@article{VonhofSiren1991,
  author    = {Vonhof, S. and Sir{\´e}n, Anna-Leena},
  title     = {Reversal of µ-opioid-mediated respiratory depression by α2-adrenoceptor antagonism},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-47454},
  year      = {1991},
  abstract  = {The present study was performed in order to evaluate the effects of the selective 02- adrenoceptor antagonist 6-chloro-2,3,4,5-tetrahydro-3-methyl-1H-3-benzazepine (SK\&F 86466) on dermorphin-induced analgesia, respiratory depression and inhibition of locomotor activity in the conscious rat. Intracerebroventricular (icv) administration of dermorphin (3 nmol/rat) decreased respiration rate and relative ventilatory minute volume maximally by 38 \% and 50 \% of baseline respectively. SK\&F 86466 dose-dependently reversed the dermorphin-induced depression of ventilatory parameters, while SK\&F 86466 exerted no effect on dermorphin-induced analgesia or depression of locomotor activity due to catalepsia. It appears, therefore, that a 2-adrenoceptors selectively interact with Jl2-opioid-receptor mediated effects, such as respiratory depression, but are not involved in the modulation of Jl,-opioid-related effects, such as supraspinal analgesia and depression of locomotor activity.},
  subject      = {Biowissenschaften},
  language  = {en}
}