@article{TemmeAdamAhnenetal.2017,
  author    = {Temme, Fabian and Adam, Jan and Ahnen, Max L. and Baack, Dominik and Balbo, Matteo and Bergmann, Matthias and Biland, Adrian and Blank, Michael and Bretz, Thomas and Br{\"u}gge, Kai A. and Buss, Jens and Dmytriiev, Anton and Dorner, Daniela and Einecke, Sabrina and Hempfling, Christina and Hildebrand, Dorothee and Hughes, Gareth and Linhoff, Lena and Mannheim, Karl and M{\"u}ller, Sebastian and Neise, Dominik and Neronov, Andrii and N{\"o}the, Max and Paravac, Aleksander and Pauss, Felicitas and Rhode, Wolfgang and Shukla, Amit and Thaele, Julia and Walter, Roland},
  title     = {Long-Term monitoring of bright blazars in the multi-GeV to TeV range with FACT},
  series = {Galaxies},
  volume    = {5},
  journal   = {Galaxies},
  number    = {1},
  publisher = {MDPI},
  issn      = {2075-4434},
  doi       = {10.3390/galaxies5010018},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-198088},
  pages     = {18},
  year      = {2017},
  abstract  = {Blazars like Markarian 421 or Markarian 501 are active galactic nuclei (AGN), with their jets orientated towards the observer. They are among the brightest objects in the very high energy (VHE) gamma ray regime (>100 GeV). Their emitted gamma-ray fluxes are extremely variable, with changing activity levels on timescales between minutes, months, and even years. Several questions are part of the current research, such as the question of the emission regions or the engine of the AGN and the particle acceleration. A dedicated longterm monitoring program is necessary to investigate the properties of blazars in detail. A densely sampled and unbiased light curve allows for observation of both high and low states of the sources, and the combination with multi-wavelength observation could contribute to the answer of several questions mentioned above. FACT (First G-APD Cherenkov Telescope) is the first operational telescope using silicon photomultiplier (SiPM, also known as Geigermode—Avalanche Photo Diode, G-APD) as photon detectors. SiPM have a very homogenous and stable longterm performance, and allow operation even during full moon without any filter, leading to a maximal duty cycle for an Imaging Air Cherenkov Telescope (IACT). Hence, FACT is an ideal device for such a longterm monitoring of bright blazars. A small set of sources (e.g., Markarian 421, Markarian 501, 1ES 1959+650, and 1ES 2344+51.4) is currently being monitored. In this contribution, the FACT telescope and the concept of longterm monitoring of bright blazars will be introduced. The results of the monitoring program will be shown, and the advantages of densely sampled and unbiased light curves will be discussed.},
  language  = {en}
}
@article{SchleicherArbetEngelsBaacketal.2019,
  author    = {Schleicher, Bernd and Arbet-Engels, Axel and Baack, Dominik and Balbo, Matteo and Biland, Adrian and Blank, Michael and Bretz, Thomas and Bruegge, Kai and Bulinski, Michael and Buss, Jens and Doerr, Manuel and Dorner, Daniela and Elsaesser, Dominik and Grischagin, Sergej and Hildebrand, Dorothee and Linhoff, Lena and Mannheim, Karl and Mueller, Sebastian Achim and Neise, Dominik and Neronov, Andrii and Noethe, Maximilian and Paravac, Aleksander and Rhode, Wolfgang and Schulz, Florian and Sedlaczek, Kevin and Shukla, Amit and Sliusar, Vitalii and Willert, Elan and Walter, Roland},
  title     = {Fractional Variability—A Tool to Study Blazar Variability},
  series = {Galaxies},
  volume    = {7},
  journal   = {Galaxies},
  number    = {2},
  issn      = {2075-4434},
  doi       = {10.3390/galaxies7020062},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-197348},
  year      = {2019},
  abstract  = {Active Galactic Nuclei emit radiation over the whole electromagnetic spectrum up to TeV energies. Blazars are one subtype with their jets pointing towards the observer. One of their typical features is extreme variability on timescales, from minutes to years. The fractional variability is an often used parameter for investigating the degree of variability of a light curve. Different detection methods and sensitivities of the instruments result in differently binned data and light curves with gaps. As they can influence the physics interpretation of the broadband variability, the effects of these differences on the fractional variability need to be studied. In this paper, we study the systematic effects of completeness in time coverage and the sampling rate. Using public data from instruments monitoring blazars in various energy ranges, we study the variability of the bright TeV blazars Mrk 421 and Mrk 501 over the electromagnetic spectrum, taking into account the systematic effects, and compare our findings with previous results. Especially in the TeV range, the fractional variability is higher than in previous studies, which can be explained by the much longer (seven years compared to few weeks) and more complete data sample.},
