@article{MontalbandelBarrioPenskiSchlahsaetal.2016,
  author    = {Montalb{\´a}n del Barrio, Itsaso and Penski, Cornelia and Schlahsa, Laura and Stein, Roland G. and Diessner, Joachim and W{\"o}ckel, Achim and Dietl, Johannes and Lutz, Manfred B. and Mittelbronn, Michel and Wischhusen, J{\"o}rg and H{\"a}usler, Sebastian F. M.},
  title     = {Adenosine-generating ovarian cancer cells attract myeloid cells which differentiate into adenosine-generating tumor associated macrophages - a self-amplifying, CD39- and CD73-dependent mechanism for tumor immune escape},
  series = {Journal for ImmunoTherapy of Cancer},
  volume    = {4},
  journal   = {Journal for ImmunoTherapy of Cancer},
  number    = {49},
  doi       = {10.1186/s40425-016-0154-9},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-146624},
  year      = {2016},
  abstract  = {Background Ovarian cancer (OvCA) tissues show abundant expression of the ectonucleotidases CD39 and CD73 which generate immunomodulatory adenosine, thereby inhibiting cytotoxic lymphocytes. Little, however, is known about the effect of adenosine on myeloid cells. Considering that tumor associated macrophages (TAM) and myeloid-derived suppressor cells (MDSC) constitute up to 20 \% of OvCA tissue, we investigated the effect of adenosine on myeloid cells and explored a possible contribution of myeloid cells to adenosine generation in vitro and ex vivo. Methods Monocytes were used as human blood-derived myeloid cells. After co-incubation with SK-OV-3 or OAW-42 OvCA cells, monocyte migration was determined in transwell assays. For conversion into M2-polarized "TAM-like" macrophages, monocytes were co-incubated with OAW-42 cells. Ex vivo TAMs were obtained from OvCA ascites. Macrophage phenotypes were investigated by intracellular staining for IL-10 and IL-12. CD39 and CD73 expression were assessed by FACS analysis both on in vitro-induced TAM-like macrophages and on ascites-derived ex situ-TAMs. Myeloid cells in solid tumor tissue were analyzed by immunohistochemistry. Generation of biologically active adenosine by TAM-like macrophages was measured in luciferase-based reporter assays. Functional effects of adenosine were investigated in proliferation-experiments with CD4+ T cells and specific inhibitors. Results When CD39 or CD73 activity on OvCA cells were blocked, the migration of monocytes towards OvCA cells was significantly decreased. In vivo, myeloid cells in solid ovarian cancer tissue were found to express CD39 whereas CD73 was mainly detected on stromal fibroblasts. Ex situ-TAMs and in vitro differentiated TAM-like cells, however, upregulated the expression of CD39 and CD73 compared to monocytes or M1 macrophages. Expression of ectonucleotidases also translated into increased levels of biologically active adenosine. Accordingly, co-incubation with these TAMs suppressed CD4+ T cell proliferation which could be rescued via blockade of CD39 or CD73. Conclusion Adenosine generated by OvCA cells likely contributes to the recruitment of TAMs which further amplify adenosine-dependent immunosuppression via additional ectonucleotidase activity. In solid ovarian cancer tissue, TAMs express CD39 while CD73 is found on stromal fibroblasts. Accordingly, small molecule inhibitors of CD39 or CD73 could improve immune responses in ovarian cancer.},
  language  = {en}
}
@article{SteinWollschlaegerKreienbergetal.2016,
  author    = {Stein, Roland Gregor and Wollschl{\"a}ger, Daniel and Kreienberg, Rolf and Janni, Wolfgang and Wischnewsky, Manfred and Diessner, Joachim and St{\"u}ber, Tanja and Bartmann, Catharina and Krockenberger, Mathias and Wischhusen, J{\"o}rg and W{\"o}ckel, Achim and Blettner, Maria and Schwentner, Lukas},
  title     = {The impact of breast cancer biological subtyping on tumor size assessment by ultrasound and mammography - a retrospective multicenter cohort study of 6543 primary breast cancer patients},
  series = {BMC Cancer},
  volume    = {16},
  journal   = {BMC Cancer},
  number    = {549},
  doi       = {10.1186/s12885-016-2426-7},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-161050},
