@article{EisenhardtSprengerRoeringetal.2016,
  author    = {Eisenhardt, Anja E. and Sprenger, Adrian and R{\"o}ring, Michael and Herr, Ricarda and Weinberg, Florian and K{\"o}hler, Martin and Braun, Sandra and Orth, Joachim and Diedrich, Britta and Lanner, Ulrike and Tscherwinski, Natalja and Schuster, Simon and Dumaz, Nicolas and Schmidt, Enrico and Baumeister, Ralf and Schlosser, Andreas and Dengjel, J{\"o}rn and Brummer, Tilman},
  title     = {Phospho-proteomic analyses of B-Raf protein complexes reveal new regulatory principles},
  series = {Oncotarget},
  volume    = {7},
  journal   = {Oncotarget},
  number    = {18},
  doi       = {10.18632/oncotarget.8427},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-166529},
  pages     = {26628-26652},
  year      = {2016},
  abstract  = {B-Raf represents a critical physiological regulator of the Ras/RAF/MEK/ERK-pathway and a pharmacological target of growing clinical relevance, in particular in oncology. To understand how B-Raf itself is regulated, we combined mass spectrometry with genetic approaches to map its interactome in MCF-10A cells as well as in B-Raf deficient murine embryonic fibroblasts (MEFs) and B-Raf/Raf-1 double deficient DT40 lymphoma cells complemented with wildtype or mutant B-Raf expression vectors. Using a multi-protease digestion approach, we identified a novel ubiquitination site and provide a detailed B-Raf phospho-map. Importantly, we identify two evolutionary conserved phosphorylation clusters around T401 and S419 in the B-Raf hinge region. SILAC labelling and genetic/biochemical follow-up revealed that these clusters are phosphorylated in the contexts of oncogenic Ras, sorafenib induced Raf dimerization and in the background of the V600E mutation. We further show that the vemurafenib sensitive phosphorylation of the T401 cluster occurs in trans within a Raf dimer. Substitution of the Ser/Thr-residues of this cluster by alanine residues enhances the transforming potential of B-Raf, indicating that these phosphorylation sites suppress its signaling output. Moreover, several B-Raf phosphorylation sites, including T401 and S419, are somatically mutated in tumors, further illustrating the importance of phosphorylation for the regulation of this kinase.},
  language  = {en}
}
@article{Koehler2020,
  author    = {K{\"o}hler, Britta},
  title     = {A Room of One's Own : Weiblichkeit, Schreiben und kollektive Erfahrung in Elena Ferrantes Tetralogie L'amica geniale (2011-2014) und Annie Ernaux' Les Ann{\´e}es (2008)},
  series = {promptus - W{\"u}rzburger Beitr{\"a}ge zur Romanistik},
  volume    = {6},
  journal   = {promptus - W{\"u}rzburger Beitr{\"a}ge zur Romanistik},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-244246},
  pages     = {87-104},
  year      = {2020},
  abstract  = {With her famous suggestion to «give her [the woman] a room of her own and five hundred a year, let her speak her mind» from 1929, Virginia Woolf verbalized a core issue of female writing by hinting at the socioeconomic circumstances and domestic obligations of most women - valid at her times, but still today. Both Elena Ferrante and Annie Ernaux discuss, in their respective novels, the topics of being women in the particular sociocultural landscape (in Italy and, respectively, in France) after World War II and up to these days, the themes of marriage and motherhood, employment and especially (female) authorship. This article aims to show in a close reading of both Ferrante and Ernaux that the two writers play with the literary form of the (auto-)biography on a diegetic, but also extradiegetic level, while formulating at the same time a collective work that embraces the experience of womanhood but circumvents the hazard of a merely subjective and sensitive writing, as female writing has sometimes been claimed to be.},
  language  = {de}
}