clinically relevant cartilage therapies, such as cartilage biomaterials, for their regenerative potential, for evaluation of drug and cell therapies, or to study mechanisms of cartilage regeneration. It will undoubtedly reduce the number of animals needed for in vivotesting.},
  language  = {en}
}
@article{SchusterKruegerSubotaetal.2017,
  author    = {Schuster, Sarah and Kr{\"u}ger, Timothy and Subota, Ines and Thusek, Sina and Rotureau, Brice and Beilhack, Andreas and Engstler, Markus},
  title     = {Developmental adaptations of trypanosome motility to the tsetse fly host environments unravel a multifaceted in vivo microswimmer system},
  series = {eLife},
  volume    = {6},
  journal   = {eLife},
  doi       = {10.7554/eLife.27656},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-158662},
  pages     = {e27656},
  year      = {2017},
  abstract  = {The highly motile and versatile protozoan pathogen Trypanosoma brucei undergoes a complex life cycle in the tsetse fly. Here we introduce the host insect as an expedient model environment for microswimmer research, as it allows examination of microbial motion within a diversified, secluded and yet microscopically tractable space. During their week-long journey through the different microenvironments of the fly´s interior organs, the incessantly swimming trypanosomes cross various barriers and confined surroundings, with concurrently occurring major changes of parasite cell architecture. Multicolour light sheet fluorescence microscopy provided information about tsetse tissue topology with unprecedented resolution and allowed the first 3D analysis of the infection process. High-speed fluorescence microscopy illuminated the versatile behaviour of trypanosome developmental stages, ranging from solitary motion and near-wall swimming to collective motility in synchronised swarms and in confinement. We correlate the microenvironments and trypanosome morphologies to high-speed motility data, which paves the way for cross-disciplinary microswimmer research in a naturally evolved environment.},
  language  = {en}
}
@article{SchulzRuppertHermsetal.2017,
  author    = {Schulz, Herbert and Ruppert, Ann-Kathrin and Herms, Stefan and Wolf, Christiane and Mirza-Schreiber, Nazanin and Stegle, Oliver and Czamara, Darina and Forstner, Andreas J. and Sivalingam, Sugirthan and Schoch, Susanne and Moebus, Susanne and P{\"u}tz, Benno and Hillmer, Axel and Fricker, Nadine and Vatter, Hartmut and M{\"u}ller-Myhsok, Bertram and N{\"o}then, Markus M. and Becker, Albert J. and Hoffmann, Per and Sander, Thomas and Cichon, Sven},
  title     = {Genome-wide mapping of genetic determinants influencing DNA methylation and gene expression in human hippocampus},
  series = {Nature Communications},
  volume    = {8},
  journal   = {Nature Communications},
  doi       = {10.1038/s41467-017-01818-4},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-173168},
  year      = {2017},
  abstract  = {Emerging evidence emphasizes the strong impact of regulatory genomic elements in neurodevelopmental processes and the complex pathways of brain disorders. The present genome-wide quantitative trait loci analyses explore the \(cis\)-regulatory effects of single-nucleotide polymorphisms (SNPs) on DNA methylation (meQTL) and gene expression (eQTL) in 110 human hippocampal biopsies. We identify \(cis\)-meQTLs at 14,118 CpG methylation sites and \(cis\)-eQTLs for 302 3′-mRNA transcripts of 288 genes. Hippocampal \(cis\)-meQTL-CpGs are enriched in flanking regions of active promoters, CpG island shores, binding sites of the transcription factor CTCF and brain eQTLs. \(Cis\)-acting SNPs of hippocampal meQTLs and eQTLs significantly overlap schizophrenia-associated SNPs. Correlations of CpG methylation and RNA expression are found for 34 genes. Our comprehensive maps of \(cis\)-acting hippocampal meQTLs and eQTLs provide a link between disease-associated SNPs and the regulatory genome that will improve the functional interpretation of non-coding genetic variants in the molecular genetic dissection of brain disorders.},
  language  = {en}
}
@article{SchuhmannLanghauserKraftetal.2017,
  author    = {Schuhmann, Michael K. and Langhauser, Friederike and Kraft, Peter and Kleinschnitz, Christoph},
  title     = {B cells do not have a major pathophysiologic role in acute ischemic stroke in mice},
  series = {Journal of Neuroinflammation},
  volume    = {14},
  journal   = {Journal of Neuroinflammation},
  number    = {112},
  doi       = {10.1186/s12974-017-0890-x},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-158155},
  year      = {2017},