  year      = {2016},
  abstract  = {Background Mammography and ultrasound are the gold standard imaging techniques for preoperative assessment and for monitoring the efficacy of neoadjuvant chemotherapy in breast cancer. Maximum accuracy in predicting pathological tumor size non-invasively is critical for individualized therapy and surgical planning. We therefore aimed to assess the accuracy of tumor size measurement by ultrasound and mammography in a multicentered health services research study. Methods We retrospectively analyzed data from 6543 patients with unifocal, unilateral primary breast cancer. The maximum tumor diameter was measured by ultrasound and/or mammographic imaging. All measurements were compared to final tumor diameter determined by postoperative histopathological examination. We compared the precision of each imaging method across different patient subgroups as well as the method-specific accuracy in each patient subgroup. Results Overall, the correlation with histology was 0.61 for mammography and 0.60 for ultrasound. Both correlations were higher in pT2 cancers than in pT1 and pT3. Ultrasound as well as mammography revealed a significantly higher correlation with histology in invasive ductal compared to lobular cancers (p < 0.01). For invasive lobular cancers, the mammography showed better correlation with histology than ultrasound (p = 0.01), whereas there was no such advantage for invasive ductal cancers. Ultrasound was significantly superior for HR negative cancers (p < 0.001). HER2/neu positive cancers were also more precisely assessed by ultrasound (p < 0.001). The size of HER2/neu negative cancers could be more accurately predicted by mammography (p < 0.001). Conclusion This multicentered health services research approach demonstrates that predicting tumor size by mammography and ultrasound provides accurate results. Biological tumor features do, however, affect the diagnostic precision.},
  language  = {en}
}
@article{DiessnerWischnewskyBlettneretal.2016,
  author    = {Diessner, Joachim and Wischnewsky, Manfred and Blettner, Maria and H{\"a}usler, Sebastian and Janni, Wolfgang and Kreienberg, Rolf and Stein, Roland and St{\"u}ber, Tanja and Schwentner, Lukas and Bartmann, Catharina and W{\"o}ckel, Achim},
  title     = {Do Patients with Luminal A Breast Cancer Profit from Adjuvant Systemic Therapy? A Retrospective Multicenter Study},
  series = {PLoS ONE},
  volume    = {11},
  journal   = {PLoS ONE},
  number    = {12},
  doi       = {10.1371/journal.pone.0168730},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-178217},
  year      = {2016},
  abstract  = {Background Luminal A breast cancers respond well to anti-hormonal therapy (HT), are associated with a generally favorable prognosis and constitute the majority of breast cancer subtypes. HT is the mainstay of treatment of these patients, accompanied by an acceptable profile of side effects, whereas the added benefit of chemotherapy (CHT), including anthracycline and taxane-based programs, is less clear-cut and has undergone a process of critical revision. Methods In the framework of the BRENDA collective, we analyzed the benefits of CHT compared to HT in 4570 luminal A patients (pts) with primary diagnosis between 2001 and 2008. The results were adjusted by nodal status, age, tumor size and grading. Results There has been a progressive reduction in the use of CHT in luminal A patients during the last decade. Neither univariate nor multivariate analyses showed any statistically significant differences in relapse free survival (RFS) with the addition of CHT to adjuvant HT, independent of the nodal status, age, tumor size or grading. Even for patients with more than 3 affected lymph nodes, there was no significant difference (univariate: p = 0.865; HR 0.94; 95\% CI: 0.46-1.93; multivariate: p = 0.812; HR 0.92; 95\% CI: 0.45-1.88). Conclusions The addition of CHT to HT provides minimal or no clinical benefit at all to patients with luminal A breast cancer, independent of the RFS-risk. Consequently, risk estimation cannot be the initial step in the decisional process. These findings-that are in line with several publications-should encourage the critical evaluation of applying adjuvant CHT to patients with luminal A breast cancer.},
