@techreport{MeyerJobLaneretal.2022, author = {Meyer, Constantin and Job, Hubert and Laner, Peter and Omizzolo, Andrea and Kollmann, Nadia and Clare, Jasmin and Vesely, Philipp and Riedler, Walter and Plassmann, Guido and Coronado, Oriana and Praper Gulič, Sergeja and Gulič, Andrej and Koblar, Simon and Teofili, Corrado and Rohringer, Verena and Schoßleitner, Richard and Ainz, Gerhard}, title = {OpenSpaceAlps Planungshandbuch: Perspektiven f{\"u}r eine konsistente Freiraumsicherung im Alpenraum}, doi = {10.25972/OPUS-27307}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-273070}, pages = {114}, year = {2022}, abstract = {Im Alpenraum l{\"a}sst sich nach wie vor die kontinuierliche Inanspruchnahme von Freir{\"a}umen f{\"u}r Siedlungsfl{\"a}chen und technische Infrastrukturen und die damit verbundene Bodenversiegelung beobachten. Dies f{\"u}hrt in erster Linie zum Verlust von landwirtschaftlichen Fl{\"a}chen. Je nach Ausmaß der Bebauung kommt es auch zu einer verst{\"a}rkten Landschaftszerschneidung, die zur Isolierung nat{\"u}rlicher Lebensr{\"a}ume und zur Einschr{\"a}nkung des {\"o}kologischen Verbundes sowie zu weiteren negativen Folgewirkungen f{\"u}hrt. Das OpenSpaceAlps Projekt hat sich dieser Thematik angenommen und, basierend auf kooperativen Verfahren in mehreren Pilotregionen, Handlungsans{\"a}tze und Strategien f{\"u}r eine nachhaltige Sicherung von Freir{\"a}umen entwickelt. Dieses Handbuch stellt eine Handlungs- und Entscheidungshilfe f{\"u}r verschiedene Akteure/Akteurinnen dar, allen voran Planer*innen in {\"o}ffentlichen Planungsbeh{\"o}rden. Ausgehend von einer Analyse der Herausforderungen und Rahmenbedingungen im Alpenraum, werden in diesem Handbuch zentrale „Prinzipien" der Freiraumplanung vorgestellt und verglichen. Außerdem werden integrierte Planungsstrategien f{\"u}r verschiedene Raumkategorien diskutiert.}, subject = {Raumordnung}, language = {de} } @article{BrumbergSchroeterBlazhenetsetal.2020, author = {Brumberg, Joachim and Schr{\"o}ter, Nils and Blazhenets, Ganna and Frings, Lars and Volkmann, Jens and Lapa, Constantin and Jost, Wolfgang H. and Isaias, Ioannis U. and Meyer, Philipp T.}, title = {Differential diagnosis of parkinsonism: a head-to-head comparison of FDG PET and MIBG scintigraphy}, series = {NPJ Parkinsons Disease}, volume = {6}, journal = {NPJ Parkinsons Disease}, doi = {10.1038/s41531-020-00141-y}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-230675}, year = {2020}, abstract = {[\(^{18}\)F]fluorodeoxyglucose (FDG) PET and [\(^{123}\)I]metaiodobenzylguanidine (MIBG) scintigraphy may contribute to the differential diagnosis of neurodegenerative parkinsonism. To identify the superior method, we retrospectively evaluated 54 patients with suspected neurodegenerative parkinsonism, who were referred for FDG PET and MIBG scintigraphy. Two investigators visually assessed FDG PET scans using an ordinal 6-step score for disease-specific patterns of Lewy body diseases (LBD) or atypical parkinsonism (APS) and assigned the latter to the subgroups multiple system atrophy (MSA), progressive supranuclear palsy (PSP), or corticobasal syndrome. Regions-of-interest analysis on anterior planar MIBG images served to calculate the heart-to-mediastinum ratio. Movement disorder specialists blinded to imaging results established clinical follow-up diagnosis by means of guideline-derived case vignettes. Clinical follow-up (1.7 +/- 2.3 years) revealed the following diagnoses: n = 19 LBD (n = 17 Parkinson's disease [PD], n = 1 PD dementia, and n = 1 dementia with Lewy bodies), n = 31 APS (n = 28 MSA, n = 3 PSP), n = 3 non-neurodegenerative parkinsonism; n = 1 patient could not be diagnosed and was excluded. Receiver operating characteristic analyses for discriminating LBD vs. non-LBD revealed a larger area under the curve for FDG PET than for MIBG scintigraphy at statistical trend level for consensus rating (0.82 vs. 0.69, p = 0.06; significant for investigator \#1: 0.83 vs. 0.69, p = 0.04). The analysis of PD vs. MSA showed a similar difference (0.82 vs. 0.69, p = 0.11; rater \#1: 0.83 vs. 0.69, p = 0.07). Albeit the notable differences in diagnostic performance did not attain statistical significance, the authors consider this finding clinically relevant and suggest that FDG PET, which also allows for subgrouping of APS, should be preferred.