@article{TackeLangeBentlageetal.1983,
  author    = {Tacke, Reinhold and Lange, Hartwig and Bentlage, Anke and Sheldrick, William S. and Ernst, Ludger},
  title     = {2.2.5.5-Tetraorganyl-1.4-dioxa-2.5-disilacyclohexane/2,2,5,5-Tetraorganyl-1,4-dioxa-2,5-disilacyclohexanes},
  series = {Zeitschrift f{\"u}r Naturforschung B},
  volume    = {38},
  journal   = {Zeitschrift f{\"u}r Naturforschung B},
  number    = {2},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-128423},
  pages     = {190-193},
  year      = {1983},
  abstract  = {The 2,2,5,5-tetraorganyl-1,4-dioxa-2,5-disilacyclohexanes 2a-2c were prepared by condensation of the corresponding (hydroxymethyl)diorganylsilanes 1 a-1 c. The constitution of the heterocycles was confirmed by elemental analyses, cryoscopic measurements, mass spectrometry, and NMR-spectroscopic \((^1H, ^{13}C)\) investigations. The molecular structure of 2 b was determined by X-ray diffraction analysis.},
  language  = {de}
}
@article{TackeLangeSheldricketal.1983,
  author    = {Tacke, Reinhold and Lange, Hartwig and Sheldrick, William S. and Lambrecht, G{\"u}nter and Moser, Ulrich and Mutschler, Ernst},
  title     = {Sila-Pharmaka, 31. Mitt. [1] Synthese, Struktur und pharmakologische Eigenschaften von Diphenyl(2-piperidinoethoxymethyl)silanol und seinem Kohlenstoff-Analogon},
  series = {Zeitschrift f{\"u}r Naturforschung B},
  volume    = {38},
  journal   = {Zeitschrift f{\"u}r Naturforschung B},
  number    = {6},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-128410},
  pages     = {738-746},
  year      = {1983},
  abstract  = {In the course of systematic investigations on sila-substituted parasympatholytics the diphenyl(2-aminoethoxymethyl)silanols 3b and 4b (and its carbon analogue 4a) were synthesized and characterized by their physical and chemical properties. In the solid state 4a and 4b form strong O-H---N hydrogen bonds, which are intramolecular (4a) and intermolecular (4b), respectively. 4a and 4b were found to be weak antimuscarinic agents (4b >4a) and strong papaverine-like spasmolytics (4a ≈4b).},
  language  = {de}
}
@article{TackeLinohAttarBashietal.1982,
  author    = {Tacke, Reinhold and Linoh, Haryanto and Attar-Bashi, Moayad T. and Sheldrick, William S. and Ernst, Ludger and Niedner, Roland and Frohnecke, Joachim},
  title     = {Sila-Pharmaka, 26. Mitt. [1] Darstellung und Eigenschaften potentiell curarewirksamer Silicium-Verbindungen, III},
  series = {Zeitschrift f{\"u}r Naturforschung B},
  volume    = {37},
  journal   = {Zeitschrift f{\"u}r Naturforschung B},
  number    = {11},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-128402},
  pages     = {1461-1471},
  year      = {1982},
  abstract  = {The potentially curare-like silicon compounds 8a- 8f were synthesized and investigated with respect to their structure-activity relationships. The conformations of the compounds in the solid state and in solution were studied by X-ray diffraction analysis (8a- 8e) and IR NMR spectroscopy (8a- 8f), respectively. The muscle relaxing properties of 8a- 8f were investigated on the mouse. The observed structure-activity relationships are not in accordance with the classical "14 {\AA} model" for neuromuscular blocking agents.},
  language  = {de}
}
@article{JaiswalLambrechtMutschleretal.1991,
  author    = {Jaiswal, Neelam and Lambrecht, G{\"u}nter and Mutschler, Ernst and Tacke, Reinhold and Malik, Kafait U.},
