@article{FeuersteinSiren1988,
  author    = {Feuerstein, G. and Sir{\´e}n, Anna-Leena},
  title     = {Hypothalamic µ-receptors in the cardiovascular control: a review},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-63228},
  year      = {1988},
  abstract  = {The endogenous opioid system includes three major families of peptides [22): dynorphins (derived from pre-proenkephalin B); endorphins (derived from pre-proopiomelanocortin) and enkephalins (derived from pre-proenkephalin A). Multiple species of opioid peptides are derived from these major precursors and many of them possess potent cardiovascular properties. Multiple forms of opioid receptors have been defined in the central nervous system. Although the relationship of these receptors to the multiple actions of the opioid systems is not weil understood, some predications can be made: in vitro the dynorphin-related peptidesbind preferentially to kappa-opioid receptors; the enkephalins bind preferentially to delta and JL-opioid receptors and while beta-endorphin binds to mu- and delta-, but not to kappa-opioid receptors. While littleis known on the roJe ofthe opioid system in normal cardiovascular regulation, it has become clear that cardiovascular stress situations substantially modify the activity ofthe endogenous opioid system. This review focuses on the mu-opioid system in the hypothalamus with special emphasis on its potential roJe in cardiovascular control of both normal and pathophysiologic states.},
  subject      = {Neurobiologie},
  language  = {en}
}
@article{FeuersteinZerbeSiren1991,
  author    = {Feuerstein, G. and Zerbe, R. L. and Sir{\´e}n, Anna-Leena},
  title     = {Supraoptic nuclei in vasopressin and hemodynamic responses to hemorrhage in rats},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-63057},
  year      = {1991},
  abstract  = {CARDIOVASCULAR and vasopressin (A VP) responses to hcmorrhagc wcrc studicd in rats with lesions of the hypothalamic supraoptic nuclei (SONL). Bleeding caused hypotension and increase in heart rate (HR) and A VP. SONL rats failed to fully recover from bleeding as compared to normal rats. Plasma A VP in SONL rats was in the normal in basal conditions, but failed to increase to levels attained in normal rats throughout the post-hemorrhage period. These data suggcst that the supraoptic nuclei are the primary regulatory sitcs for A VP release in rcsponse to hemorrhage and that lack of adequate A VP release significantly retards blood pressure recovery after bleeding.},
  subject      = {Neurobiologie},
  language  = {en}
}