@article{KarppanenSirenEskeliKaivosoja1979,
  author    = {Karppanen, H. and Sir{\´e}n, Anna-Leena and Eskeli-Kaivosoja, Alice},
  title     = {Central cardiovascular and thermal effects of Prostaglandin F2α in rats},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-47955},
  year      = {1979},
  abstract  = {Administration of PGF 2IX (0.2-6.4 J.lg) into the lateral cerebral ventricle (i.c.v.) induced dosedependent increases in blood pressure , heart rate and body temperature in urethane-anaesthetised rats, but had no effect on these parameters when the same dose range was administered intravenously. Peripheral pretreatment with sodium meclofenamate (50 mg/kg s.c.) sltifted all the dose-response curves for PGF 2IX (i.c.v.) to the left, but indomethacin (50 mg/kg s.c.) did not significantly affect those changes. Central pretreatment with sodiurn meclofenamate or indomethacin (1.25 mg per rat i.c.v.) failed to modify significantly the effects of centrally administered PGF 2IX' The results support previous suggestions that PGF 2IX may participate in the central control of the cardiovascular and thermoregulatory systems, and also suggest that there may be differences in the sites and/or modes of action between sodiurn meclofenamate and indomethacin.},
  subject      = {Prostaglandine},
  language  = {en}
}
@article{Siren1981,
  author    = {Sir{\´e}n, Anna-Leena},
  title     = {Central cardiovascular and thermal effects of prostacyclin in rats},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-47943},
  year      = {1981},
  abstract  = {Prostacyclin (PGI2) induced a dose-dependent decrease in blood pressure with slight increases in heart rate and body temperature, when administered at the doses of 0.1-100 ~g into the lateral cerebral ventricle (i.c.v.) of the urethane-anaesthetised rat. When the same doses were administered intravenously, both the blood pressure and heart rate decreased. Central pretreatment wib~ sodiurn meclofenamate (1 mg/rat i.c.v.) antagonised the central hypotensive effect of PGI2 but i.c.v. pretreatrnent of the rats with indomethacin (1 mg/rat) failed to affect the PGI 2-induced hypotension. Central pretreatment with two histamine H2-receptor antagonists, cimetidine (500 ~g/rat i.c.v.) or metiamide (488 ~g/rat i.c.v.), antagonised the blood pressure lowering effect of 0.1 ~g dose of PGI2 but failed to affect the hypotension induced by higher PGI2 doses. Therefore the main central hypotensive effect of PGI2 seems not to be associated with the stimulation of histamine H2 -receptors in the brain. The hypotensive effect of i.c.v. administered PGI2 appears to be due to an action upon the central nervous system rather than to a leakage into the peripheral circulation. This assurnption is supported by the fact that sodiurn meclofenamate i.c.v. antagonised the effect of PGI 2. In addition, the chronotropic response to i.c.v. PGI2 was opposite to that induced by intravenous administration. The results also suggest that there may be differences in the mode of action between sodiurn meclofenamate and indomethacin.},
  subject      = {Prostaglandine},
  language  = {en}
}
@article{SirenKarppanen1980,
  author    = {Sir{\´e}n, Anna-Leena and Karppanen, H.},
  title     = {Influence of analgesic antipyretics on the central cardiovascular effects of clonidine in rats},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-48640},
  year      = {1980},
  abstract  = {No abstract available},
  subject      = {Prostaglandine},
  language  = {en}
}