}, language = {en} } @techreport{MeyerJobLaneretal.2022, author = {Meyer, Constantin and Job, Hubert and Laner, Peter and Omizzolo, Andrea and Kollmann, Nadia and Clare, Jasmin and Vesely, Philipp and Riedler, Walter and Plassmann, Guido and Coronado, Oriana and Praper Gulič, Sergeja and Gulič, Andrej and Koblar, Simon and Teofili, Corrado and Rohringer, Verena and Schoßleitner, Richard and Ainz, Gerhard}, title = {Izhodišča za usklajeno ohranjanje odprtega prostora na območju Alp: Načrtovalski priročnik projekta OpenSpaceAlps}, doi = {10.25972/OPUS-28651}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-286518}, pages = {114}, year = {2022}, abstract = {Na območju Alp že dalj časa poteka preobrazba odprtega prostora zaradi gradnje in širjenja naselij ter tehnične infrastrukture. Navedeni procesi povzročajo zlasti izgubo kmetijskih zemljišč, stalno pokritje površine tal z nepropustnimi snovmi in razdrobljenost krajine. Razdrobljenost je odvisna od vrst posegov in stopnje pozidanosti prostora, poglavitna negativna učinka pa sta izolacija naravnih habitatov in slabšanje ekološke povezljivosti. Opisana problematika je bila glavna tema projekta OpenSpaceAlps, v katerem so bili ob sodelovanju z deležniki na več pilotnih območjih razviti pristopi in rešitve, ki omogočajo trajnostno ohranjanje odprtega prostora. Načrtovalski priročnik povzema del rezultatov projekta. Namenjen je različnim deležnikom, zlasti načrtovalcem v javnih službah, kot pripomoček pri izvajanju načrtovalskih nalog in odločanju. V priročniku so predstavljeni analiza izzivov in okvirnih pogojev v Alpah ter opis in primerjava poglavitnih načel načrtovanja odprtega prostora, obravnavane pa so tudi celostne načrtovalske strategije za različne kategorije prostora.}, subject = {Raumordnung}, language = {mul} } @techreport{MeyerJobLaneretal.2022, author = {Meyer, Constantin and Job, Hubert and Laner, Peter and Omizzolo, Andrea and Kollmann, Nadia and Clare, Jasmin and Vesely, Philipp and Riedler, Walter and Plassmann, Guido and Coronado, Oriana and Praper Gulič, Sergeja and Gulič, Andrej and Koblar, Simon and Teofili, Corrado and Rohringer, Verena and Schoßleitner, Richard and Ainz, Gerhard}, title = {OpenSpaceAlps Planning Handbook: Perspectives for consistent safeguarding of open spaces in the Alpine region}, doi = {10.25972/OPUS-27040}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-270401}, pages = {110}, year = {2022}, abstract = {In the Alpine region, the continuous consumption of open spaces for settlement areas and technical infrastructure and the associated soil sealing can be observed. This leads primarily to the loss of agricultural land. Depending on the extent of development, there is also increased landscape fragmentation, which is associated with the isolation of natural habitats and the restriction of ecological connectivity, as well as other negative consequences. The OpenSpaceAlps project has addressed this issue and, based on cooperative procedures in several pilot regions, has developed approaches and solution strategies for the sustainable safeguarding of open spaces. This handbook supports the activities and decision-making of various stakeholders, first and foremost planners in public planning authorities. Based on an analysis of the challenges and framework conditions in the Alpine region, the handbook presents and compares central "principles" of open space planning. Furthermore, integrated planning strategies for different spatial categories are discussed.