@article{ChengOthmanStopperetal.2017,
  author    = {Cheng, Cheng and Othman, Eman M. and Stopper, Helga and Edrada-Ebel, RuAngelie and Hentschel, Ute and Abdelmohsen, Usama Ramadan},
  title     = {Isolation of petrocidin A, a new cytotoxic cyclic dipeptide from the marine sponge-derived bacterium \(Streptomyces\) sp. SBT348},
  series = {Marine Drugs},
  volume    = {15},
  journal   = {Marine Drugs},
  number    = {12},
  doi       = {10.3390/md15120383},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-172644},
  year      = {2017},
  abstract  = {A new cyclic dipeptide, petrocidin A (\(\textbf{1}\)), along with three known compounds—2,3-dihydroxybenzoic acid (\(\textbf{2}\)), 2,3-dihydroxybenzamide (\(\textbf{3}\)), and maltol (\(\textbf{4}\))—were isolated from the solid culture of \(Streptomyces\) sp. SBT348. The strain \(Streptomyces\) sp. SBT348 had been prioritized in a strain collection of 64 sponge-associated actinomycetes based on its distinct metabolomic profile using liquid chromatography/high-resolution mass spectrometry (LC-HRMS) and nuclear magnetic resonance (NMR). The absolute configuration of all α-amino acids was determined by HPLC analysis after derivatization with Marfey's reagent and comparison with commercially available reference amino acids. Structure elucidation was pursued in the presented study by mass spectrometry and NMR spectral data. Petrocidin A (\(\textbf{1}\)) and 2,3-dihydroxybenzamide (\(\textbf{3}\)) exhibited significant cytotoxicity towards the human promyelocytic HL-60 and the human colon adenocarcinoma HT-29 cell lines. These results demonstrated the potential of sponge-associated actinomycetes for the discovery of novel and pharmacologically active natural products.},
  language  = {en}
}
@article{ShadyElHossaryFouadetal.2017,
  author    = {Shady, Nourhan Hisham and El-Hossary, Ebaa M. and Fouad, Mostafa A. and Gulder, Tobias A. M. and Kamel, Mohamed Salah and Abdelmohsen, Usama Ramadan},
  title     = {Bioactive natural products of marine sponges from the Genus Hyrtios},
  series = {Molecules},
  volume    = {22},
  journal   = {Molecules},
  number    = {5},
  doi       = {10.3390/molecules22050781},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-158227},
  pages     = {781},
  year      = {2017},
  abstract  = {Marine sponges are known as a rich source for novel bioactive compounds with valuable pharmacological potential. One of the most predominant sponge genera is Hyrtios, reported to have various species such as Hyrtios erectus, Hyrtios reticulatus, Hyrtios gumminae, Hyrtios communis, and Hyrtios tubulatus and a number of undescribed species. Members of the genus Hyrtios are a rich source of natural products with diverse and valuable biological activities, represented by different chemical classes including alkaloids, sesterterpenes and sesquiterpenes. This review covers the literature until June 2016, providing a complete survey of all compounds isolated from the genus Hyrtios with their corresponding biological activities whenever applicable.},
  language  = {en}
}