@article{BarnekowPaulSchartl1987, author = {Barnekow, A. and Paul, E. and Schartl, Manfred}, title = {Expression of the c-src protooncogene in human skin tumors}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-61870}, year = {1987}, abstract = {No abstract available}, subject = {Physiologische Chemie}, language = {en} } @article{BarnekowSchartl1987, author = {Barnekow, A. and Schartl, Manfred}, title = {Comparative studies on the src proto-oncogene and its gene product pp60\(^{c-src}\) in normal and neoplastic tissues of lower vertebrates}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-61869}, year = {1987}, abstract = {No abstract available}, subject = {Physiologische Chemie}, language = {en} } @article{BenaventeRoseReimeretal.1987, author = {Benavente, Ricardo and Rose, Kathleen M. and Reimer, Georg and H{\"u}gle-D{\"o}rr, Barbara and Scheer, Ulrich}, title = {Inhibition of nucleolar reformation after microinjection of antibodies to RNA polymerase I into mitotic cells}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-33247}, year = {1987}, abstract = {The formation of daughter nuclei and the reformation of nucleolar structures was studied after microinjection of antibodies to RNA polymerase I into dividing cultured cells (PtK2). The fate of several nucleolar proteins representing the three main structural subcomponents of the nucleolus was examined by immunofluorescence and electron microscopy. The results show that the RNA polymerase I antibodies do not interfere with normal mitotic progression or the early steps of nucleologenesis, i.e. , the aggregation of nucleolar material into prenucleolar bodies. However,they inhibit the telophasic coalescence of the prenucleolar bodies into the chromosomal nucleolar organizer regions, thus preventing the formation of new nucleoli. These prenucleolar bodies show a fibrillar organization that also compositionally resembles the dense fibrillar component of interphase nucleoli . We conclude that during normal nucleologenesis the dense fibrillar component forms from preformed entities around nucleolar organizer regions, and that this association seems to be dependent on the presence of an active form of RNA polymerase I.}, language = {en} } @article{BoeschFriederichLutzetal.1987, author = {B{\"o}sch, R. and Friederich, U. and Lutz, Werner K. and Brocker, E. and Bachmann, M. and Schlatter, C.}, title = {Investigations on DNA binding in rat liver and in Salmonella and on mutagenicity in the Ames test by emodin, a natural anthraquinone}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-60913}, year = {1987}, abstract = {Emodin (1,6,8-trihydroxy-3-methylanthraquinone), an important aglycone found in natural anthraquinone glycosides frequently used in Iaxative drugs, was mutagenic in the Salmonellajmammalian microsome assay (Ames test) with a specificity for strain TA1537. The mutagenic activity was activationdependent with an optimal amount of S9 from Aroclor 1254-treated male Sprague-Dawley rats of 20\% in the S9 mix (v jv) for 10 p.g emodin per plate. Heat inactivation of the S9 for 30 min at 60 ° C prevented mutagenicity. The addition of the cytochrome P-448 inhibitor 7,8-benzoflavone (18.5 nmoles per plate) reduced the mutagenic activity of 5.0 p.g emodin per plate to about one third, whereas the P-450 inhibitor metyrapone (up to 1850 nmoles per plate) was without effect. To test whether a metabolite" binds covalently to Salmonella DNA, [10-\(^{14}\)C]emodin was radiosynthesized, large batches of bacteria were incubated with [10-\(^{14}\)C]emodin and DNA was isolated. [G- \(^{3}\)H]Aflatoxin B1 (AFB1) was used as a positive control mutagen known to act via DNA binding. DNA obtained after aflatoxin treatment could be purified to constant specific activity. With emodin, the specific activity of DNA did not remain constant after repeated precipitations so that it is unlikely that the mutagenicity of emodin is due to covalent interaction of a metabolite with DNA. The antioxidants vitamin C and E or glutathione did not reduce the mutagenicity. Emodin was also negative with strain TA102. Thus, oxygen radicals are probably not involved. When emodin was incubated with S9 alone for up to 50 h before heat-inactivation of the enzymes and addition of bacteria, the mutagenic activity did not decrease. It is concluded that the mutagenicity of emodin is due to a chemically stable, oxidized metabolite forming physico-chemical associations with DNA, possibly of the intercalative type. In order to check whether an intact mammalian organism might be able to activate emodin to a DNA-binding metabolite, radiolabelled emodin was administered by oral gavage to male SD rats and liver DNA was isolated after 72 h. Very little radioactivity was associated with the DNA. Considering that DNA radioactivity could also be due to sources other than covalent interactions, an upper limit for the · covalent binding index, CBI = (p.moles chemical bound per moles DNA nucleotides)/(mmoles chemical administered per kg body weight) of 0.5 is deduced. This is 104 times below the CBI of AFB1. The demonstration of a lack of covalent interaction with DNA bothin Salmonellaandin rat liver is discussed in terms of a reduced hazard posed by emodin as a mutagenic drug in use in humans.