@article{GorlovaSvirinPavlovetal.2023,
  author    = {Gorlova, Anna and Svirin, Evgeniy and Pavlov, Dmitrii and Cespuglio, Raymond and Proshin, Andrey and Schroeter, Careen A. and Lesch, Klaus-Peter and Strekalova, Tatyana},
  title     = {Understanding the role of oxidative stress, neuroinflammation and abnormal myelination in excessive aggression associated with depression: recent input from mechanistic studies},
  series = {International Journal of Molecular Sciences},
  volume    = {24},
  journal   = {International Journal of Molecular Sciences},
  number    = {2},
  issn      = {1422-0067},
  doi       = {10.3390/ijms24020915},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-304917},
  year      = {2023},
  abstract  = {Aggression and deficient cognitive control problems are widespread in psychiatric disorders, including major depressive disorder (MDD). These abnormalities are known to contribute significantly to the accompanying functional impairment and the global burden of disease. Progress in the development of targeted treatments of excessive aggression and accompanying symptoms has been limited, and there exists a major unmet need to develop more efficacious treatments for depressed patients. Due to the complex nature and the clinical heterogeneity of MDD and the lack of precise knowledge regarding its pathophysiology, effective management is challenging. Nonetheless, the aetiology and pathophysiology of MDD has been the subject of extensive research and there is a vast body of the latest literature that points to new mechanisms for this disorder. Here, we overview the key mechanisms, which include neuroinflammation, oxidative stress, insulin receptor signalling and abnormal myelination. We discuss the hypotheses that have been proposed to unify these processes, as many of these pathways are integrated for the neurobiology of MDD. We also describe the current translational approaches in modelling depression, including the recent advances in stress models of MDD, and emerging novel therapies, including novel approaches to management of excessive aggression, such as anti-diabetic drugs, antioxidant treatment and herbal compositions.},
  language  = {en}
}
@incollection{Chetvertak2022,
  author    = {Chetvertak, Іevgeniia},
  title     = {Cyber aggression in the stance of communicative approach},
  series = {Studies in Modern English},
  booktitle = {Studies in Modern English},
  editor    = {Lazebna, Nataliia and Kumar, Dinesh},
  publisher = {W{\"u}rzburg University Press},
  address   = {W{\"u}rzburg},
  doi       = {10.25972/WUP-978-3-95826-199-0-1},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-296152},
  publisher      = {W{\"u}rzburg University Press},
  pages     = {1-9},
  year      = {2022},
  abstract  = {The article deals with the notion of internet aggression (cyber aggression). It considers the mentioned term from both psychological and communicative approaches. The paper also provides detailed analyses of the cyber aggression in political discourse. The provided ex-amples are taken from the speeches of politicians during the time of Covid pandemic. The author also identifies several types of cyber aggression.},
  language  = {en}
}
@article{NandiCrombachElbertetal.2020,
  author    = {Nandi, Corina and Crombach, Anselm and Elbert, Thomas and Bambonye, Manass{\´e} and Pryss, R{\"u}diger and Schobel, Johannes and Weierstall-Pust, Roland},
  title     = {The cycle of violence as a function of PTSD and appetitive aggression: A longitudinal study with Burundian soldiers},
  series = {Aggressive Behavior},
  volume    = {46},
  journal   = {Aggressive Behavior},
  number    = {5},
  doi       = {10.1002/ab.21895},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-218235},
  pages     = {391 -- 399},
  year      = {2020},