  language  = {en}
}
@article{DiessnerWischnewskyStueberetal.2016,
  author    = {Diessner, Joachim and Wischnewsky, Manfred and St{\"u}ber, Tanja and Stein, Roland and Krockenberger, Mathias and H{\"a}usler, Sebastian and Janni, Wolfgang and Kreienberg, Rolf and Blettner, Maria and Schwentner, Lukas and W{\"o}ckel, Achim and Bartmann, Catharina},
  title     = {Evaluation of clinical parameters influencing the development of bone metastasis in breast cancer},
  series = {BMC Cancer},
  volume    = {16},
  journal   = {BMC Cancer},
  number    = {307},
  doi       = {10.1186/s12885-016-2345-7},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-161173},
  year      = {2016},
  abstract  = {Background The development of metastases is a negative prognostic parameter for the clinical outcome of breast cancer. Bone constitutes the first site of distant metastases for many affected women. The purpose of this retrospective multicentre study was to evaluate if and how different variables such as primary tumour stage, biological and histological subtype, age at primary diagnosis, tumour size, the number of affected lymph nodes as well as grading influence the development of bone-only metastases. Methods This retrospective German multicentre study is based on the BRENDA collective and included 9625 patients with primary breast cancer recruited from 1992 to 2008. In this analysis, we investigated a subgroup of 226 patients with bone-only metastases. Association between bone-only relapse and clinico-pathological risk factors was assessed in multivariate models using the tree-building algorithms "exhausted CHAID (Chi-square Automatic Interaction Detectors)" and CART(Classification and Regression Tree), as well as radial basis function networks (RBF-net), feedforward multilayer perceptron networks (MLP) and logistic regression. Results Multivariate analysis demonstrated that breast cancer subtypes have the strongest influence on the development of bone-only metastases (χ2 = 28). 29.9 \% of patients with luminal A or luminal B (ABC-patients) and 11.4 \% with triple negative BC (TNBC) or HER2-overexpressing tumours had bone-only metastases (p < 0.001). Five different mathematical models confirmed this correlation. The second important risk factor is the age at primary diagnosis. Moreover, BC subcategories influence the overall survival from date of metastatic disease of patients with bone-only metastases. Patients with bone-only metastases and TNBC (p < 0.001; HR = 7.47 (95 \% CI: 3.52-15.87) or HER2 overexpressing BC (p = 0.007; HR = 3.04 (95 \% CI: 1.36-6.80) have the worst outcome compared to patients with luminal A or luminal B tumours and bone-only metastases. Conclusion The bottom line of different mathematical models is the prior importance of subcategories of breast cancer and the age at primary diagnosis for the appearance of osseous metastases. The primary tumour stage, histological subtype, tumour size, the number of affected lymph nodes, grading and NPI seem to have only a minor influence on the development of bone-only metastases.},
  language  = {en}
}
@article{HaeuslerdelBarrioDiessneretal.2014,
  author    = {H{\"a}usler, Sebastian F. M. and del Barrio, Itsaso Montalb{\´a}n and Diessner, Joachim and Stein, Roland G. and Strohschein, Jenny and H{\"o}nig, Arnd and Dietl, Johannes and Wischhusen, J{\"o}rg},
  title     = {Anti-CD39 and anti-CD73 antibodies A1 and 7G2 improve targeted therapy in ovarian cancer by blocking adenosine-dependent immune evasion},
  series = {American Journal of Translational Research},
  volume    = {6},
  journal   = {American Journal of Translational Research},
  number    = {2},
  issn      = {1943-8141},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-120016},
  pages     = {129-139},
  year      = {2014},