}, subject = {Toxikologie}, language = {en} } @article{BuesserLutz1987, author = {B{\"u}sser, M. T. and Lutz, Werner K.}, title = {Stimulation of DNA synthesis in rat and mouse liver by various tumor promoters}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-60908}, year = {1987}, abstract = {In order to investigate whether the Stimulation of liver DNA synthesis might be used to detect one class of hepatic tumor promoters, the incorporation of orally administered radiolabelled thymidine into liver DNA was detennined in rats and mice 24 h after a single oral gavage of test compounds at various dose Ievels. Three DNA-binding hepatocarcinogens, aflatoxin B1; benzidine and carbon tetrachloride, did not stimulate but rather inhibited DNA synthesis (not for CCla). Four hepatic tumor promoters, clofibrate, DDT, phenobarbital and thioacetamide, gave rise to a Stimulation in a dosedependent manner. Single oral doses between 0.02 and 0.3 mmol/kg were required to double the level of thymidine incorporation into liver DNA (= doubling dose, DD). Differentes between species or sex as obsprved in long-term carcinogenicity studies were reflected by a different stimulation of liver DNA synthesis. In agreement with the bioassay data, aldrin was positive only in male mice (DD = 0.007 mmol/kg) but not in male rats or female mice. 2,3, 7,8-TCDD was positive in male mice (DD = 10\(^{-6}\) mmol/kg) andin female rats (DD = 2 x 10\(^{-6}\) mmol/kg) but not in male rats. The assay was also able to distinguish between structural isomers with different carcinogenicities. [alpha]Hexachlorocyclohexane stimulated Iiver DNA synthesis with a doubling dose of about 0.2 mmol/kg in male rats whereas the [gamma]isomer was ineffective even at l mmol/kg. So far, only one result was inconsistent with carcinogenicity bioassay data. The different carcinogenicity of di(2-ethylhexyl)adipate (negative in rats) and di(2-ethylhe.xyl)phthalate (positive) was not detectable. 8oth plasticizers were positive in.this short-term system with DD's of 0. 7 mmol/kg for DEHA and 0.5 mmol/kg for DEHP. The proposed assay is discussed as an attempt to devise short-term assays for carcinogens not detected by the routine genotoxicity test systems.}, subject = {Toxikologie}, language = {en} } @article{ChakrabortyKathariouHackeretal.1987, author = {Chakraborty, Trinad and Kathariou, Sophia and Hacker, J{\"o}rg and Hof, Herbert and Huhle, Burkhard and Wagner, Wilma and Kuhn, Michael and Goebel, Werner}, title = {Molecular analysis of bacterial cytolysins}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-40328}, year = {1987}, abstract = {Results of molecular and pathogenic studies of three different bacterial hemolysins (cytolysins) are presented. These exoproteins derive from the two gram-negative bacteria Escherichia coli and Aeromonas hydrophila and from the gram-positive pathogen Listeria monocytogenes. The hemolysin of E. coli is determined by an 8-kilobase (kb) region that includes four clustered genes (hlyC, hlyA, hlyB, and hlyD). This hemolysin determinant is part either of large transmissible plasmids or of the chromosome. The genes located chromosomally are found predominantly in E. coli strains that can cause pyelonephritis and/or other extraintestinal infections. A detailed analysis of the chromosomal hly determinants of one nephropathogenic E. coli strain revealed the existence of specific, large chromosomal insertions 75 kb and lOO kb in size that carry the hly genes but that also influence the expression of other virulence properties, i.e., adhesion and serum resistance. The direct involvement of E. coli hemolysin in virulence could be demonstrated in several model systems. The genetic determinants for hemolysin (cytolysin) formation in , A. hydrophila (aerolysin) and L. monocytogenes (listeriolysin) are less complex. Both cytolysins seem to be encoded by single genes, although two loci (aerB and aerC) that affect the expression and activity of aerolysin have been identified distal and proximal to the structural gene for aerolysin (aerA). Cytolysin-negative mutants of both bacteria were obtained by site-specific deletion and/or transposon mutagenesis. These mutants show a drastic reduction in the virulence of the respective bacteria.