@article{GesslerBarnekow1984,
author = {Gessler, Manfred and Barnekow, Angelika},
title = {Differential expression of the cellular oncogenes c-src and c-yes in embryonal and adult chicken tissues},
url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-59289},
year = {1984},
abstract = {The cellular onc-genes c-src and c-yes are expressed very differently during chicken embryonic development. The c-src mRNA and its translational product are detectable at high levels in brain extracts of chicken embryos and adult chickens, whereas muscle extracts show an age-dependent decrease in the amounts of c-src-specific mRNA and pp60c-src kinase activity. In contrast, the Ievels of c-yes mRNA in brain, heart, and muscle are relatively low in early embryonic stages and increase later on to values comparable to those found for liver, while in adult animals the pattern of c-yes expression is similar to that of the c-src gene. From the close correlation between the Ievels of pp60c-src, its enzymatic activity, and its corresponding mRNA at a given stage of development and in given tissues, it appears that the expression of pp60c-src is primarily controlled at the level of transcription. It is suggested that because of the different patterns of expression, the two cellular oncogenes, c-src and c-yes, play different roles in cell proliferation during early embryonic stages as weil as in ensuing differentiation processes.},
subject = {Biochemie},
language = {en}
}
@article{SchwartzNeveEisenmanetal.1994,
author = {Schwartz, Faina and Neve, Rachel and Eisenman, Robert and Gessler, Manfred and Bruns, Gail},
title = {A WAGR region gene between PAX-6 and FSHB expressed in fetal brain},
url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-59125},
year = {1994},
abstract = {Developmental delay or mental retardation is a frequent component of multi-system anomaly syndromes associated with chromosomal deletions. Isolation of genes involved in the mental dysfunction in these disorders should define loci important in brain formation or function. We have identified a highly conserved locus in the distal part of 11 p 13 that is prominently expressed in fetal brain. Minimal expression is observed in a number of other fetal tissues. The gene maps distal to PAX-6 but proximal to the loci for brain-derived neurotrophic factor (BDNF) and the beta subunit of follicle stimulating hormone (FSHB), within a region previously implicated in the mental retardation component of some WAGR syndrome patients. Within fetal brain, the corresponding transcript is prominent in frontal, motor and primary visual cortex as weil as in the caudate-putamen. The characteristics of this gene, including the striking evolutionary conservation at the locus, suggest that the encoded protein may function in brain development.},
subject = {Biochemie},
language = {en}
}
@article{GesslerHameisterHenryetal.1990,
author = {Gessler, Manfred and Hameister, H. and Henry, I. and Junien, C. and Braun, T. and Arnold, H. H.},
title = {The human MyoD1 (MYF3) gene maps on the short arm of chromosome 11 but is not associated with the WAGR locus or the region for the Beckwith-Wiedemann syndrome},
url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-59221},
year = {1990},
abstract = {The human gene encoding the myogenic determination factor myf3 (mouse MyoD1) has been mapped to the short arm of chromosome 11. Analysis of several somatic cell hybrids containing various derivatives with deletions or translocations revealed that the human MyoD (MYF3) gene is not associated with the WAGR locus at chromosomal band 11pl3 nor with the loss of the heterozygosity region at 11p15.5 related to the Beckwith-Wiedemann syndrome. Subregional mapping by in situ hybridization with an myf3 specific probe shows that the gene resides at the chromosomal band llp14, possibly at llp14.3.},
subject = {Biochemie},
language = {en}
}
@article{vanHeyningenBickmoreSeawrightetal.1990,
author = {van Heyningen, V. and Bickmore, W. A. and Seawright, A. and Fletcher, J. M. and Maule, J. and Fekete, G. and Gessler, Manfred and Bruns, G. A. and Huerre-Jeanpierre, C. and Junien, C.},
title = {Role for the Wilms tumor gene in genital development?},
url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-59238},
year = {1990},
abstract = {No abstract available},
subject = {Biochemie},
language = {en}
}
@article{GesslerBruns1989,
author = {Gessler, Manfred and Bruns, G. A. P.},
title = {A physical map around the WAGR complex on the short arm of chromosome 11},
url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-59246},
year = {1989},