  abstract  = {During deployment, soldiers face situations in which they are not only exposed to violence but also have to perpetrate it themselves. This study investigates the role of soldiers' levels of posttraumatic stress disorder (PTSD) symptoms and appetitive aggression, that is, a lust for violence, for their engaging in violence during deployment. Furthermore, factors during deployment influencing the level of PTSD symptoms and appetitive aggression after deployment were examined for a better comprehension of the maintenance of violence. Semi-structured interviews were conducted with 468 Burundian soldiers before and after a 1-year deployment to Somalia. To predict violent acts during deployment (perideployment) as well as appetitive aggression and PTSD symptom severity after deployment (postdeployment), structural equation modeling was utilized. Results showed that the number of violent acts perideployment was predicted by the level of appetitive aggression and by the severity of PTSD hyperarousal symptoms predeployment. In addition to its association with the predeployment level, appetitive aggression postdeployment was predicted by violent acts and trauma exposure perideployment as well as positively associated with unit support. PTSD symptom severity postdeployment was predicted by the severity of PTSD avoidance symptoms predeployment and trauma exposure perideployment, and negatively associated with unit support. This prospective study reveals the importance of appetitive aggression and PTSD hyperarousal symptoms for the engagement in violent acts during deployment, while simultaneously demonstrating how these phenomena may develop in mutually reinforcing cycles in a war setting.},
  language  = {en}
}
@article{EderMitschkeGollwitzer2020,
  author    = {Eder, Andreas B. and Mitschke, Vanessa and Gollwitzer, Mario},
  title     = {What stops revenge taking? Effects of observed emotional reactions on revenge seeking},
  series = {Aggressive Behavior},
  volume    = {46},
  journal   = {Aggressive Behavior},
  number    = {4},
  doi       = {10.1002/ab.21890},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-214686},
  pages     = {305 -- 316},
  year      = {2020},
  abstract  = {What reaction stops revenge taking? Four experiments (total N = 191) examined this question where the victim of an interpersonal transgression could observe the offender's reaction (anger, sadness, pain, or calm) to a retributive noise punishment. We compared the punishment intensity selected by the participant before and after seeing the offender's reaction. Seeing the opponent in pain reduced subsequent punishment most strongly, while displays of sadness and verbal indications of suffering had no appeasing effect. Expression of anger about a retributive punishment did not increase revenge seeking relative to a calm reaction, even when the anger response was disambiguated as being angry with the punisher. It is concluded that the expression of pain is the most effective emotional display for the reduction of retaliatory aggression. The findings are discussed in light of recent research on reactive aggression and retributive justice.},
  language  = {en}
}
@article{GutknechtPoppWaideretal.2015,
  author    = {Gutknecht, Lise and Popp, Sandy and Waider, Jonas and Sommerlandt, Frank M. J. and G{\"o}ppner, Corinna and Post, Antonia and Reif, Andreas and van den Hove, Daniel and Strekalova, Tatyana and Schmitt, Angelika and Colaςo, Maria B. N. and Sommer, Claudia and Palme, Rupert and Lesch, Klaus-Peter},
  title     = {Interaction of brain 5-HT synthesis deficiency, chronic stress and sex differentially impact emotional behavior in Tph2 knockout mice},
  series = {Psychopharmacology},
  volume    = {232},
  journal   = {Psychopharmacology},
  doi       = {10.1007/s00213-015-3879-0},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-154586},
  pages     = {2429 -- 2441},
  year      = {2015},