}, language = {en} } @article{ChristlHegmannReuchleinetal.1987, author = {Christl, Manfred and Hegmann, J. and Reuchlein, H. and Peters, K. and Peters, E.-M. and Schnering, H. G. von}, title = {{\"U}berbr{\"u}ckte neungliedrige α,β-unges{\"a}ttigte Enollactone - Synthese aus 5-Phenyl-1,3,4-oxadiazin-6-on-2-carbons{\"a}ure-methylester und Konfigurationsanalyse}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-58395}, year = {1987}, abstract = {The γ-oxoketenes, which are formed from oxadiazinone Ja and strained cyclopentene der1vat1ves, are shown to undergo a pericyclic ring enlargement to give the title compounds 2a, 2b, and 5. In the case of 5, two configurations, one having a cis and the other a trans Iactone functionality, are in equilibrium.}, subject = {Organische Chemie}, language = {de} } @article{ChristlHerzog1987, author = {Christl, Manfred and Herzog, C.}, title = {3-(Phenylsulfonyl)tricyclo[4.1.0.0\(^{2,7}\)]hept-4-en-3-yllithium}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-58340}, year = {1987}, abstract = {Phenyl(tricyclo[4.1.0.0\^(^{2,7}\)] hept-4-en-3-yl)sulfone 8 has been prepared in two steps from 4,S-dlbromohomobenzvalene (6) and deprotonated to give the title compound 9. The carbon-13 NMR spectrum of 9 reveals a considerable interaction between the allyl anion moiety and the bicyclobutane system.}, subject = {Organische Chemie}, language = {de} } @article{ChristlSchreck1987, author = {Christl, Manfred and Schreck, M.}, title = {7-Arylbicyclo[4.2.0]oct-1-ene - Synthese durch [2+2]-Cycloadditionen von 1,2-Cyclohexadien sowie 1-Methyl-1,2-cyclohexadien und thermische {\"A}quilibrierung der exo/endo-Isomeren}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-58352}, year = {1987}, abstract = {Das exo/endo--lsomerenverh{\"a}ltnis Ja: Jb bei der bekannten [2 + 2]-Cycloaddition von Styrol an 1,2-Cyclohexadien (2) wurde als tempcraturabhingiaaefunden. Der Einsatz von (Z)-Dcutcriostyrollicfene den Beweis der Zweistufiakeit dieser Reaktion, und das Diradikal 4 wird als wahrscheinlichste Zwischenstufe anaesehen. Erhitzen von Jb auf 140-170°C f{\"u}hrte zur Binstellung des thermodynamischen Gleichgewichts mit Ja (Ja:3b = 93:7), wobei wieder das Diradikal4 als Zwischenstufe fungieren d{\"u}rfte. Mit Hilfe kinetischer Messungen ermittelte man die Aktivierungsparameter f{\"u}r das System Ja~ 3b. - Aus 2 und den Abfangreagenzien p-Methoxystyrol, 1,1-Diphenylethylen sowie 1-Phenylpropen gingen mit bescheidenen Ausbeuten die Titelverbindungen 6a, b, 7 bzw. 8 hervor. Analoa zu 2 wurde sein l-Methylderivat 13 aus 6,6-Dibrom-1-methylbicyclo[3.1.0]hexan (9) durch Methyllithium freigesetzt. In Gegenwart von Styrol entstand neben den Abfanaprodukten 14a, b auch das Dimere 12 von lJ. - Die 1H-NMR-Spektren der Titelverbindungen belegen eine starre Halbsesselkonformation des Cyclohexentcils mit {\"a}quatorial anellienem Cyclobutanring.}, subject = {Organische Chemie}, language = {de} } @article{ChristlSchreck1987, author = {Christl, Manfred and Schreck, Michael}, title = {1,2,3,5,8,8a-Hexahydronaphthalin aus 1,2-Cyclohexadien}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-31656}, year = {1987}, abstract = {Reaktionen von 1,3-Butadien und einigen seiner Methylderivate mit 1a und 1- Methyl-1,2-cyclohexadien 1b sowie den {\"U}bergang der [2 + 2]-Cycloaddukte 2 und 3 in das bisher unbekannte 1,2,3,5,8,8a-HexahydronaphthaJin 4a und einige seiner Methylderivate}, subject = {Chemie}, language = {en} } @article{DandekarSchulz1987, author = {Dandekar, Thomas and Schulz, R.}, title = {Evidence for the expression of peptides derived from three opioid precursors in NG 108CC15 hybrid cells}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-29909}, year = {1987}, abstract = {No abstract available}, language = {en} } @article{DickneiteSchorlemmerSedlaceketal.1987, author = {Dickneite, G. and Schorlemmer, H. U. and Sedlacek, H. H. and Falk, W. and Ulrichs, Karin and M{\"u}ller-Ruchholtz, W.}, title = {Suppression of macrophage function and prolongation of graft survival by the new guanidinic-like structure, 15-deoxyspergualin}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-86991}, year = {1987}, abstract = {No abstract available.