@article{StraussMoskalenkoTiurbeetal.2012,
  author    = {Strauss, Armin and Moskalenko, Vasily and Tiurbe, Christian and Chodnevskaja, Irina and Timm, Stephan and Wiegering, Verena A. and Germer, Chrioph Thomas and Ulrichs, Karin},
  title     = {Goettingen Minipigs (GMP): Comparison of Two Different Models for Inducing Diabetes},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-75119},
  year      = {2012},
  abstract  = {Purpose: Preclinical experiments on large animals are indispensable for evaluating the effectiveness of diabetes therapies. Miniature swine are well suited for such studies due to their physiological and pathophysiological responses. Methods: We compare two methods for inducing diabetes in Goettingen minipigs (GMP), in five with the beta cell toxin streptozotocin (STZ) and in five other GMP by total pancreatectomy (PE). Glucose homeostasis was assessed with the intravenous glucose-tolerance test (IVGTT) and continual monitoring of interstitial glucose levels. At conclusion of the observation period, the pancreata were examined histologically. Three non-diabetic GMP served as control group. Results: The IVGTT revealed markedly diabetic profiles in both GMP groups. STZ-GMP were found to harbor residual C-peptides and scattered insulin-positive cells in the pancreas. PE-GMP survived the total pancreatectomy only with intensive postoperative care. Conclusions: Although both methods reliably induced diabetes in GMP, the PE-GMP clearly had more health problems and required a greater expenditure of time and resources. The PE-GMP model, however, was better at eliminating endogenous insulin and C-peptide than the STZ-GMP model.},
  subject      = {G{\"o}ttingen},
  language  = {en}
}
@article{LausUlrichsMuellerRuchholtz1986,
  author    = {Laus, R. and Ulrichs, Karin and M{\"u}ller-Ruchholtz, W.},
  title     = {Molecular Specificity of Human Heterophile Antibodies (HHA) in Normal Human Serum (NHS) Reacting with Xenogeneic Cells.},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-72921},
  year      = {1986},
  abstract  = {No abstract available},
  subject      = {Immunobiologie},
  language  = {en}
}
@article{UlrichsKellerMuellerRuchholtz1985,
  author    = {Ulrichs, Karin and Keller, R. and M{\"u}ller-Ruchholtz, W.},
  title     = {Serological demonstration and manipulation of passenger cells (PC) in pancreas islet grafts},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-72944},
  year      = {1985},
  abstract  = {No abstract available},
  subject      = {Immunobiologie},
  language  = {en}
}
@article{KekowUlrichs1986,
  author    = {Kekow, J. and Ulrichs, Karin},
  title     = {Determination of total immunoreactive rat insulin (IRI) in culture supernatants of rat islets by an enzyme linked immunosorbent assay (ELISA) as a routine method to assess the viability of rat islets prior to their use in islet transplantation},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-72989},
  year      = {1986},
  abstract  = {No abstract available},
  subject      = {Immunobiologie},
  language  = {en}
}
@article{KrzymanskiWaagaUlrichsetal.1991,
  author    = {Krzymanski, Maciej and Waaga, Ana M. and Ulrichs, Karin and Deja, Aadam and Oko, Andrzej and Rommel, Thomas and M{\"u}ller-Ruchholtz, Wolfgang},
  title     = {The influence of MHC class II antigen blockade by perfusion with a monoclonal antibody on rat renal graft survival},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-64431},
  year      = {1991},
  abstract  = {To decrease immunogenicity of the rat kidney, grafts were perfused with an anti-MHC class li monoclonal antibody (mAb ). How effectively this procedure blocked dass li-positive cells, which were mainly dendritic in appearance, was checked by immunostaining renal sections after perfusion and comparing them with in vitro stained sections. Optimum conditions were applied for graft pretreatment before transplantation. This procedure prolonged graft survival, though not satisfactorily from the biological point ofview (9.6 ± 0.8 versus 7.7 ± 0.5 days in the control group; P < 0.02). The dendritic cells were not killed but blocked. Several hours after transplantation, the mAb dissociated from these dass li-positive cells. It was also shown that donor cells migrate into the recipient's spieen early after transplantation. The number of these cells was smaller when the transplanted organ was perfused with the mAb. Further studies are suggested to deplete the graft of donor dendritic cells more adequately. They should also combine graft perfusion with antidass II mAb and recipient immunosuppression at reduced doses.},
  subject      = {Chirurgie},
  language  = {en}
}
@inproceedings{HeiserUlrichsMuellerRuchholtz1994,
  author    = {Heiser, A. and Ulrichs, Karin and M{\"u}ller-Ruchholtz, W.},
  title     = {Enzyme Kinetics of Commercial Collagenases and their Influence on Porcine Islet Isolation},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-45488},
  year      = {1994},
  abstract  = {No abstract available},
  subject      = {Heterotransplantation},
  language  = {en}
}
@inproceedings{HeiserUlrichsEcksteinetal.1992,
  author    = {Heiser, A. and Ulrichs, Karin and Eckstein, V. and M{\"u}ller-Ruchholtz, W.},
  title     = {Xenogeneic Cellular Response of Human Lymphocytes Against Porcine Lymphocytes and Isolated Pancreatic Islets},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-45479},
  year      = {1992},
  abstract  = {no abstract available},
  language  = {en}
