@inproceedings{AndersSchartlBarnekow1984, author = {Anders, Fritz and Schartl, Manfred and Barnekow, Angelika}, title = {Xiphophorus as an in vivo model for studies on oncogenes}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-86398}, year = {1984}, abstract = {The capacity of Xiphophorus to develop neoplasia can be formally assigned to a "tumor gene" (Tu), which appears to be a normal part of the genome of all individuals. The wild fish have evolved population-specific and cell type-specific systems of regulatory genes (R) for Tu that protect the fish from neoplasia. Hybridization of members of different wild populations in the laborstory followed by treatment of the hybrids with carcinogens led to disintegration of the R systems permitting excessive expression of Tu and thus resulting in neoplasia. Certain hybrids developed neoplasia even spontaneously. Observations on the genuine phenotypic effect of the derepressed Tu in the early embryo indicated an essential normal function of this oncogene in cell differentiation, proliferation and cell-cell communication. Tu appeared to be indispensable in the genome but may also be present in accessory copics. Recently, c-src, the cellular homolog of the Rous sarcoma virus oncogene v-src, was detected in Xiphophorus. The protein product of c-src, pp60c-src, was identified and then examined by its associated kinase activity. This pp60c-src was found in all individuals tested, but, depending on the genotype, its kinase activity was different. The genetic characters of c-src, such as linkage relations, dosage relations, expression, etc., correspond to those of Tu. From a systematic study which showed that pp60c-src was present in all metazoa tested ranging from mammals down to sponges, we concluded that c-src has evolved with the multicellular organization of animals. Neoplasia of animals and humans is a characteristic closely related to this evolution. Our data showed that small aquariurn fish, besides being used successfully because they are time-, space-, and money-saving systems for carcinogenicity testing, are also highly suitable for basic studies on neoplasia at the populational, morphological, developmental, cell biological, and molecular levels.}, subject = {Schwertk{\"a}rpfling}, language = {en} } @inproceedings{HeiserUlrichsEcksteinetal.1992, author = {Heiser, A. and Ulrichs, Karin and Eckstein, V. and M{\"u}ller-Ruchholtz, W.}, title = {Xenogeneic Cellular Response of Human Lymphocytes Against Porcine Lymphocytes and Isolated Pancreatic Islets}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-45479}, year = {1992}, abstract = {no abstract available}, language = {en} } @inproceedings{Schmitz2010, author = {Schmitz, Barbara}, title = {War, violence and Tyrannicide in the Book of Judith}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-67058}, year = {2010}, abstract = {No abstract available}, subject = {Judit }, language = {en} } @inproceedings{SchneiderWeinert1989, author = {Schneider, Wolfgang and Weinert, Franz E.}, title = {Universal trends and individual differences in memory development}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-86518}, year = {1989}, abstract = {No abstract available.}, subject = {Ged{\"a}chtnisbildung}, language = {en} } @inproceedings{TrendelenburgFrankeSpringetal.1975, author = {Trendelenburg, M. F. and Franke, Werner W. and Spring, H. and Scheer, Ulrich}, title = {Ultrastructure of transcription in the nucleoli of the green algae Acetabularia major and A. mediterranea}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-33779}, year = {1975}, abstract = {No abstract available}, language = {en} } @inproceedings{EcksteinUlrichsMeinckeetal.1991, author = {Eckstein, V. and Ulrichs, Karin and Meincke, G. and M{\"u}lller-Ruchholtz, W.}, title = {Transplantation of Diabetic Patients With Xenogeneic Pancreatic Islets Has to Consider Natural Xenophile Antibodies (NXA) In Patients Sera As a Major Obstacle to Success}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-45707}, year = {1991}, abstract = {No abstract available}, subject = {Immunbiologie}, language = {en} } @inproceedings{ScheerFranke1976, author = {Scheer, Ulrich and Franke, Werner W.}, title = {Transcriptional complexes of nucleolar genes}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-41072}, year = {1976}, abstract = {No abstract available}, language = {en} } @inproceedings{RethwilmBaunachMorietal.1990, author = {Rethwilm, Axel and Baunach, Gerald and Mori, Kazuyasu and ter Meulen, Volker}, title = {Transactivation of HIV by human spumaretrovirus}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-86436}, year = {1990}, abstract = {To study the activation of HIV by human spumaretrovirus (HSRV) the long terminal repeats (LTRs) of HSRV, HIVl and HIV2 were examined with respect to their ability to function as transcriptional promoters in virus infected and uninfected cells. Transient transfections using plasmids in which the L TRs of the three viruses were coupled to the bacterial chloramphenicol acetyltransferase (CA T) gene revealed (i) the level of cat gene expression directed by the HSRV LTR was markedly increased in HSRV infected cells compared to uninfected cells, (ii) cat gene expression driven by the HIV1 LTR, but not by the HIV2 LTR could be enhanced upon HSRV infection, whereas (iii) neither in HIV1 nor in HIV2 infected cells an effect on HSRV LTR driven cat geneexpression was detected.}, subject = {HIV}, language = {en} } @inproceedings{AbendscheinDesaiAstell2023, author = {Abendschein, Robin and Desai, Shital and Astell, Arlene J.}, title = {Towards Accessibility Guidelines for the Metaverse : A Synthesis of Recommendations for People Living With Dementia}, series = {Conference on Human Factors in Computing Systems (CHI'23) : Workshop "Towards an Inclusive and Accessible Metaverse"}, booktitle = {Conference on Human Factors in Computing Systems (CHI'23) : Workshop "Towards an Inclusive and Accessible Metaverse"}, doi = {10.25972/OPUS-32019}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-320199}, pages = {6}, year = {2023}, abstract = {Given the growing interest of corporate stakeholders in Metaverse applications, there is a need to understand accessibility of these technologies for marginalized populations such as people living with dementia to ensure inclusive design of Metaverse applications. We assessed the accessibility of extended reality technology for people living with mild cognitive impairment and dementia to develop accessibility guidelines for these technologies. We used four strategies to synthesize evidence for barriers and facilitators of accessibility: (1) Findings from a non-systematic literature review, (2) guidelines from well-researched technology, (3) exploration of selected mixed reality technologies, and (4) observations from four sessions and video data of people living with dementia using mixed reality technologies. We utilized template analysis to develop codes and themes towards accessibility guidelines. Future work can validate our preliminary findings by applying them on video recordings or testing them in experiments.}, subject = {CHI Conference}, language = {en} } @inproceedings{SchneiderWeinert1990, author = {Schneider, Wolfgang and Weinert, Franz E.}, title = {The role of knowledge, strategies, and aptitudes in cognitive Performance: Concluding Comments}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-87190}, year = {1990}, abstract = {No abstract available.}, subject = {Kognitive Entwicklung}, language = {en} }