@article{HornburgDrepperButteretal.2014,
  author    = {Hornburg, Daniel and Drepper, Carsten and Butter, Falk and Meissner, Felix and Sendtner, Michael and Mann, Matthias},
  title     = {Deep Proteomic Evaluation of Primary and Cell Line Motoneuron Disease Models Delineates Major Differences in Neuronal Characteristics*},
  series = {Molecular \& Cellular Proteomics : MCP},
  volume    = {13},
  journal   = {Molecular \& Cellular Proteomics : MCP},
  number    = {12},
  issn      = {1535-9484},
  doi       = {10.1074/mcp.M113.037291},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-120954},
  pages     = {3410-20},
  year      = {2014},
  abstract  = {The fatal neurodegenerative disorders amyotrophic lateral sclerosis and spinal muscular atrophy are, respectively, the most common motoneuron disease and genetic cause of infant death. Various in vitro model systems have been established to investigate motoneuron disease mechanisms, in particular immortalized cell lines and primary neurons. Using quantitative mass-spectrometry-based proteomics, we compared the proteomes of primary motoneurons to motoneuron-like cell lines NSC-34 and N2a, as well as to non-neuronal control cells, at a depth of 10,000 proteins. We used this resource to evaluate the suitability of murine in vitro model systems for cell biological and biochemical analysis of motoneuron disease mechanisms. Individual protein and pathway analysis indicated substantial differences between motoneuron-like cell lines and primary motoneurons, especially for proteins involved in differentiation, cytoskeleton, and receptor signaling, whereas common metabolic pathways were more similar. The proteins associated with amyotrophic lateral sclerosis also showed distinct differences between cell lines and primary motoneurons, providing a molecular basis for understanding fundamental alterations between cell lines and neurons with respect to neuronal pathways with relevance for disease mechanisms. Our study provides a proteomics resource for motoneuron research and presents a paradigm of how mass-spectrometry-based proteomics can be used to evaluate disease model systems.},
  language  = {en}
}
@article{GhanawiHennleinZareetal.2021,
  author    = {Ghanawi, Hanaa and Hennlein, Luisa and Zare, Abdolhossein and Bader, Jakob and Salehi, Saeede and Hornburg, Daniel and Ji, Changhe and Sivadasan, Rajeeve and Drepper, Carsten and Meissner, Felix and Mann, Matthias and Jablonka, Sibylle and Briese, Michael and Sendtner, Michael},
  title     = {Loss of full-length hnRNP R isoform impairs DNA damage response in motoneurons by inhibiting Yb1 recruitment to chromatin},
  series = {Nucleic Acids Research},
  volume    = {49},
  journal   = {Nucleic Acids Research},
  number    = {21},
  doi       = {10.1093/nar/gkab1120},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-265687},
  pages     = {12284-12305},
  year      = {2021},
  abstract  = {Neurons critically rely on the functions of RNA-binding proteins to maintain their polarity and resistance to neurotoxic stress. HnRNP R has a diverse range of post-transcriptional regulatory functions and is important for neuronal development by regulating axon growth. Hnrnpr pre-mRNA undergoes alternative splicing giving rise to a full-length protein and a shorter isoform lacking its N-terminal acidic domain. To investigate functions selectively associated with the full-length hnRNP R isoform, we generated a Hnrnpr knockout mouse (Hnrnpr\(^{tm1a/tm1a}\)) in which expression of full-length hnRNP R was abolished while production of the truncated hnRNP R isoform was retained. Motoneurons cultured from Hnrnpr\(^{tm1a/tm1a}\) mice did not show any axonal growth defects but exhibited enhanced accumulation of double-strand breaks and an impaired DNA damage response upon exposure to genotoxic agents. Proteomic analysis of the hnRNP R interactome revealed the multifunctional protein Yb1 as a top interactor. Yb1-depleted motoneurons were defective in DNA damage repair. We show that Yb1 is recruited to chromatin upon DNA damage where it interacts with gamma-H2AX, a mechanism that is dependent on full-length hnRNP R. Our findings thus suggest a novel role of hnRNP R in maintaining genomic integrity and highlight the function of its N-terminal acidic domain in this context.},