  abstract  = {The ectonucleotidases CD39 and CD73 degrade ATP to adenosine which inhibits immune responses via the \(A_{2A}\) adenosine receptor (ADORA2A) on T and NK cells. The current study investigates the potential therapeutic use of the specific anti CD39- and anti CD73-antibodies A1 (CD39) and 7G2 (CD73) as these two ectonucleotidases are overexpressed in ovarian cancer (OvCA). As expected, NK cell cytotoxicity against the human ovarian cancer cell lines OAW-42 or SK-OV-3 was significantly increased in the presence of A1 or 7G2 antibody. While this might partly be due to antibody-dependent cell-mediated cytotoxicity, a luciferase-dependent assay for quantifying biologically active adenosine further showed that A1 and 7G2 can inhibit CD39 and CD73-dependent adenosine-generation. In turn, the reduction in adenosine levels achieved by addition of A1 and 7G2 to OAW-42 or SK-OV-3 cells was found to de-inhibit the proliferation of \(CD4^+\) T cells in coculture with OvCA cells. Likewise, blocking of CD39 and CD73 on OvCA cells via A1 and 7G2 led to an increased cytotoxicity of alloreactive primed T cells. Thus, antibodies like A1 and 7G2 could improve targeted therapy in ovarian cancer not only by specifically labeling overexpressed antigens but also by blocking adenosine-dependent immune evasion in this immunogenic malignancy.},
  language  = {en}
}
@article{DiessnerBruttelBeckeretal.2013,
  author    = {Diessner, Joachim and Bruttel, Valentin and Becker, Kathrin and Pawlik, Miriam and Stein, Roland and H{\"a}usler, Sebastian and Dietl, Johannes and Wischhusen, J{\"o}rg and H{\"o}nig, Arnd},
  title     = {Targeting breast cancer stem cells with HER2-specific antibodies and natural killer cells},
  series = {American Journal of Cancer Research},
  volume    = {3},
  journal   = {American Journal of Cancer Research},
  number    = {2},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-128633},
  pages     = {221-220},
  year      = {2013},
  abstract  = {Breast cancer is the most common cancer among women worldwide. Every year, nearly 1.4 million new cases of breast cancer are diagnosed, and about 450.000 women die of the disease. Approximately 15-25\% of breast cancer cases exhibit increased quantities of the trans-membrane receptor tyrosine kinase human epidermal growth factor receptor 2 (HER2) on the tumor cell surface. Previous studies showed that blockade of this HER2 proto-oncogene with the antibody trastuzumab substantially improved the overall survival of patients with this aggressive type of breast cancer. Recruitment of natural killer (NK) cells and subsequent induction of antibody-dependent cell-mediated cytotoxicity (ADCC) contributed to this beneficial effect. We hypothesized that antibody binding to HER2-positive breast cancer cells and thus ADCC might be further improved by synergistically applying two different HER2-specific antibodies, trastuzumab and pertuzumab. We found that tumor cell killing via ADCC was increased when the combination of trastuzumab, pertuzumab, and NK cells was applied to HER2-positive breast cancer cells, as compared to the extent of ADCC induced by a single antibody. Furthermore, a subset of \(CD44^{high}CD24^{low}HER2^{low}\) cells, which possessed characteristics of cancer stem cells, could be targeted more efficiently by the combination of two HER2-specific antibodies compared to the efficiency of one antibody. These in vitro results demonstrated the immunotherapeutic benefit achieved by the combined application of trastuzumab and pertuzumab. These findings are consistent with the positive results of the clinical studies, CLEOPATRA and NEOSPHERE, conducted with patients that had HER2-positive breast cancer. Compared to a single antibody treatment, the combined application of trastuzumab and pertuzumab showed a stronger ADCC effect and improved the targeting of breast cancer stem cells.},
  language  = {en}
}
@phdthesis{Stein2012,
  author    = {Stein, Roland Gregor},
  title     = {Immunhistochemische Marker f{\"u}r die Prognose und Proliferation in Ependymomen bei Kindern und Erwachsenen},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-71082},