  title     = {Pharmacological characterization of the vascular muscarinic receptors mediating relaxation and contraction in rabbit aorta},
  series = {Journal of Pharmacology and Experimental Therapeutics},
  volume    = {258},
  journal   = {Journal of Pharmacology and Experimental Therapeutics},
  number    = {3},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-128358},
  pages     = {842-850},
  year      = {1991},
  abstract  = {Studies were performed in the rabbit aortic rings, precontracted with norepinephrine, to determine the subtype(s) of muscarinic receptors involved in endothelium-dependent relaxation and contraction in the absence of endothelium elicited by cholinergic stimuli. Acetylcholine (ACh) and arecaidine propargyl ester (APE), a M2 and M3 agonist, produced a dose-dependent relaxation and contraction in endothelium-intact and endothelium-denuded rabbit aortic rings, respectively. Both of these responses were blocked by the muscarinic receptor antagonist atropine. M1 selective agonist McN-A-343 [4-[N-(3-chlorophenyl)carbamoyloxy]-2-butinyltrimethylammonium+ ++ chloride] did not produce any effect on the tone of precontracted aortic rings. ACh- and APE-induced relaxation in aortic rings with intact endothelium was selectively blocked by M3 receptor antagonists hexahydrosila-difenidol and p-fluoro-hexahydro-sila-difenidol (pA2 of 7.84 and 7.18) but not by M1 antagonist pirenzepine or M2 receptor antagonists AF-DX 116 [11-(2-[(diethylamino)methyl]- 1-piperidinyl]acetyl)-5, 11-dihydro-6H-pyrido-[2,3-b][1,4]-benzo-diazepin-6-one] and methoctramine. ACh- and APE-induced contraction was inhibited by M2 receptor antagonists AF-DX 116 and methoctramine (pA2 of 7.11 and 6.71) but not by pirenzepine, hexahydro-sila-difenidol or p-fluoro-hexahydro-sila-difenidol. ACh- and APE-induced relaxation or contraction were not altered by nicotinic receptor antagonist hexamethonium or cyclooxygenase inhibitor indomethacin. These data suggest that relaxation elicited by cholinergic stimulin in endothelium-intact aortic rings is mediated via release of endothelium-derived relaxing factor consequent to activation of M3 receptors located on endothelial cells, whereas the contraction in aortic rings denuded of their endothelium is mediated via stimulation of M2 receptors located on smooth muscle cells.},
  language  = {en}
}
@article{TackeLinohStumpfetal.1983,
  author    = {Tacke, Reinhold and Linoh, Haryanto and Stumpf, Burghard and Abraham, Wolf-Rainer and Kieslich, Klaus and Ernst, Ludger},
  title     = {Mikrobiologische Umwandlung von Silicium-Verbindungen: Enantioselektive Reduktion von Acetessigs{\"a}ure-(trimethylsilylalkyl)estern und deren Carba-Analoga},
  series = {Zeitschrift f{\"u}r Naturforschung B},
  volume    = {38},
  journal   = {Zeitschrift f{\"u}r Naturforschung B},
  number    = {5},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-128304},
  pages     = {616-620},
  year      = {1983},
  abstract  = {The trimethylsilylalkyl acetoacetates 1 b and 2 b as well as their carba analogues 1 a and 2 a have been reduced microbiologically by Kloeckera corticis (ATCC 20109), leading to the corresponding ( + )-3(S)-hydroxybutanoates 3b, 4b, 3a, and 4a. The enantiomeric purity was found to be 80\% (3a, 3b, 4b) and 65\% (4a), respectively. The reduction of lb and 2b is - to our knowledge - the first example for a controlled microbiological transformation of organosilicon substrates.},
  language  = {de}
}
@article{TackeLinkBentlageFeltenetal.1985,
  author    = {Tacke, Reinhold and Link, Matthias and Bentlage-Felten, Anke and Zilch, Harald},
