@article{LjaschenkoEhmannKittel2013,
  author    = {Ljaschenko, Dmitrij and Ehmann, Nadine and Kittel, Robert J.},
  title     = {Hebbian Plasticity Guides Maturation of Glutamate Receptor Fields In Vivo},
  series = {Cell Reports},
  volume    = {3},
  journal   = {Cell Reports},
  number    = {5},
  doi       = {10.1016/j.celrep.2013.04.003},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-128804},
  pages     = {1407-1413},
  year      = {2013},
  abstract  = {Synaptic plasticity shapes the development of functional neural circuits and provides a basis for cellular models of learning and memory. Hebbian plasticity describes an activity-dependent change in synaptic strength that is input-specific and depends on correlated pre- and postsynaptic activity. Although it is recognized that synaptic activity and synapse development are intimately linked, our mechanistic understanding of the coupling is far from complete. Using Channelrhodopsin-2 to evoke activity in vivo, we investigated synaptic plasticity at the glutamatergic Drosophila neuromuscular junction. Remarkably, correlated pre- and postsynaptic stimulation increased postsynaptic sensitivity by promoting synapse- specific recruitment of GluR-IIA-type glutamate receptor subunits into postsynaptic receptor fields. Conversely, GluR-IIA was rapidly removed from synapses whose activity failed to evoke substantial postsynaptic depolarization. Uniting these results with developmental GluR-IIA dynamics provides a comprehensive physiological concept of how Hebbian plasticity guides synaptic maturation and sparse transmitter release controls the stabilization of the molecular composition of individual synapses.},
  language  = {en}
}