  school      = {Universit{\"a}t W{\"u}rzburg},
  year      = {2012},
  abstract  = {Zur Identifizierung geeigneter Routinemarker f{\"u}r die Prognose von Ependymompatienten f{\"u}hrten wir immunhistochemische Untersuchungen und statistische Auswertungen an Ependymomen und Daten von 32 Erwachsenen und 23 p{\"a}diatrischen Patienten durch. Davon wurden bei drei Tumoren auch Rezidive untersucht, so dass insgesamt 59 Ependymome in die Untersuchung eingeschlossen wurden. Im Einzelnen handelte es sich um 11 myxopapill{\"a}re Ependymome, 6 Subependymome, 19 Ependymome und 23 anaplastische Ependymome. Die gr{\"o}ßten Fallgruppen bildeten p{\"a}diatrische Patienten unter drei Jahren und Erwachsene zwischen 50 und 70 Jahren. Bei Kindern war mit 45,8\% die infratentorielle, bei Erwachsenen mit 65\% die spinale Tumorlokalisation am h{\"a}ufigsten. Die untersuchten spinalen Ependymome entsprachen zu gleichen Teilen myxopapill{\"a}ren Ependymomen WHO Grad I und Ependymomen WHO Grad II. In supratentorieller Lage fanden sich mit 67\% {\"u}berwiegend anaplastische Ependymome WHO Grad III. Auch bei den infratentoriell gelegenen Ependymomen waren mit 63\% die Mehrzahl anaplastische Ependymome, daneben fanden sich 29,6\% Ependymome WHO Grad II. Beim Vergleich des von uns definierten und bestimmten Ki67-Scores als Zeichen f{\"u}r die Ependymomproliferation und der immunhistochemischen Positivit{\"a}t f{\"u}r HCK fiel nach Anwendung des Chi-Quadrat-Tests mit p=0,067 ein deutlicher Trend zu schw{\"a}cherer punktf{\"o}rmiger Positivit{\"a}t bei h{\"o}herem Ki67-Score auf. Dieser Trend setzte sich in der Erwachsenengruppe separat fort, w{\"a}hrend er in der Kindergruppe allein nicht nachweisbar war. In der Erwachsenengruppe war mit 28\% ein deutlicher Anteil myxopapill{\"a}rer Ependymome vorhanden, welche bei den Kindern nur 8\% ausmachten.M{\"o}glicherweise spielt die ver{\"a}nderte HCK-Expression in der Subgruppe der myxopapill{\"a}ren Ependymome eine Rolle. Unsere Untersuchungen zeigten außerdem mit p=0,057 einen deutlichen Trend zu l{\"a}ngerem {\"U}berleben bei immunohistochemischer DBC1-Negativit{\"a}t. Die Multivarianzanalyse mittels Cox-Regression wies eine Positivit{\"a}t f{\"u}r DBC1 als unabh{\"a}ngigen Risikofaktor f{\"u}r eine k{\"u}rzere {\"U}berlebenszeit nach. Des Weiteren konnte eine mit p=0,013 signifikante Korrelation zwischen immunhistochemischer Positivit{\"a}t f{\"u}r DBC1 und h{\"o}herem Ki67-Score gezeigt werden. Auch mit h{\"o}herem WHO-Grad korrelierte die DBC1-Positivit{\"a}t mit p=0,009. Besonders infratentoriell gelegene Ependymome zeigten DBC1-Reaktivit{\"a}t. Hier treten bekannterweise h{\"a}ufiger anaplastische Ependymome mit h{\"o}herem Proliferationsindex auf. Unsere Ergebnisse legen somit die Eignung des Markers DBC1 als immunhistochemische Routineuntersuchung f{\"u}r die Beurteilung der vom Resektionsstatus unabh{\"a}ngigen Prognose und {\"U}berlebenszeit von Ependymompatienten nahe.},
  subject      = {Ependymom},
  language  = {de}
}
@incollection{Stein1994,
  author    = {Stein, Roland},
  title     = {Lernen},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-40202},
  publisher      = {Universit{\"a}t W{\"u}rzburg},
  year      = {1994},
  abstract  = {No abstract available},
  subject      = {Sonderp{\"a}dagogik / W{\"o}rterbuch},
  language  = {de}
}
@incollection{Stein1994,
  author    = {Stein, Roland},
  title     = {MCD},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-40210},
  publisher      = {Universit{\"a}t W{\"u}rzburg},
  year      = {1994},
  abstract  = {No abstract available},
  subject      = {Sonderp{\"a}dagogik / W{\"o}rterbuch},
  language  = {de}
}
@incollection{Stein1994,
  author    = {Stein, Roland},
  title     = {Lernbehinderung},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-40198},
  publisher      = {Universit{\"a}t W{\"u}rzburg},
  year      = {1994},
  abstract  = {No abstract available},
  subject      = {Sonderp{\"a}dagogik / W{\"o}rterbuch},
  language  = {de}
}
@incollection{Stein1994,