}, subject = {Makrophage}, language = {en} } @incollection{Ellgring1987, author = {Ellgring, Johann Heinrich}, title = {Zur Entwicklung der Mimik als Verst{\"a}ndigungsmittel}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-56811}, publisher = {Universit{\"a}t W{\"u}rzburg}, year = {1987}, abstract = {No abstract available}, subject = {Mimik}, language = {de} } @incollection{Ellgring1987, author = {Ellgring, Johann Heinrich}, title = {Ausdrucksforschung}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-50350}, publisher = {Universit{\"a}t W{\"u}rzburg}, year = {1987}, abstract = {No abstract available}, subject = {Psychologie}, language = {de} } @incollection{Ellgring1987, author = {Ellgring, Johann Heinrich}, title = {Ausdruck}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-50363}, publisher = {Universit{\"a}t W{\"u}rzburg}, year = {1987}, abstract = {No abstract available}, subject = {Psychologie}, language = {de} } @incollection{Ellgring1987, author = {Ellgring, Johann Heinrich}, title = {Nichtverbale Kommunikation}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-50383}, publisher = {Universit{\"a}t W{\"u}rzburg}, year = {1987}, abstract = {No abstract available}, subject = {Psychologie}, language = {de} } @incollection{Ellgring1987, author = {Ellgring, Johann Heinrich}, title = {FACS [Facial Action Coding System]}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-50370}, publisher = {Universit{\"a}t W{\"u}rzburg}, year = {1987}, abstract = {FACS, Abk. f. Facial Action Coding System, ein von EKMAN u. FRIESEN 1978, entwickeltes, auf den schwedischen Anatomen HJORTSJ{\"O} 1970 zur{\"u}ckgehendes System zur Beschreibung der Mimik. [W{\"o}rterbucheintrag]}, subject = {Psychologie}, language = {de} } @article{EllgringKlos1987, author = {Ellgring, Johann Heinrich and Klos, Thomas}, title = {Manuelle versus elektronische Analyse von Sprechpausen}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-43233}, year = {1987}, abstract = {Es wird gezeigt, daß die digitale Sprachanalyse bei der Messung von Sprechpausen unter bestimmten Umst{\"a}nden Fehler aufweist. Am Beispiel von 16 standardisierten Interviews mit depressiven Patienten wurden Sprechpausen von Patienten und Interviewern nach zwei Methoden gemessen: mit einer einfachen manuellen Methode deren Interraterreliabilit{\"a}t bei .88 und h{\"o}her lag und nach Methoden der digitalen Sprachverarbeitung. Die Ergebnisse beider Analysen wurden verglichen. Dabei zeigte sich, daß die manuelle Methode f{\"u}r Sprechpausen oberhalb 390 ms reliabel ist und gleiche oder bessere Ergebnisse bringt. Bei qualitativ schlechten Tonaufnahmen ist diese manuelle Methode vorteilhaft.}, language = {de} } @incollection{EllgringVogelBungard1987, author = {Ellgring, Johann Heinrich and Vogel, Peter and Bungard, Walter}, title = {Methoden und Techniken der Verhaltensuntersuchung}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-33684}, publisher = {Universit{\"a}t W{\"u}rzburg}, year = {1987}, abstract = {No abstract available}, language = {de} } @article{EngelsPeyerimhoffDavidson1987, author = {Engels, Bernd and Peyerimhoff, S.D. and Davidson, E.R.}, title = {Calculation of hyperfine coupling constants : An ab initio MRD-CI study for nitrogen to analyse the effects of the basis sets and CI parameter}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-58784}, year = {1987}, abstract = {The hyperfine coupling constant for the nitrogen atom is evaluated by large-scale MRD-CI calculations. A detailed analysis of the charge density at the nucleus and the spin polarization in the ls and 2s shell as a function of various technical parameters is undertaken. Various (s, p) AO basis sets and the inftuence of correlation orbitals is investigated as weil as selection threshold and other properlies in CI calculations. The best value, obtained for the isotropic hyperfine coupling constant in an s, p, d basis, based on theoretical judgment of' best' quantities, is 9·9 MHz compared to 10·4509 MHz.}, subject = {Organische Chemie}, language = {en} } @incollection{FalesTusaWilhelmetal.1987, author = {Fales, Frederick Marion and Tusa, Sebastiano and Wilhelm, Gernot and Zaccagnini, Carlo}, title = {German-Italian expedition to Iraq: preliminary report on the first campaign of excavations within the Saddam Dam Reservoir Archaeological Rescue Project (1984)}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-78053}, publisher = {Universit{\"a}t W{\"u}rzburg}, year = {1987}, abstract = {No abstract available}, subject = {Orientalistik}, language = {en} } @article{FalkUlrichsMuellerRuchholtz1987, author = {Falk, W. and Ulrichs, Karin and M{\"u}ller-Ruchholtz, W.}, title = {15-Deoxyspergualin (a new guanidine-like drug) blocks T lymphocyte proliferation}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-45215}, year = {1987}, abstract = {No abstract available}, subject = {Chirurgie}, language = {en} } @article{FeuersteinLeaderSirenetal.1987, author = {Feuerstein, G. and Leader, P. and Sir{\´e}n, Anna-Leena and Braquet, P.