  abstract  = {Rationale While brain serotonin (5-HT) function is implicated in gene-by-environment interaction (GxE) impacting the vulnerability-resilience continuum in neuropsychiatric disorders, it remains elusive how the interplay of altered 5-HT synthesis and environmental stressors is linked to failure in emotion regulation. Objective Here, we investigated the effect of constitutively impaired 5-HT synthesis on behavioral and neuroendocrine responses to unpredictable chronic mild stress (CMS) using a mouse model of brain 5-HT deficiency resulting from targeted inactivation of the tryptophan hydroxylase-2 (Tph2) gene. Results Locomotor activity and anxiety- and depression-like behavior as well as conditioned fear responses were differentially affected by Tph2 genotype, sex, and CMS. Tph2 null mutants (Tph2\(^{-/-}\)) displayed increased general metabolism, marginally reduced anxiety- and depression-like behavior but strikingly increased conditioned fear responses. Behavioral modifications were associated with sex-specific hypothalamic-pituitary-adrenocortical (HPA) system alterations as indicated by plasma corticosterone and fecal corticosterone metabolite concentrations. Tph2\(^{-/-}\) males displayed increased impulsivity and high aggressiveness. Tph2\(^{-/-}\) females displayed greater emotional reactivity to aversive conditions as reflected by changes in behaviors at baseline including increased freezing and decreased locomotion in novel environments. However, both Tph2\(^{-/-}\) male and female mice were resilient to CMS-induced hyperlocomotion, while CMS intensified conditioned fear responses in a GxE-dependent manner. Conclusions Our results indicate that 5-HT mediates behavioral responses to environmental adversity by facilitating the encoding of stress effects leading to increased vulnerability for negative emotionality.},
  language  = {en}
}
@phdthesis{Eujen2009,
  author    = {Eujen, Andrea},
  title     = {Serotonerge Gene und NOS1 als Risikofaktoren f{\"u}r gewaltt{\"a}tiges Verhalten},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-36479},
  school      = {Universit{\"a}t W{\"u}rzburg},
  year      = {2009},
  abstract  = {Pers{\"o}nlichkeit im Allgemeinen wird, neben Umwelteinfl{\"u}ssen, durch genetische Komponenten beeinflusst. Bisher konnten jedoch nur wenige funktionelle Genvarianten mit Verhaltensz{\"u}gen assoziiert werden. Aggressives Verhalten als spezifisches Verhaltensmuster wird durch eine Reihe von Genvariationen beeinflusst, die in serotonerge, dopaminerge und nitrinerge Regelkreise eingreifen. Neben der genetischen Komponente pr{\"a}disponieren aber hier ganz erheblich auch {\"a}ußere Faktoren in der Umwelt, wie z.B. das soziale Umfeld, in dem Kinder und Jugendliche aufwachsen, f{\"u}r die Entwicklung von gewaltt{\"a}tigem Verhalten. Ziel der vorliegenden Arbeit war es, einen m{\"o}glichen Einfluss von vier verschiedenen funktionellen Gen-Polymorphismen (MAOA-uVNTR, DAT-uVNTR, NOS1 Ex1f-uVNTR und NOS1 Ex1c-SNP) auf Gewaltt{\"a}tigkeit bzw. Aggressivit{\"a}t zu untersuchen. Außerdem wurden Gen x Umweltinteraktionen im Bezug auf ung{\"u}nstige soziale Bedingungen in der Kindheit untersucht. Eine aus 184 M{\"a}nnern bestehende Stichprobe von Straff{\"a}lligen wurde in eine Gruppe von gewaltt{\"a}tigen und eine Gruppe von nicht-gewaltt{\"a}tigen Straft{\"a}tern unterteilt. Durch die logistische Regressionsanalyse konnte ermittelt werden, dass der MAO-A Genotyp, wie auch ung{\"u}nstige soziale Bedingungen in der Kindheit, unabh{\"a}ngig voneinander f{\"u}r gewaltt{\"a}tiges Verhalten pr{\"a}dispositionieren. 45\% der Gewaltt{\"a}tigen, aber nur 30\% der nicht-gewaltt{\"a}tigen Studienteilnehmer sind Tr{\"a}ger des niedrig-aktiven kurzen MAO-A Allels. Die neuronale Isoform der Stickstoffmonoxid-Synthase (NOS-I) wurde, ebenso wie MAO-A, in Tierversuchen mit aggressiven Verhaltensweisen assoziiert. In der vorliegenden Arbeit konnte gezeigt werden, dass es auch einen Zusammenhang zwischen einem funktionellen Promotorpolymorphismus von NOS1 und menschlicher Aggressivit{\"a}t gibt. Im Gegensatz zu MAOA und NOS1 beeinflusst ein funktioneller Polymorphismus im DAT1-Gen Gewaltt{\"a}tigkeit nicht. Diese Ergebnisse legen komplexe Interaktionen zwischen genetischer Variation und Umweltfaktoren nahe und zeigen gleichzeitig, dass aggressives Verhalten nicht durch einfache Vererbungsmodi zu erkl{\"a}ren ist.},