abstract = {A long-range restriction map of part of the short arm of ehromosome 11 including the WAGR region has been constructed using pulsed-field gel electrophoresis and a number of infrequently cutting restriction enzymes. A total of 15.4 Mbp has been mapped in detall, extending from proximal 11p14 to the distal part of 11p12. The map localizes 35 different DNA probes and reveals at least nine areas with features eharaeteristle of BTF islands, some of which may be candidates for the different loci underlying the phenotype of the WAGR syndrome. This map will furthermore allow screening of DNA from individuals with WAGR-related phenotypes and from Wilms tumors for associated chromosomal rearrangements.},
subject = {Biochemie},
language = {en}
}
@article{GesslerThomasCouillinetal.1989,
author = {Gessler, Manfred and Thomas, G. H. and Couillin, P. and Junien, C. and McGillivray, B. C. and Hayden, M. and Jaschek, G. and Bruns, G. A.},
title = {A deletion map of the WAGR region on chromosome II},
url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-59255},
year = {1989},
abstract = {The WAGR (Wilms tumor, aniridia, genitourinary anomalies, and mental retardation) region has been assigned to chromosome 11p13 on the basis of overlapping constitutional deletions found in affected individuals. We have utilized 31 DNA probes which map to the WAGR deletion region, together with six reference loci and 13 WAGR-related deletions, to subdivide this area into 16 intervals. Specific intervals have been correlated with phenotypic features, leading to the identification of individual subregions for the aniridia and Wilms tumor loci. Delineation, by specific probes, of multiple intervals above and below the critical region and of five intervals within the overlap area provides a framework map for molecular characterization of WAGR gene loci and of deletion boundary regions.},
subject = {Biochemie},
language = {en}
}
@article{PoulatMorinKonigetal.1993,
author = {Poulat, F. and Morin, D. and Konig, A. and Brun, P. and Giltay, J. and Sultan, C. and Dumas, R. and Gessler, Manfred and Berta, P.},
title = {Distinct molecular origins for Denys-Drash and Frasier syndromes},
url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-59172},
year = {1993},
abstract = {The direct involvment of the Wilm's tumor suppressor gene (WTl) in Denys-Drash syndrome through mutations within exons 8 or 9 has recently been established. The absence of such alterations in three patients with Frasier syndrome provides a molecular basis for distinguishing these two syndromes that are associated with streak gonads, pseudohermaphroditism and renal failure.},
subject = {Biochemie},
language = {en}
}
@article{GesslerGrupeGrzeschiketal.1992,
author = {Gessler, Manfred and Grupe, Andrew and Grzeschik, Karl-Heinz and Pongs, Olaf},
title = {The potassium channel gene HK1 maps to human chromosome 11p14.1, close to the FSHB gene},
url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-59184},
year = {1992},
abstract = {Transiently activating (A-type) potassium (K) channels are important regulators of action potential and action potential firing frequencies. HK1 designates the firsthuman cDNA that is highly homologous to the rat RCK4 cDNA that codes for an A-type K-channel. The HK1 channel is expressed in heart. By somatic cell hybrid analysis, the HK1 gene has been assigned to human chromosome 11p13-pl4, the WAGR deletion region (Wilms tumor, aniridia, genito-urinary abnormalities and mental retardation). Subsequent pulsed field gel (PFG) analysis and comparison with the well-established PFG map of this region localized the gene to 11p14, 200-600 kb telomeric to the FSHB gene.},
subject = {Biochemie},
language = {en}
}
@article{GesslerKoenigBruns1992,
author = {Gessler, Manfred and K{\"o}nig, A. and Bruns, G. A. P.},
title = {The genomic organization and expression of the WT1 gene},
url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-59195},
year = {1992},
abstract = {The Wilms tumor gene WTl, a proposed tumor suppressor gene, has been identifled based on its location within a homozygous deletion found in tumor tissue. The gene encodes a putative transcription factor containing a Cys/His zinc finger domain. The critical homozygous deletions, however, are rarely seen, suggesting that in many cases the gene may be inactivated by more subtle alterations. To facilitate the seareh for smaller deletions and point mutations we have established the genomic organization of the WTl gene and have determined the sequence of all 10 exons and flanking intron DNA. The pattern of alternative splicing in two regions has been characterized in detail. These results will form the basis for future studies of mutant alleles at this locus.},
subject = {Biochemie},
language = {en}
}
@article{WolfKlugHackenbergetal.1992,
author = {Wolf, Markus and Klug, J{\"o}rg and Hackenberg, Reinhard and Gessler, Manfred and Grzeschik, Karl-Heinz and Beato, Miguel and Suske, Guntram},
title = {Human CC10, the homologue of rabbit uteroglobin: genomic cloning, chromosomal localization and expression in endometrial cell lines},
url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-59206},
year = {1992},
abstract = {No abstract available},
subject = {Biochemie},
language = {en}
}