}, title = {Protective effect of PAF-acether antagonist, BN 52021, in trichothecen toxicosis}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-63244}, year = {1987}, abstract = {Trichothecenes are mycotoxins which produce Iethai toxicosis in humans and animals, yet no adequate therapeutic regimen has been developed. This study provides evidence that the selective platelet activating factor (PAF) antagonist, BN 52021 (5-15 mg/kg i.v.) can prolong the survival of conscious rats exposed to a highly Iethai T -2 toxicosis. These data also suggest that P AF is an important mediator of this unique toxicosis.}, subject = {Neurobiologie}, language = {en} } @misc{FeuersteinSiren1987, author = {Feuerstein, G. and Sir{\´e}n, Anna-Leena}, title = {Opioid peptides: A role in hypertension? [Brief Review]}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-63262}, year = {1987}, abstract = {This review is an attempt to highlight evidence that may implicate the endogenaus opioid system in the pathogenesis of hypertension in humans. The evidence raised includes biochemical, physiological, pharmacological, and behavioral studies con~ucted in in vitro andin vivo systems, experimental models of hypertension, and hornans with essential hypertension. While the compelling biochemical and pharmacological evidence in experimental animals clearly shows the presence of opioid peptides and their receptors in strategic sites of cardiovascular control and potent cardiovascular response to opioid peptides, opioid antagonists show no consistent blockade or reversal of hypertension in experimental animals or humans. One possible explanation for this phenomenon could be the vast redundancy in systems regulating blood pressure (i.e., the blockade ofone system stillleaves many other systerils fully able to rapidly offset the eliminated system). Regarding the opioid system, the situation is much more complex, since some opioid receptors (\(\mu\)-type) niediate pressor responses, while other receptors (\(\kappa\)type) mediate depressor responses. Therefore, nonselective opioid receptor antagonists (e.g., naloxone), which block both types ofreceptors, can be devoid ofany cardiovascular activity, while a selective \(\mu\)-receptor antagonist or a selective arid potent \(\kappa\)-receptor agonist may produce the desired antihypertensive elfect. A combination of both actions (i.e., a drug that is both \(\mu\)antagonist and a \(\kappa\)antagonist) might be even more advantageous. Until such compounds are developed, this hypothesis will be hard to prove.}, subject = {Neurobiologie}, language = {en} } @article{FeuersteinSiren1987, author = {Feuerstein, G. and Sir{\´e}n, Anna-Leena}, title = {Cardiovascular effects of enkephalins}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-49048}, year = {1987}, abstract = {Enkephalins and their receptors are found in neurons and nerve terminals known to be involved in central cardiovascular control as well as the peripheral sympathetic and parasympathetic systems. Enkephalins and opioid receptors were also iden tified in the heart, kidneys, and blood vessels. The enkephalins interact with several specific receptors, of which p, 0, and K have been best characterized. Enkephalins administered to humans or animals produce cardiovascular effects which depend on the spedes, route of administration, anesthesia, and the selectivity for receptor subtype. While little information exists on the role of enkephalins in normal cardiovascular control, current data suggest that enkephalins might have a role in cardiovascular stress responses such os in shock and trauma.}, subject = {Medizin}, language = {en} } @article{FeuersteinSiren1987, author = {Feuerstein, Giora and Sir{\´e}n, Anna-Leena}, title = {The Opioid System in cardiac and vascular regulation of normal and hypertensive states}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-47418}, year = {1987}, abstract = {The endogenous opioid system includes three major families of peptides: dynorphins (derived from pre-proenkephalin B), endorphins (derived from pre-proopiomelanocortin), and enkephalins (derived from pre-proenkephalin A). Multiple species of opioid peptides are derived from these major precursors and many of them possess potent cardiovascular properties. Opioid peptides and opioid receptors, of which multiple forms have been defined, are present in the central nervous system and peripheral neural elements. In the central nervous system, opioid peptides and receptors are found in forebrain and hindbrain nuclei involved in baroregulation, sympathoadrenal activation, and several other vital autonomic functions. In the periphery, opioid peptides are found in autonomic ganglia, adrenal gland, heart, and other organs; multiple opioid receptors are also found in vascular tissue, heart, and kidneys. Although little is known to date on the regulatory mechanisms of the opioid system in normal cardiovascular states, it became clear that cardiovascular stress situations substantially modify the activity of the endogenous opioid system. The purpose of this review is to clarify the sites of interaction of the opioid system with all major components of the cardiovascular system and indicate the potential role of this system in the ontogenesis of cardiac malfunction, vascular diseases, and hypertension.