  subject      = {Aggression},
  language  = {de}
}
@phdthesis{Hoyer2007,
  author    = {Hoyer, Susanne Christine},
  title     = {Neuronal Correlates of Aggression in Drosophila melanogaster},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-25871},
  school      = {Universit{\"a}t W{\"u}rzburg},
  year      = {2007},
  abstract  = {Aggression ist ein facettenreiches Ph{\"a}nomen, das sowohl in Vertebraten als auch in Invertebraten auftritt. Trotz der weiten Verbreitung dieses Verhaltens sind die neuronalen Netzwerke, die der Aggression zugrunde liegen, noch kaum bekannt. Zahlreiche Studien weisen den biogenen Aminen eine prominente Rolle in der Modulation von Aggression zu. Das Ziel dieser Doktorarbeit war mit Hilfe des Modellorganismus Drosophila melanogaster zu der Aufschl{\"u}sselung der neuronalen Korrelate von Aggression beizutragen, insbesondere im Hinblick auf das biogene Amin Oktopamin. In Drosophila sind aggressive Interaktionen aus einer Vielzahl von offensiven und defensiven Verhaltensweisen zusammengesetzt, von denen einige bez{\"u}glich der H{\"a}ufigkeit ihres Auftretens geschlechtsspezifisch sind. Um die Auswertung dieser vielseitigen Verhaltensweisen zu vereinfachen, wurde die Analyse auf einen einzigen Indikator f{\"u}r Aggression beschr{\"a}nkt: den „lunge". Diese bemerkenswerte Verhaltensweise tritt nur im Kontext der Aggression auf und ist charakteristisch f{\"u}r M{\"a}nnchen. In Kooperation mit Andreas Eckart habe ich ein Computerprogramm entwickelt, das eine automatische Ausz{\"a}hlung der lunges in einem vom Forscher gew{\"a}hlten Zeitraum durchf{\"u}hrt. Zus{\"a}tzlich erh{\"a}lt man u.a. Informationen {\"u}ber die Laufstrecke der einzelnen Tiere wie auch {\"u}ber ihre Gr{\"o}ße. Dank eines weiteren von uns entwickelten Programms ist es m{\"o}glich, K{\"a}mpfe zweier Drosophila M{\"a}nnchen unabh{\"a}ngig von deren Genotyp wahlweise automatisch oder halb-automatisch auszuwerten. Mit Hilfe dieser Programme wurde gezeigt, dass (1) die gemeinsame Laufaktivit{\"a}t der beiden M{\"a}nnchen mit der Anzahl aller aufgetretenen lunges korreliert und, dass (2) ein Gr{\"o}ßenunterschied von 8\% ausreichend ist, um zu beeinflussen, welches Tier mehr lunges durchf{\"u}hrt. Ebenfalls konnte festgestellt werden, dass (3) eine Nullmutation im ‚white' Gen, welches einen ABC-Transporter kodiert, aggressives Verhalten fast vollst{\"a}ndig unterdr{\"u}ckt, was teilweise auf eine visuelle Beeintr{\"a}chtigung zur{\"u}ckzuf{\"u}hren ist. Außerdem f{\"u}hrt (4) das Absenken des White-Levels in verschiedenen Bereichen des Zentralgehirns zu reduzierter Aggression; ein Effekt, der auch durch die chemische Entfernung der Pilzk{\"o}rper, einer Struktur des zentralen Gehirns, hervorgerufen werden kann. Dies weist darauf hin, dass die Integrit{\"a}t verschiedener neuronaler Netzwerke/Gehirnbereiche erforderlich ist, um wildtypische Aggression zu erm{\"o}glichen. Zus{\"a}tzlich konnte (5) anhand von Mutationen in zwei Genen der Oktopaminsynthese, die beide die Oktopamin-Konzentration zwar erniedrigen, die Tyramin-Konzentration jedoch heben bzw. senken, demonstriert werden, dass Oktopaminmangel Aggression fast vollst{\"a}ndig zum Erliegen bringt. Wird ein lunge durchgef{\"u}hrt, so ist dessen Ausf{\"u}hrung fast wildtypisch. Rettungsversuche, in denen Oktopamin- und/oder Tyramin-Konzentrationen wiederhergestellt werden, legen nahe, dass ein sehr spezifisches Muster von Oktopamin r{\"a}umlich und zeitlich gew{\"a}hrleistet sein muss, um ein so komplexes und faszinierendes Verhalten wie die Aggression in Drosophila hervorzurufen.},
  subject      = {Biogene Amine},
  language  = {en}
}