}, subject = {Raumordnung}, language = {en} } @techreport{MeyerJobLaneretal.2022, author = {Meyer, Constantin and Job, Hubert and Laner, Peter and Omizzolo, Andrea and Kollmann, Nadia and Clare, Jasmin and Vesely, Philipp and Riedler, Walter and Plassmann, Guido and Coronado, Oriana and Praper Gulič, Sergeja and Gulič, Andrej and Koblar, Simon and Teofili, Corrado and Rohringer, Verena and Schoßleitner, Richard and Ainz, Gerhard}, title = {OpenSpaceAlps - Manuale di Pianificazione: Prospettive per la salvaguardia coerente degli Spazi Aperti nella regione alpina}, doi = {10.25972/OPUS-27704}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-277042}, pages = {114}, year = {2022}, abstract = {Nella regione alpina, si pu{\`o} osservare il continuo consumo di spazi aperti a causa dell'aumento di aree di insediamento e di infrastrutture tecniche e la conseguente impermeabilizzazione del suolo. Questo fenomeno porta principalmente alla perdita di suolo agricolo. A seconda dell'estensione dello sviluppo, si riscontra anche una maggiore frammentazione del paesaggio, che {\`e} associata all'isolamento degli habitat naturali e alla perdita della connettivit{\`a} ecologica, cos{\`i} come ad altre conseguenze negative. Il progetto OpenSpaceAlps ha affrontato questo problema e, sulla base di procedure cooperative partecipate attuate in diverse regioni pilota alpine, ha sviluppato approcci e strategie di soluzione per la salvaguardia sostenibile degli spazi aperti. Questo manuale supporta le attivit{\`a} e il processo decisionale di vari stakeholder, in primo luogo i pianificatori delle autorit{\`a} pubbliche di pianificazione. Sulla base di un'analisi delle sfide e delle condizioni generali nella regione alpina, il manuale presenta e confronta i "principi" centrali della pianificazione degli spazi aperti. Inoltre, vengono discusse strategie di pianificazione integrata per diverse categorie spaziali.}, subject = {Raumordnung}, language = {it} } @article{HartrampfLapaSerflingetal.2021, author = {Hartrampf, Philipp E. and Lapa, Constantin and Serfling, Sebastian E. and Buck, Andreas K. and Seitz, Anna Katharina and Meyer, Philipp T. and Ruf, Juri and Michalski, Kerstin}, title = {Development of Discordant Hypermetabolic Prostate Cancer Lesions in the Course of [\(^{177}\)Lu]PSMA Radioligand Therapy and Their Possible Influence on Patient Outcome}, series = {Cancers}, volume = {13}, journal = {Cancers}, number = {17}, issn = {2072-6694}, doi = {10.3390/cancers13174270}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-245168}, year = {2021}, abstract = {Simple Summary Discordant FDG-positive but PSMA-negative (FDG+/PSMA-) metastases constitute a negative prognostic marker of overall survival in patients undergoing PSMA radioligand therapy (RLT). The aim of this analysis was to investigate the prognostic implications of new FDG+/PSMA- lesions, which occur during or after PSMA RLT. In a retrospective bicentric analysis of 32 patients undergoing PSMA RLT and follow-up dual tracer staging with PSMA and FDG PET/CT, FDG+/PSMA- lesions occurred in a limited number of patients. However, the presence of FDG+/PSMA- lesions appears not to have a significant impact on the OS, but further studies are needed to establish the clinical relevance of such lesions. Abstract Introduction: Positron emission tomography/computer tomography (PET/CT) targeting the prostate-specific membrane antigen (PSMA) is crucial for the assessment of adequate PSMA expression in patients with metastatic castration-resistant prostate cancer (mCRPC) prior to PSMA radioligand therapy (PSMA RLT). Moreover, initial dual tracer staging using combined PSMA and [\(^{18}\)F]fluorodeoxyglucose (FDG) PET/CT provides relevant information, since discordant FDG-positive but PSMA-negative (FDG+/PSMA-) lesions constitute a negative prognostic marker of overall survival (OS) after PSMA RLT. However, little is known about the prognostic implications of dual tracer imaging for restaging at follow-up. The aim of this analysis was to investigate the prognostic implications of new FDG+/PSMA- lesions during or after PSMA RLT. Methods: This bicentric analysis included 32 patients with mCRPC who underwent both FDG and PSMA PET/CT imaging after two or four cycles of PSMA RLT. Patients with FDG+/PSMA- lesions prior to PSMA RLT were not considered. The presence of FDG+/PSMA- lesions was assessed with follow-up dual tracer imaging of patients after two or four cycles of PSMA RLT. Patients with at least one new FDG+/PSMA- lesion were compared to patients without any FDG+/PSMA- lesions at the respective time points. A log-rank analysis was used to assess the difference in OS between subgroups. Results: After two cycles of PSMA RLT, four of 32 patients (13\%) had FDG+/PSMA- metastases. No significant difference in OS was observed (p = 0.807), as compared to patients without FDG+/PSMA- lesions. Follow-up dual tracer imaging after the 4th cycle of PSMA RLT was available in 18 patients. Of these, four patients presented with FDG+/PSMA- findings (n = 2 already after two cycles). After the fourth cycle of PSMA RLT, no significant difference in OS was observed between patients with and without FDG+/PSMA- lesions (p = 0.442). Conclusion: This study shows that FDG+/PSMA- lesions develop in a limited number of patients undergoing PSMA RLT. Further studies are needed to establish the clinical relevance of such lesions.}, language = {en} } @article{MeyerPetersThieletal.2021, author = {Meyer, Constantin and Peters, Jan Christoph and Thiel, Michael and Rathmann, Joachim and Job, Hubert}, title = {Monitoring von Freifl{\"a}cheninanspruchnahme und -versiegelung f{\"u}r eine nachhaltige Raumentwicklung in Bayern}, series = {Raumforschung und Raumordnung}, volume = {79}, journal = {Raumforschung und Raumordnung}, number = {2}, doi = {10.14512/rur.40}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-261622}, pages = {172-189}, year = {2021}, abstract = {Im Freistaat Bayern wird intensiv diskutiert, wie die nach wie vor hohe Freifl{\"a}cheninanspruchnahme f{\"u}r Siedlungs- und Verkehrszwecke reduziert werden kann. Wissenschaftliche Grundlage f{\"u}r Steuerungsans{\"a}tze in der Stadt- und Regionalentwicklung sollte ein verbessertes staatliches Fl{\"a}chenmonitoring sein, welches {\"u}ber die amtliche Statistik und deren Hauptindikator "Siedlungs- und Verkehrsfl{\"a}che" hinaus auch die qualitative Dimension der Fl{\"a}cheninanspruchnahme einbezieht. Daf{\"u}r stellt dieser Beitrag methodische Erweiterungsans{\"a}tze f{\"u}r das Fl{\"a}chenmonitoring vor, welche kleinr{\"a}umige Analysen der Zersiedelung, Freiraumstruktur, Fl{\"a}chenversiegelung und {\"O}kosystemleistungen am Beispiel des Landkreises Rh{\"o}n-Grabfeld aufzeigen. Diese werden im Kontext der Debatte zu Ursachen und Steuerung der Freifl{\"a}cheninanspruchnahme sowie zu aktuellen Anforderungen an das Fl{\"a}chenmonitoring diskutiert. Betont wird deren Bedeutung f{\"u}r das Monitoring rechtlicher Vorgaben und politischer Ziele zur nachhaltigen Fl{\"a}chennutzung.