}
@article{KekowUlrichsMuellerRuchholtzetal.1988,
  author    = {Kekow, J{\"o}rn and Ulrichs, Karin and M{\"u}ller-Ruchholtz, Wolfgang and Gross, Wolfgang L.},
  title     = {Measurement of rat insulin. Enzyme-linked immunosorbent assay with increased sensitivity, high accuracy, and greater practicability than established radioimmunoassay},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-45543},
  year      = {1988},
  abstract  = {Total immunoreactive insulin (IRI) is conventionally determined by radioimmunoassays. IR! measurement in rats can be made more sensitive, accurate, and practical, as demonstrated by a new modified enzyme-linked immunosorbent assay (ELlSA). It is characterized by indirect binding of an anti-insulin antibody by an antiglobulin antibody and uses the principle of competitive saturation. In this ELlSA, IRI can be determined in a wide range of concentrations, corresponding to the standards. The standard curve ranges from 100 to 0.049 ng/mllRI (1 ng/ml - 23.4 JLU/ml - 172 pM rat insulin). The statistical analysis shows between- and within-assay coefficients of variation of :515\%. Diabetes 37:321-26,1988},
  subject      = {Chirurgie},
  language  = {en}
}
@article{VonGaudeckerUlrichsMuellerRuchholtz1989,
  author    = {Von Gaudecker, Brita and Ulrichs, Karin and M{\"u}ller-Ruchholtz, Wolfgang},
  title     = {Immunoelectron microscopic localization of MHC structures in isolated pancreatic rat islets},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-45596},
  year      = {1989},
  abstract  = {An immunogold-silver enhancement technique, which combines effective labeling of viable isolated islets with the ultrastructural resolution of cytological details, was applied in electron microscopy to identify major histocompatibility complex (MHC) structures on islet cells. Incubation of freshly isolated islets from CAP (RT1C) and LEW (RT1') rats with OX18, an MHC class I antibody, showed strong positive reactivity in macrophages and/or dendritic-like cells (M0-DCs) and vascular endothelial cells (VEs) and a comparatively weaker reactivity in endocrine a-, p-, and 8-ce"s. With MHC class" antibody OX6 (anti-I-A), M0-DCs were strongly labeled in both rat strains on the surface and on internal structures. Three of five particularly high titered batches of OX6 revealed MHC class" expression on VE and p-ce"s. Four days of in vitro culture in combination with a high concentration of glucose and interferon-'Y induced strong enhancement of MHC class I structures and, to a lesser extent, class " structures on p-ce"s.},
  subject      = {Immunbiologie},
  language  = {en}
}
@misc{UlrichsMuellerRuchholtz1989,
  author    = {Ulrichs, Karin and M{\"u}ller-Ruchholtz, W.},
  title     = {Identification and Manipulation of Human Islet Alloimmunogenicity: Morphologic and Functional in Vitro Studies with Various Islet Preparations},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-45584},
  year      = {1989},
  abstract  = {No abstract available},
  subject      = {Immunbiologie},
  language  = {en}
}
@article{UlrichsSchangKelleretal.1984,
  author    = {Ulrichs, Karin and Schang, T. and Keller, R. and M{\"u}ller-Ruchholtz, W.},
  title     = {Reactivity of pancreas islet cells with antisera of known specificity},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-45466},
  year      = {1984},
  abstract  = {No abstract available},
  language  = {en}
}
@article{UlrichsBosseWackeretal.1994,
  author    = {Ulrichs, Karin and Bosse, M. and Wacker, HH and Heiser, A. and M{\"u}ller-Ruchholtz, W.},
  title     = {Histologic analysis of the porcine pancreas to improve islet yield and integrity after collagenase digestion},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-45166},
  year      = {1994},
  abstract  = {No abstract available},
  subject      = {Chirurgie},
  language  = {en}
}
@article{UlrichsEcksteinMuellerBuchholtz1994,
  author    = {Ulrichs, Karin and Eckstein, V. and M{\"u}ller-Buchholtz, W.},
  title     = {Xenogeneic T-cell-mediated immune reactivity in the model of pig-to-humans: first findings with native stimulator cells},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-44755},
  year      = {1994},
  abstract  = {No abstract available},
  subject      = {Chirurgie},
  language  = {en}
}
@article{WaagaUlrichsKrzymanskietal.1990,
  author    = {Waaga, AM and Ulrichs, Karin and Krzymanski, M. and Treumer, J. and Hansmann, ML and Rommel, T. and M{\"u}ller-Ruchholz, W.},
  title     = {The immunosuppressive agent 15-deoxyspergualin induces tolerance and modulates MHC-antigen expression and interleukin-1 production in the early phase of rat allograft responses},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-45253},
  year      = {1990},
  abstract  = {No abstract available},
  subject      = {Chirurgie},
  language  = {en}
}
@article{UlrichsMuellerRuchholtz1988,
  author    = {Ulrichs, Karin and M{\"u}ller-Ruchholtz, W.},
  title     = {Expression of MHC Structures on Immunologically Reactive and Non Reactive Cells in Islets of Langerhans and Other Tissues},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-45557},
  year      = {1988},
  abstract  = {No abstract available},
  subject      = {Chirurgie},
  language  = {en}
}
@article{UlrichsMuellerRuchholtz1985,
  author    = {Ulrichs, Karin and M{\"u}ller-Ruchholtz, W.},
  title     = {Further Analyses of Pancreas Islet Immunogenicity, a Major Barrier to Successful Islet Transplantation},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-45563},