  abstract  = {Background Lymphocytes have been shown to play an important role in the pathophysiology of acute ischemic stroke, but the properties of B cells remain controversial. The aim of this study was to unravel the role of B cells during acute cerebral ischemia using pharmacologic B cell depletion, B cell transgenic mice, and adoptive B cell transfer experiments. Methods Transient middle cerebral artery occlusion (60 min) was induced in wild-type mice treated with an anti-CD20 antibody 24 h before stroke onset, JHD\(^{-/-}\) mice and Rag1\(^{-/-}\) mice 24 h after adoptive B cell transfer. Stroke outcome was assessed at days 1 and 3. Infarct volumes were calculated from 2,3,5-triphenyltetrazolium chloride (TTC)-stained brain sections, and neurological scores were evaluated. The local inflammatory response was determined by real-time PCR and immunohistochemistry. Apoptosis was analyzed by TUNEL staining, and astrocyte activation was revealed using immunohistochemistry and Western blot. Results Pharmacologic depletion of B cells did not influence infarct volumes and functional outcome at day 1 after stroke. Additionally, lack of circulating B cells in JHD\(^{-/-}\) mice also failed to influence stroke outcome at days 1 and 3. Furthermore, reconstitution of Rag1\(^{-/-}\) mice with B cells had no influence on infarct volumes. Conclusion Targeting B cells in experimental stroke did not influence lesion volume and functional outcome during the acute phase. Our findings argue against a major pathophysiologic role of B cells during acute ischemic stroke.},
  language  = {en}
}
@article{SchuhmannGuthmannStolletal.2017,
  author    = {Schuhmann, Michael K. and Guthmann, Josua and Stoll, Guido and Nieswandt, Bernhard and Kraft, Peter and Kleinschnitz, Christoph},
  title     = {Blocking of platelet glycoprotein receptor Ib reduces "thrombo-inflammation" in mice with acute ischemic stroke},
  series = {Journal of Neuroinflammation},
  volume    = {14},
  journal   = {Journal of Neuroinflammation},
  number    = {18},
  doi       = {10.1186/s12974-017-0792-y},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-157582},
  year      = {2017},
  abstract  = {Background: Ischemic stroke causes a strong inflammatory response that includes T cells, monocytes/macrophages, and neutrophils. Interaction of these immune cells with platelets and endothelial cells facilitates microvascular dysfunction and leads to secondary infarct growth. We recently showed that blocking of platelet glycoprotein (GP) receptor Ib improves stroke outcome without increasing the risk of intracerebral hemorrhage. Until now, it has been unclear whether GPIb only mediates thrombus formation or also contributes to the pathophysiology of local inflammation. Methods: Focal cerebral ischemia was induced in C57BL/6 mice by a 60-min transient middle cerebral artery occlusion (tMCAO). Animals were treated with antigen-binding fragments (Fab) against the platelet surface molecules GPIb (p0p/B Fab). Rat immunoglobulin G (IgG) Fab was used as control treatment. Stroke outcome, including infarct size and functional deficits as well as the local inflammatory response, was assessed on day 1 after tMCAO. Results: Blocking of GPIb reduced stroke size and improved functional outcome on day 1 after tMCAO without increasing the risk of intracerebral hemorrhage. As expected, disruption of GPIb-mediated pathways in platelets significantly reduced thrombus burden in the cerebral microvasculature. In addition, inhibition of GPIb limited the local inflammatory response in the ischemic brain as indicated by lower numbers of infiltrating T cells and macrophages and lower expression levels of inflammatory cytokines compared with rat IgG Fab-treated controls. Conclusion: In acute ischemic stroke, thrombus formation and inflammation are closely intertwined ("thrombo-inflammation"). Blocking of platelet GPIb can ameliorate thrombo-inflammation.},
  language  = {en}
}
@article{SchuhmannFluri2017,
  author    = {Schuhmann, Michael K. and Fluri, Felix},
  title     = {Effects of fullerenols on mouse brain microvascular endothelial cells},
  series = {International Journal of Molecular Sciences},
  volume    = {18},
  journal   = {International Journal of Molecular Sciences},
  number    = {8},
  issn      = {1422-0067},
  doi       = {10.3390/ijms18081783},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-158072},
  year      = {2017},