}, language = {de} } @article{JobMeyerCoronadoetal.2022, author = {Job, Hubert and Meyer, Constantin and Coronado, Oriana and Koblar, Simon and Laner, Peter and Omizzolo, Andrea and Plassmann, Guido and Riedler, Walter and Vesely, Philipp and Schindelegger, Arthur}, title = {Open spaces in the European Alps — GIS-based analysis and implications for spatial planning from a transnational perspective}, series = {Land}, volume = {11}, journal = {Land}, number = {9}, issn = {2073-445X}, doi = {10.3390/land11091605}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-288207}, year = {2022}, abstract = {This article presents an open space concept of areas that are kept permanently free from buildings, technical infrastructure, and soil sealing. In the European Alps, space is scarce because of the topography; conflicts often arise between competing land uses such as permanent settlements and commercial activity. However, the presence of open spaces is important for carbon sequestration and the prevention of natural hazards, especially given climate change. A GIS-based analysis was conducted to identify an alpine-wide inventory of large-scale near-natural areas, or simply stated, open spaces. The method used identified the degree of infrastructure development for natural landscape units. Within the Alpine Convention perimeter, near-natural areas (with a degree of infrastructural development of up to 20\%) account for a share of 51.5\%. Only 14.5\% of those areas are highly protected and are mostly located in high altitudes of over 1500 m or 2000 m above sea level. We advocate that the remaining Alpine open spaces must be preserved through the delimitation of more effective protection mechanisms, and green corridors should be safeguarded through spatial planning. To enhance the ecological connectivity of open spaces, there is the need for tailored spatial and sectoral planning strategies to prevent further landscape fragmentation and to coordinate new forms of land use for renewable energy production.}, language = {en} } @article{BrumbergBlazhenetsSchroeteretal.2019, author = {Brumberg, Joachim and Blazhenets, Ganna and Schr{\"o}ter, Nils and Frings, Lars and Jost, Wolfgang H. and Lapa, Constantin and Meyer, Philipp T.}, title = {Imaging cardiac sympathetic innervation with MIBG: linear conversion of the heart-to-mediastinum ratio between different collimators}, series = {EJNMMI Physics}, volume = {6}, journal = {EJNMMI Physics}, doi = {10.1186/s40658-019-0250-2}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-221675}, year = {2019}, abstract = {Background The heart-to-mediastinum (H/M) ratio is a commonly used parameter to measure cardiac I-123 metaiodobenzylguanidine (MIBG) uptake. Since the H/M ratio is substantially influenced by the collimator type, we investigated whether an empirical linear conversion of H/M ratios between camera systems with low-energy (LE) and medium-energy (ME) collimator is possible. Methods We included 18 patients with parkinsonism who were referred to one of the two participating molecular imaging facilities for the evaluation of cardiac sympathetic innervation by MIBG scintigraphy. Two consecutive planar image datasets were acquired with LE and ME collimators at 4 h after MIBG administration. Linear regression analyses were performed to describe the association between the H/M ratios gained with both collimator settings, and the accuracy of a linear transfer of the H/M ratio between collimators and across centers was assessed using a leave-one-out procedure. Results H/M ratios acquired with LE and ME collimators showed a strong linear relationship both within each imaging facility (R\(^2\) = 0.99, p < 0.001 and R\(^2\) = 0.90, p < 0.001) and across centers (H/M-LE = 0.41 × H/M-ME + 0.63, R\(^2\) = 0.97, p < 0.001). A linear conversion of H/M ratios between collimators and across centers was estimated to be very accurate (mean absolute error 0.05 ± 0.04; mean relative absolute error 3.2 ± 2.6\%). Conclusions The present study demonstrates that a simple linear conversion of H/M ratios acquired with different collimators is possible with high accuracy. This should greatly facilitate the exchange of normative data between settings and pooling of data from different institutions.}, language = {en} }