  year      = {1985},
  abstract  = {No abstract available},
  subject      = {Chirurgie},
  language  = {en}
}
@article{UlrichsWinotoMorbachHeringetal.1990,
  author    = {Ulrichs, Karin and Winoto-Morbach, S. and Hering, B. and M{\"u}ller-Ruchholtz, W.},
  title     = {A Useful Biotechnological Approach to Solve the Problem of Graft Purity in Human Pancreatic Islet Transplantation},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-45619},
  year      = {1990},
  abstract  = {No abstract available},
  subject      = {Chirurgie},
  language  = {en}
}
@article{UlrichsMuellerRuchholtz1989,
  author    = {Ulrichs, Karin and M{\"u}ller-Ruchholtz, W.},
  title     = {Significant manipulative procedures to reduce immunogenicity of human islet allografts},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-45155},
  year      = {1989},
  abstract  = {No abstract available},
  subject      = {Chirurgie},
  language  = {en}
}
@article{WinotoMorbachLeyhausenSchuenkeetal.1989,
  author    = {Winoto-Morbach, S. and Leyhausen, G. and Sch{\"u}nke, M. and Ulrichs, Karin and M{\"u}ller-Buchholtz, W.},
  title     = {Magnetic microspheres (MMS) coupled to selective lectins: a new tool for large-scale extraction and purification of human pancreatic islets},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-44789},
  year      = {1989},
  abstract  = {No abstract available},
  subject      = {Chirurgie},
  language  = {en}
}
@article{EcksteinMuellerBuchholtzUlrichs1994,
  author    = {Eckstein, V. and M{\"u}ller-Buchholtz, W. and Ulrichs, Karin},
  title     = {Reaction patterns of natural xenophile antibodies in human sera with pancreatic islet cells and porcine lymphocytes},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-44742},
  year      = {1994},
  abstract  = {No abstract available},
  subject      = {Chirurgie},
  language  = {en}
}
@article{UlrichsMuellerBuchholtz1985,
  author    = {Ulrichs, Karin and M{\"u}ller-Buchholtz, W.},
  title     = {MHC class II antigen expression on the various cells of normal and activated isolated pancreatic islets},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-44722},
  year      = {1985},
  abstract  = {It is the aim of this study to characterize and quantify the cells within isolated rat islets that express MHC class 11 antigens. A set of five monoelonal antibodies and two polyclonal antisera of defined specificlty were used in combination with a newly devised procedure for three·dimensional immunofluorescence evaluation of intact islets. It is shown that in addition to passen· ger cells, such as Iymphocytes, macro· phages, and dendrlticlike cells, vascular endothelial and endocrine cells are also capable of expressing class 11 antigens. This expression Is strongly influenced by in vitro culture. pregnancy, streptozotocin- induced diabetes, transplantation trauma, and alloantigenic stimuli. The pos· sible role of the above cells in antigen presentation related to islet transplantation is discussed.},
  language  = {en}
}
@article{UlrichsDeltzThiedeetal.1982,
  author    = {Ulrichs, Karin and Deltz, E. and Thiede, A. and M{\"u}ller-Ruchholtz, W.},
  title     = {Lymphoid tissue transplantation in rats leads to a GVHR, inducing a specific T-cell mediated autoreactivity against MHC-antigens},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-45420},
  year      = {1982},
  abstract  = {No abstract available},
  language  = {en}
}
@article{UlrichsKuhlencordtMuellerRuchholtz1979,
  author    = {Ulrichs, Karin and Kuhlencordt, KM and M{\"u}ller-Ruchholtz, W.},
  title     = {Plating inhibition assay (PIA): a new test for cell mediated cytotoxicity},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-45443},
  year      = {1979},
  abstract  = {No abstract available},
  language  = {en}
}
@article{UlrichsMuellerRuchholtz1990,
  author    = {Ulrichs, Karin and M{\"u}ller-Ruchholtz, W.},
  title     = {Mixed lymphocyte islet culture (MLIC) and its use in manipulation of human islet alloimmunogenicity},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-45515},
  year      = {1990},
  abstract  = {No abstract available},
  language  = {en}
}
@inproceedings{HeusermannNoethlingHansmannetal.1987,
  author    = {Heusermann, U. and N{\"o}thling, R. and Hansmann, M. L. and Ulrichs, Karin},
  title     = {Immunhistochemische und immunelektronenmikroskopischeUntersuchungen zum Vorkommen von dendritischen Zellen im Pankreas der Ratte},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-45689},
  year      = {1987},
  abstract  = {Dendritic cells, first described by STEINMAN and COHN in the mouse spleen and now called lymphoid dendritic cells (LDC), were investigated in the rat pancreas with the monoclonal antibodies 29AI-L. T. and MRC-OX17, which both recognize the la-antigen immunohistochemically and immune electron microscopically. la-positive cells with a dendritic morphology were found in the connective tissue of the cxocrine and endocrine pancreas. Immune e1ectron microscopically, the Ia-antibodies were 10- calized on the cell surface and in sm all vesicles. A small portion of the la-positive cells showed additional acid phosphatase positivity, i. e. were la-positive macrophages. The other la-positive cells were probably LDC, which may be important in the elimination of foreign antigens, e. g. bacteria and vIruses.},
  language  = {de}
}
@article{WinotoMorbachUlrichsLeyhausenetal.1989,
