@article{LutzBuesserSagelsdorff1984,
  author    = {Lutz, Werner K. and B{\"u}sser, M. T. and Sagelsdorff, P.},
  title     = {Potency of carcinogens derived from covalent DNA binding and stimulation of DNA synthesis in rat liver},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-61026},
  year      = {1984},
  abstract  = {~n order to investigate the role of the stimu~ation of ceU division for the initiation (and possi:bly promotion) of live·r tumors by chemical carcinogens, the incorporation of radiolabeUed thymidine into liver DNA was dete:rmined in male rats. Single doses of various level!s of af.latoxin 81, benzidine and carbon tetrachloride (aU known to be genotoxic via DNA binding} did not affect cell division, whereas several hepatoca:rcinogens known not to bind to DNA (alphaHCH, dofibrate, and 2,3;7,8-t!etrachlorodiibenzo~p~dioxin) gave rise to a dosedependent stimulation of Ii ver DNA synthesis within 24 h. An equation combining the infl.uences of mitotic stimu:lation, expressed as dose required to double the contro~ Ievei of DNA synthesis, and DNA binding potency, exp:ressed as t.he Covalent Binding Index, correliated weil with the cardnogenk potency for both dasses of hepatocardnogens.},
  subject      = {Toxikologie},
  language  = {en}
}