@article{DoronMcCarronHeldmanetal.1992,
  author    = {Doron, D. A. and McCarron, D. M. and Heldman, E. and Sir{\´e}n, Anna-Leena and Spatz, M. and Feuerstein, G. and Pollard, H. B. and Hallenbeck, J. M.},
  title     = {Comparison of stimulated tissue factor expression by brain microvascular endothelial cells from normotensive (WKY) and hypertensive (SHR) rats},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-63032},
  year      = {1992},
  abstract  = {The amounts of tissue factor (TF) expressed by brain microvascular endothelial cells (BMECs) from normotensive Wistar-Kyoto rats (WKY) and spontaneously hypertensive rats (SHR) were compared after stimulating the cells with different doses of lipopolysaccharide (LPS), thrombin, phorbol myristic acid (PMA), Ca\(^{2+}\)·ionophore (A23187), or tumor necrosis factor (TNF) and interleukin·l (IL.l). Treatment ofcultured BMECs fron. WKY and SHR with all of these factors dose·dependently increased their total amount of TF; no substantive differences in the Ieveis of enhanced TF expression were observed between WKY and SHR BMECs. We conclude that stimulated endothelium from rats with hypertension, a major stroke risk factor, is not hyperresponsive with respect to TF expression when compared to normotensive controls.},
  subject      = {Neurobiologie},
  language  = {en}
}