  author    = {Winoto-Morbach, Supandi and Ulrichs, Karin and Leyhausen, Gaby and M{\"u}ller-Ruchholtz, Wolfgang},
  title     = {New principle for large-scale preparation of purified human pancreas islets},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-45600},
  year      = {1989},
  abstract  = {Because successful human islet transplantation requires large quantities of viable islets that must be separated from the highly immunogenic exocrine tissue and because handpicking is too time-consuming and laborious to be clinically relevant, a new approach for solving this problem has been established in rat models. It is based on the principle that magnetic microspheres (MMSs) coupled to lectins with binding specificity for the exocrine tissue portion are trapped in an electromagnetic field, thus providing effluent islets of a high degree of purity. In this study our aim was to adapt this princip'le to human islet preparations. In this context our prime interest was focused on a lectin suitable for human pancreatic tissue. Of 19 different lectins tested, only 1, Wisteria floribunda agglutinin (WFA), is suitable, as shown by immunofluorescence, MMS-Iectin binding, and magnetic separation},
  subject      = {Immunbiologie},
  language  = {en}
}
@article{HeiserUlrichsMuellerBuchholtz1994,
  author    = {Heiser, Axel and Ulrichs, Karin and M{\"u}ller-Buchholtz, Wolfgang},
  title     = {Isolation of porcine pancreatic islets: low trypsin activity during the isolation procedure guarantees reproducible high islet yields},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-44719},
  year      = {1994},
  abstract  = {During the past few years, interest in xenotransplantation of porcine islets of Langerhans for the future therapy of type I diabetes has Increased markedly. Therefore, we established a semiautomated digestion method for isolating islets from the porcine pancreas. However, although the isolation technique was standardized and collagenase of controlled quality was used, we were unable to attain high islet yields with a satisfactory degree of reproducibility. One hypothesis was that varying degrees of interference by donor pancreatic enzymes were responsible for this failure. The aim of this stUdy was to examine the kinetics of four types of enzymatic activity during the isolation procedure, as well as their effects on islet yield: collagenase, trypsin, neutral protease, and clostripaln. Our results indicate that while exogenous collagenase activity decreases slightly during the isolation procedure, the activity of the pancreas enzymes neutral protease and trypsin increases. In some cases, trypsin activity increases very strongly. A strong increase in trypsin activity correlates with poor islet yield, whereas low trypsin activity always correlates with high islet yield. Addition of the protease inhibitor Pefabloc to the isolation medium results in low trypsin activity and reproducible high islet yields.},
  subject      = {Langerhans-Inseln},
  language  = {en}
}
@article{WaagaKrzymanskiUlrichsetal.1993,
  author    = {Waaga, AM and Krzymanski, M. and Ulrichs, Karin and Wierusz-Wysocka, Bogna and M{\"u}ller-Buchholtz, Wolfgang},
  title     = {Hematological effects of the new immunosuppressive drug 15-deoxyspergualin},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-44701},
  year      = {1993},
  abstract  = {Since systematic hematological studies on blood and bone marrow changes after treatment with 15-Deoxyspergualin (DOS) are lacking, a quantitative assessment was performed fourteen or twenty eight days after intraperitoneal application of DOS to rats. Further observations done 7 and 14 days after discontinuation of DOS administration allowed analysis of banc marrow regeneration. DOS induced lymphocytopenia, granUlocytopenia and anemia with a decrease of bone marrow cellularity due to suppression of cell maturation. The effect was dose-dependent and bone marrow as well as blood changes were observed in animals treated with doses from 0.5 to 10.0 mg/kg DOS. Within 14 days after termination of the treatment, rapid recovery with normalization of all hematological parameters was observed. In the light of our data, these hematological side effects may not be a major disadvantage, if DOS is used in doses below 2.5 mg/kg, and for a course of therapy which is limited to 7 to 14 days.},
  subject      = {Chirurgie},
  language  = {en}
}
@article{DeltzMuellerHermelinkUlrichsetal.1981,
  author    = {Deltz, E. and M{\"u}ller-Hermelink, HK and Ulrichs, Karin and Thiede, A. and M{\"u}ller-Ruchholtz, W.},
  title     = {Development of graft-versus-host reaction in various target organs after small intestine transplantation},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-45459},
  year      = {1981},
  abstract  = {The GVHRIL foHowing transplantation of small intestine are different from those found after bone marrow transplantation or spleen cell injections in that they show a remarka ble, significant prevalence of lesions within the intestinal mucosa. These findings are consistent with the observation that jntestinal lymphocytes newly formed in mesenteric lymph nodes predominantly home in on the intestine again.\& The degree of histologic alteration within different tissues indicates that the graft and the host may survive the lesions of the lymphatic tissues, whereas the severe intestinal lesions following GVHR may easily cause death of the recipient. With regard to clinical sman bowel transplantation two statements can be made: (l) GVHRIL play a significant role in small bowel trans~ plantation. (2) To minimize their biologic importance, a selective elimination of the graft's Jymph nodes by irradiation or surgical resection should be considered in view of the remarkable difference between GVHRIL in lymph nodes and in the graft's intestinal wall itself.},