  author    = {Stein, Roland},
  title     = {Ausbildung},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-40187},
  publisher      = {Universit{\"a}t W{\"u}rzburg},
  year      = {1994},
  abstract  = {No abstract available},
  subject      = {Sonderp{\"a}dagogik},
  language  = {de}
}
@article{Stein1994,
  author    = {Stein, Roland},
  title     = {Lernbeeintr{\"a}chtigte nach der Schule - Arbeit oder Sozialhilfe? : Erfahrungen aus der Berufsausbildung ehemaliger Sondersch{\"u}ler},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-40091},
  year      = {1994},
  abstract  = {Nach der Schulzeit droht Lernbeeintr{\"a}chtigten durch die allgemeine Entwicklung auf dem Arbeits- und Ausbildungsmarkt eine schwierige Berufsfindung, hochgradig unbefriedigende Hilfsarbeiter-T{\"a}tigkeit und - in erheblich zunehmendem Maße - Arbeitslosigkeit und der Verlust von Lebensperspektiven. Der Beitrag zeigt M{\"o}glichkeiten und Grenzen der qualifizierten und zukunfts orientierten Berufsausbildung dieser Gruppe auf, wobei sowohl moderne technologische Entwicklungen als auch die F{\"o}rderung personaler und sozialer Kompetenzen Ber{\"u}cksichtigung finden. Die Fragestellung der Integration Lernbeeintr{\"a}chtigter wird nicht mit der Schulzeit abgeschlossen - sie stellt sich umso st{\"a}rker danach.},
  subject      = {Sonderp{\"a}dagogik / Zeitschrift},
  language  = {de}
}
@incollection{Stein1994,
  author    = {Stein, Roland},
  title     = {Werkstatt f{\"u}r Behinderte},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-40239},
  publisher      = {Universit{\"a}t W{\"u}rzburg},
  year      = {1994},
  abstract  = {No abstract available},
  subject      = {Sonderp{\"a}dagogik / W{\"o}rterbuch},
  language  = {de}
}
@incollection{Stein1994,
  author    = {Stein, Roland},
  title     = {Verhaltensauff{\"a}lligkeit},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-40222},
  publisher      = {Universit{\"a}t W{\"u}rzburg},
  year      = {1994},
  abstract  = {No abstract available},
  subject      = {Sonderp{\"a}dagogik / W{\"o}rterbuch},
  language  = {de}
}
@article{KleberStein1993,
  author    = {Kleber, Eduard W. and Stein, Roland},
  title     = {Konzentrationsprobleme: Fehldiagnose oder Zeitkrankheit?},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-40116},
  year      = {1993},
  abstract  = {Konzentration ist ein psychologisches Konstrukt, das hochkomplexe Interaktions-Situations-Ph{\"a}nomene bezeichnet. Die hohe Komplexit{\"a}t l{\"a}ßt unmittelbare Folgerungen f{\"u}r therapeutische Maßnahmen nicht zu und enth{\"a}lt spezielle Probleme der Validit{\"a}t bei niedrigen Leistungswerten in Tests. Die Diagnose von Konzentrationsproblemen dient nicht selten Lehrern, Sch{\"u}lern und Eltern als Entlastung. Dabeif{\"u}hren oberfl{\"a}chliche Analysen oft zu Mißverst{\"a}ndnissen und Fehldiagnosen. Bei solchen Diagnosen werden dann Konzentration, Interesse, Motivation, Belastbarkeit, "aus dem Felde gehen" und "auswandern" konfundiert. Ohne eine sorgf{\"a}ltige und m{\"o}glichst umfassende Analyse der Aufmerksamkeitssituation k{\"o}nnen Maßnahmen zur Beseitigung oder Reduktion der Schwierigkeiten nicht effektiv ausgew{\"a}hlt werden.},
  subject      = {Sonderp{\"a}dagogik},
  language  = {de}
}
@article{Stein1992,
  author    = {Stein, Roland},
  title     = {Zur Raumvorstellungs-F{\"a}higkeit Lernbeeintr{\"a}chtigter - eine Untersuchung mit dem LPS-Untertest 8},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-40137},
  year      = {1992},
  abstract  = {Die hier untersuchten Lernbeeintr{\"a}chtigten, die eine vereinfachte Ausbildung zum Dreher oder Fr{\"a}ser absolvieren, liegen bereits zu Ausbildungsbeginn hinsichtlich der Gruppen-Ergebnisse im LPS-Untertest 82, der das r{\"a}umliche Vorstellen untersucht, gemessen an der Eichstichprobe gut im Bev{\"o}lkerungsdurchschnitt. Es wurde vergleichend eine Variante des LPS-8 eingesetzt, die eine Erleichterung f{\"u}r die Probanden bedeuten sollte. Sie erbrachte jedoch keine Verbesserung der Testergebnisse. Die Durchf{\"u}hrung einer "power" -Variante des Tests bel{\"a}ßt f{\"u}r einen Teil der Stichprobe die Rangreihen, verglichen mit einer Durchf{\"u}hrung der Original-( speed)Version, auf signifikantem Niveau gleich. F{\"u}r einen zweiten Teil der Stichprobe findet sich diese Signifikanz allerdings nicht.},