  language  = {en}
}
@phdthesis{Blank2003,
  author    = {Blank, Sebastian},
  title     = {Einfluß der Morphologie ventrikul{\"a}rer Extrasystolen auf die Heart-Rate-Turbulence bei Patienten nach Myokardinfarkt},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-11092},
  school      = {Universit{\"a}t W{\"u}rzburg},
  year      = {2003},
  abstract  = {Die Heart-Rate Turbulence (HRT) stellt eine neue, aussagekr{\"a}ftige Methode der Risikostratifizierung nach Myokardinfarkt dar. Die initiale Beschleunigung der Herzfrequenz nach einer ventrikul{\"a}ren Extrasystole (VES) wird durch den Turbulence-Onset (TO), die folgende Dezeleration durch den Turbulence-Slope (TS) quantifiziert. In der vorliegenden Arbeit wurde der Einfluß der Morphologie ventrikul{\"a}rer Extasystolen auf die HRT untersucht. Dazu wurden konsekutiv 100 24-Stunden-Langzeit-EKG`s des MABIS-Kollektivs ausgewertet, jedoch bei nur 61 Langzeit-EKG´s konnten die Parameter der HRT bestimmt werden. Um einen statistisch robusten TS zu gew{\"a}hrleisten, wurde ein modifizierter TS vorgeschlagen. Es konnte gezeigt werden, daß der modifizierte TS, nicht aber der TO, von der Morphologie der VES abh{\"a}ngt. Die Morphologie der VES ist jedoch nur einer von vielen Faktoren (Kopplungsintervall, Ausgangsfrequenz, Tageszeit, Alter ...), die die HRT beeinflussen.},
  language  = {de}
}
@article{ScheerVokuhlBlanketal.2019,
  author    = {Scheer, Monika and Vokuhl, Christian and Blank, Bernd and Hallmen, Erika and von Kalle, Thekla and M{\"u}nter, Marc and Wessalowski, R{\"u}diger and Hartwig, Maite and Sparber-Sauer, Monika and Schlegel, Paul-Gerhardt and Kramm, Christof M. and Kontny, Udo and Spriewald, Bernd and Kegel, Thomas and Bauer, Sebastian and Kazanowska, Bernarda and Niggli, Felix and Ladenstein, Ruth and Ljungman, Gustaf and Jahnukainen, Kirsi and Fuchs, J{\"o}rg and Bielack, Stefan S. and Klingebiel, Thomas and Koscielniak, Ewa},
  title     = {Desmoplastic small round cell tumors: Multimodality treatment and new risk factors},
  series = {Cancer Medicine},
  volume    = {8},
  journal   = {Cancer Medicine},
  number    = {2},
  doi       = {10.1002/cam4.1940},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-228444},
  pages     = {527-545},
  year      = {2019},
  abstract  = {Background To evaluate optimal therapy and potential risk factors. Methods Data of DSRCT patients <40 years treated in prospective CWS trials 1997-2015 were analyzed. Results Median age of 60 patients was 14.5 years. Male:female ratio was 4:1. Tumors were abdominal/retroperitoneal in 56/60 (93\%). 6/60 (10\%) presented with a localized mass, 16/60 (27\%) regionally disseminated nodes, and 38/60 (63\%) with extraperitoneal metastases. At diagnosis, 23/60 (38\%) patients had effusions, 4/60 (7\%) a thrombosis, and 37/54 (69\%) elevated CRP. 40/60 (67\%) patients underwent tumor resection, 21/60 (35\%) macroscopically complete. 37/60 (62\%) received chemotherapy according to CEVAIE (ifosfamide, vincristine, actinomycin D, carboplatin, epirubicin, etoposide), 15/60 (25\%) VAIA (ifosfamide, vincristine, adriamycin, actinomycin D) and, 5/60 (8\%) P6 (cyclophosphamide, doxorubicin, vincristine, ifosfamide, etoposide). Nine received high-dose chemotherapy, 6 received regional hyperthermia, and 20 received radiotherapy. Among 25 patients achieving complete remission, 18 (72\%) received metronomic therapies. Three-year event-free (EFS) and overall survival (OS) were 11\% (±8 confidence interval [CI] 95\%) and 30\% (±12 CI 95\%), respectively, for all patients and 26.7\% (±18.0 CI 95\%) and 56.9\% (±20.4 CI 95\%) for 25 patients achieving remission. Extra-abdominal site, localized disease, no effusion or ascites only, absence of thrombosis, normal CRP, complete tumor resection, and chemotherapy with VAIA correlated with EFS in univariate analysis. In multivariate analysis, significant factors were no thrombosis and chemotherapy with VAIA. In patients achieving complete remission, metronomic therapy with cyclophosphamide/vinblastine correlated with prolonged time to relapse. Conclusion Pleural effusions, venous thrombosis, and CRP elevation were identified as potential risk factors. The VAIA scheme showed best outcome. Maintenance therapy should be investigated further.},
  language  = {en}
}