  subject      = {Chirurgie},
  language  = {en}
}
@article{UlrichsNoethlingKelleretal.1987,
  author    = {Ulrichs, Karin and N{\"o}thling, R. and Keller, R. and Heusermann, U. and M{\"u}ller-Buchholtz, W.},
  title     = {Genetically determined variation of constitutive major histocompatibility complex class II antigen expression in various rat strains and cell types},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-44769},
  year      = {1987},
  abstract  = {No abstract available},
  subject      = {Chirurgie},
  language  = {en}
}
@article{MuellerBuchholtzLeyhausenPetersonetal.1987,
  author    = {M{\"u}ller-Buchholtz, W. and Leyhausen, G. and Peterson, P. and Schubert, G. and Ulrichs, Karin},
  title     = {A simple methodological principle for large scale extraction and purification of collagenase-digested islets},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-44770},
  year      = {1987},
  abstract  = {No abstract available},
  subject      = {Chirurgie},
  language  = {en}
}
@article{BreitkreuzUlrichsEcksteinetal.1993,
  author    = {Breitkreuz, A. and Ulrichs, Karin and Eckstein, V. and M{\"u}ller-Ruchholz, W.},
  title     = {Long-term suppression of natural and graft-induced xenophile antibodies by short-term antigen-cyclophosphamide treatment},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-45262},
  year      = {1993},
  abstract  = {No abstract available},
  subject      = {Chirurgie},
  language  = {en}
}
@article{UlrichsEulerSchroederetal.1992,
  author    = {Ulrichs, Karin and Euler, HH and Schroeder, JO and M{\"u}ller-Ruchhholtz, W.},
  title     = {Long-term specific suppression of antibody production by plasmapheresis and a short-term course of cyclophosphamide},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-45198},
  year      = {1992},
  abstract  = {No abstract available},
  subject      = {Chirurgie},
  language  = {en}
}
@inproceedings{EcksteinUlrichsMeinckeetal.1991,
  author    = {Eckstein, V. and Ulrichs, Karin and Meincke, G. and M{\"u}lller-Ruchholtz, W.},
  title     = {Transplantation of Diabetic Patients With Xenogeneic Pancreatic Islets Has to Consider Natural Xenophile Antibodies (NXA) In Patients Sera As a Major Obstacle to Success},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-45707},
  year      = {1991},
  abstract  = {No abstract available},
  subject      = {Immunbiologie},
  language  = {en}
}
@inproceedings{WinotoMorbachUlrichsMuellerRuchholtz1991,
  author    = {Winoto-Morbach, S. and Ulrichs, Karin and M{\"u}ller-Ruchholtz, W.},
  title     = {New Developments in Biodegradable Microspheres For Magnetic Separation Techniques},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-45712},
  year      = {1991},
  abstract  = {No abstract available},
  subject      = {Immunbiologie},
  language  = {en}
}
@article{UlrichsYuDunckeretal.1984,
  author    = {Ulrichs, Karin and Yu, MY and Duncker, D. and M{\"u}ller-Ruchholtz, W.},
  title     = {Immunosuppression by cytostatic drugs?},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-45574},
  year      = {1984},
  abstract  = {In the present study, an attempt was made to characterize the immunomodulating abilities of the cytostatic drugs cydophosphamide, ifosfamide, vinblastine, vincristine, procarbazine, dacarbazine, 6-mercaptopurine, methotrexate, 5-f/uor-uracil and adriamycine in a defined experimental model. Varying combinations of drug plus transplantation alloantigen, (C3H-lymphocytes) were injected into Balb/c mice at different time intervals in vivo. The resulting T-effector cell reactivity was determined in vitro with the microcytotoxicity assay on day + 5 for primary (r) and day + 7 for secondary (2°) sensitized mice. According to the type of drug (alkylating agent vs. vinca alkaloid vs. antimetabolite vs. cytostatic antibiotic), the dosage (20\% LD50 vs. 60\% LD50), the state of sensitization (r vs. 2° sensitized recipients), and the time of drug application in relation to the antigen treatment on day 0 (in varying steps from day -6 to day +4), so-called "pharmaconantigen- variation-effects" (PA VE) were established for each of the investigated drugs in form of reaction profiles. The results were as folIows: (1) For almost alt substances, characteristic reaction profiles involving immunostimulation and/or immunosuppression could be established. Similarities in the profiles of different substances made it possible to classify the drugs according to different reaction types. The reaction type however is not definitely correlated to the biochemical mechanism of drug action. (2) The PA VE are decisively inf/uenced by so me of the biological parameters, such as the time of drug application in relation to the antigen treatment and the state of sensitization but relatively !ittle by the dosage of the drug. (3) Considering the different processes occurring du ring primary and secondary immune responses, the PAVE may give hints for a distinct manipulation of the immunoregulation and thus information on the immunobiological mechanism of drug action.},
  subject      = {Immunologie},
  language  = {en}
}
@article{EngemannUlrichsThiedeetal.1990,