  language  = {en}
}
@phdthesis{Mann2017,
  author    = {Mann, Daniel},
  title     = {"The smell of Ujamaa is still there" - Tanzania's Path of Development between Grassroots Socialism and Central State Control in Ruvuma},
  edition   = {1. Auflage},
  publisher = {W{\"u}rzburg University Press},
  address   = {W{\"u}rzburg},
  isbn      = {978-3-95826-066-5 (print)},
  issn      = {0510-9833},
  doi       = {10.25972/WUP-978-3-95826-067-2},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-154079},
  school      = {W{\"u}rzburg University Press},
  pages     = {332},
  year      = {2017},
  abstract  = {In the 1960s, when most African nations gained their independence after the age of colonialism, several theories and strategies emerged with the goal of "developing" these apparently "underdeveloped" territories. One of the most influential approaches for this task was represented in Julius K. Nyerere´s idea of Ujamaa, the Tanzanian version of African socialism. Even before the Arusha Declaration established Ujamaa as a national development strategy in 1967, several groups of politicized young farmers took to the empty countryside of Tanzania to implement their own version of cooperative development. From one of these attempts emerged the Ruvuma Development Association (RDA), which organized up to 18 villages in southwestern Tanzania. The RDA became the inspiration for Nyerere´s concretization of Ujamaa and its implementation on national level. Yet, the central state could not replicate the success of the peasants, which was based on voluntariness and intrinsic motivation. In 2015, this exploratory study has revisited the Region of Ruvuma. Through a case study approach, relying mostly on qualitative methods, new insights into the local history of Ujamaa and its perception have been gathered. In particular, narrative interviews with contemporary witnesses and group interviews with the present-day farmers' groups have been conducted. Furthermore, NGOs active within the region, as well as regional and local government institutions were among the key stakeholders identified to concretize the local narrative of Ujamaa development. All interviews were analyzed according to the principles of qualitative content analysis. Additionally, individual villager questionnaires were used to achieve a more holistic picture of the local perception of development, challenges and the Ujamaa era. None of the original Ujamaa groups of the times of the RDA was still operational at the time of research and no case of village-wide organization of collective agriculture could be observed. Nevertheless, in all of the three case study villages, several farmers' groups (vikundi) were active in organizing development activities for their members. Furthermore, the perception of the Ujamaa era was generally positive throughout all of the case study sites. Yet, there have been significant differences in this perception, based on the village, age, gender and field size of the recipients. Overall, the period of Ujamaa was seen as an inspiration for present-day group activities, and the idea of such activities as a remedy for the developmental challenges of these villages was common among all stakeholders. This thesis concludes that the positive perception of group activities as a vehicle for village development and the perception of Ujamaa history as a positive asset for the inception and organization of farmers' groups would be highly beneficial to further attempts to support such development activities. However, the limitations in market access and capital availability for these highly-motivated group members have to be addressed by public and private development institutions. Otherwise, "the smell of Ujamaa" will be of little use for the progress of these villages.},
