@inproceedings{RethwilmBaunachMorietal.1990, author = {Rethwilm, Axel and Baunach, Gerald and Mori, Kazuyasu and ter Meulen, Volker}, title = {Transactivation of HIV by human spumaretrovirus}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-86436}, year = {1990}, abstract = {To study the activation of HIV by human spumaretrovirus (HSRV) the long terminal repeats (LTRs) of HSRV, HIVl and HIV2 were examined with respect to their ability to function as transcriptional promoters in virus infected and uninfected cells. Transient transfections using plasmids in which the L TRs of the three viruses were coupled to the bacterial chloramphenicol acetyltransferase (CA T) gene revealed (i) the level of cat gene expression directed by the HSRV LTR was markedly increased in HSRV infected cells compared to uninfected cells, (ii) cat gene expression driven by the HIV1 LTR, but not by the HIV2 LTR could be enhanced upon HSRV infection, whereas (iii) neither in HIV1 nor in HIV2 infected cells an effect on HSRV LTR driven cat geneexpression was detected.}, subject = {HIV}, language = {en} } @inproceedings{MoriRethwilmSchwinnetal.1990, author = {Mori, Kazuyasu and Rethwilm, Axel and Schwinn, Andreas and Horak, Ivan}, title = {Replication of human immunodeficiency virus type 1 in human t-cells expressing antisense RNA}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-86426}, year = {1990}, abstract = {No abstract available.}, subject = {HIV}, language = {en} } @inproceedings{MaurerBannertRethwilmetal.1988, author = {Maurer, B. and Bannert, H. and Rethwilm, Axel and Darai, B. and Fl{\"u}gel, R. M.}, title = {Characterization of the env gene and of two novel coding regions of the human spumaretrovirus}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-86334}, year = {1988}, abstract = {Recombinant clones harboring retroviral DNA were established. The nucleotide sequence of the central and 3' region of the genome of the human spumaretrovirus was determined. The 5' end of the deduced protein sequence was homologaus to the endonuclease domain of retroviral reverse transcriptases. A small intergenic region is followed by a lang open reading frame of 985 aminoacid residues that according to its genomic location and structural features is a typical retroviral env gene. Surprisingly, the postenv region contains two open reading frames that encodes two novel retroviral genes, termed bel-l and bel-2. The 3' LTR is 963 nucleotides lang and contains the signal sequences characteristic for transcriptional regulation of retrovirus genomes.}, subject = {Spumaviren}, language = {en} }