  abstract  = {Fullerenols, water-soluble C60-fullerene derivatives, have been shown to exert neuroprotective effects in vitro and in vivo, most likely due to their capability to scavenge free radicals. However, little is known about the effects of fullerenols on the blood-brain barrier (BBB), especially on cerebral endothelial cells under inflammatory conditions. Here, we investigated whether the treatment of primary mouse brain microvascular endothelial cells with fullerenols impacts basal and inflammatory blood-brain barrier (BBB) properties in vitro. While fullerenols (1, 10, and 100 µg/mL) did not change transendothelial electrical resistance under basal and inflammatory conditions, 100 µg/mL of fullerenol significantly reduced erk1/2 activation and resulted in an activation of NFκB in an inflammatory milieu. Our findings suggest that fullerenols might counteract oxidative stress via the erk1/2 and NFκB pathways, and thus are able to protect microvascular endothelial cells under inflammatory conditions.},
  language  = {en}
}
@article{SchubertKoernerLindauetal.2017,
  author    = {Schubert, Lisa and K{\"o}rner, Anita and Lindau, Berit and Strack, Fritz and Topolinski, Sascha},
  title     = {Open-Minded Midwifes, Literate Butchers, and Greedy Hooligans - The Independent Contributions of Stereotype Valence and Consistency on Evaluative Judgments},
  series = {Frontiers in Psychology},
  volume    = {8},
  journal   = {Frontiers in Psychology},
  number    = {1723},
  doi       = {10.3389/fpsyg.2017.01723},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-170222},
  year      = {2017},
  abstract  = {Do people evaluate an open-minded midwife less positively than a caring midwife? Both open-minded and caring are generally seen as positive attributes. However, consistency varies—the attribute caring is consistent with the midwife stereotype while open-minded is not. In general, both stimulus valence and consistency can influence evaluations. Six experiments investigated the respective influence of valence and consistency on evaluative judgments in the domain of stereotyping. In an impression formation paradigm, valence and consistency of stereotypic information about target persons were manipulated orthogonally and spontaneous evaluations of these target persons were measured. Valence reliably influenced evaluations. However, for strongly valenced stereotypes, no effect of consistency was observed. Parameters possibly preventing the occurrence of consistency effects were ruled out, specifically, valence of inconsistent attributes, processing priority of category information, and impression formation instructions. However, consistency had subtle effects on evaluative judgments if the information about a target person was not strongly valenced and experimental conditions were optimal. Concluding, in principle, both stereotype valence and consistency can play a role in evaluative judgments of stereotypic target persons. However, the more subtle influence of consistency does not seem to substantially influence evaluations of stereotyped target persons. Implications for fluency research and stereotype disconfirmation are discussed.},
  language  = {en}
}
@article{ScholzGuanNieberleretal.2017,
  author    = {Scholz, Nicole and Guan, Chonglin and Nieberler, Matthias and Grotmeyer, Alexander and Maiellaro, Isabella and Gao, Shiqiang and Beck, Sebastian and Pawlak, Matthias and Sauer, Markus and Asan, Esther and Rothemund, Sven and Winkler, Jana and Pr{\"o}mel, Simone and Nagel, Georg and Langenhan, Tobias and Kittel, Robert J},
  title     = {Mechano-dependent signaling by Latrophilin/CIRL quenches cAMP in proprioceptive neurons},
  series = {eLife},
  volume    = {6},
  journal   = {eLife},
  number    = {e28360},
  doi       = {10.7554/eLife.28360},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-170520},
  year      = {2017},
  abstract  = {Adhesion-type G protein-coupled receptors (aGPCRs), a large molecule family with over 30 members in humans, operate in organ development, brain function and govern immunological responses. Correspondingly, this receptor family is linked to a multitude of diverse human diseases. aGPCRs have been suggested to possess mechanosensory properties, though their mechanism of action is fully unknown. Here we show that the Drosophila aGPCR Latrophilin/dCIRL acts in mechanosensory neurons by modulating ionotropic receptor currents, the initiating step of cellular mechanosensation. This process depends on the length of the extended ectodomain and the tethered agonist of the receptor, but not on its autoproteolysis, a characteristic biochemical feature of the aGPCR family. Intracellularly, dCIRL quenches cAMP levels upon mechanical activation thereby specifically increasing the mechanosensitivity of neurons. These results provide direct evidence that the aGPCR dCIRL acts as a molecular sensor and signal transducer that detects and converts mechanical stimuli into a metabotropic response.},