  title     = {Zum thermischen Verhalten einiger Kohlens{\"a}ure[(methylphenylsilyl)methyl]ester-Derivate},
  series = {Zeitschrift f{\"u}r Naturforschung B},
  volume    = {40},
  journal   = {Zeitschrift f{\"u}r Naturforschung B},
  number    = {7},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-128293},
  pages     = {942-947},
  year      = {1985},
  abstract  = {The synthesis and the thermal behaviour of the (methylphenylsilyl)methyl carbonates \(CH_3(C_6H_5)Si(H)CH_2OC(O)X (6: X = OCH_3; 7: X = Cl; 8: X = N(CH_3)_2)\) is described. 8 rearranges in toluene solution at 100 °C quantitatively to give the carbam oyloxysilane \(C_6H_5(CH_3)_2SiOC(O)N(CH_3)_2\) (11), whereas neat 6 and 7 at 135 °C undergo quantitative formation of \(C_6H_5(CH_3)_2SiOCH_3\) (12) and \(C_6H_5(CH_3)_2SiCl\) (13), respectively. The formation of 12 and 13 is explained by a rearrangement reaction (by analogy to the rearrangement of 8), follow ed by a decarboxylation. The thermally induced transformations 6 →12, 7 →13, and 8 →11 were found to be first-order reactions with half-lifes of ~2.6 h (135 °C, neat), ~4.5 h (135 °C, neat), and ~3.7 h (100 °C, in toluene), respectively.},
  language  = {de}
}
@article{TackeNiederer1978,
  author    = {Tacke, Reinhold and Niederer, Reinhold},
  title     = {Sila-Pharmaka, 9. Mitt. [1] Darstellung und Eigenschaften potentiell curarewirksamer Silicium-Verbindungen, I},
  series = {Zeitschrift f{\"u}r Naturforschung B},
  volume    = {33},
  journal   = {Zeitschrift f{\"u}r Naturforschung B},
  number    = {4},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-128277},
  pages     = {412-416},
  year      = {1978},
  abstract  = {Organosilicon compounds 8, 9 and 10 with potential curare-like action and their precursors 0, 6 and 7 were synthesized for the first time. 0-10 were characterized by their physical and chemical properties, and their structures were confirmed by analyses, IH NMR and mass spectroscopy (only for 0-7). The pharmacological and toxicological data of 8, 9 and 10 are reported.},
  language  = {de}
}
@article{SaadTacke1977,
  author    = {Saad, S. M. and Tacke, Reinhold},
  title     = {Zur Darstellung von 1,1,3,3-Tetramethyl-1,3-disila-2,4,7-trioxa-cycloheptan (1) und 1,1,3,3-Tetramethyl-1,3-disila-2,4,8-trioxa-cyclooctan (2)},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-86958},
  year      = {1977},
  abstract  = {No abstract available.},
  subject      = {Anorganische Analyse},
  language  = {de}
}
@article{TackeBentlageFeltenLinohetal.1986,
  author    = {Tacke, Reinhold and Bentlage-Felten, Anke and Linoh, Haryanto and Magda, Stephen},
  title     = {Sila-Analoga des Triparanols und Ethamoxytriphetols: Synthese sowie pharmakologische und toxikologische Eigenschaften},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-86940},
  year      = {1986},
  abstract  = {No abstract available.},
  language  = {de}
}
@article{TackeLinkJoppienetal.1986,
  author    = {Tacke, Reinhold and Link, Matthias and Joppien, Hartmut and Ernst, Ludger},
  title     = {Sila-Substitution des Akarizids Fenbutatinoxid und einiger seiner Derivate: Synthese und Eigenschaften von Hexakis[(dimethylphenylsilyl)methyl]distannoxan und Tris[(dimethylphenylsilyl)methyl](1,2,4-triazol-1-yl)stannan},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-86937},
  year      = {1986},
  abstract  = {No abstract available.},
  subject      = {Chemische Synthese},
  language  = {de}
}