  author    = {Engemann, R. and Ulrichs, Karin and Thiede, A. and M{\"u}ller-Ruchholtz, W. and Hamelmann, H.},
  title     = {Value of a physiological liver transplant model in rats. Induction of specific graft tolerance in a fully allogeneic strain combination},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-45622},
  year      = {1990},
  abstract  = {No abstract available},
  language  = {en}
}
@article{HeiserUlrichsMuellerRuchholtz1994,
  author    = {Heiser, A. and Ulrichs, Karin and M{\"u}ller-Ruchholtz, W.},
  title     = {Prophylactic trypsin inhibition during the isolation procedure guarantees reproducible, high porcine islet yields},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-45531},
  year      = {1994},
  abstract  = {Abstract: For isolating islets from the porcine pancreas, we established a semiautomated digestion method. Although the isolation technique was standardized and collagenase of controlled quality was used, until now the reproducibility of high islet yields was unsatisfactory. Our hypothesis was that pancreatic trypsin was responsible for this failure. The aim of this study was to investigate the effect of endogenous trypsin on islet yield. Our results demonstrate that a high trypsin level correlates with poor islet yield, whereas low trypsin activity always correlates with high islet yield. Specific inhibition of trypsin results in low trypsin activity and reproducible, high islet yields.},
  language  = {en}
}
@article{EngemannGasselUlrichsetal.1986,
  author    = {Engemann, R. and Gassel, HJ and Ulrichs, Karin and Thiede, A. and Hamelmann, H.},
  title     = {Suppressorzellmechanismen nach Cyclosporin A (CsA) induzierter Toleranz allogener Rattenlebertransplantate},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-45503},
  year      = {1986},
  abstract  = {No abstract available},
  language  = {de}
}
@inproceedings{UlrichsEulerMuellerRuchholtz1991,
  author    = {Ulrichs, Karin and Euler, HH and M{\"u}ller-Ruchholtz, W.},
  title     = {A Clinically Successful Protocol to Suppress Autoantibody Production in SLE Patients Is Analyzed For Its Efficacy To Inhibit Natural Xenophile Antibodies (NXA)},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-45693},
  year      = {1991},
  abstract  = {No abstract available},
  language  = {en}
}
@inproceedings{HeiserUlrichsEcksteinetal.1992,
  author    = {Heiser, A. and Ulrichs, Karin and Eckstein, V. and M{\"u}ller-Ruchholtz, W.},
  title     = {The Human Cell Mediated Response to Xenogeneic (Porcine) Transplantation Antigen Depends on the Stimulator Cell Compartment},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-45670},
  year      = {1992},
  abstract  = {No abstract available},
  language  = {en}
}
@inproceedings{HedkeEcksteinMayetal.1993,
  author    = {Hedke, K. and Eckstein, V. and May, G. and Kaden, J. and M{\"u}ller-Ruchholtz, W. and Ulrichs, Karin},
  title     = {Production of Xenophile Antibodies (XA) in Type I Diabetic Patients is Strongly Influenced by Diabetes and/or Dialysis},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-45642},
  year      = {1993},
  abstract  = {No abstract available},
  language  = {en}
}
@inproceedings{UlrichsEcksteinKorsgrenetal.1993,
  author    = {Ulrichs, Karin and Eckstein, V. and Korsgren, O. and M{\"u}ller-Ruchholtz, W.},
  title     = {Expression of Porcine Pancreatic Islet Antigens Varies and Determines Binding of Human Natural Xenophile Antibodies (NXA)},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-45655},
  year      = {1993},
  abstract  = {No abstract available},
  subject      = {Immunbiologie},
  language  = {en}
}
@inproceedings{WangUlrichsMuellerRuchholtz1993,
  author    = {Wang, HY and Ulrichs, Karin and M{\"u}ller-Ruchholtz, W.},
  title     = {Down-Regulation of Xenophile Antibodies by Specific Immunosuppressive Protocols to Facilitate Xenogeneic Organ Transplantation},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-45669},
  year      = {1993},
  abstract  = {No abstract available},
  subject      = {Immunbiologie},
  language  = {en}
}
@inproceedings{HeiserUlrichsMuellerRuchholtz1994,
  author    = {Heiser, A. and Ulrichs, Karin and M{\"u}ller-Ruchholtz, W.},
  title     = {Enzyme Activities in Commercial Collagenase Preparations and Their Kinetics During Islet Isolation Procedure},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-45633},
  year      = {1994},
  abstract  = {No abstract available},
  subject      = {Transplantation},
  language  = {en}
}
@article{DeltzUlrichsSchacketal.1986,
  author    = {Deltz, Eberhard and Ulrichs, Karin and Schack, Thorsten and Friedrichs, Birgit and M{\"u}ller-Ruchholtz, Wolfgang and M{\"u}ller-Hermelink, Hans K. and Thiede, Arnulf},
  title     = {Graft-versus-host reaction in small bowel transplantation and possibilities for its circumvention},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-64425},
  year      = {1986},
  abstract  = {No abstract available},
  subject      = {D{\"u}nndarm},
  language  = {en}
}
@article{LausUlrichsMuellerRuchholtz1988,
  author    = {Laus, R. and Ulrichs, Karin and M{\"u}ller-Ruchholtz, W.},
  title     = {Carbohydrate-specific human heterophile antibodies in normal human sera that react with xenogeneic cells},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-78271},
  year      = {1988},