  language  = {en}
}
@article{SchneiderNiklas2017,
  author    = {Schneider, Wolfgang and Niklas, Frank},
  title     = {Intelligence and verbal short-term memory/working memory: their interrelationships from childhood to young adulthood and their impact on academic achievement},
  series = {Journal of Intelligence},
  volume    = {5},
  journal   = {Journal of Intelligence},
  number    = {2},
  issn      = {2079-3200},
  doi       = {10.3390/jintelligence5020026},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-198004},
  pages     = {26},
  year      = {2017},
  abstract  = {Although recent developmental studies exploring the predictive power of intelligence and working memory (WM) for educational achievement in children have provided evidence for the importance of both variables, findings concerning the relative impact of IQ and WM on achievement have been inconsistent. Whereas IQ has been identified as the major predictor variable in a few studies, results from several other developmental investigations suggest that WM may be the stronger predictor of academic achievement. In the present study, data from the Munich Longitudinal Study on the Genesis of Individual Competencies (LOGIC) were used to explore this issue further. The secondary data analysis included data from about 200 participants whose IQ and WM was first assessed at the age of six and repeatedly measured until the ages of 18 and 23. Measures of reading, spelling, and math were also repeatedly assessed for this age range. Both regression analyses based on observed variables and latent variable structural equation modeling (SEM) were carried out to explore whether the predictive power of IQ and WM would differ as a function of time point of measurement (i.e., early vs. late assessment). As a main result of various regression analyses, IQ and WM turned out to be reliable predictors of academic achievement, both in early and later developmental stages, when previous domain knowledge was not included as additional predictor. The latter variable accounted for most of the variance in more comprehensive regression models, reducing the impact of both IQ and WM considerably. Findings from SEM analyses basically confirmed this outcome, indicating IQ impacts on educational achievement in the early phase, and illustrating the strong additional impact of previous domain knowledge on achievement at later stages of development.},
  language  = {en}
}
@article{SchmidtSkafGavriletal.2017,
  author    = {Schmidt, Marianne and Skaf, Josef and Gavril, Georgiana and Polednik, Christine and Roller, Jeanette and Kessler, Michael and Holzgrabe, Ulrike},
  title     = {The influence of Osmunda regalis root extract on head and neck cancer cell proliferation, invasion and gene expression},
  series = {BMC Complementary and Alternative Medicine},
  volume    = {17},
  journal   = {BMC Complementary and Alternative Medicine},
  number    = {518},
  doi       = {10.1186/s12906-017-2009-4},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-158704},
  year      = {2017},
  abstract  = {Background: According to only a handful of historical sources, Osmunda regalis, the royal fern, has been used already in the middle age as an anti-cancer remedy. To examine this ancient cancer cure, an ethanolic extract of the roots was prepared and analysed in vitro on its effectiveness against head and neck cancer cell lines. Methods: Proliferation inhibition was measured with the MTT assay. Invasion inhibition was tested in a spheroid-based 3-D migration assay on different extracellular matrix surfaces. Corresponding changes in gene expression were analysed by qRT-PCR array. Induction of apoptosis was measured by fluorescence activated cell sorting (FACS) with the Annexin V binding method. The plant extract was analysed by preliminary phytochemical tests, liquid chromatography/mass spectroscopy (LC-MS) and thin layer chromatography (TLC). Anti-angiogenetic activity was determined by the tube formation assay. Results: O. regalis extract revealed a growth inhibiting effect on the head and neck carcinoma cell lines HLaC78 and FaDu. The toxic effect seems to be partially modulated by p-glycoprotein, as the MDR-1 expressing HLaC79-Tax cells were less sensitive. O. regalis extract inhibited the invasion of cell lines on diverse extracellular matrix substrates significantly. Especially the dispersion of the highly motile cell line HlaC78 on laminin was almost completely abrogated. Motility inhibition on laminin was accompanied by differential