  subject      = {Ujamaa-Sozialismus},
  language  = {en}
}
@article{SchwaabBjarnasonWehrensMengetal.2021,
  author    = {Schwaab, Bernhard and Bjarnason-Wehrens, Birna and Meng, Karin and Albus, Christian and Salzwedel, Annett and Schmid, Jean-Paul and Benzer, Werner and Metz, Matthes and Jensen, Katrin and Rauch, Bernhard and B{\"o}nner, Gerd and Brzoska, Patrick and Buhr-Schinner, Heike and Charrier, Albrecht and Cordes, Carsten and D{\"o}rr, Gesine and Eichler, Sarah and Exner, Anne-Kathrin and Fromm, Bernd and Gielen, Stephan and Glatz, Johannes and Gohlke, Helmut and Grilli, Maurizio and Gysan, Detlef and H{\"a}rtel, Ursula and Hahmann, Harry and Herrmann-Lingen, Christoph and Karger, Gabriele and Karoff, Marthin and Kiwus, Ulrich and Knoglinger, Ernst and Krusch, Christian-Wolfgang and Langheim, Eike and Mann, Johannes and Max, Regina and Metzendorf, Maria-Inti and Nebel, Roland and Niebauer, Josef and Predel, Hans-Georg and Preßler, Axel and Razum, Oliver and Reiss, Nils and Saure, Daniel and von Schacky, Clemens and Sch{\"u}tt, Morten and Schultz, Konrad and Skoda, Eva-Maria and Steube, Diethard and Streibelt, Marco and St{\"u}ttgen, Martin and St{\"u}ttgen, Michaela and Teufel, Martin and Tschanz, Hansueli and V{\"o}ller, Heinz and Vogel, Heiner and Westphal, Ronja},
  title     = {Cardiac rehabilitation in German speaking countries of Europe — evidence-based guidelines from Germany, Austria and Switzerland LLKardReha-DACH — part 2},
  series = {Journal of Clinical Medicine},
  volume    = {10},
  journal   = {Journal of Clinical Medicine},
  number    = {14},
  issn      = {2077-0383},
  doi       = {10.3390/jcm10143071},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-242645},
  year      = {2021},
  abstract  = {Background: Scientific guidelines have been developed to update and harmonize exercise based cardiac rehabilitation (ebCR) in German speaking countries. Key recommendations for ebCR indications have recently been published in part 1 of this journal. The present part 2 updates the evidence with respect to contents and delivery of ebCR in clinical practice, focusing on exercise training (ET), psychological interventions (PI), patient education (PE). In addition, special patients' groups and new developments, such as telemedical (Tele) or home-based ebCR, are discussed as well. Methods: Generation of evidence and search of literature have been described in part 1. Results: Well documented evidence confirms the prognostic significance of ET in patients with coronary artery disease. Positive clinical effects of ET are described in patients with congestive heart failure, heart valve surgery or intervention, adults with congenital heart disease, and peripheral arterial disease. Specific recommendations for risk stratification and adequate exercise prescription for continuous-, interval-, and strength training are given in detail. PI when added to ebCR did not show significant positive effects in general. There was a positive trend towards reduction in depressive symptoms for "distress management" and "lifestyle changes". PE is able to increase patients' knowledge and motivation, as well as behavior changes, regarding physical activity, dietary habits, and smoking cessation. The evidence for distinct ebCR programs in special patients' groups is less clear. Studies on Tele-CR predominantly included low-risk patients. Hence, it is questionable, whether clinical results derived from studies in conventional ebCR may be transferred to Tele-CR. Conclusions: ET is the cornerstone of ebCR. Additional PI should be included, adjusted to the needs of the individual patient. PE is able to promote patients self-management, empowerment, and motivation. Diversity-sensitive structures should be established to interact with the needs of special patient groups and gender issues. Tele-CR should be further investigated as a valuable tool to implement ebCR more widely and effectively.},