}, subject = {Medizin}, language = {en} } @article{FluegelMaurerBannertetal.1987, author = {Fl{\"u}gel, Rolf M. and Maurer, Bernd and Bannert, Helmut and Rethwilm, Axel and Schnitzler, Paul and Darai, Gholamreza}, title = {Nucleotide sequence analysis of a cloned DNA fragment from human cells reveals homology to retrotransposons}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-61525}, year = {1987}, abstract = {During molecular cloning of proviral DNA of human. spumaretroVirus, various recombinant clones were estabUshed and analyzed. Blot hybridization revealed that one of the recoinbinant plasmids bad the characteristic features of a member of the long interspersed repetitive sequences famlly. The DNA element was analyzed by restrictioil mapping and nuelootide sequencing. It showed a high degree of amino acid sequence homology of 54.3\% when conipared with the 5'-terminal part of the pol gelie product of the murine retrotransposon LIMd. The 3' region of the cloned DNA element encodes proteins witb an even higher degree of homology of 67.4\% in comparison to the corresponding parts of a member of the primate Kpnl sequence family.}, subject = {Virologie}, language = {en} } @article{FluegelRethwilmMaureretal.1987, author = {Fl{\"u}gel, Rolf M. and Rethwilm, Axel and Maurer, Bernd and Darai, Gholamreza}, title = {Nucleotide sequence analysis of the env gene and its flanking regions of the human spumaretrovirus reveals two novel genes}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-61509}, year = {1987}, abstract = {Recombinant clonesthat represent the 3' part ofthe genome of the human spumaretrovirus (foamy virus) were established from viral DNA and from DNA complementary to viral RNA. The recombinant clones were characterized by blot hybridizations and nucleotide sequence analysis. The deduced protein sequence of the clones at their 5' ends was found to be homologous to the 3' domain of retroviral reverse transcriptases. Downstream of a small intergerne pol-env region a long open reading frame of 985 amino acid residues was identified that according to its genomic location, size, glycosylation signals, and hydrophobicity protile closely resembles the lentiviral env genes. The spumaretroviral env gene is followed by two open reading frames, termed bel-l and bel-2 which are located between env and the long terminal repeat region. The long terminal repeat of 1259 nucleotides is preceded by a polypurine tract and contains the canonical signal sequences characteristic for transcriptional regulation of retroviruses. The provisional classitication of the spumaretrovirus subfamily is discussed.}, subject = {Virologie}, language = {en} } @article{FoersterSchartl1987, author = {Foerster, Wolfgang and Schartl, Manfred}, title = {Karyotype and isozyme patterns of five species of Aulonocara REGAN, 1922}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-86774}, year = {1987}, abstract = {No abstract available.}, subject = {Aulonocara}, language = {en} } @article{GrilliLutzParodi1987, author = {Grilli, S. and Lutz, Werner K. and Parodi, S.}, title = {Possible implications from results of animal studies in human risk estimations for benzene: nonlinear dose-response relationship due to saturation of metabolism}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-60936}, year = {1987}, abstract = {To date, all risk assessment studies on benzene have been based almost exclusively on epiderniological data. Wehave attempted a more integrated and quantitative evaluation of carcinogenic risk for hurnans, trying to utilize, in addition to the epidemiological data, all data available, specifically data on metabolism, genotoxicity, and carcinogenicity in small rodents. An integrated evaluation of the globality of the available data seems to suggest a progressive saturation of metabolic capacity both for man and rodents between 10 and 100 ppm. The most susceptible target cells seem tobe different in humans (predominant induction of myelogenous leukemia) and small rodents (induction of a wide variety of tumors). Nevertheless, both epidemiological and experimental carcinogenicity data tend to indicate a flattening ofthe response for the highest dosages, again suggesting a general Saturation of mechanisms of metabolic activation, extended to different target tissues. From a quantitative point of view, the data suggest a carcinogenic potency at 10 ppm two to three times higher than that computable by a linear extrapolation from data in the 100 ppm range. These observations are in accord with the recent proposal of the European Economic Community of reducing benzene time-weighted average occupationallevels from 10 to 5 ppm.