gene regulation of a variety of genes involved in cell adhesion and metastasis. Furthermore, O. regalis extract triggered apoptosis in HNSCC cell lines and inhibited tube formation of endothelial cells. Preliminary phytochemical analysis proved the presence of tannins, glycosides, steroids and saponins. Liquid chromatography/mass spectroscopy (LC-MS) revealed a major peak of an unknown substance with a molecular mass of 864.15 Da, comprising about 50\% of the total extract. Thin layer chromatography identified ferulic acid to be present in the extract. Conclusion: The presented results justify the use of royal fern extracts as an anti-cancer remedy in history and imply a further analysis of ingredients.},
  language  = {en}
}
@article{SchmidFalterWeberetal.2017,
  author    = {Schmid, Tobias and Falter, Lena and Weber, Sabine and M{\"u}ller, Nils and Molitor, Konstantin and Zeller, David and Weber-Steffens, Dorothea and Hehlgans, Thomas and Wajant, Harald and Mostb{\"o}ck, Sven and M{\"a}nnel, Daniela N.},
  title     = {Chronic inflammation increases the sensitivity of mouse Treg for TNFR2 costimulation},
  series = {Frontiers in Immunology},
  volume    = {8},
  journal   = {Frontiers in Immunology},
  doi       = {10.3389/fimmu.2017.01471},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-173259},
  year      = {2017},
  abstract  = {TNF receptor type 2 (TNFR2) has gained attention as a costimulatory receptor for T cells and as critical factor for the development of regulatory T cells (Treg) and myeloid suppressor cells. Using the TNFR2-specific agonist TNCscTNF80, direct effects of TNFR2 activation on myeloid cells and T cells were investigated in mice. \(In\) \(vitro\), TNCscTNF80 induced T cell proliferation in a costimulatory fashion, and also supported \(in\) \(vitro\) expansion of Treg cells. In addition, activation of TNFR2 retarded differentiation of bone marrow-derived immature myeloid cells in culture and reduced their suppressor function. \(In\) \(vivo\) application of TNCscTNF80-induced mild myelopoiesis in na{\"i}ve mice without affecting the immune cell composition. Already a single application expanded Treg cells and improved suppression of CD4 T cells in mice with chronic inflammation. By contrast, multiple applications of the TNFR2 agonist were required to expand Treg cells in na{\"i}ve mice. Improved suppression of T cell proliferation depended on expression of TNFR2 by T cells in mice repeatedly treated with TNCscTNF80, without a major contribution of TNFR2 on myeloid cells. Thus, TNFR2 activation on T cells in na{\"i}ve mice can lead to immune suppression \(in\) \(vivo\). These findings support the important role of TNFR2 for Treg cells in immune regulation.},
  language  = {en}
}
@article{SchindlerRichterEysser2017,
  author    = {Schindler, Julia and Richter, Tobias and Eyßer, Carolin},
  title     = {Mood moderates the effect of self-generation during learning},
  series = {Frontline Learning Research},
  volume    = {5},
  journal   = {Frontline Learning Research},
  number    = {4},
  doi       = {10.14786/flr.v5i4.296},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-159282},
  pages     = {76-88},
  year      = {2017},
  abstract  = {Generating information, compared to reading, improves learning and enhances long-term retention of the learned content. This so-called generation effect has been demonstrated repeatedly for recall and recognition of single words. However, before adopting generating as a learning strategy in educational contexts, conditions moderating the effect need to be identified. This study investigated the impact of positive and negative mood states on the generation effect with short expository texts. According to the dual-force framework (Fiedler, Nickel, Asbeck, \& Pagel, 2003), positive mood should facilitate generation by enhancing creative knowledge-based top-down processing (assimilation). Negative mood, however, should facilitate learning in the read-condition by enhancing critical stimulus-driven bottom-up processing (accommodation). In contrast to our expectations, we found no general generation effect but an overall learning advantage of read compared to generated texts. However, a significant interaction of learning condition and mood indicates that learners in a better mood recall generated texts better than learners in a more negative mood, whereas no mood effect was found when the texts were read. The results of the present study partially support the predictions of the dual-force framework and are discussed in the context of recent theoretical approaches to the generation effect.},
  language  = {en}
}