@article{vanOorschotRadesLordick2013,
  author    = {van Oorschot, Birgitt and Rades, Dirk and Lordick, Florian},
  title     = {Connections Are Clearly More Complex},
  series = {Deutsches {\"A}rzteblatt international},
  volume    = {110},
  journal   = {Deutsches {\"A}rzteblatt international},
  number    = {44},
  doi       = {10.3238/arztebl.2013.0753a},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-128837},
  pages     = {753},
  year      = {2013},
  abstract  = {No abstract available.},
  language  = {en}
}
@article{KuonBlasiUnsoeldetal.2022,
  author    = {Kuon, Jonas and Blasi, Miriam and Uns{\"o}ld, Laura and Vogt, Jeannette and Mehnert, Anja and Alt-Epping, Bernd and Oorschot, Birgitt van and Sistermanns, Jochen and Ahlborn, Miriam and Ritterbusch, Ulrike and Stevens, Susanne and Kahl, Christoph and Ruellan, Anne and Matthias, Kathrin and Kubin, Thomas and Stahlhut, Kerstin and Heider, Andrea and Lordick, Florian and Thomas, Michael},
  title     = {Impact of molecular alterations on quality of life and prognostic understanding over time in patients with incurable lung cancer: a multicenter, longitudinal, prospective cohort study},
  series = {Supportive Care in Cancer},
  volume    = {30},
  journal   = {Supportive Care in Cancer},
  number    = {4},
  organization    = {Arbeitsgemeinschaft Palliativmedizin (APM) of the German Cancer Society (DKG)},
  issn      = {0941-4355},
  doi       = {10.1007/s00520-021-06736-2},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-308211},
  pages     = {3131-3140},
  year      = {2022},
  abstract  = {Purpose The purpose of this study is to investigate changes over time in quality of life (QoL) in incurable lung cancer patients and the impact of determinants like molecular alterations (MA). Methods In a prospective, longitudinal, multicentric study, we assessed QoL, symptom burden, psychological distress, unmet needs, and prognostic understanding of patients diagnosed with incurable lung cancer at the time of the diagnosis (T0) and after 3 (T1), 6 (T2) and 12 months (T3) using validated questionnaires like FACT-L, National Comprehensive Cancer Network (NCCN) Distress Thermometer (DT), PHQ-4, SCNS-SF-34, and SEIQoL. Results Two hundred seventeen patients were enrolled, 22 (10\%) with reported MA. QoL scores improved over time, with a significant trend for DT, PHQ-4, and SCNS-SF-34. Significant determinants for stable or improving scores over time were survival > 6 months, performance status at the time of diagnosis, and presence of MA. Patients with MA showed better QoL scores (FACT-L at T1 104.4 vs 86.3; at T2 107.5 vs 90.0; at T3 100.9 vs 92.8) and lower psychological distress (NCCN DT at T1 3.3 vs 5; at T2 2.7 vs 4.5; at T3 3.7 vs 4.5; PHQ-4 at T1 2.3 vs 4.1; at T2 1.7 vs 3.6; at T3 2.2 vs 3.6), but also a worsening of the scores at 1 year and a higher percentage of inaccurate prognostic understanding (27 vs 17\%) compared to patients without MA. Conclusion Patients with tumors harboring MA are at risk of QoL deterioration during the course of the disease. Physicians should adapt their communication strategies in order to maintain or improve QoL.},
  language  = {en}
}