@article{RoedelBaumannGrolletal.2018,
  author    = {R{\"o}del, Michaela and Baumann, Katrin and Groll, J{\"u}rgen and Gbureck, Uwe},
  title     = {Simultaneous structuring and mineralization of silk fibroin scaffolds},
  series = {Journal of Tissue Engineering},
  volume    = {9},
  journal   = {Journal of Tissue Engineering},
  doi       = {10.1177/2041731418788509},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-226427},
  pages     = {1-16},
  year      = {2018},
  abstract  = {Silk fibroin is commonly used as scaffold material for tissue engineering applications. In combination with a mineralization with different calcium phosphate phases, it can also be applied as material for bone regeneration. Here, we present a study which was performed to produce mineralized silk fibroin scaffolds with controlled macroporosity. In contrast to former studies, our approach focused on a simultaneous gelation and mineralization of silk fibroin by immersion of frozen silk fibroin monoliths in acidic calcium phosphate solutions. This was achieved by thawing frozen silk fibroin monoliths in acidic calcium phosphate solution, leading to the precipitation of monocalcium phosphate within the silk fibroin matrix. In the second approach, a conversion of incorporated -tricalcium phosphate particles into brushite was successfully achieved. Furthermore, a controlled cryostructuring process of silk fibroin scaffolds was carried out leading to the formation of parallel-oriented pores with diameters of 30-50 mu m.},
  language  = {en}
}
@article{BoehmMeiningerTeschetal.2018,
  author    = {Boehm, Anne and Meininger, Susanne and Tesch, Annemarie and Gbureck, Uwe and M{\"u}ller, Frank A.},
  title     = {The mechanical properties of biocompatible apatite bone cement reinforced with chemically activated carbon fibers},
  series = {Materials},
  volume    = {11},
  journal   = {Materials},
  number    = {2},
  issn      = {1996-1944},
  doi       = {10.3390/ma11020192},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-197808},
  pages     = {192},
  year      = {2018},
  abstract  = {Calcium phosphate cement (CPC) is a well-established bone replacement material in dentistry and orthopedics. CPC mimics the physicochemical properties of natural bone and therefore shows excellent in vivo behavior. However, due to their brittleness, the application of CPC implants is limited to non-load bearing areas. Generally, the fiber-reinforcement of ceramic materials enhances fracture resistance, but simultaneously reduces the strength of the composite. Combining strong C-fiber reinforcement with a hydroxyapatite to form a CPC with a chemical modification of the fiber surface allowed us to adjust the fiber-matrix interface and consequently the fracture behavior. Thus, we could demonstrate enhanced mechanical properties of CPC in terms of bending strength and work of fracture to a strain of 5\% (WOF5). Hereby, the strength increased by a factor of four from 9.2 ± 1.7 to 38.4 ± 1.7 MPa. Simultaneously, the WOF5 increased from 0.02 ± 0.004 to 2.0 ± 0.6 kJ∙m-2, when utilizing an aqua regia/CaCl2 pretreatment. The cell proliferation and activity of MG63 osteoblast-like cells as biocompatibility markers were not affected by fiber addition nor by fiber treatment. CPC reinforced with chemically activated C-fibers is a promising bone replacement material for load-bearing applications.},
  language  = {en}
}