}, subject = {Toxikologie}, language = {en} } @article{HackerUlmerFasskeetal.1987, author = {Hacker, J{\"o}rg and Ulmer, E. and Fasske, E. and Schmidt, G.}, title = {Isolation and characterization of coliphage Omega18A specific for Escherichia coli O18ac strains}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-73001}, year = {1987}, abstract = {The bactedophage Q18A, specific for Escherichia coli 018ac srrains, was isolated frorn sewage. The results of host range and conjugation experiments showed that the sensitivity of bacteria to the phage is associated with rhe presence of 018ac antigens. With sorne of rhe 018 strains rhe phage Q18A produces clear Iysis on bacterial lawns only when applied at a high multiplicity and moreover the phage does not multiply. With rhe help of the phage Ql8A, E. coli 0 18ac strains could be divided inro rwo serologically clistinct subgroups called 018A and 018A1• E. coli strains belanging to the sugroup 0 ISAare sensitive to phage Q t8A wheteas bacteria of subgroup A1 are resistanr.}, subject = {Escherichia coli}, language = {en} } @incollection{HandmanMitchellMcConvilleetal.1987, author = {Handman, E. and Mitchell, G. F. and McConville, M. J. and Moll, Heidrun}, title = {Towards a carbohydrate-based vaccine against leishmaniasis}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-33827}, publisher = {Universit{\"a}t W{\"u}rzburg}, year = {1987}, abstract = {No abstract available}, language = {en} } @article{HarthPeter1987, author = {Harth-Peter, Waltraud}, title = {Zur Einf{\"u}hrung (Das Kind (1987) 1-2)}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-42827}, year = {1987}, abstract = {No abstract available}, subject = {Kind}, language = {de} } @misc{HarthPeter1987, author = {Harth-Peter, Waltraud}, title = {Maria Montessori: Texte und Gegenwartsdiskussion / Winfried B{\"o}hm (Hrsg.)}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-42817}, year = {1987}, abstract = {Rezension zu Winfried B{\"o}hm (Hrsg.): Maria Montessori. Texte und Gegenwartsdiskussion. 3., neu bearbeitete Auflage. Bad Heilbrunn 1985}, language = {de} } @article{HarthPeter1987, author = {Harth-Peter, Waltraud}, title = {{\"U}ber die (Un-)Kenntnis der ausl{\"a}ndischen P{\"a}dagogik in Deutschland, dargestellt am Beispiel der p{\"a}dagogischen Literatur Frankreichs, Italiens und Spaniens}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-56889}, year = {1987}, abstract = {No abstract available}, subject = {ausl{\"a}ndische P{\"a}dagogik}, language = {de} } @article{HarthPeter1987, author = {Harth-Peter, Waltraud}, title = {{\"U}ber moralische und soziale Erziehung / Maria Montessori ({\"U}bersetzung)}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-51069}, year = {1987}, abstract = {No abstract available}, subject = {Erziehung}, language = {de} } @article{HegmannChristlPetersetal.1987, author = {Hegmann, J. and Christl, Manfred and Peters, K. and Peters, E.-M. and Schnering, H. G. von}, title = {Intramolekulare [2+2]-Cycloadditionen von γ-Oxoketenen}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-58384}, year = {1987}, abstract = {The 1-oxoketenes, which are accessible from methyl 1,3,4-oxadiazin-6-one-2-carboxyIate 1 and cycloalkenes, are shown to undergo an intramolecular [2+2] cycloaddition either on heating or on photolysis to give different sterecisemers of ß-lactones of the 3-oxo-2-oxabicyclo[ 2.2.0]hexane-type.}, subject = {Organische Chemie}, language = {de} } @article{Hess1987, author = {Hess, G{\"u}nter}, title = {Die Arche Noah auf dem Hubland : Tagebuchnotizen zur zweiten Folge der Werkstattgespr{\"a}che mit Autoren der deutschen Gegenwartsliteratur}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-52233}, year = {1987}, abstract = {Tagebuchnotizen {\"u}ber die Werkstattgespr{\"a}che in der Universit{\"a}tsbibliothek W{\"u}rzburg. - Martin Walser 12. November 1986 - G{\"u}nter Kunert 10. Dezember 1986 - Hermann Burger 14. Januar 1987 - Peter R{\"u}hmkopf 18. Februar 1987}, subject = {W{\"u}rzburg / Werkstattgespr{\"a}che mit Autoren der Deutschen Gegenwartsliteratur}, language = {de} } @inproceedings{HeusermannNoethlingHansmannetal.1987, author = {Heusermann, U. and N{\"o}thling, R. and Hansmann, M. L. and Ulrichs, Karin}, title = {Immunhistochemische und immunelektronenmikroskopischeUntersuchungen zum Vorkommen von dendritischen Zellen im Pankreas der Ratte}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-45689}, year = {1987}, abstract = {Dendritic