  subject      = {Sonderp{\"a}dagogik},
  language  = {de}
}
@article{KleberSteinAmannetal.1991,
  author    = {Kleber, Eduard W. and Stein, Roland and Amann, Fritz and Brenner, G{\"u}nther},
  title     = {Neue Wege f{\"u}r die Integration Lernbehinderter in die Berufswelt? : Oder neue Wege, um niedrigere Lohngruppen zu schaffen ... ?(Bericht {\"u}ber einen 1989 angelaufenen Modellversuch)},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-40163},
  year      = {1991},
  abstract  = {In Hessen wurde 1989 ein Modellversuch gestartet. der die Chancen Lernbehinderter f{\"u}r qualifizierte Arbeitspl{\"a}tze im Bereich Metall verbessern soll. Ziel ist die Erarbeitung einer differenzierten Ausbildung im Berufsbild ,Werkzeugmaschinenspaner', einer reduzierten Variante des aktuellen Metallberufes ,Zerspanungsmechaniker·. Dabei geht es auch um die Integration von Arbeiten an computergesteuerten Dreh- und Fr{\"a}smaschinen. Berufsbildungswerke f{\"u}r die Ausbildung Lernund K{\"o}rperbehinderter sowie Betriebe der freien Wirtschaft bilden im Rahmen des Versuchs modellhaft Gruppen von Werkzeugmaschinenspanern aus. Ziele sind Fachkompetenz, Selbst{\"a}ndigkeit, Kooperations- und Kommunikationsf{\"a}higkeit.},
  subject      = {Sonderp{\"a}dagogik / Zeitschrift},
  language  = {de}
}
@article{KleberStein1991,
  author    = {Kleber, Eduard W. and Stein, Roland},
  title     = {Lernbehinderte und CNC-Technologie : Bericht {\"u}ber einen in Deutschland laufenden Modellversuch},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-40172},
  year      = {1991},
  abstract  = {Im Rahmen eines Modellversuches sollen in Hessen neue Ausbildungsg{\"a}nge im Metallbereich f{\"u}r Lernbehinderte umgesetzt und evaluiert werden. Dabei geht es insbesondere um eine Pr{\"u}fung der M{\"o}glichkeiten und Grenzen einer Ausbildung an computergesteuerten Dreh- und Fr{\"a}smaschinen. Berufsbildungswerke f{\"u}r die Ausbildung Lern- und K{\"o}rperbehinderter sowie Betriebe der freien Wirtschaft bilden im Rahmen des Versuches modellhaft Gruppen von Werkzeugmaschinenspanern aus. Ziele des p{\"a}dagogischen Rahmenprogrammes sind gr{\"o}sstm{\"o}gliche Fachkompetenz, Selbst{\"a}ndigkeit, Kooperations- und Kommunikationsf{\"a}higkeit. Von dem Projekt sind Erkenntnisse hinsichtlich der M{\"o}glichkeiten des qualifizierten Einsatzes Lernbeeintr{\"a}chtigter in Bereichen moderner industrieller Fertigung zu erwarten.},
  subject      = {Sonderp{\"a}dagogik / Zeitschrift},
  language  = {de}
}
@incollection{KleberStein1991,
  author    = {Kleber, Eduard W. and Stein, Roland},
  title     = {Neue Wege f{\"u}r die Integration Lernbehinderter ins Berufsleben},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-40127},
  publisher      = {Universit{\"a}t W{\"u}rzburg},
  year      = {1991},
  abstract  = {No abstract available},
  subject      = {Integrationsp{\"a}dagogik / Deutsches Sprachgebiet / Kongress / Saarbr{\"u}cken <1990>},
  language  = {de}
}
@article{KleberStein1991,
  author    = {Kleber, Eduard W. and Stein, Roland},
  title     = {Neue Wege in die moderne Berufswelt},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-40157},
  year      = {1991},
  abstract  = {No abstract available},
  language  = {de}
}
@article{KleberStein1991,
  author    = {Kleber, Eduard W. and Stein, Roland},
  title     = {Neue Wege in die moderne Berufswelt},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-40105},
  year      = {1991},
  abstract  = {In Hessen wurde 1989 ein Modellversuch zum Einsatz neuer Technologien in der Berufsausbildung lernbehinderter Jugendlicher gestartet. Die Chancen Lernbehinderter f{\"u}r qualifizierte Arbeitspl{\"a}tze im Bereich Metall der Fachrichtungen Drehen, Fr{\"a}sen und Produktionstechnik sollen dadurch verbessert werden.},
  subject      = {Sonderp{\"a}dagogik},
  language  = {de}
}