  abstract  = {Human heterophile antibodies (HHA) that are present in normal human sera (NHS)play an important role in hyperacute xenograft rejection. The aim of this study was to analyze the occurrence, mode of action and molecular specificity of HHA in NHS that are directed against xenogeneic Iymphocytes (isolated from mouse, rat, guinea pig, rabbit, cattle and pig) and isolated rat pancreatic islets. All sera contained variable amounts of HHA that killed the target cells via the classical complement pathway. The cytotoxic activity of these HHA was specifically inhibited by certain carbohydrates (a-D-melibiose, ß-Iactose, ß-gentiobiose, ß-cellobiose, D-mannose, N-acetyl-ß-D-mannosamine and a-D-rhamnose) and by rat IgM. By means of affinity chromatography with immobilized inhibitors we obtained an antibody preparation of mainly IgG type from NHS (up to 3.5 mg/IO ml serum) that reacted strongly with rat lymphocytes and isolated rat pancreatic islets. Though thus far residual xenospecific antibody activity has remained in the sera even after multiple affinity chromatography, these data suggest that specific elimination of HHA is feasible and that it may be thus possible to overcome a major obstacle to xenotransplantation.},
  subject      = {Immunobiologie},
  language  = {de}
}
@article{UlrichsMuellerRuchholtz1991,
  author    = {Ulrichs, Karin and M{\"u}ller-Ruchholtz, Wolfgang},
  title     = {Modulation of pancreatic islet allo immunogenicity and immunobiological in vitro and in vivo consequences},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-78261},
  year      = {1991},
  abstract  = {No abstract available.},
  subject      = {Immunobiologie},
  language  = {en}
}
@article{KrzymanskiWaagaUlrichsetal.1991,
  author    = {Krzymanski, M. and Waaga, A. M. and Ulrichs, Karin and M{\"u}ller-Ruchholtz, Wolfgang},
  title     = {Long-standing rat kidney graft survival by a combination of organ perfusion with MHC class II monoclonal antibody and immunosuppression with reduced doses of 15-deoxyspergualin.},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-64442},
  year      = {1991},
  abstract  = {No abstract available},
  subject      = {Niere},
  language  = {en}
}
@article{WinotoMorbachLeyhausenMuellerRuchholtzetal.1988,
  author    = {Winoto-Morbach, S. and Leyhausen, G. and M{\"u}ller-Ruchholtz, W. and Ulrichs, Karin},
  title     = {The Electromagnetic Separation Principle: A Basis for Human Pancreatic Islet Transplantation},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-82520},
  year      = {1988},
  abstract  = {No abstract available},
  subject      = {Allergie},
  language  = {en}
}
@article{UlrichsWangMuellerBuchholtz1994,
  author    = {Ulrichs, Karin and Wang, H. and M{\"u}ller-Buchholtz, W.},
  title     = {Down-regulation of xenophile antibodies by 15-deoxyspergualin in an experimental animal model},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-44733},
  year      = {1994},
  abstract  = {No abstract available},
  subject      = {Chirurgie},
  language  = {en}
}
@article{WinotoMorbachKroutHeiseretal.1994,
  author    = {Winoto-Morbach, S. and Krout, OS and Heiser, A. and Ulrichs, Karin and M{\"u}ller-Ruchholtz, W.},
  title     = {Lectin binding to acinar tissue for complete magnetophoretic purification of porcine pancreatic islets depends on the composition and pH of the incubation medium},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-45183},
  year      = {1994},
  abstract  = {No abstract available},
  subject      = {Chirurgie},
  language  = {en}
}
@article{HeiserUlrichsMuellerRuchholtz1994,
  author    = {Heiser, A. and Ulrichs, Karin and M{\"u}ller-Ruchholtz, W.},
  title     = {Influence of porcine strain, age, and pH of the isolation medium on porcine pancreatic islet isolation success},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-45171},
  year      = {1994},
  abstract  = {No abstract available},
  subject      = {Chirurgie},
  language  = {en}
}
@article{KekowUlrichsMuellerRuchholtzetal.1987,
  author    = {Kekow, J. and Ulrichs, Karin and M{\"u}ller-Ruchholtz, W. and Gross, WL},
  title     = {Pancreas transplantation: a study of insulin secretion in isolated islets of Langerhans and in sera using a new enzyme-linked immunosorbent assay},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-45229},
  year      = {1987},
  abstract  = {No abstract available},
  subject      = {Chirurgie},
  language  = {en}
}
@article{FalkUlrichsMuellerRuchholtz1987,
  author    = {Falk, W. and Ulrichs, Karin and M{\"u}ller-Ruchholtz, W.},
  title     = {15-Deoxyspergualin (a new guanidine-like drug) blocks T lymphocyte proliferation},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-45215},
  year      = {1987},
  abstract  = {No abstract available},
  subject      = {Chirurgie},
  language  = {en}
}
@article{UlrichsKaitschickBartlettetal.1992,
  author    = {Ulrichs, Karin and Kaitschick, J. and Bartlett, R. and M{\"u}ller-Ruchholtz, W.},
  title     = {Suppression of natural xenophile antibodies with the novel immunomodulating drug leflunomide},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-45202},
  year      = {1992},
  abstract  = {No abstract available},
  subject      = {Chirurgie},
  language  = {en}
}
@article{UlrichsKellerMuellerRuchholtz1986,
  author    = {Ulrichs, Karin and Keller, R. and M{\"u}ller-Ruchholtz, W.},
  title     = {Vorkommen und Manipulation von MHC Klasse II Antigenen auf Zellen isolierter Langerhans-Inseln},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-45499},
  year      = {1986},
  abstract  = {No abstract available},
  subject      = {Langerhans-Inseln},
  language  = {de}
}