  language  = {en}
}
@phdthesis{Mann2024,
  author    = {Mann, Daniel},
  title     = {Empowerment bei Krebspatient:innen},
  doi       = {10.25972/OPUS-34752},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-347524},
  school      = {Universit{\"a}t W{\"u}rzburg},
  year      = {2024},
  abstract  = {Die Fragestellung, ob Question-Prompt-Lists (QPLs) interaktionales Empowerment f{\"o}rdern, wurde nach derzeitigem Kenntnisstand noch nicht untersucht. Bei QPLs handelt es sich um kurze Fragensets oder Kernfragen bez{\"u}glich der eigenen Erkrankung oder der Behandlung, die Patient:innen beispielsweise unmittelbar vor einem Aufkl{\"a}rungsgespr{\"a}ch erhalten, um sich aktiv auf dieses vorzubereiten. Der Nutzen einer solchen QPL konnte bereits in zahlreichen Studien belegt werden. Ebenso kommt der Thematik Empowerment bei der Behandlung von Krebspatient:innen eine wichtige Rolle zu: die Betroffenen sollen dahingehend ermutigt und best{\"a}rkt werden, sich aktiv mit der eigenen Erkrankung, deren Folgen und Behandlung auseinanderzusetzen, um so schließlich ein h{\"o}heres Maß an Kontrolle und Lebensqualit{\"a}t zu erlangen. Ziel der Studie war es, den positiven Effekt einer QPL bez{\"u}glich des Empowerments der Teilnehmer:innen aufzuzeigen. Die Fragestellung dieser prospektiv randomisiert kontrollierten Studie war es, ob eine QPL einen signifikanten Effekt auf das Empowerment von Krebspatient:innen haben kann. Die Datenerhebung erfolgte in der Ambulanz f{\"u}r Strahlentherapie des Universit{\"a}tsklinikums W{\"u}rzburgs. Insgesamt konnten 279 Patient:innen in die Studie eingeschlossen werden, 140 Teilnehmer:innen in der Interventionsgruppe und 139 Teilnehmer:innen in der Kontrollgruppe, die nach Randomisierung jeweils ihrer Gruppe zugeteilt wurden. Die Patient:innen der Interventionsgruppe erhielten unmittelbar vor dem Gespr{\"a}ch mit dem behandelnden Arzt/ der behandelnden {\"A}rztin eine QPL, anhand derer sie sich individuelle Fragen als Vorbereitung auf das Aufkl{\"a}rungsgespr{\"a}ch {\"u}berlegen konnten, wohingegen die Teilnehmer:innen der Kontrollgruppe keine solche QPL erhielten. Die aufkl{\"a}renden {\"A}rzte/ {\"A}rztinnen wussten jeweils nicht, welche Patient:innen zuvor eine QPL erhalten hatten. Nach dem Aufkl{\"a}rungsgespr{\"a}ch f{\"u}llten beide Gruppen von Teilnehmer:innen dann einen Fragebogen aus, mit Hilfe dessen nach Addition der einzelnen Fragewerte zu einem Summen-Score das Maß an Empowerment gemessen werden sollte. Hierbei konnte gezeigt werden, dass sich der Mittelwert des Summen-Scores signifikant zwischen der Interventionsgruppe (M=21,7; SE=0,22; SD=2,65) und der Kontrollgruppe (M=20,8; SE=0,26; SD=3,08) bei einem Signifikanzlevel von alpha=0,05 und einer Effektgr{\"o}ße von d=0,29 (r=0,16): t(277)=2,71; p=0,007, 95\% CI [-1,61, -0,26] unterschied. Außerdem konnte beim Vergleich der einzelnen Fragen des Auswertungsbogens selbst bei 4 von 8 Frageitems ein signifikanter Unterschied zwischen Interventionsgruppe und Kontrollgruppe gezeigt werden. Hierbei handelte es sich um Fragen, die den Fokus auf die relationale, also die beziehungsorientierte Komponente des Aufkl{\"a}rungsgespr{\"a}chs legten, im Gegensatz zu den Fragen, die den Fokus auf den reinen Zuwachs von Informationen, also die informative Komponente des Aufkl{\"a}rungsgespr{\"a}chs legten. Somit kann abschließend von einem signifikanten Effekt der Intervention, dem Gebrauch einer QPL, in Bezug auf das Konstrukt Empowerment bei Krebspatient:innen ausgegangen werden. Mit der QPL konnte ein einfaches, gut durchf{\"u}hrbares Instrument in den klinischen Alltag der Strahlenambulanz des Universit{\"a}tsklinikums W{\"u}rzburg implementiert werden, das von einem Großteil der Patient:innen gut angenommen und als hilfreich bewertet wurde.  },
  subject      = {Krebskranker},
  language  = {de}
}