@article{FeuersteinZerbeSiren1991, author = {Feuerstein, G. and Zerbe, R. L. and Sir{\´e}n, Anna-Leena}, title = {Supraoptic nuclei in vasopressin and hemodynamic responses to hemorrhage in rats}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-63057}, year = {1991}, abstract = {CARDIOVASCULAR and vasopressin (A VP) responses to hcmorrhagc wcrc studicd in rats with lesions of the hypothalamic supraoptic nuclei (SONL). Bleeding caused hypotension and increase in heart rate (HR) and A VP. SONL rats failed to fully recover from bleeding as compared to normal rats. Plasma A VP in SONL rats was in the normal in basal conditions, but failed to increase to levels attained in normal rats throughout the post-hemorrhage period. These data suggcst that the supraoptic nuclei are the primary regulatory sitcs for A VP release in rcsponse to hemorrhage and that lack of adequate A VP release significantly retards blood pressure recovery after bleeding.}, subject = {Neurobiologie}, language = {en} }