@article{WinotoMorbachUlrichsHeringetal.1990,
  author    = {Winoto-Morbach, S. and Ulrichs, Karin and Hering, BJ and Leyhausen, G. and M{\"u}ller-Ruchholtz, W.},
  title     = {Lectins for electromagnetic purification of islets from humans and large mammals},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-45430},
  year      = {1990},
  abstract  = {No abstract available},
  subject      = {Chirurgie},
  language  = {en}
}
@article{HeiserMuellerRuchholtzUlrichs1994,
  author    = {Heiser, A. and M{\"u}ller-Ruchholtz, W. and Ulrichs, Karin},
  title     = {Isolation of Islets of Langerhans: Improvement of the Isolation Technique Using the Pig Model.},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-87765},
  year      = {1994},
  abstract  = {During the last view years, interest in pancreatic islet transplantation for the cure of type I diabetes has increased markedly. A serious barrier to clinical islet transplantation is the isolation of a sufficient mass of viable and functional islets. We used a porcine islet isolation model to examine various parameters of the isolation procedure and to improve isolation technique.},
  subject      = {Langerhans-Inseln},
  language  = {en}
}
@article{UlrichsEcksteinHeiseretal.1992,
  author    = {Ulrichs, Karin and Eckstein, V. and Heiser, A. and M{\"u}ller-Ruchholtz, W.},
  title     = {Die zellvermittelte Immunantwort des menschlichen Transplantat Empf{\"a}ngers gegen xenogenes Antigen (Schwein) ist abh{\"a}ngig vom Spenderkompartiment.},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-86978},
  year      = {1992},
  abstract  = {No abstract available.},
  subject      = {Transplantation},
  language  = {de}
}
@article{BreitkreuzUlrichsEcksteinetal.1992,
  author    = {Breitkreuz, A. and Ulrichs, Karin and Eckstein, V. and M{\"u}ller-Ruchholtz, W.},
  title     = {Induktion von Transplantat-Toleranz gegen Xenoantigen durch eine Pharmakon-Antigen-Kombinationsbehandlung},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-86969},
  year      = {1992},
  abstract  = {No abstract available.},
  subject      = {Transplantat},
  language  = {de}
}
@article{HeiserUlrichsWinotoMorbachetal.1992,
  author    = {Heiser, A. and Ulrichs, Karin and Winoto-Morbach, S. and Vanucchi, A. and J{\"a}ger, H. and M{\"u}ller-Ruchholtz, W.},
  title     = {Erste Kieler Erfahrungen mit 45 Isolierungen von Langerhansinseln aus Schweinepankreas},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-73205},
  year      = {1992},
  abstract  = {No abstract available.},
  subject      = {Langerhans-Inseln},
  language  = {de}
}
@article{UlrichsMuellerRuchholtz1993,
  author    = {Ulrichs, Karin and M{\"u}ller-Ruchholtz, W.},
  title     = {Pharmakologische Beeinflussung nat{\"u}rlicher Antik{\"o}rper als Vorbedingung f{\"u}r die erfolgreiche Xenotransplantation},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-73216},
  year      = {1993},
  abstract  = {No abstract available.},
  subject      = {Heterotransplantation},
  language  = {de}
}
@article{HeiserUlrichsGieretal.1993,
  author    = {Heiser, A. and Ulrichs, Karin and Gier, C. and M{\"u}ller-Ruchholtz, W.},
  title     = {Isolierung Langerhans'scher Inseln aus dem Pankreas von Schweinen: Einfluss biologischer und technischer Parameter auf die Inselausbeite und -integrit{\"a}t},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-73223},
  year      = {1993},
  abstract  = {No abstract available.},
  subject      = {Langerhans-Inseln},
  language  = {de}
}
@article{UlrichsHeiserBosseetal.1993,
  author    = {Ulrichs, Karin and Heiser, A. and Bosse, M. and Wacker, H. H. and M{\"u}ller-Ruchholtz, W.},
  title     = {Histologische Untersuchungen des Schweinepankreas zur Verbesserung der Inselausbeute und -integrit{\"a}t nach Kollagenase-Verdauung},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-73237},
  year      = {1993},
  abstract  = {No abstract available.},
  subject      = {Schwein},
  language  = {de}
}
@article{DickneiteSchorlemmerSedlaceketal.1987,
  author    = {Dickneite, G. and Schorlemmer, H. U. and Sedlacek, H. H. and Falk, W. and Ulrichs, Karin and M{\"u}ller-Ruchholtz, W.},
  title     = {Suppression of macrophage function and prolongation of graft survival by the new guanidinic-like structure, 15-deoxyspergualin},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-86991},
  year      = {1987},
  abstract  = {No abstract available.},
  subject      = {Makrophage},
  language  = {en}
}
@article{UlrichsEcksteinTibelletal.1994,
  author    = {Ulrichs, Karin and Eckstein, V. and Tibell, A. and Groth, C. G. and Korsgren, O. and M{\"u}ller-Ruchholtz, W. and Thiede, A.},
  title     = {Nat{\"u}rliche und induzierte xenoreaktive Antik{\"o}rper vor und nach klinischer Transplantation f{\"o}taler porziner Pankreasinselzellen},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-72967},
  year      = {1994},
  abstract  = {No abstract available.},
  subject      = {Antik{\"o}rper},
  language  = {de}
}
@article{UlrichsEcksteinKorsgrenetal.1994,
  author    = {Ulrichs, Karin and Eckstein, V. and Korsgren, O. and Tibell, A. and Groth, C. G. and M{\"u}ller-Ruchholtz, W.},
  title     = {Characterization of natural and induced human xenophile antibodies before and after transplantation of the fetal porcine endocrine pancreas},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-86985},
  year      = {1994},
  abstract  = {No abstract available.},
  subject      = {Bauspeicheldr{\"u}se},
  language  = {de}
}