cells, first described by STEINMAN and COHN in the mouse spleen and now called lymphoid dendritic cells (LDC), were investigated in the rat pancreas with the monoclonal antibodies 29AI-L. T. and MRC-OX17, which both recognize the la-antigen immunohistochemically and immune electron microscopically. la-positive cells with a dendritic morphology were found in the connective tissue of the cxocrine and endocrine pancreas. Immune e1ectron microscopically, the Ia-antibodies were 10- calized on the cell surface and in sm all vesicles. A small portion of the la-positive cells showed additional acid phosphatase positivity, i. e. were la-positive macrophages. The other la-positive cells were probably LDC, which may be important in the elimination of foreign antigens, e. g. bacteria and vIruses.}, language = {de} } @article{HollerFischerWeberetal.1987, author = {Holler, E. and Fischer, H. and Weber, C. and Stopper, Helga and Steger, H. and Simek, H.}, title = {A DNA polymerase with unusual properties from the slime mold Physarum polycephalum}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-63501}, year = {1987}, abstract = {Two forms of a DNA polymerase have been purified from microplasmodia of Physarum polycephalum by poly(ethyleneimine) precipitation and chromatography on DEAE-Sephacel, phosphocellulose, heparin Sepharose, hydroxyapatite, DNA-agarose, blue-Sepharose. They were separated from DNA polymerase cx on phosphocellulose and from each other on heparin-Sepharose. Form HS1 enzymewas 30-40\% pure and form HS2 enzyme 60\% with regard toprotein contents of the preparations. Form HS2 enzymewas generated from form HS1 enzyme on prolonged standing of enzyme preparations. The DNA polymerases were obtained as complexes of a 60-kDa protein associated with either a 135-kDa (HS1) or a 110-kDa (HS2) DNA-polymerizing polypeptidein a 1:1 molar stoichiometry. The biochemical function of the 60-kDa protein remained unknown. The complexes tended to dissociate during gradient centrifugation and during partition chromatography as weil as during polyacrylamide gradient gel electrophoresis under nondenaturing conditions at high dilutions of samples. Both forms existed in plasmodia extracts, their proportions depending on several factors including those which promoted proteolysis. The DNA polymerases resembled eucaryotic DNA polymerase ß by several criteria and were functionally indistinguishable from each other. It is suggested that lower eucaryotes contain repair DNA polymerases, which are similar to those of eubacteria on a molecular mass basis.}, subject = {Toxikologie}, language = {en} } @article{Hommers1987, author = {Hommers, Wilfried}, title = {Anti-Typen: Zur psychologischen Validit{\"a}t eines methodischen Konstrukts der Konfigurationsfrequenzanalyse}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-43437}, year = {1987}, abstract = {Das Konzept des Anti-Typus wird theoretisch und empirisch-analytisch untersucht. Empirische Grundlage bilden Problem-Kommentierungen zur Erfassung von Therapiemotivationskonstrukten und Antworten auf Fragen eines multivariaten Pers{\"o}nlichkeits-Inventars von 187 Jugendgerichtlich-Inhaftierten und 361 Polizeianw{\"a}rtern. Im ersten Schritt des analytischen Teils werden mit der Konfigurationsfrequenzanalyse (KFA) Hypothesen {\"u}ber Typen und Anti-Typen von Selbstbeschreibungskonstrukten zur Therapiemotivation gewonnen. Zus{\"a}tzlich werden die Inventar-Profile der dabei gebildeten typologischen Pbn-Gruppen multidimensional skaliert und multivariat auf Unterschiedlichkeit gepr{\"u}ft. Im zweiten Schritt werden die KFA-Hypothesen {\"u}ber die Typen und Anti-Typen der "Therapiemotivation" mit Hilfe eines Bayes-statistischen Verfahrens durch ihre Trennung von einer Restgruppe gepr{\"u}ft. Die Inventar-Profile der entstehenden Gruppen werden erneut multidimensional und multivariat verglichen. Von den zwei Bedeutungen des "Anti" im Anti-Typ-Begriff bew{\"a}hrt sich die geometrische Interpretation des "Anti" an den Profilen nicht. Die Interpretation "konsistenter Andersartigkeit" dagegen kann auf der Grundlage der Bayes-statistischen Klassifikation beibehalten werden. Die Untersuchung des Anti-Typ-Begriffs lohnt m{\"o}glicherweise auch in anderen Bereichen.}, subject = {Psychologische Diagnostik / Psychologie / Differentielle Psychologie / Zeitschrift}, language = {de} } @incollection{Hommers1987, author = {Hommers, Wilfried}, title = {Implizite Willenstheorien des rechtlichen Denkens aus empirisch psychologischer Perspektive}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-44128}, publisher = {Universit{\"a}t W{\"u}rzburg}, year = {1987}, abstract = {No abstract available}, subject = {Wille / Aufsatzsammlung / Rottach-Egern <1987> / Kongress / Ringberg